AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
Neovascularization, PathologicAngiogenesis InhibitorsNeovascularization, PhysiologicAngiogenesis Inducing AgentsVascular Endothelial Growth Factor AEndothelial CellsVascular Endothelial Growth FactorsEndothelial Growth FactorsEndothelium, VascularVascular Endothelial Growth Factor Receptor-2LymphokinesAngiogenic ProteinsAngiogenesis Modulating AgentsHuman Umbilical Vein Endothelial CellsCell MovementChorioallantoic MembraneCapillariesFibroblast Growth Factor 2Mice, NudeBlood VesselsAllantoisAntigens, CD31Cell ProliferationReceptors, Vascular Endothelial Growth FactorCorneal NeovascularizationAngiopoietin-2Angiopoietin-1Cells, CulturedIschemiaThrombospondin 1Umbilical VeinsReceptor, TIE-2Signal TransductionCell Line, TumorChorionHindlimbMicrovesselsMice, Inbred C57BLHypoxia-Inducible Factor 1, alpha SubunitNeoplasmsVascular Endothelial Growth Factor Receptor-1ImmunohistochemistryEndostatinsMicrocirculationIntegrin alphaVbeta3Neoplasm TransplantationRetinal NeovascularizationIntercellular Signaling Peptides and ProteinsLamininCell DivisionCarcinoma, Lewis LungDrug CombinationsDisease Models, AnimalWound HealingXenograft Model Antitumor AssaysRNA, MessengerChick EmbryoCyclohexanesAngiostatinsPericytesCollagenTransplantation, HeterologousProteoglycansReceptors, Growth FactorApoptosisReverse Transcriptase Polymerase Chain ReactionCell HypoxiaRetinal VesselsBlotting, WesternGene Expression Regulation, NeoplasticMice, KnockoutMice, Inbred BALB CLymphangiogenesisAngiopoietinsNeoplasms, ExperimentalUp-RegulationReceptor Protein-Tyrosine KinasesMice, SCIDAngiostatic ProteinsCorneaMatrix Metalloproteinase 2Neoplasm InvasivenessTumor Cells, CulturedMatrix Metalloproteinase 9Culture Media, ConditionedNeoplasm MetastasisAntineoplastic AgentsProto-Oncogene Proteins c-aktRNA, Small InterferingThrombospondinsAnoxiaHypoxia-Inducible Factor 1Collagen Type XVIIITime FactorsTransfectionCapillary PermeabilityGenetic TherapySesquiterpenesPhosphorylationMice, Transgenic
Mesenchymal StemApoptosisHypoxia-induced angiogenesisVivoPromising therapeuticNanoparticlesHepatocellular carcinomaProliferationPathological retinalInhibitionProgressionInhibitEndothelial CellsVascularAngiogenicAdiposeMigrationInhibitsEpigeneticBlood-brain bRadiation-inducedPathwaysMetastasisCarcinogenesisXenograftsPhosphorylationDownregulationInhibitorsRegulationTherapeutic agentsExpressionMiceMetabolismFormationNeuronalTumorsAnticancerReplicationStronglyFactorCancerCompoundsAntineoplasticRoleBoneGlucoseOxygenDamageReceptorDiseaseClinicalExperimental
Mesenchymal Stem1
  • In recent years, one of the main research strategies used to induce angiogenesis in vivo has been via stem cell therapy, especially therapy using mesenchymal stem cells (MSCs). (minervamedica.it)
Apoptosis8
  • Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation in NPC xenografts. (scielo.br)
  • Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
  • These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
  • Targets that have been identified as having the potential to improve survival in patients with castration-resistant prostate cancer stem from research in angiogenesis, bone metabolism, immunotherapy, androgen metabolism and receptor regulation, and apoptosis. (cancernetwork.com)
  • By Western blot, this antibody recognizes a 116 kDa protein which corresponds to PARP and the 85 kDa apoptosis-induced cleavage product of prICE and CPP32 from rat thymus extract. (thermofisher.com)
  • These findings indicate that the doenjang attenuated colon carcinogenesis induced by AOM and DSS by ameliorating the symptoms of colon cancer, reducing the occurrence of neoplasia, regulating proinflammatory cytokine levels, and controlling the expressions of inflammation- and apoptosis-related genes in the colonic tissue. (carcinogenesis.com)
  • 5 ], inducing apoptosis through phosphorylation and downregulation of the anti-apoptotic proteins BCL-2 and BCL-XL respectively [ 6 - 9 ]. (oncotarget.com)
  • They went on to state that the silver nanoparticles "exhibited a significant cytotoxic effect on HEp 3B cell lines in vitro through induction of apoptosis and by inhibiting cell proliferation and angiogenesis. (thesilveredge.com)
Hypoxia-induced angiogenesis1
  • The contribution of CXCL12 to hypoxia-induced angiogenesis was examined in vivo using a subcutaneous murine model of neovascularization. (haematologica.org)
Vivo6
  • In addition, the triterpenoid fraction (800 micrograms/mL) inhibited angiogenesis induced by Matrigel (a soluble basement membrane extract of the Engelbreth-Holm-Swam (EHS) tumor) supplemented with vascular endothelial growth factor (VEGF) and heparin in an in vivo model. (nih.gov)
  • Next, we attempted to isolate the active substance(s) using the in vivo assay system of Matrigel-induced angiogenesis. (nih.gov)
  • Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
  • RC-3095, a BBS/GRP antagonist, attenuated BBS-stimulated tumor growth and angiogenesis in vivo. (qxmd.com)
  • All in vitro doses were physiologically relevant and based on in vivo doses that induced significant pulmonary disorders in animal models. (cdc.gov)
  • Impact of the integrated in vivo-in vitro approach also includes that it supports the utility of the in vitro models as rapid screening tools for risk assessment of nanomaterial -induced pathologies. (cdc.gov)
Promising therapeutic1
  • Therefore, improving the angiogenesis of patients has been increasingly recognized as a promising therapeutic strategy for the treatment of ischemic stroke. (hindawi.com)
Nanoparticles5
  • Ginsenoside Rg1 composite nanoparticles were employed to induce the expression of several key epigenetic enzymes and then activate the VEGF and Notch pathways after the onset of ischemic brain lesions. (cbinsights.com)
  • Conclusion: The ginsenoside Rg1 nanoparticles may be an available blood-brain barrier penetrating agent for ischemic stroke. (cbinsights.com)
  • We conclude that MFP induces an increase in vessels during tissue remodeling, favoring the selective accumulation of nanoparticles inside the tumors. (oncotarget.com)
  • Researchers noted significant cancer cell death, and found that the silver nanoparticles induced cell death in a dose-dependent manner, i.e., the higher the dose, the greater the toxic effect on the cancer cells. (thesilveredge.com)
  • Cellular self-destruction began after 24 hours of incubation with silver nanoparticles, which "induced nucleosomal DNA fragmentation of Hep3B cells," causing cell death. (thesilveredge.com)
Hepatocellular carcinoma1
  • Chronic hepatitis B virus (HBV) carriers may develop hepatocellular carcinoma (HCC) by a wide range of mechanisms including angiogenesis. (akjournals.com)
Proliferation3
  • It has potential as an anticancer agent targeting deregulated tumor cell proliferation as well as angiogenic parameters. (wikipedia.org)
  • Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
  • The objective of this study was to evaluate clinical and microscopic features of squamous cell carcinomas using immunohistochemical analysis and assessing biological markers of angiogenesis and tumor vascular activity (anti-CD31, anti-CD34, Factor VIII), cell proliferation (Ki-67), and loss of cell suppression (p53). (bvsalud.org)
Pathological retinal1
  • This study demonstrated that overexpression of miR-203 suppressed the angiogenesis in mice with pathological retinal neovascularization disease via the inactivation of GSK-3 β / β -catenin pathway by inhibiting SNAI2. (hindawi.com)
Inhibition3
  • This suggested that the antitumor and antimetastatic activities of the triterpenoid fraction of G. lucidum might be due to the inhibition of tumor-induced angiogenesis. (nih.gov)
  • Results: Enterostatin induced a 50% or greater inhibition in the angiogenic response of human fat cells and had a U-shaped bimodal dose-response effect in inhibiting angiogenesis in a human placental vein angiogenesis model. (fao.org)
  • The AMPK activator 5-aminoimidazole-4-carboximide ribonucleoside (AICAR) induced VEGF-A expression.Summary: These data suggest that enterostatin has an antiangiogenic effect and suggest that it regulates VEGF-A gene expression through inhibition of AMPK activity. (fao.org)
Progression3
  • For restoring the blood supply, the progression of the angiogenesis will undergo when the body suffered insufficient blood supply [ 4 ]. (hindawi.com)
  • Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis. (haematologica.org)
  • Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)
Inhibit3
  • The results showed that miR-429 was significantly upregulated in the serums of the patients, and overexpressed miR-429 could extremely inhibit the viability, migration, and tube formation of OGD-induced HBMECs. (hindawi.com)
  • It has shown that miR-429 could inhibit the development of colorectal cancer via targeting in large tumor suppressor kinase (LATS2), and decreased miR-429 could promote the expression of SRY-box transcription factor 2 (SOX2) and B-cell lymphoma 2 (BCL2) to attenuate the neuronal injury induced by accumulation of amyloid β -protein [ 12 ]. (hindawi.com)
  • There is evidence that at the clinically relevant doses, itraconazole has potent anti-angiogenic activity, and that it can inhibit the Hedgehog signalling pathway and may also induce autophagic growth arrest. (ecancer.org)
Endothelial Cells2
  • SNAI2, an angiogenesis-related factor, was highly expressed under the high glucose condition and also led to viability and migration of human brain microvascular endothelial cells (HBMECs) [ 13 ]. (hindawi.com)
  • 7 Besides, new vascular endothelial cells can release a variety of cytokines to nourish nerve cells and induce neurogenesis, and communication between nerves could also be repaired. (cbinsights.com)
Vascular3
  • Stroke is an acute cerebrovascular disease induced by the sudden rupture of blood vessels or vascular obstruction, which seriously threaten the health of millions of people all over the world in each year [ 1 , 2 ]. (hindawi.com)
  • One of these agents, sunitinib, is an orally administered tyrosine kinase inhibitor with multiple targets, including vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR)-α, and PDGFR-β. (biomedcentral.com)
  • 8 Vascular endothelial growth factor and Notch signaling pathway have a crucial role in brain angiogenesis. (cbinsights.com)
Angiogenic4
  • However, the use of MSCs in angiogenesis has also been limited due to the low angiogenic potency of MSCs. (minervamedica.it)
  • However, clinical experience with anti-angiogenic agents has shown that this is not always the case. (nature.com)
  • We show that HBV replication induces the expression of angiogenic proteins interleukin 6 (IL6) and cyclooxygenase-2 (Cox2). (akjournals.com)
  • Method: To investigate this hypothesis, we studied the effect of enterostatin as an antiangiogenic agent in two angiogenic tissue culture model systems. (fao.org)
Adipose1
  • Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
Migration1
  • 6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)
Inhibits2
  • It also inhibits VEGF-induced angiogenesis in a murine implant model. (wikipedia.org)
  • In conclusion, this study suggests that miR-429 inhibits the angiogenesis of HBMECs through SNAI2-mediated GSK-3 β / β -catenin pathway. (hindawi.com)
Epigenetic1
  • 4. Induces epigenetic alterations usual y arises as the cell attempts to repair the DNA damage. (who.int)
Blood-brain b1
  • The expression of angiogenesis markers and blood-brain barrier hyperpermeability was markedly reduced after L-dopa-ropinirole cotreatment compared with L-dopa monotreatment. (lu.se)
Radiation-induced2
  • We present a computational model for calculating the yield of radiation-induced chromosomal aberrations in human cells based on a stochastic Monte Carlo approach and calibrated using the relative frequencies and distributions of chromosomal aberrations reported in the literature. (bioone.org)
  • Characteristics of radiation-induced meningiomas include an average latent period of 36-38 years for patients who were exposed to low-dose radiation to the head, whereas patients who develop meningiomas after exposure to high-dose radiation may show signs as early as 5 years postradiation. (medscape.com)
Pathways2
  • Weis, S. M. & Cheresh, D. A. Tumor angiogenesis: molecular pathways and therapeutic targets. (nature.com)
  • Despite efforts to develop novel therapeutic anticancer agents to block specific signaling pathways, chemotherapy is still the gold standard for advanced breast cancer treatment. (oncotarget.com)
Metastasis1
  • Some agents may also reduce angiogenesis, and metastasis. (medscape.com)
Carcinogenesis2
  • The inhibitory effects of the doenjang prepared with the grain-type meju using mixed starter cultures were investigated in azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colon carcinogenesis mice model. (carcinogenesis.com)
  • AOM and DSS colon carcinogenesis was induced in female C57BL/6 mice, and doenjang was orally administered for 4 weeks. (carcinogenesis.com)
Xenografts1
  • We sought to determine the effects of BBS on the growth of neuroblastoma xenografts and on angiogenesis. (qxmd.com)
Phosphorylation2
  • In cells, growth factor-induced EGFR and ErbB2 phosphorylation was also efficiently inhibited with IC50s of 11 and 220 nM, respectively. (wikipedia.org)
  • It efficiently inhibited growth factor-induced EGFR and ErbB2 phosphorylation in tumors for >72 h, a phenomenon correlating with the antitumor efficacy of intermittent treatment schedules. (wikipedia.org)
Downregulation1
Inhibitors1
Regulation2
  • Moreover, the Targetscan, dual-luciferase reporter assay, and Western blot were used to reveal the downstream target and regulation mechanism of miR-429 in OGD-induced HBMECs. (hindawi.com)
  • 3-MA pretreatment counteracted the cytokine regulation induced by flavopiridol. (researchsquare.com)
Therapeutic agents2
  • The success of inorganic nanomaterial-based therapeutic agents depends on the degree to which these nanostructures satisfy general requirements for drug safety regarding biocompatibility, biodegradability, and stability and on their antitumor efficacy. (infim.ro)
  • Importantly, these findings suggest that novel therapeutic agents, targeting BBS-mediated angiogenesis, may be useful adjuncts in patients with advanced-stage neuroblastomas. (qxmd.com)
Expression2
  • Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
  • Striatal expression of ∆FosB and angiogenesis markers were studied immunohistochemically. (lu.se)
Mice2
  • Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
  • In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
Metabolism1
  • 14 , 15 HIF-1 and HIF-2 mediate adaptive responses to hypoxia by inducing the transcription of genes associated with erythropoiesis, glycolytic metabolism, cell survival and angiogenesis. (haematologica.org)
Formation1
  • Since copper is indispensable for the formation of new blood vessels, angiogenesis, a different antitumor approach based on the administration of copper sequestering agents has been attempted and its effectiveness is currently under evaluation by clinical trials. (gla.ac.uk)
Neuronal1
  • These agents stabilize the neuronal membrane so the neuron is less permeable to ions. (medscape.com)
Tumors1
  • MFP induced tissue remodeling in PRA-overexpressing tumors, increasing the stromal/tumor cell ratio and the number of functional vessels. (oncotarget.com)
Anticancer1
  • The proven essentiality of copper for angiogenesis, together with the marked sensitivity shown by several cancer cell lines to the copper toxicity, open a new perspective in the anticancer strategy: exploiting the tumor need of copper to accumulate toxic amount of the metal inside its cells. (gla.ac.uk)
Replication3
  • Interestingly, ibuprofen (a Cox2 inhibitor) is found to attenuate the levels of IL6 and Cox 2 which are induced by HBV replication. (akjournals.com)
  • Taken together, our findings provide new insights on the angiogenesis induced by HBV replication. (akjournals.com)
  • The classic examples of necessarily be processed by the cel replication fidelity can confer strong chemical agents that require met- into a mutation (see Chapter 12, by mutator phenotypes that result in ge- abolic activation to become carci- DeMarini). (who.int)
Strongly1
  • It is well established that angiogenesis is strongly associated with improvement of neurological deficits after stroke [ 3 , 4 ]. (hindawi.com)
Factor1
  • Furthermore, it was found that SNAI2 was a downstream factor of miR-429, and SNAI2 could rescue the effects of miR-429 on OGD-induced HBMECs. (hindawi.com)
Cancer4
  • Given the evidence presented, a case is made that itraconazole warrants further clinical investigation as an anti- cancer agent. (ecancer.org)
  • Since the current gold standard for approval of drugs in castration-resistant prostate cancer is based on overall survival, prospective evaluation of these types of markers as a surrogate for survival is clearly needed, particularly with the plethora of new agents. (cancernetwork.com)
  • Several new agents have recently been approved or are soon to be approved by the FDA for the treatment of cancer. (worthingtoncaron.com)
  • [1] These agents are very interesting compounds, and further research is needed to determine their precise role in the treatment of cancer. (worthingtoncaron.com)
Compounds1
  • Evidences are rising about the ability of some copper compounds to induce alternative non-apoptotic form of programmed cell death. (gla.ac.uk)
Antineoplastic1
Role4
  • BACKGROUND: Angiogenesis plays an important role in tissue repair. (minervamedica.it)
  • This study is aimed at revealing the role of miR-429 in the angiogenesis of HBMECs. (hindawi.com)
  • The study has indicated that the angiogenesis play an important role in the repair of cerebral ischemia, which may prevent the patients away from stroke [ 5 ]. (hindawi.com)
  • Studies from our laboratory suggest a role for the CXCL12 chemokine in this process, with circulating levels of CXCL12 correlating with bone marrow angiogenesis in patients with multiple myeloma. (haematologica.org)
Bone1
  • New imaging studies using positron emission tomography (PET) along with novel tracers such as F-18 choline, 2-[18F]-fluoro-2-deoxy-D-glucose, and [18F]-dihydrotestosterone also are demonstrating promise as imaging agents in bone. (cancernetwork.com)
Glucose1
  • To further understand this response, we tested enterostatin's effect in a human hepatoma cell line (HepG2 cells) that was subjected to glucose deprivation, a condition known to induce angiogenesis in other tumor cell lines. (fao.org)
Oxygen2
  • 5 The damaged brain tissue could be restored by angiogenesis, which provides oxygen and nutrients to improve recovery in the penumbra area, 6 and allows macrophages to clear necrotic nerve cells or tissues. (cbinsights.com)
  • A therapeutic intervention for PAD is to induce angiogenesis, the growth of new microvessels, to improve blood flow and oxygen delivery. (jhu.edu)
Damage2
  • Examples of direct-acting elec- all have an impact on the outcome trophilic carcinogens are formalde- The term "genotoxic" refers to an of this proces s (Arana and Kunkel, hyde, sulfur mustard, and ethylene agent that induces DNA damage, 2010) . (who.int)
  • Thus, carcinogens nogenic are polycyclic aromatic hy- to induce DNA damage, it can be may act not only by producing DNA drocarbons and benzene, which by cal ed a genotoxicant or a genotox- damage directly but also by altering themselves are relatively inert chem- in, and if it is shown that the agent the processes that control normal ical y. (who.int)
Receptor1
  • This information, together with reported properties of the enterostatin receptor, suggested that enterostatin may have an effect on angiogenesis. (fao.org)
Disease1
  • 3] On April 28, 2011, abiraterone, a 17,20 lyase inhibitor that can induce the near total abrogation of testosterone, was approved for patients with chemoresistant disease. (cancernetwork.com)
Clinical1
  • Recently, several new targeted agents were introduced in the clinical treatment of metastatic RCC. (biomedcentral.com)
Experimental1
  • The agents documented and list- ed that carcinogens commonly show tween tumour sites in humans and ed as carcinogenic to humans one or more of 10 key characteristics experimental animals. (who.int)