AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Angina PectorisAngina, StableNifedipineAngina, UnstableNitroglycerinChronic DiseaseExercise TestAcetanilidesAngina Pectoris, VariantIsosorbide DinitrateDouble-Blind MethodAtenololCoronary AngiographyCounterpulsationCalcium Channel BlockersCardiovascular AgentsCoronary Artery DiseaseMyocardial InfarctionCoronary DiseaseElectrocardiographyMyocardial IschemiaAdrenergic beta-AntagonistsNeopterinElectrocardiography, AmbulatoryAngioplasty, Balloon, CoronaryBenzazepinesCoronary VesselsVasodilator AgentsProspective StudiesHeart RateTreatment OutcomeBiological MarkersC-Reactive ProteinMicrovascular AnginaDrug Therapy, CombinationCoronary VasospasmLudwig's AnginaFollow-Up StudiesAtherectomy, CoronaryRisk FactorsAdministration, CutaneousAcute Coronary SyndromeTime FactorsPrognosisBlood PressureVerapamilDiltiazemMyocardial RevascularizationErgonovineClinical Trials as TopicChest PainCoronary Artery BypassMetoprololDelayed-Action PreparationsPlaque, AtheroscleroticCoronary StenosisUltrasonography, InterventionalNatriuretic Peptide, BrainTrimetazidineCoronary CirculationNicorandilPlatelet Aggregation InhibitorsStentsHeart FailureExercise ToleranceAngioscopyCoronary ThrombosisPredictive Value of TestsRupture, SpontaneousRecurrenceAspirinTroponin TSyndromePercutaneous Coronary InterventionSeverity of Illness IndexHemodynamicsBisoprololDose-Response Relationship, DrugCardiac CatheterizationCollateral CirculationDihydropyridinesCalciumPhysical ExertionCoronary RestenosisFractional Flow Reserve, MyocardialAcute DiseaseCross-Over StudiesPropranololHeartRisk AssessmentMultivariate AnalysisCalcium Channels, L-TypeNicardipineHypertensionRetrospective Studies
PectorisVasospastic anginaUnstable anginaHypertensionChest painPrinzmetal'sReduces arterial pressureSpasmRaynaud'sExertionCalciumProcardiaVariant anginaMyocardial oxygen demandIschemiaAdalatArterialSymptomaticOccursCardiacPharmacokineticsSymptoms of anginaDescription of anginaVascularAntianginalClassical anginaAcute anginaDiagnosisPulmonaryOrallyMyocardiumNitroglycerinReductionLiverDosesPrecipitateDysfunctionCapsulesHigh Blood PrPalpitationsOralFrequencyTabletsRecurrentHeartTreatmentAtherosclerosis
Pectoris26
Vasospastic angina5
  • Nifedipine is indicated for the management of vasospastic angina confirmed by any of the following criteria: 1) classical pattern of angina at rest accompanied by ST segment elevation, 2) angina or coronary artery spasm provoked by ergonovine, or 3) angiographically demonstrated coronary artery spasm. (rxlist.com)
  • In those patients who have had angiography , the presence of significant fixed obstructive disease is not incompatible with the diagnosis of vasospastic angina, provided that the above criteria are satisfied. (rxlist.com)
  • However, they cannot detect potential abnormalities in the small arteries, and the doctor may ask for more tests in order to rule out other heart conditions, such as Prinzmetal's angina (variant/vasospastic angina, coronary artery spasm) which has similar symptoms. (wikipedia.org)
  • For the management of vasospastic angina, chronic stable angina and hypertension. (pharmacycode.com)
  • ➡️ Vasospastic Angina - This type of chest pain occurs when the coronary artery delivering oxygenated blood to the heart suddenly becomes narrow because of the spasm. (healthstatus.com)
Unstable angina7
  • Nifedipine of rapid release is contraindicated in unstable angina and in case of having suffered a myocardial infarction in the last 4 weeks. (activeingredients.online)
  • Unlike stable or unstable angina, no pathological plaque or deposition is present within the coronary arteries that elicits the presentation. (medscape.com)
  • Unstable angina - is characterized by sudden pain that doesn't go away on its own or respond to rest or medication. (rxharun.com)
  • This is a specific form of unstable angina that can occur at any time (no trigger event causes it to happen). (rxharun.com)
  • Stable angina is less serious than unstable angina, but it can be very painful or uncomfortable. (rxharun.com)
  • Most deaths occur due to MI in unstable angina. (howmed.net)
  • Stable angina may change into unstable angina due to rupture of atherosclerotic plaque releasing fatty acids, fatty cells, etc. (howmed.net)
Hypertension2
  • Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. (pharmacycode.com)
  • He had history of hypertension, atrial fibrillation with slow ventricular response, angina, abdominal aortic aneurysm, and stage 3 chronic kidney disease. (sch.ac.kr)
Chest pain10
Prinzmetal's3
  • This property increases myocardial oxygen delivery in patients with coronary artery spasm,and is responsible for the effectiveness of nifedipine in vasospastic (Prinzmetal's or variant) angina. (nih.gov)
  • Abnormal cardiac stress test: ST changes are typically similar to those of coronary artery disease, and the opposite of those of Prinzmetal's angina. (wikipedia.org)
  • An angiogram with acetylcholine can demonstrate microvascular dysfunction which can affect the microvessels and larger coronary arteries leading to either microvascular angina or coronary artery spasms (Prinzmetal's angina). (wikipedia.org)
Reduces arterial pressure1
  • Nifedipine regularly reduces arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing the total peripheral resistance (afterload) against which the heart works. (nih.gov)
Spasm5
  • Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. (nih.gov)
  • This suggests that, in general, relief of spasm or dilation of coronary arteries is not an important factor in classical angina. (nih.gov)
  • Esophageal spasm There is no specific known cause for microvascular angina but rather a multitude of risk factors that act together. (wikipedia.org)
  • By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure. (pharmacycode.com)
  • Variant angina - is caused by a spasm in a coronary artery, causing it to temporarily narrow. (rxharun.com)
Raynaud's2
Exertion2
  • Nifedipine may also be used where the clinical presentation suggests a possible vasospastic component but where vasospasm has not been confirmed, e.g., where pain has a variable threshold on exertion or when angina is refractory to nitrates and/or adequate doses of beta blockers . (rxlist.com)
  • Because myocardial oxygen demand is determined mainly by heart rate, systolic wall tension, and contractility, narrowing of a coronary artery typically results in angina that occurs during exertion and is relieved by rest. (msdmanuals.com)
Calcium7
  • Nifedipine is an antianginal drug belonging to a class of pharmacological agents, the calcium channel blockers. (nih.gov)
  • Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. (nih.gov)
  • Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without changing serum calcium concentrations. (nih.gov)
  • Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. (nih.gov)
  • The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
  • Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. (pharmacycode.com)
  • In the in-vitro studies, research shows that felodipine has a higher selectivity than other commonly used dihydropyridine calcium channel blockers like amlodipine and nifedipine for vascular tissue in comparison to cardiac tissue. (statpearls.com)
Procardia3
Variant angina2
  • This is a distinct diagnosis from variant angina. (wikipedia.org)
  • Prinzmetal angina or variant angina occurs as a result of transient coronary artery spasms. (medscape.com)
Myocardial oxygen demand1
  • If angina is not relieved, unmet myocardial oxygen demand increases further, making MI more likely. (rxharun.com)
Ischemia7
  • In stable angina, the relationship between workload or demand and ischemia is usually relatively predictable. (msdmanuals.com)
  • 1 Another description of angina states that it is a "discomfort in the chest or adjacent areas caused by myocardial ischemia. (rxharun.com)
  • These increases may be the cause of rest angina or the result of ischemia induced by plaque rupture and thrombus formation. (rxharun.com)
  • If chronic heart disease occurs, some collaterals do develop in ischemia. (howmed.net)
  • 10. Sasayama S, Nonogi H , Asanoi H, Yamanishi K, Kawai C: Effects of nifedipine on pacing-induced ischemia:modification of regional myocardial function and coronary hemodynamics. (fiercecert.com)
  • 11. Sasayama S, Asanoi H, Kameyama T, Nonogi H , Kawai C: The mechanism of improvement of pacing-induced ischemia by nifedipine in patients with coronary artery disease. (fiercecert.com)
  • 15. Nakamura Y, Sasayama S, Nonogi H , Miyazaki S, Fujita M, Kihara Y, Konishi T, Kawai C: Effects of pacing-induced ischemia on early left ventricular filling and regional myocardial dynamics and their modification by nifedipine. (fiercecert.com)
Adalat1
  • The Adalat Gastrointestinal Therapeutic System (GITS) is a technology that allows nifedipine a sustained release over a 24 hour period.The antihypertensive efficacy and safety profile of the Adalat GITS formulation has been demonstrated in large-scale, randomized, clinical trials. (vyal.co)
Arterial3
  • The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and the resulting reduction in peripheral vascular resistance. (nih.gov)
  • Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. (nih.gov)
  • Thus, more people have angina in the morning, when arterial tone is relatively high. (msdmanuals.com)
Symptomatic2
  • Nifedipine is indicated for the management of chronic stable angina (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta blockers and/or organic nitrates or who cannot tolerate those agents. (rxlist.com)
  • This is unusual and may have episodes of symptomatic angina with it. (howmed.net)
Occurs1
  • Angina decubitus - Is angina that occurs spontaneously during rest. (rxharun.com)
Cardiac3
  • Controlled studies in small numbers of patients suggest concomitant use of nifedipine and beta-blocking agents may be beneficial in patients with chronic stable angina, but available information is not sufficient to predict with confidence the effects of concurrent treatment, especially in patients with compromised left ventricular function or cardiac conduction abnormalities. (rxlist.com)
  • Cardiac MRI can be used to diagnose microvascular angina. (wikipedia.org)
  • Patient will demonstrate stable cardiac rhythm and rate within patient's normal range. (affordablenursingessays.com)
Pharmacokinetics2
  • Since hepatic biotransformation is the predominant route for the disposition of nifedipine, the pharmacokinetics may be altered in patients with chronic liver disease. (nih.gov)
  • A slight alteration of the pharmacokinetics of nifedipine may be seen in the elderly therefore caution advised. (medscape.co.uk)
Symptoms of angina2
  • If there is no improvement in symptoms of angina within 3 months after start of treatment, treatment of ivabradine should be discontinued. (medicines.org.uk)
  • Symptoms of angina occur when the coronary arteries are narrowed or blocked by atherosclerosis or by a blood clot. (rxharun.com)
Description of angina1
  • [ 1 ] The first description of angina as a medical disorder came from William Heberden. (medscape.com)
Vascular1
  • Angina - what is it and is there a way to deal with vascular lesions? (vsebolezni.com)
Antianginal1
  • Angina (Antianginal) cardiovascular related symptoms - Nitrate drugs such as Nitroglycerin, Nitrostat, Nitrolingual, Isosorbide dinitrate, Imdur, Rectiv, Nitro-Time, and Nitronal as well as Ranexa (Ranolazine) are not approved by the FAA. (leftseat.com)
Classical angina2
  • Whether this effect plays any role in classical angina is not clear, but studies of exercise tolerance have not shown an increase in the maximum exercise rate-pressure product, a widely accepted measure of oxygen utilization. (nih.gov)
  • It is also known as exercise induced angina or angina of effort (classical angina). (howmed.net)
Acute angina2
  • For rapid effect in acute angina or hypertensive crisis, capsules can be bitten into and liquid can be swallowed. (medscape.co.uk)
  • If the discomfort appears to be acute angina, physicians will stabilize the patient and send them along 1 of 4 treatment paths. (atrainceu.com)
Diagnosis2
  • Microvascular angina is a diagnosis of exclusion. (wikipedia.org)
  • Microvascular angina can be diagnosed using different tests and exams, but it is mainly a diagnosis of exclusion. (wikipedia.org)
Pulmonary1
Orally1
  • There is little difference in relative bioavailability when nifedipine capsules are given orally and either swallowed whole, bitten and swallowed, or bitten and held sublingually. (nih.gov)
Myocardium1
  • 8. Nonogi H , Sasayama S, Miyazaki S, Asanoi H, Yamanishi K, Kawai C, Eiho S, Kuwahara M: Modification of pacing-induced alterations in diastolic properties of the regional myocardium by nifedipine in patients with coronary artery disease. (fiercecert.com)
Nitroglycerin1
Reduction1
  • The objectives in chronic heart failure (CHF) treatment are relief of symptoms, reduction of hospital admissions, halt of disease progress, prolongation of survival and modification of endogenous pathophysiological processes. (docksci.com)
Liver2
  • Patients with hepatic impairment (liver cirrhosis) have a longer disposition half-life and higher bioavailability of nifedipine than healthy volunteers. (nih.gov)
  • Nifedipine is metabolised primarily in the liver. (medscape.co.uk)
Doses1
  • All doses had been stable for several months. (sapub.org)
Precipitate1
  • A decreased oxygen supply, as in severe anemia or hypoxia, can precipitate or aggravate angina. (msdmanuals.com)
Dysfunction4
  • While there is no formal definition of microvascular angina, the general consensus is that it entails all of the following: Angina: This usually does not cause dysfunction on echocardiogram and can last longer than that of heart disease. (wikipedia.org)
  • There is growing evidence that microvascular angina is caused by a functional disorder of the microvessels, coronary microvascular dysfunction. (wikipedia.org)
  • Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is ≥ 75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated. (medicines.org.uk)
  • Areas covered: This article reviews the outpatient pharmacological management of chronic HF due to left ventricular systolic dysfunction and offers recommendations on the use of various drugs. (docksci.com)
Capsules1
  • Nifedipine capsules are formulated as soft gelatin capsules for oral administration each containing 10 mg nifedipine. (nih.gov)
High Blood Pr2
Palpitations1
  • She denied angina, dyspnea, palpitations or infectious symptoms. (sapub.org)
Oral3
  • Nifedipine is rapidly and fully absorbed after oral administration. (nih.gov)
  • Each extended-release tablet, formulated as a once-a-day controlled release tablet for oral administration, delivers 30 or 60 mg of nifedipine. (nih.gov)
  • The elimination half-life of oral CARDATEN is approximately 6 to 7 hours and there is no alteration of the kinetic profile of the drug by chronic administration. (sgpharma.com)
Frequency3
  • In chronic stable angina (effort-associated angina) nifedipine has been effective in controlled trials of up to eight weeks duration in reducing angina frequency and increasing exercise tolerance, but confirmation of sustained effectiveness and evaluation of long-term safety in these patients are incomplete. (rxlist.com)
  • is clinically worsening angina (eg, angina at rest or with increasing frequency and/or intensity of episodes). (msdmanuals.com)
  • With the progression of angina duration, severity and frequency increases. (vsebolezni.com)
Tablets1
  • Nifedipine Extended-release Tablets meet USP Dissolution Test 3. (nih.gov)
Recurrent1
  • Nocturnal angina may also be a sign of recurrent LV failure, an equivalent of nocturnal dyspnea. (rxharun.com)
Heart10
Treatment6
  • The foundation for treating all forms of CAD is the basic treatment plan for stable angina. (atrainceu.com)
  • The disease is known as angina, the symptoms and treatment of which we will explore in more detail. (vsebolezni.com)
  • Stable angina, the main symptoms and treatment of which we will describe below, is divided into four functional classes. (vsebolezni.com)
  • Once your blood pressure is stable, you'll need yearly checks up to make sure your blood pressure is still responding to treatment. (zavamed.com)
  • If person is only suffering from this type of angina, the treatment is different. (howmed.net)
  • Imatinib, marketed by Novartis as Gleevec (U.S.) or Glivec (Europe/Australia/Latin America), and sometimes referred to by its investigational name STI-571, is a tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). (keralapharmacist.com)
Atherosclerosis1
  • In such cases, angina can result whether atherosclerosis is present or not. (msdmanuals.com)