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  • fetus
  • This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA in the maternal blood. (clinicaltrials.gov)
  • heterogeneous
  • the potential therapeutic strategy towards these heterogeneous aneuploidy populations with high adaptability, a root for the clinical challenge in treating aneuploidy diseases such as cancer. (ku.edu)
  • Short-term exposure to Hsp90 stress, which produced an aneuploidy population with heterogeneous karyotypes, potentiated fast adaptation to unrelated cyto-toxic compounds through different aneuploid chromosome stoichiometries. (ku.edu)
  • We designed an evolutionary trap to harness the adaptability of heterogeneous aneuploidy populations with high adaptability. (ku.edu)
  • Maternal Age
  • Taranissi M, El-Toukhy T, Gorgy A, Verlinsky Y. Influence of maternal age on the outcome of PGD for aneuploidy in patients with recurrent implantation failure. (springer.com)
  • diseases
  • Such scaling explains the challenge of treating aneuploidy diseases with diverse different karyotypes by imposing a single mode of inhibition, yet specific karyotype features can be highly targetable. (ku.edu)
  • abnormality
  • Cytogenetic analysis is recommended even if the typical features of a recognized aneuploidy are present so that any associated abnormality may be detected. (biomedsearch.com)
  • severe
  • Whereas polyploidy is reasonably well tolerated on both the cellular and organismal level, aneuploidy is not, with the condition frequently being associated with death and severe developmental abnormalities in all organisms analyzed to date ( 1 ). (aacrjournals.org)
  • In cases in which aneuploidy is observed system-wide, the degree of aneuploidy is limited to only one additional chromosome and the consequences for the individual are severe. (aacrjournals.org)