• Andrographolide is a labdane diterpenoid that has been isolated from the stem and leaves of Andrographis paniculata. (wikipedia.org)
  • While andrographolide is a relatively simple diterpene lactone, the biosynthesis by Andrographis paniculata was determined in the 2010s. (wikipedia.org)
  • Given that the TLC of Andrographis paniculata extracts showed that andrographolide was present in all the three Andrographis paniculata extracts, it was concluded that the observed antimicrobial activity was due to other active principle(s) present in the extracts used in this investigation. (scialert.net)
  • The bioactive component of andrographolide in Andrographis paniculata (Kalmegh) was quantified using HPLC. (icar.gov.in)
  • Andrographolide (AGP), the major phytoconstituent isolated from Andrographis paniculata was found to exhibit growth inhibition and cytotoxicity against the hormone-independent (PC-3 and DU-145) and hormone-dependent (LNCaP) prostate cancer cell lines via the microculture tetrazolium (MTT) assay. (upm.edu.my)
  • Quantification of Andrographolide in Andrographis paniculata (Burm.f. (phcogj.com)
  • Home / Pharmacogn J, Vol 13, Issue 6, Nov-Dec, 2021 / Quantification of Andrographolide in Andrographis paniculata (Burm.f. (phcogj.com)
  • Andrographolide, myricetin, and brazilin are bioactive compounds from Andrographis paniculata , Syzygium cumini, and Caesalpinia sappan plants that have potential as medicinal ingredients. (phcogj.com)
  • Andrographolide (Andro), a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, is known to possess potent anti-inflammatory activity. (elsevierpure.com)
  • The patent, 'Treatment of Alzheimer's and Cognitive Impairment with Andrographolides,' describes how Andrographolide (ANDRO), a labdane diterpene and a major component of Andrographis paniculata (NeuroActin) was found to prevent and reverse neuropathology and stimulate neurogenesis. (nutraceuticalsworld.com)
  • NeuroActin is an Andrographis paniculata extract standardized to contain not less than about 50% (w/w) andrographolide, 14-deoxyandrographolide, neoandrographolide and a combination thereof. (nutraceuticalsworld.com)
  • One major constituent of andrographis, andrographolide, helps modulate certain undesirable responses. (theherbsplace.com)
  • Andrographolide, the main active substance in the Asian plant Andrographis paniculata , boosts testosterone levels and improves sexual performance . (ergo-log.com)
  • This is because andrographolide, probably the most important bioactive substance in Andrographis paniculata , is amazingly versatile. (ergo-log.com)
  • Analyses show that gross extracts of Andrographis paniculata only contain several percent of andrographolides. (ergo-log.com)
  • The strongest Andrographis paniculata extract that we know contains about 50 percent andrographolides. (ergo-log.com)
  • Andrographolide, a major active component from Andrographis paniculata , has shown to possess anti-inflammatory activity. (naturalproductsinsider.com)
  • Recent scientific research has indicated that the active constituents in Andrographis, known as andrographolides may help to support a healthy and balanced immune system response. (frysfood.com)
  • The purpose of this study was to determine the effect of andrographolide in aberrantly activated Notch signaling in SW-480 cells in vitro. (notchgene.com)
  • An increase in sexual activity is likely to be linked to a raised testosterone level, so the researchers set up an animal study in which they examined specifically the effect of andrographolide on the testosterone level. (ergo-log.com)
  • Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells. (upm.edu.my)
  • Furthermore, we conducted Annexin V-FITC/PI apoptosis assay and Western blotting to determine whether andrographolide has an impact on the death pattern of RSV-infected cells. (researchsquare.com)
  • These results suggested that andrographolide might attenuate RSV-induced inflammation by suppressing apoptosis and promoting pyroptosis of infected epithelial cells and thus inducing effective viral clearance. (researchsquare.com)
  • Hepatoprotective efficacy of A. paniculata and its major diterpenoid lactone, andrographolide, was studied in CCl4 -induced hepatotoxicity in rats comparing with glycyrrhizin. (chula.ac.th)
  • Objectives: To determine the levels of andrographolide in A. paniculata herb extract (APE), myricetin in S. cumini leaf extract (SCE), and brazilin in C. sappan wood extract (CSE) as marker compounds for extract quality control using the HPLC method. (phcogj.com)
  • Andrographolide (Andro, a clinical-available anti-inflammation phytochemical agent) could inhibit different types of cancer including HCC, but the molecular mechanisms involved are yet unclear. (authorea.com)
  • In doing so, Andrographolide induces post-synaptic proteins and synaptic function, improves memory and spatial learning in APP Alzheimer model mice, and stimulates neurogenesis. (nutraceuticalsworld.com)
  • Patent co-inventor Nibaldo Inestrosa stated, 'We found that Andrographolide activates Wnt signaling and inhibits GSK-3b. (nutraceuticalsworld.com)
  • Background: Andrographolide and its benzylidene derivatives, SRJ09 and SRJ23, potentially bind oncogenic K-Ras to exert anticancer activity. (upm.edu.my)
  • Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF-κB axis. (physiciansweekly.com)
  • Kalmegh has antioxidant features of andrographolide. (cowurine.com)
  • Study has shown that andrographolide may bind to a spectrum of protein targets including NF-κB and actin by covalent modification. (wikipedia.org)
  • Then, using online databases, we discovered 25 potential targets of andrographolide in the treatment of RSV-infected airway epithelial cells. (researchsquare.com)
  • While our specific in vitro experiments entail markers for Alzheimer's disease, our research indicates a much broader potential for Andrographolide to treat other forms of cognitive impairment. (nutraceuticalsworld.com)
  • In-vitro experiments on blood vessels showed that andrographolide had a widening effect on these. (ergo-log.com)
  • They gave male mice an oral dose of 50 mg andrographolide and put them in a cage with sexually receptive females. (ergo-log.com)
  • The researchers recorded when and how often the male mice mounted the females, and discovered that andrographolide had a greater sex stimulatory effect than sildenafil two hours after intake at least. (ergo-log.com)
  • The study lasted eight weeks, and after the mice had been given 50 mg andrographolide every day for two weeks their testosterone levels had not changed. (ergo-log.com)
  • The Thai researchers gave their mice 50 mg andrographolide per kg bodyweight. (ergo-log.com)
  • Andrographolide sulfonate reduces mortality in Enterovirus 71 infected mice by modulating immunity. (bvsalud.org)
  • Herein, in this study we quantified RSV virus load, IL-6 and IL-8 in A549 cell supernatant, and found andrographolide decreased the viral load and attenuated RSV-induced inflammation. (researchsquare.com)
  • However, despite the wide clinical application of andrographolide in viral infection, there are few relevant research focusing on its effects and mechanism on RSV infection so far. (researchsquare.com)
  • The green chiretta contains Andrographolides which are effective in inhibiting viral replication, and also has anti-inflammatory qualities. (aap.com.au)
  • Thin Layer Chromatography (TLC) analysis was used to authenticate the AP extracts as judged by the detection of andrographolide (AND). (scialert.net)
  • This method can be used for the identification and quantification of andrographolide, myricetin, and brazilin in herbal raw materials or herbal products containing these three extracts. (phcogj.com)
  • Interestingly, RSV infection decreased the protein levels of caspase-1, cleaved caspase-1, cleaved IL-1β, N terminal of GSDMD and Bcl-2, while andrographolide elevated them. (researchsquare.com)
  • In our research, we have found that andrographolide reduces neuro-inflammation, protects against neuron cell loss, reduces amyloid-beta peptide levels and prevent the breakdown of the tau protein,' explained patent co-inventor Dr. Juan Hancke. (nutraceuticalsworld.com)
  • Our formula is standardized for the active components, including andrographolide, that deliver these benefits. (puritan.com)
  • MTT assay showed a dose and time dependent cytoxicity of andrographolide on SW-480 cells. (notchgene.com)
  • Andrographolide is an extremely bitter substance. (wikipedia.org)
  • Andrographolide prevents tau hyperphosphorylation and significantly reduces the amyloid deposits in the brain," stated Dr. Hancke. (nutraceuticalsworld.com)
  • and 0,3% acetic acid - acetonitrile (85.5: 14.5 v/v) as mobile phase with flow rate 1 mL/min for andrographolide, myricetin, and brazilin determination, respectively and detection using UV detector at a wavelength of 254 nm, 369 nm, and 280 nm, respectively. (phcogj.com)
  • Researchers think that andrographolide and its natural and synthetic analogues are interesting candidates for medicines against diseases such as asthma, diabetes, stroke or arthritis, and can help inhibit inflammation, tumours and viruses. (ergo-log.com)
  • andrographolide (AND) have been reported to be effective in the treatment of dysentery, diarrhoea and upper respiratory tract infection (Gupta et al . (scialert.net)
  • Andrographolide has been found efficacious in various virus infections, however, its effects on RSV infection remains unknown. (researchsquare.com)
  • We verified the mRNA expression change of the potential target genes, which showed that andrographolide noticeably suppressed the increase of CASP1, CCL5, JAK2 and STAT1 post RSV infection. (researchsquare.com)
  • IL-1β, which is downstream of CASP1, was also up-regulated after RSV infection and down-regulated by andrographolide. (researchsquare.com)
  • This presents a significant breakdown as it shows the potential of Andrographolide to induce generation of newborn neurons, increases density of immature neurons, increases percentage of the granular cell layer and more complex morphology. (nutraceuticalsworld.com)
  • Andrographolide has been studied for its effects on cell signaling, immunomodulation, and stroke. (wikipedia.org)
  • Delivers a high level of andrographolides (40 mg)-the key component that has been researched for effectiveness. (europharmausa.com)
  • Andrographolide is a member of the isoprenoid family of natural products. (wikipedia.org)
  • Members contain andrographolide and other DITERPENES and androechin, a CHALCONE. (bvsalud.org)
  • Andrographolide plus intracellular ROS and induced G0 / G1 phase cell cycle arrest in SW480 colon cancer cells. (notchgene.com)
  • In 2015 alone, Inestrosa and Hancke had published a total of three research papers about Andrographolide and Alzheimers.The latest research titled "Andrographolide Stimulates Neurogenesis in the Adult Hippocampus" was published on Neural Plasticity in December 2015. (nutraceuticalsworld.com)
  • The biosynthesis of andrographolide begins with the addition of IPP to DMAPP, which forms geranyl pyrophosphate. (wikipedia.org)