Androgen deprivation sensitizes prostate cancer. Medical search. Frequent questions

Androgen receptor (AR) targeting is an important therapeutic strategy for treating prostate cancer. (tmu.edu.tw)
They act by blocking the androgen receptor (AR) and/or inhibiting or suppressing androgen production. (wikipedia.org)
They can be thought of as the functional opposites of AR agonists, for instance androgens and anabolic steroids (AAS) like testosterone, DHT, and nandrolone and selective androgen receptor modulators (SARMs) like enobosarm. (wikipedia.org)
Tumors that recur after this treatment are highly aggressive and able to expand in conditions of low circulating androgens by one of several mechanisms, including aberrancies in androgen receptor expression or signaling, and upregulation of enzymes that control intratumoral androgen synthesis. (oncotarget.com)
Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of androgen receptor. (bcgsc.ca)
One mechanism underlying CRPC and resistance to hormonal therapies is the expression of constitutively active splice variant(s) of androgen receptor (AR-Vs) that lack its C-terminus ligand-binding domain. (bcgsc.ca)
Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants. (bcgsc.ca)
Blocking androgen receptor (AR) transcriptional activity by androgen deprivation therapy (ADT) improves the response to radiotherapy for intermediate and high risk prostate cancer. (bcgsc.ca)
Synergistic effects of Obatoclax with androgen receptor inactivation can be observed. (oncotarget.com)
Altogether, our results suggest that MCL1 is a key molecule deciding over the fate of PCa cells upon inactivation of androgen receptor signaling. (oncotarget.com)
Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer. (cam.ac.uk)
UNLABELLED: Inhibiting the androgen receptor (AR), a ligand-activated transcription factor, with androgen deprivation therapy is a standard-of-care treatment for metastatic prostate cancer. (cam.ac.uk)
Currently, no therapeutic options exist for castration-resistant prostate cancer (CRPC) patients who have developed resistance to the second generation anti-androgen receptor (AR) axis therapy. (umn.edu)
We propose to exploit PTEN-null, androgen receptor-positive hormone therapy-resistant prostate cancer models to evaluate the therapeutic effect of the EZH2 inhibitor plus docetaxel on the growth of hormone-refractory tumors at the preclinic level (in mice). (elsevierpure.com)
Intrinsic activation of receptors or activation of androgen receptor (AR) coregulatory molecules ( e.g . (aacrjournals.org)
The authors wrote in the background that co-inhibition of the androgen receptor (AR) and PARP might result in enhanced benefit with the potential to extend efficacy of PARP inhibitors to tumours regardless of HRR gene alterations. (esmo.org)
Vav3 enhances androgen receptor (AR) activity during progression to androgen independence in prostate cancer. (biomedcentral.com)
The androgen receptor (AR) is definitely a member of the nuclear receptor superfamily that regulates ligand-dependent gene transcription [2]. (opioid-receptors.com)

LIU and COLLEAGUES, Department of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA researched at the molecular level, the inhibition of prostate cancer by selenium. (positivehealth.com)
This study exploited a potent synthetic androgen, methyltestosterone (MeT), to investigate AR agonist-induced growth inhibition. (cam.ac.uk)
Accordingly, inhibition of autophagy with CQ sensitizes cancer cells to apoptosis upon 2-DG challenge. (umn.edu)
Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death. (ucdenver.edu)
Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts. (ucdenver.edu)
A correlation was seen among bortezomib dose, proteasome inhibition, and positive modulation of serum prostate-specific antigen. (aacrjournals.org)
Abiraterone Acetate (ABT), the first compound through the inhibition of adrenal gland production of testosterone, increases the overall survival in Castrate-Resistant Prostate Cancer (CRPC) patients. (ijpsonline.com)

Migration and invasion of human prostate cancer cells is related to expression of VEGF and its receptors. (ucdenver.edu)

Most tumors progress to castration-resistant prostate cancer (CRPC) and develop the neuroendocrine (NE) phenotype under androgen deprivation therapy (ADT). (tmu.edu.tw)
The most common methods of androgen deprivation therapy currently employed to treat prostate cancer are castration (with a GnRH modulator or orchiectomy), nonsteroidal antiandrogens, and the androgen synthesis inhibitor abiraterone acetate. (wikipedia.org)
When castration is combined with a nonsteroidal antiandrogen like bicalutamide, this strategy is referred to as combined androgen blockade (also known as complete or maximal androgen blockade). (wikipedia.org)
Enzalutamide, apalutamide, and abiraterone acetate are specifically approved for use in combination with castration to treat castration-resistant prostate cancer. (wikipedia.org)
Monotherapy with the nonsteroidal antiandrogen bicalutamide is also used in the treatment of prostate cancer as an alternative to castration with comparable effectiveness but with a different and potentially advantageous side effect profile. (wikipedia.org)
Oncotarget published " Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer " which reported that Glucuronidation controls androgen levels in the prostate and the dysregulation of enzymes in this pathway is associated with castration resistant prostate cancer. (oncotarget.com)
Castration resistant recurrence following androgen deprivation therapy is a major cause of mortality in men with advanced prostate cancer. (oncotarget.com)
Therapies for lethal castration-resistant prostate cancer (CRPC) are an unmet medical need. (bcgsc.ca)
The results from a phase II trial of sipuleucel-T with or without radium-223 in patients with metastatic castration-resistant prostate cancer were recently published with intriguing findings. (nature.com)
Randomized phase II trial of sipuleucel-T with or without radium-223 in men with bone-metastatic castration-resistant prostate cancer. (nature.com)
Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. (nature.com)
Sipuleucel-T immunotherapy for castration-resistant prostate cancer. (nature.com)
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. (nature.com)
Final analysis of the ipilimumab versus placebo following radiotherapy phase III trial in postdocetaxel metastatic castration-resistant prostate cancer identifies an excess of long-term survivors. (nature.com)
A systematic review of the emerging role of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: will combination strategies improve efficacy? (nature.com)
The BH3-mimetic Obatoclax induces apoptosis and decreases MCL1 expression in androgen-sensitive PCa cells, while castration-resistant PCa cells are less sensitive and react with an upregulation of MCL1 expression. (oncotarget.com)
Findings from this study will fundamentally advance our understanding of the biological significance of the functional connection between PTEN loss and activation of EZH2 in prostate cancer development and castration-resistant progression. (elsevierpure.com)
Currently, most men with advanced prostate cancer develop castration-resistant prostate cancer(CRPC) [6]. (asmepress.com)
Base of the skull metastases in metastatic castration-resistant prostate cancer. (ucdenver.edu)
The results from the primary analysis of the all-comers population in the phase III TALAPRO-2 study support the consideration of the novel combination of talazoparib plus enzalutamide versus a standard of care, enzalutamide, as a first-line treatment option in patients with metastatic castration-resistant prostate cancer (mCRPC). (esmo.org)
There is a need for improved therapeutic approaches for patients with advanced metastatic castration-resistant prostate cancer (mCRPC), whilst on the other extreme, there is a need to accurately identify clinically significant prostate cancer in individuals presenting with elevated PSA levels or inconclusive MRI results. (pcf.org)
Therapy targeting Vav3 in combination with docetaxel may have practical implications for managing castration-resistant prostate cancer. (biomedcentral.com)
Metastatic Castration-Resistant Prostate (MCRP) cancer is a major category of malignance, which is one of the most common cancers in the United States and the second most common cause of cancer death among men. (ijpsonline.com)

Patients with stage III prostate cancer are curable and have a number of treatment options, including external beam radiation therapy (EBRT) with or without hormone therapy, surgical removal of the cancer with radical prostatectomy, or active surveillance without immediate treatment. (texasoncology.com)
The current standard treatment for stage III prostate cancer is external beam radiation therapy (EBRT) in conjunction with long-term androgen deprivation therapy (ADT). (texasoncology.com)
Treatment with surgery or radiation is referred to as local therapy because they treat prostate cancer in or near the prostate only. (texasoncology.com)
In accordance, therapeutic modalities that reduce androgen signaling in the prostate gland, referred to collectively as androgen deprivation therapy, are able to significantly slow the course of prostate cancer and extend life in men with the disease. (wikipedia.org)
Although antiandrogens are effective in slowing the progression of prostate cancer, they are not generally curative, and with time, the disease adapts and androgen deprivation therapy eventually becomes ineffective. (wikipedia.org)
Randomized phase II trial of sipuleucel-T immunotherapy preceded by sensitizing radiation therapy and sipuleucel-T alone in patients with metastatic castrate resistant prostate cancer. (nature.com)
As a soluble, zinc-coordinated homotrimeric protein, it has emerged as a promising candidate for cancer therapy through its capacity to trigger apoptosis in many types of cancers without causing significant toxicity to normal cells [ 7 , 8 ]. (biomedcentral.com)
Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. (oncotarget.com)
Androgen deprivation therapy (ADT) is a first-line therapy for locally advanced and metastatic prostate cancer (PCa). (oncotarget.com)
Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy. (themednet.org)
Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial. (themednet.org)
Androgen suppression plus radiation versus radiation alone for patients with stage D1/pathologic node-positive adenocarcinoma of the prostate: updated results based on national prospective randomized trial Radiation Therapy Oncology Group 85-31. (themednet.org)
Addition of radiation therapy to androgen ablation improves outcome for subclinically node-positive prostate cancer. (themednet.org)
Neoadjuvant Chemoradiation Therapy Followed by Extrafascial Hysterectomy in Locally Advanced Type II Endometrial Cancer Clinically Extending to Cervix. (themednet.org)
ATLAS: randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer. (themednet.org)
Here we report that co-deletion of Pten and p53 in murine prostate epithelium, often observed in human CRPC, leads to AR-independent CRPC and thus confers de novo resistance to second generation androgen deprivation therapy (ADT) in multiple independent yet complementary preclinical mouse models. (umn.edu)
At present, androgen deprivation therapy (ADT) is the mainstay of treatment for advanced/disseminated prostate cancer. (elsevierpure.com)
In contrast, an oncogene termed EZH2 has been shown to be frequently overexpressed in human prostate cancers, especially in hormone therapy-resistant cancers. (elsevierpure.com)
Although both PTEN and EZH2 are highly implicated in prostate cancer, PTEN-EZH2 functional interaction and the roles of these proteins in prostate cancer pathogenesis and hormonal therapy resistance are incompletely understood. (elsevierpure.com)
Finally, we showed that treatment of therapy-resistant prostate cancer cells with the small molecule (chemical) inhibitor of EZH2 largely sensitizes therapy-resistant cells to be killed by docetaxel, a Food and Drug Administration (FDA)-approved chemotherapeutic agent that is currently in clinic use. (elsevierpure.com)
Management of the side effects of androgen deprivation therapy in men with prostate cancer. (ucdenver.edu)
Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma. (ucdenver.edu)
Current role of neoadjuvant and adjuvant systemic therapy for high-risk localized prostate cancer. (ucdenver.edu)
High-risk localized prostate cancer: primary surgery and adjuvant therapy. (ucdenver.edu)
Radiation therapy with concomitant hydroxyurea and fluorouracil in stage II and III head and neck cancer. (uchicago.edu)
Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. (uchicago.edu)
Gene therapy of cancer. (uchicago.edu)
Androgen ablation and chemotherapy provide effective palliation for most patients with advanced prostate cancer, but eventually progressing androgen-independent prostate cancer threatens the lives of patients usually within a few years, mandating improvement in therapy. (aacrjournals.org)
However, androgen-independent cells are eventually selected during androgen ablation therapy (4) , and progression to an androgen-independent state remains the primary cause of mortality in these patients within an average of 1.5 years. (aacrjournals.org)
Most prostate cancers are initially dependent on androgens for growth, and patients with prostate cancer receive hormonal therapy. (biomedcentral.com)
AR signalling is also critical to the initiation and progression of PCa and androgen-deprivation therapy remains the most common treatment [2-4]. (opioid-receptors.com)
The therapy for metastatic prostate cancer involves suppressing testosterone production through androgen deprivation therapy. (ijpsonline.com)
You may also receive palliative treatments similar to those meant to get rid of the cancer, such as chemotherapy, surgery, or radiation therapy. (prostateprohelp.com)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)

Given that 2-DG is recommended for phase II clinical trials for prostate cancer and CQ has been clinically used as an anti-malaria drug for many decades, the preclinical results from our proof-of-principle studies in vivo are imminently translatable to clinical trials to evaluate the therapeutic efficacy by the combination modality for a subset of currently incurable CRPC harboring PTEN and TP53 mutations. (umn.edu)
Overall, the new knowledge derived from the current study will lay the foundation for development of new therapeutic strategies that may improve the clinical outcome of hormone-refractory prostate cancer patients with deregulated PTEN and EZH2 pathways. (elsevierpure.com)
As the most important cancer vaccine based on monocytes, it is the only prostate cancer therapeutic vaccine approved by the US Food and Drug Administration at present, which plays an extremely important role in the immunotherapy of prostate cancer. (asmepress.com)
Pembrolizumab has become an important therapeutic tool for prostate cancer immunotherapy [7, 8]. (asmepress.com)
Lipid catabolism via CPT1 as a therapeutic target for prostate cancer. (ucdenver.edu)
Thus, it is vital to improve the current therapeutic strategies for CRC and find novel treatments to eradicate cancer stem cells. (researchsquare.com)
Therefore, much attention has been focused on the evolution from androgen-dependent to androgen-independent prostate cancer, and the establishment of novel therapeutic strategies against hormone-refractory prostate cancer (HRPC) is desirable. (biomedcentral.com)
Therefore, understanding the pathogenesis of cancer, identifying biomarkers that aid in the early diagnosis of digestive tract tumors, and finding therapeutic targets are of great significance in reducing the incidence of digestive tract tumors and improving prognosis. (ijbs.com)
Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)

however, knockdown of ZBTB46 sensitizes the PTGS1 inhibitor and reduces tumor malignancy. (tmu.edu.tw)
ZBTB46 is inversely correlated with SPDEF and is increased in higher tumor grades and small-cell NE prostate cancer (SCNC) patients, which are positively associated with PTGS1. (tmu.edu.tw)
The tumor has extended outside of the prostate on one side. (texasoncology.com)
The tumor has extended outside of the prostate on both sides. (texasoncology.com)
In contrast, mechanism-driven co-targeting hexokinase 2 (HK2)-mediated Warburg effect with 2-deoxyglucose (2-DG) and ULK1-dependent autophagy with chloroquine (CQ) selectively kills cancer cells through intrinsic apoptosis to cause tumor regression in xenograft, leads to a near-complete tumor suppression and remarkably extends survival in Pten. (umn.edu)
A tumor suppression gene called PTEN is one of the most frequently mutated or deleted tumor inhibitory genes in human prostate cancers. (elsevierpure.com)
In the past decades, immunotherapy has been used to treat prostate cancer through anti-tumor effects driven by immune response. (asmepress.com)
Cancer vaccines use tumor cell-associated antigens to induce a specific anti-tumor immune response that is durable and robust. (asmepress.com)
Prostate acid phosphatase (PAP) is expressed in approximately 95% of prostate cancers and is mainly limited to prostate tissue, which is a target for prostate cancer tumor vaccine development. (asmepress.com)
The active components of Sipuleucel-T are autologous APCs and PAP-GM-CSF, in addition to T cells, B cells, natural killer cells, and other cells that specifically bind to PAP expressed in prostate cancer tissue to kill tumor cells. (asmepress.com)
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. (ucdenver.edu)
Bortezomib has been studied extensively in vitro and in vivo , and anticancer activity has been seen in cell and animal models for several solid tumor types, including prostate cancer. (aacrjournals.org)
i.e ., radiation or chemotherapy) provide temporary palliation, but eventually prostate cancer cells become resistant to chemotherapy and radiation, with ensuing failure to control tumor growth. (aacrjournals.org)
In addition, loss of tumor suppressor activity or proapoptotic factors can contribute to androgen-independent growth (8) and has been reviewed (9) . (aacrjournals.org)
If successful, this project will improve understanding of tumor visibility by Micro-Ultrasound, and result in a 3-minute prostate scan and urine sample test that identifies patients at risk for prostate cancer and improves decisions on whether patients should undergo prostate biopsy or not. (pcf.org)

NF-kappaB and AP-1 transcriptional factors contribute to the development and progression of prostate malignancy by regulating the expression of genes involved in proliferation, apoptosis, angiogenesis, and metastasis. (positivehealth.com)
The above studies shows how Vitamin E succinate interacts in different ways with the complex array of genes involved in the development and progression of prostate cancer - genes involved in proliferation, apoptosis, angiogenesia and metastasis. (positivehealth.com)
Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells. (ucdenver.edu)
A number of studies have revealed that the Nanog is a biomarker of CSCs, regulating cancer progression [12], as well as playing an important role in proliferation, apoptosis, differentiation, and stress response in CSCs in many cancers such as cervical, breast, and bladder cancers [12-16]. (researchsquare.com)
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. (biomedcentral.com)
Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. (biomedcentral.com)
The abundance of literature suggests that targeting apoptosis in cancer is feasible. (biomedcentral.com)
Hence, apoptosis plays an important role in both carcinogenesis and cancer treatment. (biomedcentral.com)
This article gives a comprehensive review of apoptosis, its mechanisms, how defects along the apoptotic pathway contribute to carcinogenesis and how apoptosis can be used as a vehicle of targeted treatment in cancer. (biomedcentral.com)

Despite the prostate cancer being treated locally with radiation or surgery, over half of patients will experience recurrence of their cancer. (texasoncology.com)
Despite effective local treatment over half of patients will experience recurrence of their cancer. (texasoncology.com)
Together they can be used to predict an individual's risk of prostate cancer recurrence. (texasoncology.com)
There are a significant proportion of organ-confined prostate cancers that have been 'successfully' treated experience disease recurrence and metastasize to other organs. (elsevierpure.com)
Background: Colorectal cancer (CRC) is the third most common cancer in the world known for its poor recurrence-free prognosis. (researchsquare.com)
Colorectal cancer (CRC) is one of the most common malignant neoplasms with poor prognosis and high frequency of recurrence[1], accounting for 600,000 mortalities per year worldwide. (researchsquare.com)

This includes the use of Gonadotropin-releasing hormone (Luteinizing-hormone releasing hormone) agonists and antagonists suppressing the production of testosterone, and non-steroidal anti-androgens (e.g. (oncotarget.com)

VES supplementation also decreases the expression of anti-apoptotic XIAP and Bcl-X(L) proteins and sensitizes androgen-dependent LNCaP cells to androgen deprivation. (positivehealth.com)
All pairs showed changes in UGDH and associated enzymes and metabolites that were consistent with those these authors found in an isogenic androgen dependent and CR LNCaP prostate cancer model. (oncotarget.com)
Importantly, the knockdown of UGDH in both LNCaP AD and CR cells dramatically sensitized these cells to enzalutamide. (oncotarget.com)

After completing 6 cycles of docetaxel plus ADT for metastatic hormone-sensitive prostate cancer per CHAARTED, are there clinical scenarios in which you would add an additional AR targeted agent (ex: enzalutamide, abiraterone, or apalutamide) to ADT? (themednet.org)
The other RCTs for metastatic hormone-sensitive prostate cancer (mHSPC) included STAMPEDE- abiraterone, LATITUDE- abiraterone, STAMPEDE-docetaxel, CHAARTED-docetaxel.GETUG-AFU-15(docetaxel) did not detect a difference in survival from the early use of docetaxel. (prostatecancer.news)

Interestingly, every prostate-cancer study with survival as the endpoint has found that most patients die of causes other than prostate cancer, mostly cardiovascular disease. (medscape.com)
Alpha emitter radium-223 and survival in metastatic prostate cancer. (nature.com)
Impact of adjuvant radiotherapy on survival of patients with node-positive prostate cancer. (themednet.org)
Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. (uchicago.edu)
Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. (uchicago.edu)
Studies with bortezomib (VELCADE, formerly known as PS-341) and other proteasome inhibitors indicate that cancer cells are especially dependent on the proteasome for survival, and several mechanisms used by prostate cancer cells require proteasome function. (aacrjournals.org)
Androgen ablation remains the main initial treatment of advanced prostate cancer and provides palliation of symptoms and survival benefit. (aacrjournals.org)
The progression of prostate cancer from the androgen-dependent to androgen-independent state is the main obstacle in improving the survival and quality of life in patients with advanced prostate cancer. (biomedcentral.com)
The full results will tell us how much the prostate radiation adds, and the effect on overall survival. (prostatecancer.news)
If prostate cancer is diagnosed at an early stage, the chances of survival are generally good. (prostateprohelp.com)
According to global cancer statistics in 2020, the 5-year survival rate for pancreatic cancer is less than 10%, while the 5-year survival rate for esophageal and liver cancer is less than 20%, indicating an abysmal prognosis [ 4 ]. (ijbs.com)

Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. (positivehealth.com)
The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gastric, colorectal, liver, and pancreatic cancers). (ijbs.com)

Adjuvant androgen deprivation for high-risk prostate cancer after radical prostatectomy: SWOG S9921 study. (ucdenver.edu)
Phase III Intergroup Trial of Adjuvant Androgen Deprivation With or Without Mitoxantrone Plus Prednisone in Patients With High-Risk Prostate Cancer After Radical Prostatectomy: SWOG S9921. (ucdenver.edu)
Man With Locally Advanced, High-Risk Prostate Cancer Asks About Adding Chemotherapy to His Treatment. (ucdenver.edu)

In 2020, prostate cancer remains the most common malignancy among men worldwide. (asmepress.com)

These include AR antagonists, androgen synthesis inhibitors, and antigonadotropins. (wikipedia.org)
AR antagonists work by directly blocking the effects of androgens, while androgen synthesis inhibitors and antigonadotropins work by lowering androgen levels. (wikipedia.org)
Alterations in homologous recombination repair (HRR) genes, including BRCA1/2 , found in approximately one-quarter of patients with advanced prostate cancer, can sensitise patients to treatment with PARP inhibitors. (esmo.org)
Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)

In 2021, digestive system cancers were also the most common cancer type in the United States, accounting for 25% of all new cancer cases [ 2 ]. (ijbs.com)

Abiraterone acetate is an androgen biosynthesis inhibitor used in the treatment of prostate cancer. (ijpsonline.com)
This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)

They randomized newly diagnosed metastatic men to either prostate radiation or abiraterone or standard-of-care (SOC). (prostatecancer.news)

Selenium has been reported to inhibit the growth of prostate cancer cells in vitro. (positivehealth.com)
Paradoxically, activation of AR can also inhibit the growth of prostate cancer in some patients and experimental systems, but the mechanisms underlying this phenomenon are poorly understood. (cam.ac.uk)

Here we set out to analyze whether MCL1, a known mediator of chemotherapy resistance regulates the cellular response to androgen withdrawal. (oncotarget.com)
Neoadjuvant radiotherapy with or without chemotherapy followed by extrafascial hysterectomy for locally advanced endometrial cancer clinically extending to the cervix or parametria. (themednet.org)
Neoadjuvant and adjuvant hormonal and chemotherapy for prostate cancer. (ucdenver.edu)
Androgen depletion/repletion in combination with chemotherapy: strategy for secondary treatment of metastatic prostatic cancer. (ucdenver.edu)
Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease. (uchicago.edu)
Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer. (uchicago.edu)
Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer. (uchicago.edu)
Nanog plays key role in maintaining CSC status and evasive resistance to conventional chemotherapy in bladder cancer stem cells and lung cancer stem cells [18, 19]. (researchsquare.com)
This Phase I trial and preclinical studies support additional testing of bortezomib in combination with radiation or chemotherapy for androgen-independent prostate cancer. (aacrjournals.org)
The most common chemotherapy drug for prostate cancer is docetaxel , which is usually given with prednisone, a steroid medicine. (prostateprohelp.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)

Prostate cancer is one of the most common malignant tumors of the urinary system. (asmepress.com)
In recent years, immunotherapy to activate anti-cancer host immune cells to kill tumors has become a new area of research for the treatment of prostate cancer. (asmepress.com)
As an important component of immunotherapy, cancer vaccines have a unique position in the precise treatment of malignant tumors. (asmepress.com)
Recent studies have shown that cancer stem cells (CSCs), which are present in many tumors, are a subset of cancer cells with the ability to self-renew. (researchsquare.com)
Recently, emerging evidences have demonstrated that Nanog is expressed in a variety of cancer cell lines and tissues, and is associated with aggressive tumors [10, 11]. (researchsquare.com)

The class II PI3K isoform PI3K-C2β was downregulated in prostate cancer PC3 cells and cervical cancer HeLa cells using selective siRNAs and the effect on cell growth was determined in the absence or presence of the microtubule-stabilizing agent/anti-cancer drug docetaxel. (biomedcentral.com)
Stable and transient PI3K-C2β downregulation potentiates the effect of low concentrations of docetaxel on cancer cell growth. (biomedcentral.com)
Furthermore, data indicate that blockade of PI3K-C2β might represent a novel strategy to potentiate the effect of docetaxel on cancer cell growth. (biomedcentral.com)
Randomized, double-blinded phase II evaluation of docetaxel with or without doxercalciferol in patients with metastatic, androgen-independent prostate cancer. (ucdenver.edu)
prostate radiation reduced mortality by about a quarter in men who got docetaxel, but it was not statistically significant. (prostatecancer.news)

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. (wikipedia.org)
Androgens like testosterone and particularly DHT are importantly involved in the development and progression of prostate cancer. (wikipedia.org)

Several mechanisms have been proposed to account for the development of androgen independence in prostate cancer cells (4) . (aacrjournals.org)

These include the clinical stage of the cancer, the prostate-specific antigen (PSA) level, and the appearance of the prostate cancer cells under the microscope (the Gleason score). (texasoncology.com)
High Gleason scores and lower prostate-specific antigen levels in a single institution over the past decade. (ucdenver.edu)

Radical prostatectomy involves surgical removal of the prostate gland and a small amount of surrounding normal tissue. (texasoncology.com)
If the lymph nodes contain cancer, usually the surgeon will not proceed with a radical prostatectomy. (texasoncology.com)
A radical prostatectomy is the surgical removal of your prostate gland. (prostateprohelp.com)

Identification of novel targets that can potentiate the effect of these drugs or overcome drug resistance can provide a useful strategy to exploit the anti-cancer properties of these agents to their fullest. (biomedcentral.com)
The ineffectiveness of current cancer treatments may be the result of increased resistance of CSCs [9]. (researchsquare.com)
More specifically, in one aspect, the invention features methods of inducing differential stress resistance in a subject with cancer. (justia.com)

Background Prostate malignancy (PCa) represents probably one of the most regularly diagnosed malignancies in males worldwide [1]. (opioid-receptors.com)
Breast cancer is the most common malignancy affecting women and there remains a need for effective adjuvant therapies for this disease, for which plant sterols may play a distinctive role. (mdpi.com)

Dr. Sadar's research accomplishments and experience over 22 years is essentially entirely focused on the development of therapeutics for prostate cancer. (bcgsc.ca)
In this application, we will build upon our novel preliminary findings to understand the role of the RNA factor MALAT1 in EZH2 activation in prostate cancer, findings that will not only significantly advance our understanding of the molecular mechanism by which EZH2 drives prostate cancer, but also provide new opportunities for development of new therapeutics for prostate cancer treatment. (elsevierpure.com)

Androgens are necessary for normal prostate cell growth (1) , and in animal models, androgen ablation causes cell atrophy and death of prostate epithelial cells (2) . (aacrjournals.org)

Prostate cancer is referred to as stage III if the cancer has extended through the capsule that encloses the prostate gland and may involve nearby tissues. (texasoncology.com)
Undetectable areas of cancer outside the prostate gland are referred to as micrometastases. (texasoncology.com)
They act as growth factors in the prostate gland, stimulating cell division and tissue growth. (wikipedia.org)
This model will use data including age, PSA, DRE findings, prostate volume, and whole gland Micro-Ultrasound images to risk stratify patients following PSA screening. (pcf.org)

Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)

The peptidyl-prolyl isomerase Pin1 is frequently overexpressed in prostate cancer. (bcgsc.ca)

Combination therapies using ralaniten with ionizing radiation were evaluated for effects on proliferation, colony formation, cell cycle, DNA damage, and Western blot analyses in human prostate cancer cells that express both full-length AR and AR-Vs. Ralaniten and a potent next-generation analog (EPI-7170) decreased expression of DNA repair genes whereas enzalutamide had no effect. (bcgsc.ca)
Ralaniten and EPI-7170 sensitized prostate cancer cells that express full-length AR and AR-Vs to radiotherapy whereas enzalutamide had no added benefit. (bcgsc.ca)

The cases were 122 female patients aged 24-87 years with histopathologically confirmed breast cancer. (positivehealth.com)
Analysis of a cancer registry in the United States, which included men with prostate cancer, showed that patient-clinician information engagement leads to increased consumption of fruits and vegetables by cancer patients. (medscape.com)
This is because the majority of patients with stage III disease already have small amounts of cancer that have spread outside the prostate and were not effectively treated. (texasoncology.com)
Before a prostatectomy is performed, patients may want to have pelvic lymph nodes removed to see if they contain cancer. (texasoncology.com)
Approximately 80% of patients with surgically confined stage III prostate cancer (cancer confined to the prostate that can be surgically removed) will be alive 5 years after surgery, and most patients who die do so of causes other than prostate cancer. (texasoncology.com)
The incidence of prostate cancer is high in the elderly male patients, which seriously threatens the life and health. (asmepress.com)
A phase II trial of dexamethasone, vitamin D, and carboplatin in patients with hormone-refractory prostate cancer. (ucdenver.edu)
Prostate cancer on the internet: impact on patients and how technology helps physicians and researchers. (ucdenver.edu)
A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. (ucdenver.edu)
A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. (ucdenver.edu)
Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma. (ucdenver.edu)
Continuous infusion paclitaxel, 5-fluorouracil, and hydroxyurea with concomitant radiotherapy in patients with advanced or recurrent head and neck cancer. (uchicago.edu)
Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck. (uchicago.edu)
This trial included a large fraction of patients with androgen-independent prostate cancer. (aacrjournals.org)
In TALAPRO-2 patients were enrolled from 223 hospitals, cancer centres, and medical centres in 26 countries in North America, Europe, Israel, South America, South Africa, and the Asia-Pacific region. (esmo.org)
Current prostate cancer screening methods either lack specificity (PSA tests) or are costly and not widely available (MRI), thus many more patients undergo invasive prostate biopsies than are necessary. (pcf.org)
For example, there is a lack of widely available screening methods for esophageal cancer, and patients are often diagnosed with cancer in the late stages [ 6 ]. (ijbs.com)

CRISPEN and COLLEAGUES, Fox Chase Cancer Center, Philadelphia, PA 19111, USA studied the interaction with and modulation of Vitamin E succinate upon transcriptional factors involved in the development and progression of prostate cancer. (positivehealth.com)

We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)

High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different origins. (hindawi.com)
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
Moreover, we showed that deletion or reduction of PTEN increases the level of total and phosphorylated EZH2 proteins and enhances EZH2-mediated repression of other genes in prostate cancer cells. (elsevierpure.com)
ARA55, ARA54, ARA70, BRCA1, and heat-shock proteins) may allow cells to become independent of androgens (intrinsic activation). (aacrjournals.org)

Herein, we show that an immunocyte expression protein, ZBTB46, induces inflammatory response gene expression and contributes to NE differentiation of prostate cancer cells. (tmu.edu.tw)
We demonstrated a molecular mechanism whereby ZBTB46 can be regulated by the androgen-responsive gene, SPDEF, and is associated with NE prostate cancer (NEPC) differentiation. (tmu.edu.tw)
To understand the role of EZH2 phosphorylation in gene repression, we employed an advanced, unbiased, global approach, so-called RNA immunoprecipitation coupled sequencing (RIP-seq), to look for EZH2-associated large-size RNAs that do not encode protein, a novel class of factors that has emerged as a new, important aspect of cancer biology. (elsevierpure.com)

Increased ERV expression led to accumulation of double-stranded RNA and a "viral mimicry" response characterized by activation of IFN signaling, upregulation of MHC class I molecules, and enhanced recognition of murine prostate cancer cells by CD8+ T cells. (cam.ac.uk)

prostate radiation cut radiographic progression-free mortality in half. (prostatecancer.news)

Before making treatment recommendations, physicians who treat prostate cancer consider a number of aspects about the patient's health, life expectancy and the cancers risk of progression that help predict whether the cancer is truly confined to the prostate and how fast the cancer will grow. (texasoncology.com)
High-dose estrogen was the first functional antiandrogen used to treat prostate cancer. (wikipedia.org)

The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines. (uchicago.edu)

We found that EZH2 binds to MALAT1, a cancer metastasis-related long non-coding RNA that has been implicated in many types of human cancer. (elsevierpure.com)

Our findings propose a potential mechanism of VES-mediated anti-tumour activity and support the role of vitamin E analogs as potential chemopreventative agents against prostate cancer. (positivehealth.com)

Antiandrogens are used to treat an assortment of androgen-dependent conditions. (wikipedia.org)
Antiandrogens are used in the treatment of an assortment of androgen-dependent conditions in both males and females. (wikipedia.org)
Likewise, in the early stages of prostate cancer, the growth of cancerous prostatic epithelial cells is often androgen dependent (3) . (aacrjournals.org)

Randomization reveals unexpected acute leukemias in Southwest Oncology Group prostate cancer trial. (ucdenver.edu)

Here we investigated whether SQSTM1/p62 (p62) overexpression, as a marker of autophagic flux, was related to aggressiveness of human prostate cancer (PCa) and whether autophagy regulated the treatment response in sensitive but not resistant PCa cell lines. (biomedcentral.com)

Treatment with alpha-tocopherol succinate (VES) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen-independent PC-3, DU-145, and CA-HPV-10 cells. (positivehealth.com)
In men, antiandrogens are used in the treatment of prostate cancer, enlarged prostate, scalp hair loss, overly high sex drive, unusual and problematic sexual urges, and early puberty. (wikipedia.org)
Dr. Sadar is an expert witness for Astellas, Pfizer, and University of California on patents covering Xtandi®, used for the treatment of prostate cancer in the USA with global sales greater than $3.5 billion per year. (bcgsc.ca)
How and when are you using sipuleucel-T in metastatic prostate cancer given the increase in available treatment options? (themednet.org)
Low-dose diethylstilbestrol for the treatment of advanced prostate cancer. (ucdenver.edu)
New approaches to the treatment of advanced prostate cancer. (ucdenver.edu)
because of its essential function, this enzyme has become a new target for cancer treatment. (aacrjournals.org)
Cancer and its treatment cause physical symptoms and side effects, as well as emotional, social, and financial effects. (prostateprohelp.com)
People who receive palliative care along with treatment for the cancer often have less severe symptoms, better quality of life, and report that they are more satisfied with treatment. (prostateprohelp.com)
This treatment is an option for curing prostate cancer that has not spread beyond the prostate or has not spread very far. (prostateprohelp.com)
It's possible that prostate cancer can come back again after treatment. (prostateprohelp.com)
Your doctor should be able to explain the risk of your cancer coming back after treatment, based on things like your PSA level and the stage of your cancer. (prostateprohelp.com)
Life sciences professionals believe that immunotherapy will revolutionize cancer treatment. (hindawi.com)

In women, antiandrogens are used to treat acne, seborrhea, excessive hair growth, scalp hair loss, and high androgen levels, such as those that occur in polycystic ovary syndrome (PCOS). (wikipedia.org)
In women, antiandrogens are much better tolerated, and antiandrogens that work only by directly blocking androgens are associated with minimal side effects. (wikipedia.org)
However, because estrogens are made from androgens in the body, antiandrogens that suppress androgen production can cause low estrogen levels and associated symptoms like hot flashes, menstrual irregularities, and osteoporosis in premenopausal women. (wikipedia.org)

Furthermore, an epigenetic independent function of EZH2 has been identified in hormone refractory prostate cancers. (elsevierpure.com)
Clinical effects of gonadotropin-releasing hormone analogue in metastatic carcinoma of prostate. (ucdenver.edu)

Collectively, our study reveals that the potent androgen MeT can increase the immunogenicity of prostate cancer cells via a viral mimicry response, a finding that has potential implications for the development of strategies to sensitize this cancer type to immunotherapies. (cam.ac.uk)

More than 50 clinical trials are currently exploring the combination of immunotherapy and other approved treatments for advanced prostate cancer. (nature.com)
Several drugs targeting distinct phases of the cell cycle have been developed but the inability of many of them to discriminate between normal and cancer cells has strongly limited their clinical potential because of their reduced efficacy at the concentrations used to limit adverse side effects. (biomedcentral.com)
Currently, the complexity of immunotherapy and the specificity of prostate cancer mean that other prostate cancer vaccines have not shown expected clinical benefits in large randomized phase II and III trials, and further in-depth studies are still needed. (asmepress.com)
Cisplatin, fluorouracil, and leucovorin augmented by interferon alfa-2b in head and neck cancer: a clinical and pharmacologic analysis. (uchicago.edu)
Race and clinical outcome in breast cancer in a series with long-term follow-up evaluation. (uchicago.edu)

A previous prevention trial showed that selenium supplementation was effective in reducing (by 50%) the incidence of prostate cancer. (positivehealth.com)
The age-adjusted incidence of cancer in the US is 3 times higher than that in Asian countries, with immigrants to the US having increased risk for this condition [ 4 , 5 ]. (mdpi.com)

Anatomy11

Organisms5

Diseases37

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology7

Phenomena and Processes44

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena4

Humanities1

Information Science9

Named Groups3

Health Care36

Geographicals2

Receptor18

Inhibition7

Receptors1

Castration23

Therapy36

Therapeutic9

Tumor15

Apoptosis9

Recurrence6

Anti-androgens1

LNCaP3

Metastatic hormone sensitive prostate cancer2

Survival11

Phenotype2

High risk prostate cancer3

20201

Inhibitors5

20211

Inhibitor2

Abiraterone1

Inhibit the growth of prostate cancer2

Chemotherapy11

Tumors5

Docetaxel5

Testosterone2

Independence in prostate cancer1

Antigen2

Radical prostatectomy3

Resistance3

Malignancy2

Therapeutics for prostate cancer2

Ablation1

Gland4

Colorectal Cancer1

Frequently overexpressed1

Enzalutamide2

Patients17

Transcriptional1

Cells in vitro1

Proteins4

Gene3

Murine prostate1

Mortality1

Treat prostate cancer2

Radiation1

Binds1

Findings1

Dependent3

Oncology1

Autophagy1

Treatment13

Antiandrogens3

Hormone2

Collectively1

Clinical5

Incidence2