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  • inactivation
  • Moreover, degradation of hyperactive Plk1 T210D is impaired, suggesting that Plk1 inactivation during anaphase may be required for its timely degradation. (aacrjournals.org)
  • 25S complex containing BIMEAPC1, and bimAAPC3 mutants were sensitive to elevated CYCLIN B expression, consistent with BIMAAPC3 being a component of the APC/C. Inactivation of bimAAPC3 had little affect on the steady state levels of the B-type cyclin, NIMECyclin B. Our results indicate that BIMAAPC3, and most likely the APC/C itself, is activated in G2 in nimA mutants. (uky.edu)
  • Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex [ PMID: 17942546 ]. (ebi.ac.uk)
  • degradation
  • The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. (wikipedia.org)
  • kinase
  • Plk1 is exclusively expressed in proliferating cells regulating a diverse set of processes, including centrosome maturation, bipolar spindle formation, activation of the cyclin B/cyclin-dependent kinase 1 (Cdk1) complex, and cytokinesis. (aacrjournals.org)
  • When a cell is exposed to ionizing radiation, its chromatin can be damaged with DSB, triggering the DDR which starts with the MRN complex recruiting ATM kinase to the exposed H2AX histones on the damaged DNA. (wikipedia.org)
  • The SDT domain of the MDC1 protein is phosphorylated by caseine kinase 2 (CK2) which allows it to bind another MRN complex, the MDC1 protein can sense the DNA damage by binding to the γH2AX flag through its BRCT domain and brings the bound MRN complex to the site of damaged DNA and it facilitates the recruitment and retention of another ATM kinase. (wikipedia.org)
  • adaptor protein
  • The MDC1s role in DDR is to function both as a mediator/adaptor protein mediating a complex of other DDR proteins at the site of DNA damage and repairing DNA damage through its PST domain. (wikipedia.org)
  • Bub3
  • in this arrangement, Bub3 acts as a key component of the SAC in the formation of an inhibitory complex. (wikipedia.org)
  • while Bub3 specifically binds Mad3 and Bub1, Rae1 has more promiscuous binding as it binds both the nuclear pore complex and Bub1. (wikipedia.org)
  • The structural data suggested that Bub3 acts as a platform that mediates the interaction of SAC protein complexes. (wikipedia.org)
  • microtubule
  • Here we show that this G2 arrest is due to loss of nimA function and that it is dependent on BIMAAPC3, a component of the anaphase promoting complex/cyclosome (APC/C). Whereas nimA single mutants arrested in G2 with decondensed chromatin and interphase microtubule arrays, nimA, bimAAPC3 double mutants arrested growth with condensed chromatin and aster-like microtubule arrays. (uky.edu)
  • Saccharomyces
  • Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae (Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. (wikipedia.org)
  • 2002
  • In 1996, Peters moved to Vienna to become Junior Group Leader at the Research Institute of Molecular Pathology (IMP), and was promoted to Senior Scientist in 2002. (wikipedia.org)
  • Then in 2002 the crystal structure of human Mad1 in complex with human Mad2 forming a tetramer was published. (wikipedia.org)