• Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene. (wikipedia.org)
  • In other cell types, 23 of these genes are found in crucial adipocyte pathways: Wnt signaling or mitochondrial function. (bvsalud.org)
  • B. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for DEGs. (cams.cn)
  • The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. (wikipedia.org)
  • Genome-wide association studies (GWAS) identified 346 loci near 495 genes associated with WHRadjBMI. (bvsalud.org)
  • Key driver analysis identified genes that, in silico and putatively in vitro, regulate many others, including the 495 WHRadjBMI GWAS genes. (bvsalud.org)
  • Intended Use Human ANAPC2 ELISA Kit allows for the in vitro quantitative determination of ANAPC2 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids. (biobool.com)
  • Gene protein-protein interaction network analysis. (cams.cn)
  • The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). (utsouthwestern.edu)
  • The functional enrichment analysis of the 872 genes showed that multiple biological processes involved, such as porphyrin-containing compound metabolic process, hemoglobin complex and oxygen transporter activity. (cams.cn)
  • A. Gene Ontology (GO) terms (biological process, cellular component and molecular function) for DEGs. (cams.cn)
  • Human ANAPC2 genome location and ANAPC2 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Human APC2 genome location and APC2 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • 2000). "Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • Inquiry About Human ANAPC2 ELISA Kit If you hope to order it or contact us directly, please contact us via [email protected]. (biobool.com)
  • Key driver gene function was determined by perturbing their expression in human subcutaneous pre-adipocytes using lenti-virus or siRNA. (bvsalud.org)
  • We used single-cell expression data to select replicated key drivers expressed in adipocyte precursors and mature adipocytes, prioritized genes which have not been previously studied in adipose tissue, and used public human and mouse data to nominate 53 novel key driver genes (10 - 21 from each network) that may regulate fat distribution by altering adipocyte function. (bvsalud.org)
  • Direct comparison of the cell types were made to primary tissues using gene expression atlases and fetal human brain single-cell gene expression data, and this established that the cell types resembled early human brain cell types, including preplate cells. (uth.edu)
  • METHODS: We used two independent cohorts of adipose tissue gene expression with 362 - 444 males and 147 - 219 females, primarily of European ancestry. (bvsalud.org)
  • We selected seven genes whose expression is highly correlated with WHRadjBMI to further study their effects on adipogenesis/Wnt signaling (ANAPC2, PSME3, RSPO1, TYRO3) or mitochondrial function (C1QTNF3, MIGA1, PSME3, UBR1).Adipogenesis was inhibited in cells overexpressing ANAPC2 and RSPO1 compared to controls. (bvsalud.org)
  • RSPO1 results are consistent with a positive correlation between gene expression in the subcutaneous depot and WHRadjBMI, therefore lower relative storage in the subcutaneous depot. (bvsalud.org)
  • Differential analysis of gene expression. (cams.cn)
  • Mouse over or click genes or lines for details. (ucsc.edu)
  • The circle size reflects the fold change (FC) of genes. (cams.cn)
  • Please note that certain gene sets have special access terms. (gsea-msigdb.org)
  • We constructed sex- and depot- specific Bayesian networks to model the gene-gene interactions from 8,492 adipose tissue genes. (bvsalud.org)
  • Red dot represents down-regulated genes, blue dot represents up-regulated genes and gray dot represents not changed genes in the hypoxia group. (cams.cn)
  • Blue circles represent down-regulated genes. (cams.cn)
  • In total, 872 genes were identified as differentially expressed. (cams.cn)
  • Most of these genes have unknown roles in fat distribution, but many are expressed and putatively act in adipose tissue. (bvsalud.org)
  • RGD-PIPELINE: ftp-file-extracts # MODULE: orthologs-2-version-2022-08-26 # GENERATED-ON: 2023/08/19 # RGD Ortholog FTP file for CHINCHILLA # From: RGD # URL: http://rgd.mcw.edu # Contact: [email protected] # # Format: # Comment lines begin with '#' # Tab delimited fields, one line per CHINCHILLA gene. (mcw.edu)
  • Interaction networks can be used to expand the list of candidate trait-associated genes from genome-wide association studies. (bvsalud.org)
  • Here, we performed network-based expansion of trait-associated genes for 1,002 human traits showing that this recovers known disease genes or drug targets. (bvsalud.org)
  • We show examples of modules linked to human diseases enriched in genes with known pathogenic variants that can be used to map targets of approved drugs for repurposing. (bvsalud.org)
  • The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. (wikipedia.org)
  • Human ANAPC2 genome location and ANAPC2 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Human APC2 genome location and APC2 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Finally, we illustrate the use of network expansion scores to study genes at inflammatory bowel disease genome-wide association study loci, and implicate inflammatory bowel disease-relevant genes with strong functional and genetic support. (bvsalud.org)