• Most recent studies have found that the lipid accumulation in microalgae could be increased through altering parameters such as temperature, light, CO 2 , salinity, and nutrient concentration [ 4 - 10 ]. (hindawi.com)
  • Nutrient is the most important regulator of microalgal growth and lipid accumulation. (hindawi.com)
  • 9 ]. The lipid accumulation and growth characteristics of Chlorella kessleri under different concentration of P were investigated by El-Sheek and Rady [ 17 ]. (hindawi.com)
  • The present study systematically analyzes the changes in lipid composition in AKI for the first time and find that the degree of lipid accumulation was highly correlated with uncoupling protein 1 (UCP1). (thno.org)
  • Importantly, relieving lipid accumulation in AKI by upregulating UCP1 can significantly inhibit the progression of AKI through promoting AMPK/ULK1/autophagy pathway. (thno.org)
  • The present findings suggest that lipid accumulation in AKI is directly regulated by UCP1, which can activate cell autophagy and thus significantly inhibit disease progression. (thno.org)
  • We observed that human hepatocytes exhibited excessive lipid accumulation. (wur.nl)
  • In diet-induced obese mice, HILPDA deficiency in macrophages markedly reduced lipid accumulation in macrophages yet it did not alter any measured inflammatory or metabolic parameters. (wur.nl)
  • Treatment with the ATGL inhibitor Atglistatin rescued lipid accumulation inside lipid droplets in HILPDA-deficient macrophages. (wur.nl)
  • Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
  • This research questions the contribution of lipid droplet accumulation in adipose tissue macrophages in obesityinduced inflammation and metabolic disfunction. (wur.nl)
  • The relationship between the accumulation of adipose tissue within the different depots and organs of the body, and the risk of developing numerous diseases, has been investigated and established. (lu.se)
  • In this thesis, MR-based methods for in vivo FAC measurements were compared and validated against FAC quantification gas chromatography analysis of subcutaneous adipose tissue (Paper III). (lu.se)
  • Conclusions: The significantly higher accumulation rates during the last decades evidenced the role of mangrove sediments as sinks for anthropogenically enhanced inputs of carbon and nutrients. (usf.edu)
  • CONCLUSIONS The large accumulation of mast cells in the muscle layer of strictured bowel suggests a functional role for these cells in the hypertrophic and fibrotic response of the smooth muscle cells. (bmj.com)
  • No substantive changes impacting the data, analysis, or conclusions have been made. (chicagofed.org)
  • Accumulation of nitrogen (N) by native Hawaiian riparian plants from surface water was measured under a controlled experimental mesocosm setting. (iwaponline.com)
  • It was hypothesized that the selected species would have significantly different tissue total nitrogen (TN) concentrations, aboveground biomass, and TN accumulation rates because of habitat preference and physiological growth differences. (iwaponline.com)
  • Nitrogen accumulation rates by species were controlled by differences in plant biomass growth. (iwaponline.com)
  • Purpose: In order to assess the impact of anthropogenic activities on carbon and nutrient accumulation, total organic carbon (TOC), nitrogen (TN), and phosphorus (TP) accumulation rates were examined in a 210Pb-dated mangrove sediment core from Sepetiba Bay, Brazil, a coastal region impacted by multiple environmental changes during the previous century. (usf.edu)
  • After this period, lighter δ13C values (~ − 25‰) indicate an increased importance of the terrestrial organic matter source, while lower TOC:TN ratios (~ 11) and heavier δ15N values (~ + 9‰) suggest an increased influence of anthropogenic fertilization on inorganic nitrogen accumulation. (usf.edu)
  • Because of the importance of understanding the underlying food web when considering the accumulation and trophic transfer of a compound, stable carbon and nitrogen isotope analysis was used to characterize the food webs at the previously mentioned Ugandan study sites as well as in the East African great lake Albert. (uwaterloo.ca)
  • White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. (bvsalud.org)
  • To analyse the available evidence regarding the incidence and severity of white spot lesions (WSLs), plaque accumulation and salivary caries-associated bacteria (SCB) in clear aligners (CA) verses conventional fixed (CF) orthodontic appliances . (bvsalud.org)
  • Randomized Controlled Trials and Non-Randomized Studies that compared the incidence and severity of WSLs, plaque accumulation and SCB between CA and CF appliances in patients undergoing orthodontic treatment . (bvsalud.org)
  • The qualitative results showed lower incidence and severity of WSLs, plaque accumulation, and SCB in CA group compared to CF appliances. (bvsalud.org)
  • The pooled results showed significantly lower plaque accumulation(SMD - 1.58;95%CI-2.57,0.58;p = 0.002) in CA compared to CF appliances. (bvsalud.org)
  • A moderate-quality evidence reveals less plaque accumulation and less SCB in CA, which might be related to the reduced incidence and severity of WSLs associated with CA when compared with CF appliances. (bvsalud.org)
  • Carbon and nutrient accumulation in mangrove sediments affected by mul" by Alexander Perez, Wilson Machado et al. (usf.edu)
  • Also, studies on carbon and nutrient accumulation evidenced the need for further research in eutrophic coastal areas. (usf.edu)
  • This effect, in turn, results in the upregulation of SREBP-2 , which drives HMGCR nascent transcription and de novo cholesterol biosynthesis, leading to the increase of cholesterol accumulation. (nature.com)
  • Finally, CGS21680 reduces cholesterol accumulation (Filipin III staining), which is the main criterion currently used for identification of a compound or pathway that would be beneficial for NPC disease, and such an effect is prevented by the Ca 2+ chelator BAPTA-AM. Our findings strongly support the hypothesis that A 2A R agonists may represent a therapeutic option for NPC1 and provide insights on their mechanisms of action. (jneurosci.org)
  • Several compounds have been shown to inhibit the efflux activity of ABC transporters, thereby increasing intracellular drug accumulation and sensitising cancer cells to therapy. (spandidos-publications.com)
  • Niemann-Pick type C1 (NPC1) disease is a rare neurovisceral disorder characterized by intracellular accumulation of unesterified cholesterol, sphingolipids, and other lipids in the lysosomal compartment. (jneurosci.org)
  • Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)
  • This chapter compares the physiological and molecular mechanisms of Fe, Zn, Cd, and Pb uptake, mobilization, and accumulation in rice and discusses the progress and strategies for not only increasing Fe/Zn but also decreasing Cd/Zn accumulation in rice. (intechopen.com)
  • To avoid harmful physiological effects of pollutants' accumulation in organisms, decontamination and excretion could be effective mechanisms. (pensoft.net)
  • Nevertheless, together with benchmarking analyses, we show here that the diametric ratio approach can be applied for evaluating the physiological conditions experienced by microbes in situ. (osti.gov)
  • Using ground beetle species, as model organisms, we tested our pollution intensity-dependent disposal hypothesis in the cases of five potential pollutants (Cd, Cu, Mn, Pb and Zn) by four soil pollution intensity levels (low, moderate, high, and extreme) by categorical meta-analysis on published data. (pensoft.net)
  • According to our hypothesis, we presumed that decontamination and excretion of pollutants in ground beetles will be effective in lowly or moderately polluted habitats, while in highly or extremely polluted habitats disposal will be restricted, contributing to intense accumulation of pollutants in ground beetles. (pensoft.net)
  • In accordance with our hypothesis, we found that in extremely polluted habitats the accumulation of Cd, Pb, and Zn in ground beetles was significantly higher, than in lowly polluted ones. (pensoft.net)
  • The influx of macrophages and accumulation of T-cells and myofibroblast were quantified in orbital connective tissue. (frontiersin.org)
  • Previously, our in silico analyses identified four candidate genes that might be involved in uptake and/or accumulation of arsenics in plants: arsenate reductase 2 ( ACR2 ), phytochelatin synthase 1 ( PCS1 ) and two multi-drug resistant proteins ( MRP1 and MRP2 ) [Lund et al. (diva-portal.org)
  • Quantitative real-time PCR analysis revealed that ABA treatment around véraison resulted in the upregulation of genes encoding enzymes responsible for both general flavonoid and anthocyanin biosynthesis. (scirp.org)
  • A general linear model (GLM) analysis of variance (ANOVA) determined that species differences accounted for the greatest proportion of variance in tissue TN concentration, aboveground biomass growth, and accumulation rates, when compared with the other main effects (i.e. (iwaponline.com)
  • A post hoc test of means demonstrated that C. jamaicense had significantly higher tissue TN concentration, aboveground biomass growth, and accumulation rates than the other species under all N concentrations. (iwaponline.com)
  • Based on this, analysing and assessing the accumulation of pollutants in species is of major importance. (pensoft.net)
  • However, further species and factors need to be addressed in order to assess metal accumulation potential of ground beetles more thoroughly. (pensoft.net)
  • The most likely accumulation scenario involves complexation of Pu (IV) species produced under potential control with anions retained in the anodization film that develops during activation of the GC electrode. (ornl.gov)
  • The release mechanism likely results from the reduction of retained species to Pu (III), which has a significantly lower tendency to form complexes. (ornl.gov)
  • GO patients displayed significantly higher LBP serum concentrations than healthy controls. (frontiersin.org)
  • Microcystin concentrations in fish from several study sites followed seasonal trends that were similar to those observed for microcystin concentrations in water at these sites, suggesting that fish can rapidly respond to changes in microcystin concentrations in water through accumulation and depuration of this toxin. (uwaterloo.ca)
  • The other studied antihistamines pose a low risk based on expected exposure and the likelihood of accumulation in biota to near therapeutic concentrations, at the same time the assessment is uncertain due to insufficient efficacy data. (janusinfo.se)
  • Previous researches have shown that there are connections and discrepancies for metal absorption, translocation, and accumulation in rice. (intechopen.com)
  • The significantly lower bioaccumulation factor and translocation factor of B and Mg in the high-yield plants highlighted the importance of nutrient storage in promoting C. Oleifera yield. (authorea.com)
  • We used logistic regression analysis to assess the association between cumulative fluid balance during the first two days in ICU and subsequent risk of MAKE30, adjusted for demographic factors, comorbidities, baseline creatinine, illness severity variables, haemodynamic characteristics, chloride exposure and nephrotoxic drug exposure. (springeropen.com)
  • Accordingly, we conducted an observational multi-centre study to assess the independent association between early fluid accumulation and major adverse kidney events, a composite of death, dialysis, or sustained renal dysfunction, within 30 days (MAKE30) in ICU patients with sepsis. (springeropen.com)
  • In addition, we aimed to assess the relative importance of fluid accumulation and other potential factors for MAKE30 development. (springeropen.com)
  • Therefore, we performed transcriptome and UHPLC-MS-based targeted and untargeted metabolomics analyses in order to organize the essential genes and metabolites that are involved. (uibk.ac.at)
  • However, this analysis requires accurate reference genomes to identify the specific genes from which RNA reads originate. (osti.gov)
  • We analyzed twenty fecal samples taken from four premature infants (4-6 time points from each infant), and found significantly higher diametric ratios of genes associated with low oxygen levels in samples of infants later diagnosed with NEC than in samples without NEC. (osti.gov)
  • We assessed the strength of significant exposure variables using a relative importance analysis. (springeropen.com)
  • Exposure dependent accumulation of N-(2- hydroxypropyl)valine in hemoglobin of F344 rats exposed to propylene oxide by the inhalation route. (who.int)
  • Also, carbon and nutrient fluxes were calculated using SAR and TOC, TN, and TP contents, whereas statistical differences were evaluated by ANOVA + Tukey HSD analysis with previous data normalization. (usf.edu)
  • On separate sensitivity analyses, lower urine output and early acute kidney injury, respectively, were independently associated with MAKE30, whereas higher fluid input was not. (springeropen.com)
  • Whether early fluid accumulation is a risk factor for adverse renal outcomes in septic intensive care unit (ICU) patients remains uncertain. (springeropen.com)
  • In the secondary outcome analysis, the adjusted odds ratio for dialysis or sustained renal dysfunction was 1.06 (95% CI 1.01-1.11) per litre cumulative fluid balance. (springeropen.com)
  • In addition to fluid volume accumulation, fluid composition and adjunct ICU therapies may contribute to adverse renal outcomes. (springeropen.com)
  • Since, greater illness severity is associated with the administration of larger fluid volumes, more intense cardiovascular support, and greater use of potentially nephrotoxic drugs, the relative importance of fluid accumulation with respect to adverse renal outcomes is an important clinical question that remains uncertain. (springeropen.com)
  • We hypothesized that the degree of fluid accumulation after 2 days in ICU would be associated with subsequent MAKE30 after controlling for illness severity, level of cardiovascular support, and nephrotoxic drug use in such patients. (springeropen.com)
  • Pleural effusions are accumulations of fluid within the pleural space. (msdmanuals.com)
  • Thoracentesis and pleural fluid analysis are often required to determine cause. (msdmanuals.com)
  • The qualitative analyses of neutral lipid bodies under stress conditions were performed by confocal microscopy and revealed bright golden-yellow lipid droplets in stress exposed cells. (hindawi.com)
  • By examining these blood samples and adjusting for age, sex, body mass index, and other biological factors, the scientists were able to conduct a deeper analysis of the immune system and identify potential biomarkers. (medicalnewstoday.com)
  • Mercury dynamics were strongly linked to lake trophic status, with biomagnification rates significantly lower at the hypereutrophic study sites than at the mesotrophic and eutrophic study sites. (uwaterloo.ca)
  • The electrochemically controlled deposition and analysis of Pu should serve to lower current detection limits by preconcentration and elimination of matrix interferences. (ornl.gov)
  • Participants aged 100 years and older displayed a lower iAge at a significantly lower rate, suggesting that "iAge is associated with exceptional longevity. (medicalnewstoday.com)
  • The risk of impact is significantly lower, but not negligible, for fexofenadine. (janusinfo.se)
  • detected mainly by border entry screening, ILI screening in hospitals, health follow-up of travelers from overseas, and Statistical Analysis quarantine and testing of close contacts. (cdc.gov)
  • In our statistical analysis of a global sample of 166 countries from 2010 to 2020, we find that the most important determinant of Christian vitality is the extent to which governments give official support to Christianity through their laws and policies. (christianitytoday.com)
  • Background information on the procedures, survey components, questionnaires, examination and laboratory methods, and statistical analysis guidelines is available on the NHANES III Reference Manuals and Reports (CD-ROM). (cdc.gov)
  • Understanding the accumulation rule of nutrients is crucial to promote the production of Camellia Oleifera . (authorea.com)
  • The significantly different stoichiometry of trace elements in soil of different yields revealed that the stoichiometry of trace elements was more sensitive and reliable in reflecting the balance in soil nutrients of C. oleifera and regulating its growth. (authorea.com)
  • Moreover, serum LBP levels significantly correlated with the abundance of specific Gram-negative gut bacteria, linking the gut to local orbital inflammation. (frontiersin.org)
  • With the increase of mining depths, frequency of rock bursts in mines increases significantly and the severity of resulting disasters is also increasing. (hindawi.com)
  • Mechanistically, HILPDA interacts and increases DGAT1 protein level and activity as indicated by FRET-FLIM analysis, western blot and Dgat1 activity assay. (wur.nl)
  • As governmental support for Christianity increases, the number of Christians declines significantly. (christianitytoday.com)
  • These factors can significantly influence the protein composition of a biofluid. (wikipedia.org)
  • We found this overlap to be largely attributable to the accumulation of high-temperature requirement protein A1 (HTRA1), a serine protease with an established role in the brain vasculature, and several of its substrates. (biomedcentral.com)
  • At baseline, this protein had positive correlations with age, and its levels significantly increased at 60 years. (medicalnewstoday.com)
  • Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
  • Reverse transcriptase PCR revealed that the mutant exhibits significantly reduced expression of the ACR2 gene. (diva-portal.org)
  • In addition, defense-related gene expression and metabolite accumulation were significantly down-regulated in infected fruits. (uibk.ac.at)
  • These results support EAC early diagnosis trials using exhaled aldehyde analysis. (nature.com)
  • Published results, however, are inconsistent, as some studies showed effective decontamination and excretion of pollutants, while others demonstrated severe toxic symptoms due to extreme accumulation. (pensoft.net)
  • The results obtained from in silico analyses are in complete agreement with those obtained in laboratory experiments. (diva-portal.org)
  • In this research, we performed transcriptomics analysis on the effect of fenofibrate in mice with hepatocyte-humanized livers and compared the results with other relevant transcriptomics datasets. (wur.nl)
  • The results of surveys, analyses, and studies are made known through a number of data release mechanisms including publications, mainframe computer data files, CD-ROMs (Search and Retrieval Software, Statistical Export and Tabulation System (SETS)), and the Internet. (cdc.gov)
  • In addition, the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in pre-menopausal women. (nature.com)
  • Spectrophotometric analyses revealed that the amount of accumulated arsenic compounds in this mutant was approximately six times higher than that observed in control plants. (diva-portal.org)
  • 2D-PAGE LC-MS SELDI-TOF (or MALDI-TOF) Antibody array Tissue microarray The term metabolomic has been recently introduced to address the global analysis of all metabolites in a biological sample. (wikipedia.org)
  • Similarly, in diet-induced NASH mice, HILPDA hepatocyte deficiency modestly yet significantly reduced liver triglyceride accumulation and plasma ALT levels. (wur.nl)
  • In fibrosing colonopathy, a complication observed in children with cystic fibrosis treated with high strength pancreatic enzyme replacement therapy, an accumulation of mast cells was observed in the intestinal strictures. (bmj.com)
  • For 210Pbex analyses, gamma-ray measurements were performed in a semiplanar intrinsic germanium high purity coaxial detector, coupled to a multichannel analyzer, whereas the sediment accumulation rate (SAR) was calculated according to the constant initial concentration (CIC) method. (usf.edu)
  • Degradation of carbon tetrachloride occurs slowly in the environment, which contributes to the accumulation of the chemical in the atmosphere as well as the groundwater. (cdc.gov)
  • These analyses revealed that, for catalytic metabolism of arsenate, the arsenate binding-loop (AB-loop) and residues Phe-53, Phe-54, Cys-134, Cys-136, Cys-141, Cys-145, and Lys-135 are essential for reducing arsenate to arsenic intermediates (arsenylated enzyme-substrate intermediates) and arsenite in plants. (diva-portal.org)
  • Taken together, the decreased amount of jasmonic acid, coupled with the reduced accumulation of phenylpropanoid and the increased proliferation of indole-3-acetic acid, salicylic acid, and abscisic acid, compared to leaf midribs, may contribute largely to the enrichment of CLas in fruit piths, resulting in disorders of photosynthesis and starch and sucrose metabolism. (uibk.ac.at)
  • Multiple regression analysis and the Mantel test demonstrated that plant yield and bioaccumulation and transportation of trace elements were more closely correlated with the stoichiometry of trace elements than their content. (authorea.com)
  • The prevention of microglial accumulation and activation in the dorsal spinal cord was associated with limited development of a neuropathic pain state. (biomedcentral.com)
  • Hypotheses regarding the mechanism of electrochemical accumulation of Pu are also presented. (ornl.gov)
  • This contribution has fluctuated significantly over the last 35 years. (chicagofed.org)
  • A related term, metabonomics, was introduced to refer specifically to the analysis of metabolic responses to drugs or diseases. (wikipedia.org)
  • Significantly different FAC was found between the studied groups. (lu.se)
  • Multivariate analyses of tooth-loss rates and alveolar bone loss controlled for demographic and oral hygiene measures. (who.int)
  • In addition, larvae containing mutations in both RIM and rab3 have reduced Ca 2+ channel levels and a Brp distribution that is very similar to that of the rab3 single mutant, indicating that RIM functions to regulate Ca 2+ channel accumulation but is not a Rab3 effector for release machinery distribution across release sites. (jneurosci.org)
  • The aims of the present investigation were to determine the source of these enzymes and to ascertain whether their accumulation in tears is a phenomenon specific to PUK or a general feature of other anterior segment diseases. (bmj.com)
  • The iAge predicts multimorbidity - the accumulation of multiple chronic inflammatory diseases, longevity, and immunosenescence - that is, the age-related deterioration and improper function of the immune system. (medicalnewstoday.com)
  • Multimorbidity refers to the accumulation of multiple chronic inflammatory diseases. (medicalnewstoday.com)
  • For example, the fat accumulation in skeletal muscle of patients with lymphedema was estimated using water/fat imaging in Paper II. (lu.se)
  • A total of 14 studies met the eligibility criteria, and eight were suitable for meta-analysis . (bvsalud.org)
  • This represents the culmination of a theoretical shift in the dominant economic paradigm aimed at the unlimited accumulation of total capital, now seen as including "natural capital. (monthlyreview.org)
  • Two other crucial factors that significantly influence your financial journey are commitment and an honest understanding of your risk tolerance. (richelieu-international.com)
  • Very few studies have quantified microcystin (a broadly present cyanotoxin) in water from East African lakes, despite the large human and animal populations that rely on these lakes for both water and food, and to date there is very little information available on the accumulation of microcystin in fish from these lakes. (uwaterloo.ca)
  • Release efficacy is regulated by the many proteins that comprise the presynaptic release apparatus, including Ca 2+ channels and proteins that influence Ca 2+ channel accumulation at release sites. (jneurosci.org)
  • In particular, variations in the real rate of interest and differences between current and expected future income are likely to influence significantly both the savings behaviour of households and the investment decisions by firms. (rba.gov.au)
  • In addition, such an analysis should avoid biases in transcript counts related to differences in organism abundance. (osti.gov)
  • Continued exploitation of the world's fossil fuel reserves is unsustainable due to their depleted status and simultaneous steady accumulation of greenhouse gases in the atmosphere. (hindawi.com)
  • In this study, we analyzed DNA ploidy histograms of 25 CMs, 16 PMs, and 28 NAs, with special reference to the accumulation of cells in the late S-phase using a high-resolution DNA image cytometry. (nih.gov)
  • The excess accumulation of fat within the intermuscular and intramuscular compartments has not been demonstrated in any previous study of lymphedema. (lu.se)
  • o Some data were not ready for release at the time of this publication due to continued processing of the data or analysis of laboratory specimens. (cdc.gov)
  • In order to develop a critical analysis of the current capitalist expropriation of world ecology, it is necessary to explore the concept of natural capital in the work of Marx and other early radical critics within classical political economy. (monthlyreview.org)
  • We begin by documenting some of the broad trends in human capital accumulation that underlie estimates of worker quality growth. (chicagofed.org)
  • Our analysis of 166 nations suggests the biggest threat to Christian vitality is not persecution, affluence, education, or pluralism. (christianitytoday.com)