• This results in the formation of a quaternary structure that is characteristic of this protein. (wikipedia.org)
  • This resource allows investigators to obtain more targeted search results and quickly identify a protein of interest. (nih.gov)
  • The p53 interacting partner protein NUMB (homology of numb protein) preserves this intrinsic cellular asymmetry by preventing ubiquitin-mediated proteolysis of p53 catalyzed by the MDM2 E3 ubiquitin ligase 11 . (nature.com)
  • The BRCA2 R3052W mutated protein exacerbates genome instability, is unable to rescue homology-directed repair, and fails to complement cell survival following exposure to PARP inhibitors and crosslinking drugs. (frontiersin.org)
  • A strongly hydrophilic region was predicted at positions from 30 to 50 of the An-peNPV Polh protein by bioinformatics analysis. (scirp.org)
  • Another viral sequence encoded a protein with 70% amino acid homology to the predicted RdRp. (virology.ws)
  • Two transmembrane domains were predicted in p11.7, and a DNA binding motif was found in p31.7 by amino acid sequence analysis, therefore p11.7 and p31.7 were predicted to be envelope and capsid protein, respectively. (umass.edu)
  • Aim of this study was to generate 3D models of protein drug targets in Erysipelothrix rhusiopathiae by homology modelling. (ijpsr.com)
  • The modelled proteins were subjected to protein-ligand docking analysis with standard antibiotics such as Ribostamycin, Cefalotin, Pefloxacin, Penicillamine, Artenimol, Cycloserine against their respective drug targets. (ijpsr.com)
  • It is expected that the results from these collaborations will contribute to understanding many basic and biomedically important research problems as well as to our fundamental understanding of protein structure. (nih.gov)
  • As part of a directed effort to discover novel G protein-coupled receptors through homology searching of expressed sequence tag databases, we identified a partial clone (GPCR97) that had significant homology to biogenic amine receptors. (aspetjournals.org)
  • The GPCR97 clone was used to probe a human thalamus library, which resulted in the isolation of a full-length clone encoding a putative G protein-coupled receptor. (aspetjournals.org)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • He has contributed significantly to the state-of-the-art by frequently presenting novel ideas, methods and results and have pioneered several important proof-of-concepts relevant for the project, including the conceptualization of DNA, RNA and protein variation to Variation Ontology (Vihinen, Genome Res . (lu.se)
  • The discovery of specific repeat elements will facilitate analyses of sequence content (e.g. for SNPs discovery and for transcriptome characterization) and future genome sequence assemblies. (biomedcentral.com)
  • In this study, we undertook extensive genome-wide comparative analyses of twelve species that conform the Pectobacterium genus. (mdpi.com)
  • Based on the genome sequencing results, an analysis of structural proteins and prediction of putative microRNAs of Hz-2V was performed. (umass.edu)
  • S. Gomi, K. Majima, Maeda S. (1999) Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus. (scirp.org)
  • Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • Analysis and comparison of ar/R selectivity filters suggest that rice and maize MIPs could transport more diverse solutes than Arabidopsis MIPs. (biomedcentral.com)
  • These 77 genes were then divided into eleven subfamilies according to their homology with Arabidopsis thaliana . (biomedcentral.com)
  • 10. Filipe AR, Martins CM, Rocha H. Labora- recombination analysis between tory infection with Zika virus after vacci- isolates was determined as described newly isolated CBV5 and other HEVs nation against yellow fever. (cdc.gov)
  • Random Amplified Polymorphic DNA (RAPD)-PCR was used for a phylogenetic study to check the homology of pairs of isolates. (biomedcentral.com)
  • While the homology of the isolates was low among different patients during hospitalization, identical (9%) and similar (21%) RAPD-PCR patterns were detected between pairs of isolates from each patient. (biomedcentral.com)
  • Homologies were found to 38 of the 113 ORFs predicted for genes with known functions. (umass.edu)
  • Cytogenetic analysis and Sanger sequencing identified RUNX1-MECOM and RUNX1-RPL22 fusion genes as a result of t(3;21)(q26;q22). (bvsalud.org)
  • Mutational analysis of CYP7B1 amino acid mutations related to hereditary spastic paraplegia type 5 considered phosphorylation, ligand/substrate binding and the structural roles of mutated amino acid residues, with R112, T297 and S363 mutations expected to have a direct impact on ligand binding, while mutations involving R417 would indirectly affect ligand binding as a result of impairment in catalytic function. (nih.gov)
  • In this study, the crystallization and crystallographic analysis of MERS-CoV NP-NTD (amino acids 39-165), with a molecular weight of 14.7 kDa, are reported. (iucr.org)
  • Furthermore, using sequence analysis of human genomic DNA, researchers concluded that the amino acids important for catalysis by COX-1 are conserved and are equally important for catalysis by COX-2. (medscape.com)
  • In the article published in TravelBizmonitor.com , Tristan Chong , Professor and Area Head of Marketing, SP Jain School of Global Management, discusses the application of Persistent Homology (PH) in destination marketing, particularly in identifying target tourist groups based on their behaviour, spending patterns, and clustering. (spjain.org)
  • Its main tool is persistent homology, which is based on other homology theory, usually simplicial homology. (helsinki.fi)
  • This thesis aims to introduce the theories behind persistent homology and its application, image completion algorithm. (helsinki.fi)
  • Persistent homology is motivated by the question of which scale is the most essential to study data shape. (helsinki.fi)
  • A filtration contains all scales we want to explore, and thus it is an essential tool of persistent homology. (helsinki.fi)
  • For any image construct simplicial complexes for selected groups of uniform LBP bins and calculate persistent homology invariants (e.g. number of connected components). (spie.org)
  • Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of AMR have lacked a holistic view combining all aspects into one study. (europa.eu)
  • In summary, the overarching rationale of SATURN was to improve methodological standards and conduct research that will help to better understand the impact of antibiotic use on acquisition, selection and transmission of AMR in different environments, by combining analyses of molecular, individual patient-level and ecologic data. (europa.eu)
  • Also, SATURN had as mission to improve methodological standards and conduct research to better understand the impact of antibiotic use on acquisition, selection and transmission of antibiotic-resistant bacteria (ARB) in different environments, by combining state-of-the-art analyses of molecular, ecologic and individual patient-level data. (europa.eu)
  • The docking results suggest that the infection of Erysipelothrix rhusiopathiae could be treated with Ribostamycin antibiotic. (ijpsr.com)
  • However, both proteins exist exclusively as homodimers and do not heterodimerize with each other, as proven by co-immunoprecipitation assay analysis. (wikipedia.org)
  • Phylogenetic analysis of plant MIP sequences revealed four major subfamilies: the plasma membrane intrinsic proteins (PIPs), tonoplast intrinsic proteins (TIPs), nodulin 26-like intrinsic proteins (NIPs) and small and basic intrinsic proteins (SIPs). (biomedcentral.com)
  • These 396 proteins were employed in homology modelling through the SWISS Model. (ijpsr.com)
  • The homology model of the proteins generated in this study can be exploited in further research using computational drug discovery and design to accelerate the research on disease management and pathogen control of Erysipelothrix rhusiopathiae induced swine erysipelas. (ijpsr.com)
  • The results show that nonnative proteins are more structured and less solvent exposed than commonly believed. (lu.se)
  • Total of 131 homology structures with the Ramachandran favorable score above 95% were considered as reliable drug targets and were submitted to PMDB online database. (ijpsr.com)
  • To obtain these structures, we applied UV-fluorescence microscopy, video analysis and highly automated goniometer-based instrumentation to map and rapidly position individual crystals randomly-located on fixed target holders, resulting in the highest indexing-rates observed for a serial femtosecond crystallography (SFX) experiment. (biorxiv.org)
  • However whether or not the hosts of these viruses are Archaea or Bacteria cannot be determined by these metagenomic analyses. (virology.ws)
  • Bioinformatic databases such as Uniprot KB, Drug Bank, PMDB and online tools such as BLASTp, SWISS Model and Ramachandran plot analysis and software such as Autodock4 and Pymol were used to perform this study. (ijpsr.com)
  • Various software resources are also required to enable users to conveniently connect their experimental results with publicly, and application specific, bioinformatics databases and tools. (lu.se)
  • Areas covered include sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)
  • He has published numerous original ideas and reports, established standards and guidelines for variations and variation databases and developed tools and performed analyses for the interpretation of variations in several diseases. (lu.se)
  • Homology models of 105 MIPs from all three plant species were built. (biomedcentral.com)
  • Homology analysis indicates at least 37 different species of yeast across the dataset, with some species present in more than one sample. (awri.com.au)
  • This damage results from a buildup of harmful molecules called reactive oxygen species, which are byproducts of energy production in mitochondria. (medlineplus.gov)
  • As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
  • Current studies are devoted into analysis of variations and their effects, including prediction method development, and systems biological studies. (lu.se)
  • Subsequent analysis revealed a pharmacological profile practically indistinguishable from that for the histamine H 3 receptor. (aspetjournals.org)
  • Bioinformatics analysis and luciferase reporter assay were used to validate interactions among hsa_circ_0046060, miR-338-3p, and G6PC2. (hindawi.com)
  • High-throughput RNA sequencing and bioinformatics analysis have led to the identification of several novel circRNAs that exhibit biological characteristics and regulatory functions [ 6 , 9 ]. (hindawi.com)
  • Similarity scanning analysis and JN695051, respectively. (cdc.gov)
  • Homology analysis showed the highest similarity to M2 muscarinic acetylcholine receptors and overall low homology to all other biogenic amine receptors. (aspetjournals.org)
  • Epistasis analysis suggests that the Toll pathway acts as a downstream modulator for JNK-dependent cell death. (sdbonline.org)
  • Several downstream analyses are performed and their utility in applied ecology, evolutionary biology and molecular biology research will be discussed with guest lecturers. (lu.se)
  • Nevertheless, while Q44R led to recovery of viruses that maintained the mutation, Q44D resulted in selection of infective viruses with substitution D44E with acidic charge but with structural features similar to those of the parental virus, suggesting that Q44 is involved in functions other than 3A dimerization. (asm.org)
  • The BRCA2 R3052W mutation fails to complement chemotherapeutic sensitivity and homology-directed repair functions in BRCA2 knockout cells. (frontiersin.org)
  • [ 10 ] Analysis showed that the patient was heterozygous for a mutation, G356D. (medscape.com)
  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease. (lu.se)
  • Sequence analysis detects mutations in 95% of males and 95% of female carriers. (medscape.com)
  • Suppression of the degalactosylation by senju overexpression resulted in reduced induction of Toll-dependent expression of an antimicrobial peptide, Drosomycin , and increased susceptibility to infection with Gram-positive bacteria. (sdbonline.org)
  • On the basis of 16S rDNA phylogenetic analysis of bacteria was done. (ispub.com)
  • These ribosomal sequences was functional for the phylogenetic analysis and molecular taxonomic of any bacteria. (ispub.com)
  • L. H. Robert, Bonning B.C. (2003) Comparative analysis of the genomes of Rachiplusia ou and Autographa californica multiple nucleopolyhedroviruses Journal of General Virology 84, 1827-1842. (scirp.org)
  • In the present article, we perform cortical type analysis of the neocortex of adult rats, Rhesus macaques, and humans to propose hypotheses on homology of cortical areas applying the principles of the Hypothesis on the Dual Origin of the Neocortex. (springer.com)
  • In addition, gain of JNK signalling results in Toll pathway activation, revealed by stimulated transcription of Drosomycin ( Drs ) and increased cytoplasm-to-nucleus translocation of Dorsal. (sdbonline.org)
  • The diagnosis of measles is confirmed by laboratory test results, including a positive result for measles-specific immunoglobulin M (IgM) titre, significant increase in measles-specific immunoglobulin G (IgG) titre using paired serum, the detection of measles virus (MV) by reverse transcription polymerase chain reaction (RT-PCR) or isolation of MV in cell culture. (who.int)
  • (C) Clonogenic survival analyses of BRCA2 WT versus the two independent R3052W clones after treatment with Olaparib, cisplatin, and mitomycin C. (D) Schematic of I-SceI nuclease-induced DSB HDR luciferase assay. (frontiersin.org)
  • (G) Clonogenic survival analyses of DLD parental clones upon treatment with mitomycin C. (frontiersin.org)
  • Our results indicate that SHP-2 promotes endothelial cell survival and proliferation, possibly by growth factor dependent PI3-K and MAP kinase activation, and is necessary for new vessel formation. (uni-muenchen.de)
  • The topological data analysis studies the shape of a space at multiple scales. (helsinki.fi)
  • We are concerned with investigating topological image texture analysis techniques to assess different type of degradation. (spie.org)
  • E. A. van Strien, D. Zuidema, R.W. Goldbach, Vlak, J. M. (1992) Nucleotide sequence and transcriptional analysis of the polyhedrin gene of Spodoptera exigua nuclear polyhedrosis vi-rus. (scirp.org)
  • R. D. Possee, S. C. Howard, (1987) Analysis of the polyhedrin gene promoter of the Autographa californica nuclear polyhedro-sis virus. (scirp.org)
  • In Japan, the diagnosed prevalence of Hunter Syndrome was found to be 315 in 2021, resulting in the second highest after the US across the 7MM. (abnewswire.com)
  • We investigated image quality discriminating characteristics of these simplicial complexes by computing these models for a large dataset of face images that are affected by the presence of shadows as a result of variation in illumination conditions. (spie.org)
  • RESULTS: Here, we report the characterization of a cDNA, 1RT126I22, which contains a TNF homology domain. (usda.gov)
  • 16S rDNA analysis showed that the identified sample in this experiment was Proteus vulgaris after biofield treatment. (slideserve.com)
  • Suhandiman, Tri- strains were most closely related to Republic of China, resulting in wibowo. (cdc.gov)
  • Delayed and/or inadequate innate immune responses can result in failure to combat pathogens, whereas excessive and/or inappropriate responses cause runaway inflammation. (sdbonline.org)
  • Comparing to the primary recombination, the secondary and tertiary recombination shifted toward the proximal regions due to the increase of homology between the pairing partners. (usda.gov)
  • The 3B-3E recombinants were genotyped by high-throughput wheat 90K single nucleotide polymorphism (SNP) arrays and their recombination breakpoints physically mapped based on the FGISH patterns and SNP results. (usda.gov)
  • Research to practice potential : results of this study will emphasize importance of cleaning turnout gear, and proper handling of AFFF waste. (cdc.gov)
  • In this study, we systematically compared 12 commercially available platforms for analysis of microRNA expression. (nih.gov)
  • The results indicate that each method has its strengths and weaknesses, which help to guide informed selection of a quantitative microRNA gene expression platform for particular study goals. (nih.gov)
  • [ 7 ] In one study, it was mapped to 2q23-24 by linkage analysis. (medscape.com)
  • The analyses unveiled a noteworthy heterogeneity in the pathogenicity determinants. (mdpi.com)
  • He adds, "PH exemplifies a topographical analysis that reveals patterns within data that traditional statistical methods in tourism often overlook. (spjain.org)
  • The results of luciferase reporter assay revealed that miR-338-3p and G6PC2 were the potential targets of has_circ_0046060. (hindawi.com)
  • A logistic regression analysis was used to evaluate the association between the distribution of genotypes and their interactions with CAP in children. (bvsalud.org)
  • Simplicial homology applies to finite data in real space, and thus it is mainly used in applications. (helsinki.fi)
  • Analysis of clinical presentations of Bruton disease: a review of 20 years of accumulated data from pediatric patients at Severance Hospital. (lu.se)
  • Throughout his career, his aim has been to combine experimental, theoretical and data analysis methods to obtain holistic understanding of biological and medical problems. (lu.se)
  • This change in taxonomy was based on the results of a guanine-plus-cytosine content analysis. (medscape.com)
  • S. Gomi, C. E. Zhou, W. Y. Yih, K. Majima, Maeda S. (1997) Deletion analysis of four of eighteen late gene expression factor gene homologues of the baculovirus, BmNPV. (scirp.org)
  • In addition, analysis on culture dependent and culture independent bacteria were done, which might play a vital role in the degradation of the non-degradable compounds. (ispub.com)
  • W. B. Wang, S. Y. Zhu, L. Q. Wang, F. Yu, Shen W. D. (2005) Cloning and sequence analysis of the Antheraea pernyi nucleo-polyhedrovirus gp64 gene. (scirp.org)
  • Analysis of the RNA viral sequences revealed coding regions for a predicted RNA dependent RNA polymerase (RdRp), a hallmark of RNA viruses. (virology.ws)
  • We show, however, that when homology is used with a global metabolic network one is able to predict organismal metabolic networks that have enhanced network connectivity. (nature.com)
  • These results clearly show that at least two related but distinct RNA viruses are present in Nymph Lake. (virology.ws)
  • 3] Proteomic analysis of urine from patients with Lowe syndrome typically show low levels of megalin and cubilin denoting a decrease in the number of these multiligand receptors in the PTC. (medscape.com)
  • We will found that these provide sufficient tools to consider homology classes birth and deaths, but they are not particularly easy to use in practice. (helsinki.fi)
  • CONCLUSIONS: To our knowledge, this is the first identification and expression analysis of fish TNFSF 13b. (usda.gov)
  • Expression of the polh gene of AnpeNPV in E. coli was examined by SDS-PAGE, Western blot and Mass-spectrum analysis. (scirp.org)
  • The result showed that the bacterium expression system was suitable for the virus gene expression. (scirp.org)
  • Subsequent studies using serologic analysis of recombinant expression libraries (SEREX) and database mining ( 4 - 6 ) identified multiple families of CTAs. (aacrjournals.org)
  • In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges. (sdbonline.org)
  • Quantitative real-time polymerase chain reaction analysis identified that expression patterns of bZIP s differed, including in different organs and under various abiotic stresses. (biomedcentral.com)
  • RESULTS: Levels of OPN expression increased in smokers, smokers with COPD, and smokers with COPD and lung cancer, as compared with healthy nonsmokers. (bvsalud.org)
  • Four were human immunodeficiency virus (HIV)-negative by self-report and one had an HIV-negative test result. (cdc.gov)
  • We measured an identical set of 20 standardized positive and negative control samples, including human universal reference RNA, human brain RNA and titrations thereof, human serum samples and synthetic spikes from microRNA family members with varying homology. (nih.gov)
  • Increased insulin resistance (IR) and immune tolerance in pregnant women result in metabolic and immunological alterations, which may aggravate the development of gestational diabetes mellitus (GDM). (hindawi.com)
  • We predict organismal metabolic networks using sequence homology and a global metabolic network constructed from all available organismal networks. (nature.com)
  • While sequence homology has been a standard to annotate metabolic networks it has been faulted for its lack of predictive power. (nature.com)
  • This in turn results in aPKCζ-mediated NUMB phosphorylation, NUMB dissociation from p53, and p53 degradation (Fig. 1a ) 12 . (nature.com)
  • Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
  • Advances in genomic analysis have led to a clearer understanding of the COX pathway. (medscape.com)
  • Exploratory meta‐analyses revealed a significant increase in the foveal avascular zone area & a significant decrease in superficial parafoveal & whole vessel density in AD, although there was significant heterogeneity between studies. (ed.ac.uk)