• Quail, D. F. & Joyce, J. A. The microenvironmental landscape of brain tumors. (nature.com)
  • As the Interphone group acknowledges, it is "unlikely" that cell phones could immediately provide protection against brain tumors (see main Interphone Story ). (microwavenews.com)
  • Interphone is a case-control study, in which those with brain tumors are compared with a reference group. (microwavenews.com)
  • Researchers from Children's Hospital of Philadelphia (CHOP), the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab , the Children's Brain Tumor Network (CBTN) , the Pacific Pediatric Neuro-Oncology Consortium (PNOC) , and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors. (chop.edu)
  • Pediatric brain tumors are collectively the leading cause of cancer-related death in children in the United States. (chop.edu)
  • However, the severity of pediatric brain tumors varies wildly, with some having an almost universally fatal prognosis while others have relatively strong long-term survival rates, though all brain tumors negatively impact these children and their families to at least some degree. (chop.edu)
  • Limited access to tissue samples and patient-derived cell lines has been a significant barrier to understanding the differences between pediatric brain tumors at a molecular level. (chop.edu)
  • More than 1,000 of these tumors were sequenced to form the initial release of the Pediatric Brain Tumor Atlas (PTBA) in 2018, and data were made available without embargo so that researchers could study what variants might be driving certain types of brain tumors. (chop.edu)
  • At the time of this study, OpenPBTA contained genomic and clinical data from more than 1,000 pediatric brain tumors and 22 patient-derived cell lines from the CBTN and PNOC. (chop.edu)
  • The OpenPBTA provides an open, real-time framework to genomically characterize pediatric brain tumors. (chop.edu)
  • It is the first large-scale, collaborative, open analysis of genomic data and provides a cloud-based resource for researchers looking for more comprehensive data on pediatric brain tumors. (chop.edu)
  • OpenPBTA is already providing researchers with more insight into potential drivers of pediatric brain tumors. (chop.edu)
  • Solving pediatric brain tumors cannot be accomplished by any one institution. (chop.edu)
  • A pooled analysis was conducted to examine the association between select variants in DNA repair genes and glioblastoma multiforme, the most common and deadliest form of adult brain tumors. (cdc.gov)
  • Few studies have reported on the associations between variants in DNA repair genes and brain tumors, and few specifically have examined their impact on glioblastoma multiforme. (cdc.gov)
  • PATIENTS: Fifty-seven patients who had undergone tumor resection for colon cancer were included. (lu.se)
  • We conducted a systematic review and meta-analysis of randomized and non-randomized controlled trials that compared pure endoscopic with microscopic transsphenoidal surgery (TSS) in the resection of pituitary tumors. (scielo.br)
  • The outcomes were total tumor resection, achievement of biochemical control of functioning adenomas, hospital stay and surgery complications. (scielo.br)
  • In the 1990s, a distinct impulse came from the otorhinolaryngologists, with the use of the endoscope in functional endoscopic sinus surgery, disclosing the pathway to the sella turcica and the endoscopic approach for resection of pituitary tumors either alone or as an adjunct to the microneurosurgery. (scielo.br)
  • Some experienced neurosurgeons and otorhinolaryngologists have changed to the endoscopic surgery, claiming that this procedure is safer, less invasive, and allows a wider view of the sella turcica, improving tumor resection rates ( 1 1. (scielo.br)
  • Data collection included demographics, preoperative American Society of Anesthesiologists (ASA) status, tumor pathology, and tumor resection and remission rates. (plos.org)
  • This subgroup analysis focuses on solely surgically treated node-negative patients with complete tumour resection (n = 289). (uni-koeln.de)
  • In patients with a history of low-grade Ta disease and a noted sub-centimeter papillary tumor(s), consider in-office fulguration as an alternative to resection under anesthesia. (medscape.com)
  • One theory is that it may have arisen as the timeframe believed to be required for healing after tumor resection. (medscape.com)
  • Because of the influence on different cell cycle processes, SMARCB1 is understood to be a tumor suppressor gene. (goldenhelix.com)
  • Validation of whole genome amplification for analysis of the p53 tumor suppressor gene in limited amounts of tumor samples. (diva-portal.org)
  • In this study, researchers found that the loss of the tumor suppressor gene TP53 is a significant marker for poor overall survival in fast-growing brain and spinal cord tumors called ependymomas and certain diffuse midline gliomas, and dysregulation of the gene was also implicated in hypermutant high-grade gliomas. (chop.edu)
  • Collectively, we suggested that ATAD5 could be a novel tumor suppressor gene. (nih.gov)
  • Background - How to best support patients with neuroendocrine tumors (NETs) remains unclear. (ices.on.ca)
  • Implications for Practice - This study used population‐level, prospectively collected, validated, patient‐reported outcome measures to appraise the symptoms burden and trajectory of patients with neuroendocrine tumors (NETs) after diagnosis. (ices.on.ca)
  • Background - An increased incidence of neuroendocrine tumors (NETs) has been reported worldwide, but the reasons underlying this rise have not been identified. (ices.on.ca)
  • Neuroendocrine tumors (NETs) associated with carcinoid syndrome (CS) overproduce serotonin, mediated by tryptophan hydroxylase-1 (TPH1). (analysisgroup.com)
  • In cancer research, advancing a comprehensive understanding of the unique characteristics of individual tumor types and their microenvironment is of considerable importance for clinical translation. (nature.com)
  • Here we describe a multimodule integrated pipeline for the processing of freshly resected human brain tumor tissue and matched blood that enables analysis of the tumor microenvironment, with a particular focus on the tumor immune microenvironment (TIME). (nature.com)
  • This protocol will enable researchers to use this pipeline to address further research questions regarding the tumor microenvironment. (nature.com)
  • Herein, we report near-infrared light and tumor microenvironment (TME), dual responsive as well as size-switchable nanocapsules. (nature.com)
  • In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
  • Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize. (the-scientist.com)
  • With the deepening of the research on the immune microenvironment and immunotherapy , researches exploring tumor ablation and immunity are continuously published. (bvsalud.org)
  • Benign ovarian tumors were associated with an increased risk of ovarian cancer (pooled relative risk [RR]=1.39, 95% confidence interval [CI]: 1.01-1.90), with high heterogeneity among studies. (frontiersin.org)
  • Alternative parameters computed through textural analysis were recently proposed to quantify the heterogeneity of tracer uptake by tumors as a significant predictor of response. (snmjournals.org)
  • A Bland-Altman analysis was performed on 8 parameters based on histogram measurements and 17 parameters based on textural heterogeneity features after discretization with values between 8 and 128. (snmjournals.org)
  • Several parameters derived from textural analysis describing heterogeneity of tracer uptake by tumors on local and regional scales had reproducibility similar to or better than that of simple SUV measurements. (snmjournals.org)
  • More recently, characterization of tracer uptake heterogeneity based on textural analysis extracted from PET images has been also proposed, allowing an improved predictive and prognostic value to be derived from baseline PET scans ( 7 , 8 ). (snmjournals.org)
  • Genetic analysis of single circulating tumor cells shows high intra-patient heterogeneity. (epicsciences.com)
  • The study, titled "Intra-patient genomic heterogeneity of single circulating tumor cells (CTCs) associated to phenotypic CTC heterogeneity in metastatic castrate resistant prostate cancer (mCRPC)," was conducted in collaboration with clinical investigators at Memorial Sloan Kettering Cancer Center. (epicsciences.com)
  • There is a great deal of tumor heterogeneity in late stage cancer and identifying the individual clones and the genetic alterations driving their continued growth may help guide treatment selection and accelerate or better enable drug development. (epicsciences.com)
  • Successful treatment of cancer depends on understanding the heterogeneity of the patient's tumor burden and the driving genetic alterations behind their disease progression," said Murali Prahalad, Ph.D., president and CEO of Epic Sciences. (epicsciences.com)
  • Due to tumor heterogeneity one can only hope the biopsy sample represents the biology of the majority of tumor. (her2support.org)
  • The routine method for detecting disseminated tumor cells in lymph nodes is microscopic examination of one or a few hematoxylin and eosin-stained tissue sections by a trained pathologist. (lu.se)
  • That is the reason why they were not included in genetic analyses of cancer. (eurekalert.org)
  • An increase in risk associated with other disease, relation with family history of germ cell tumor, relation with other genetic diseases will give boost to the market growth. (databridgemarketresearch.com)
  • Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. (nottingham.ac.uk)
  • This finding may contribute to the understanding of the genetic mechanism of Wilms tumor. (jcancer.org)
  • As part of the multicenter, population-based Ohio Colorectal Cancer Prevention Initiative, tumor DNA was sequenced for 419 consecutive CRC cases undergoing standard universal tumor screening and germline genetic testing, and 46 patients with CRC known to have LS due to a germline mutation in a mismatch repair gene. (cdc.gov)
  • DESIGN: This study is a side-by-side comparison of biomarker mRNA analysis and histopathology of 185 lymph nodes from patients with colon cancer representing stages I to IV, and an investigation of the importance of lymph node tissue volume for tumor cell detection. (lu.se)
  • CONCLUSIONS: mRNA analysis of CEACAM5, KLK6, and SLC35D3 improves the detection of tumor cells in lymph nodes from patients surgically treated for colon cancer, and, together with POSTN and MUC2, it further allows characterization of the tumor cells with respect to aggressiveness and the tumor cell environment. (lu.se)
  • And as the cost of single-cell transcriptomic analysis continues to drop, oncologists can access better tumor profiling to guide the treatment of cancer patients," he says. (medicalxpress.com)
  • Ten articles (two cohorts, seven case-control studies, and one pooled analysis of eight case-control studies) with 10331 ovarian cancer patients were included. (frontiersin.org)
  • In addition to tumor characteristics, low income and rural residency portend worse survival for patients with NETs. (ices.on.ca)
  • This study aimed to analyze the special performance of 18FDG-PET/CT in pNET patients and to assess the correlation between glucose metabolism and differentiation degree of tumor. (enets.org)
  • Further, CNV alterations associated with tumor suppressor loss or oncogene amplification were predominantly observed in resistant patients. (epicsciences.com)
  • We conducted a real-world clinical practice study to explore the effects of TE on tumor growth in patients with NETs and CS. (analysisgroup.com)
  • The prevalence of patients requiring anti-tumour therapy is also of great importance, as it is directly associated with planning of health care resources. (biomedcentral.com)
  • This work proposes a population-based model for the estimation of stage-specific prevalence of CRC patients who will require active anti-tumour therapy in a given year. (biomedcentral.com)
  • Its applicability is documented on records of the Czech National Cancer Registry (CNCR), which is used to estimate the number of patients potentially treated with anti-tumour therapy in the Czech Republic in 2015. (biomedcentral.com)
  • Moreover, the model predicts that 10,074 to 11,440 CRC patients will be indicated for anti-tumour therapy in the Czech Republic in 2015. (biomedcentral.com)
  • A new model for the estimation of the number of CRC patients requiring active anti-tumour therapy is proposed in this paper. (biomedcentral.com)
  • The objective of this paper is to propose a new model for the estimation of the number of CRC patients requiring active anti-tumour therapy that is fully based on the population-based cancer registry data. (biomedcentral.com)
  • Conclusions: Our results refine the use of electropherogram profiles to optimize sample selection for subsequent high-throughput analysis and support the use of liquid biopsy followed by enzymatic conversion of unmethylated cysteines to assess the methylomes of neuroblastoma patients. (upf.edu)
  • Herein we assess the impact of implementing a protocol of more rigorous patient education, recovery room assessment for non-ICU admission, earlier mobilization and post-discharge communication for patients undergoing brain tumor surgery. (plos.org)
  • All patients undergoing craniotomy or endoscopic endonasal removal of a brain, skull base or pituitary tumor were included during two non-overlapping periods: March 2019-January 2020 (pre-pandemic epoch) versus March 2020-January 2021 (pandemic epoch with streamlined care protocol implemented). (plos.org)
  • Here we performed detailed analyses of expansion, phenotype, clonality and function of Vdl and Vd2 gd T cells isolated from patients and age-matched healthy donors (HD, n=53). (muni.cz)
  • Two 3D image analysis algorithms, nearest-neighbor tissue segmentation and surface modeling, were applied separately to serial MR images in patients with glioblastoma multiforme (GBM). (ajnr.org)
  • The nearest-neighbor tissue segmentation algorithm provides significant power in quantifying tumor volume and in tracking growth rates of contrast-enhancing tissue in patients with GBM. (ajnr.org)
  • An algorithm capable of reliably and accurately tracking changes in tumor volume would be of value as an adjunct marker in following up patients with cerebral tumors. (ajnr.org)
  • As part of a comprehensive longitudinal study of patients with high-grade gliomas, we analyzed the performance of two different algorithms in their ability to segment tissue (eg, contrast-enhancing tumor) and to follow or track changes in tumor tissue over time. (ajnr.org)
  • So far, radioimmunotherapy (RIT) has only induced significant therapeutic effect in patients with hematologic tumors, presumably due to their relatively high radiosensitivity ( 4 , 5 ). (snmjournals.org)
  • The retrospective analysis involved a review of the records of 108 patients with these neoplasms, investigating age, sex, anatomic region of the lesion and form of treatment, in addition to an analysis of the specimens submitted to histopathological examination. (bvsalud.org)
  • Patients receiving anti-tumor necrosis factor-α (anti-TNF-α) therapy are at increased risk for tuberculosis and other granulomatous diseases, but little is known about illness caused by nontuberculous mycobacteria (NTM) in this setting. (cdc.gov)
  • Giant-cell tumor of bone: analysis of two hundred and eight cases in Chinese patients. (medscape.com)
  • Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota. (medscape.com)
  • We performed a large case-control study involving 414 patients and 1199 cancer-free controls to investigate whether single nucleotide polymorphisms (SNPs) in the WDR4 gene are associated with Wilms tumor susceptibility. (jcancer.org)
  • Furthermore, the stratification analysis revealed that patients with the rs6586250 TT genotype and carriers with 1-5 risk genotypes exhibited statistically significant associations with increased Wilms tumor risk in specific subgroups. (jcancer.org)
  • Some cases progress, however, and most patients experience recurrence at least once in the follow-up period, creating the need for accurate tumor surveillance. (medscape.com)
  • For intermediate-risk patients whose first surveillance cystoscopy is negative for tumor, perform subsequent cystoscopy with cytology every 3-6 months for 2 years, then 6-12 months for years 3 and 4, and then annually thereafter. (medscape.com)
  • A universal tumor sequencing test can identify LS patients as well as guide treatment of CRC patients who do not have LS. (cdc.gov)
  • The test can identify CRC patients with MSI-high tumors who may respond well to PD1 blockade immunotherapy , recently approved by the Food and Drug Administration. (cdc.gov)
  • To the authors' knowledge, the 8305 carcinoid tumors analyzed represent the largest current epidemiology series to date. (nih.gov)
  • In addition to the insights on market scenarios such as market value, growth rate, segmentation, geographical coverage, and major players, the market reports curated by the Data Bridge Market Research also include depth expert analysis, patient epidemiology, pipeline analysis, pricing analysis, and regulatory framework. (databridgemarketresearch.com)
  • Indeed, Siegal Sadetzki , who led the Israeli Interphone team, used the same technique in her Interphone study of parotid gland tumors, which was published in the American Journal of Epidemiology, a leading journal, in 2008. (microwavenews.com)
  • The stratified analysis suggested the molecular subtype and tumor stage significantly influenced the prognostic value of FoxP3(+) Tregs in certain types of cancer. (nih.gov)
  • In conclusion, our meta-analysis suggests that the prognostic role of FoxP3(+) Tregs was highly influenced by tumor site, and was also correlated with the molecular subtype and tumor stage. (nih.gov)
  • The continuous advancement in diagnostic technologies, such as molecular imaging , next-generation sequencing , and liquid biopsies , is a significant driver for the global germ cell tumor treatment market. (databridgemarketresearch.com)
  • Personalized cancer treatment requires molecular characterization of individual tumor biopsies. (diva-portal.org)
  • Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. (nottingham.ac.uk)
  • The analysis of the electropherogram profiles revealed the presence of nucleosomal multimers, and occasionally high molecular weight DNA. (upf.edu)
  • Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
  • The study will be presented in Poster #247 (Abstract #11035), Tumor Biology Session on May 31, 8:00 a.m. (epicsciences.com)
  • Although most mutations in SMARCB1 primarily occur de novo, familial cases have been reported and if inherited leads to a condition called rhabdoid tumor predisposition syndrome (RTPS). (goldenhelix.com)
  • We also reported that haplo-insufficiency of ATAD5 in mice developed tumors and high incidences of somatic mutations of ATAD5 in human tumors. (nih.gov)
  • Tumors' mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells. (the-scientist.com)
  • This test is performed to evaluate for somatic mutations within solid tumor samples. (mayocliniclabs.com)
  • In a study of 450 CRC diagnosed under 50 years via the Ohio Colorectal Cancer Prevention Initiative, germline DNA analysis for mutations in 25 cancer susceptibility genes was done in addition to assessing microsatellite instability and/or immunohistochemistry for MMR deficiency. (cdc.gov)
  • Neuroendocrine Tumor (pNET) comprised a wide and heterogeneous group of neoplasms. (enets.org)
  • Moreover, several promising candidate genes differentially expressed in gefitinib sensitive and resistant NSCLC cell lines were revealed by a global mRNA expression analyses. (uni-muenchen.de)
  • A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. (nottingham.ac.uk)
  • Our analysis revealed that genes, such as TWIST1 , EREG , TNFRSF9 , and CTGF could drive the deregulation of various TME components. (elifesciences.org)
  • To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
  • See Targeted Genes and Methodology Details for POLE Mutation Analysis for details regarding the targeted gene regions evaluated by this test. (mayocliniclabs.com)
  • We also describe integrated modules for immunofluorescent staining of sectioned tissue, bulk tissue genomic analysis and fluorescence- or magnetic-activated cell sorting of digested tissue for subsequent culture or transcriptomic analysis by RNA sequencing. (nature.com)
  • Advances in tumor genomic sequencing have improved classification of tumor subtypes, guiding more precise cancer treatments and improving patient survival. (medicalxpress.com)
  • These samples are frequently only available in limited quantities hampering genomic analysis. (diva-portal.org)
  • Overall this data indicate a limited random loss of genomic regions supporting the use of whole genome amplification for genomic analysis. (diva-portal.org)
  • This application expands the investigational utility of Epic Sciences' "no cell left behind" platform to characterize circulating tumor cell (CTC) genomic alterations. (epicsciences.com)
  • In the meantime, new genomic research could be changing clinical and public health approaches to reducing the burden of colorectal cancer from LS and in general, by shifting the laboratory testing approach toward tumor next generation sequencing. (cdc.gov)
  • Transsphenoidal surgery (TSS) is the treatment of choice for most functioning and nonfunctioning pituitary tumors. (scielo.br)
  • The increase focus towards targeted therapies, along with the favorable government policies will additionally heighten numerous opportunities that will commence to the germination of the germ cell tumor treatment market in the above-mentioned forecast period 2023-2030. (databridgemarketresearch.com)
  • Germ cell tumor treatment refers to the medical interventions and therapies employed to treat tumors that originate from germ cells, which are cells that develop into sperm in men and eggs in women. (databridgemarketresearch.com)
  • That long sought-after data could lead to better diagnostic techniques and potential targeted therapies that could treat these deadly tumors. (chop.edu)
  • This paper does not focus on the specific anti-tumour therapies as well as their combinations. (biomedcentral.com)
  • To date, TB and NTM infections and concurrent biologic therapies that inhibit tumor necrosis factor-α (TNF-α) have been reported. (cdc.gov)
  • Tumour necrosis factor (TNF)-α is thought to be a key early cytokine in the pathogenesis of sarcoidosis, despite conflicting data. (ersjournals.com)
  • This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future. (ersjournals.com)
  • Tumour necrosis factor (TNF)-α is a key early cytokine in a variety of chronic inflammatory responses, including fibrosing alveolitis and granulomatous disease 6 - 8 . (ersjournals.com)
  • Tumor necrosis factor (TNF), the first pro-inflammatory cytokine to be released by an inflammatory response, suppresses the translation of the key enzyme of melatonin synthesis (arylalkylamine- N -acetyltransferase, Aanat ). (frontiersin.org)
  • Linear regression and longitudinal analyses assessed changes in tumor size controlling for background NET treatment. (analysisgroup.com)
  • Documented NET treatment prior to initiating TE and time between scans were not significant predictors of changes in tumor size. (analysisgroup.com)
  • Human tissue samples represent an invaluable source of information for the analysis of disease-specific cellular alterations and their variation between different pathologies. (nature.com)
  • However, investigating human brain tumor tissue is challenging due to the often-limited availability of surgical specimens. (nature.com)
  • Fig. 3: Variation in immune cell abundance and cell viability across different brain (tumor) tissue types. (nature.com)
  • Fig. 5: Immune cell yield and activation in brain (tumor) tissues differs across tissue dissociation methods. (nature.com)
  • Fig. 6: Cross-method validation of brain TIME and different isolation methods provide distinct advantages for the extraction of immune cells from brain tumor tissue. (nature.com)
  • Fig. 8: Representative data from human brain tumor tissue. (nature.com)
  • In the AMP guidelines interface the patient and sample information was entered and Central Nervous System/Brain was selected for the Tissue with Rhabdoid Meningioma (RHM) selected as the Tumor Type, Figure 2. (goldenhelix.com)
  • Rates of volumetric change were tracked for contrast-enhancing tumor tissue. (ajnr.org)
  • For specimen preparation guidance, see Tissue Requirement for Solid Tumor Next-Generation Sequencing . (mayocliniclabs.com)
  • Submit a formalin-fixed, paraffin-embedded tissue block with acceptable amount of tumor tissue. (mayocliniclabs.com)
  • Submit 1 slide stained with hematoxylin and eosin and 10 unstained, nonbaked slides with 5-micron thick sections of the tumor tissue. (mayocliniclabs.com)
  • Typically when data are presented, the fluor- escent intensity from the tissue is pseudo-colored red and the intensity from the reference green, and the logarithmic ratio of background corrected red and green intensities for each gene (spot) is subject to analysis (see Fig. 1 ). (lu.se)
  • We did a meta-analysis to assess the prognostic effect of FoxP3(+) Treg across different types of cancer and to investigate factors associated with variations in this effect. (nih.gov)
  • Robson and co-senior authors Shyam Prabhakar, a computational biologist at the Genome Institute of Singapore, and Iain Beehuat Tan, a medical oncologist at the National Cancer Centre Singapore, led an effort that screened 626 randomly selected individual cells from the colorectal tumors and adjacent normal cell samples using single-cell RNA sequencing. (medicalxpress.com)
  • These CAFs significantly contributed to the mesenchymal gene expression found in bulk tumor transcriptome data, a signature more often associated with a cancer cell process known as epithelial-mesenchymal transition. (medicalxpress.com)
  • Benign ovarian tumors were associated with an increased risk of ovarian cancer. (frontiersin.org)
  • Benign ovarian tumors may be precursors and etiological risk factors for ovarian cancer. (frontiersin.org)
  • While numerous epidemiological studies have investigated the association between benign ovarian tumors and ovarian cancer risk, the results have been inconsistent ( 5 - 14 ). (frontiersin.org)
  • Two large cohort studies based on the Danish Cancer Register indicated that benign ovarian tumors may be associated with a long-term increased risk of both mucinous and borderline ovarian cancers ( 7 , 8 ). (frontiersin.org)
  • A pooled analysis of eight case-control studies with 5207 cases and 7705 controls in multiple countries suggested that ovarian cysts may not be associated with the risk of ovarian cancer ( 9 ). (frontiersin.org)
  • Since the relationship between benign ovarian tumors and ovarian cancer risk remains unclear, this systematic review and meta-analysis aimed to assess the association based on the most recent epidemiological evidence. (frontiersin.org)
  • Malignant Rhabdoid tumors (MRT) are among the most aggressive and lethal forms of infant and child cancer (1). (goldenhelix.com)
  • With the help of the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the team of researchers was able to build an open-source version of this atlas, the Open Pediatric Brain Tumor Atlas (OpenPBTA), to analyze these data. (chop.edu)
  • In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
  • As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
  • Neuroblastoma is an extracranial solid tumor most common in children and responsible for up to 15% of cancer-related deaths. (upf.edu)
  • However, the limited blood sample size which can be obtained from children with cancer and the fact that ctDNA content may occasionally be diluted by non-tumor cell-free DNA (cfDNA) complicate optimal quantities of material for high-throughput sequencing studies. (upf.edu)
  • New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture. (the-scientist.com)
  • Moreover, in vivo studies confirm that the CTAC@MSNs-HSA are able to induce cancer cell death and efficiently inhibit tumor growth. (rsc.org)
  • diagnostic prediction of small round blue cell tumors (SRBCT) of childhood and determining the estrogen receptor (ER) status of sporadic breast cancer. (lu.se)
  • Introduction to the SEER Program The National Cancer Act of 1971 mandated the collection, analysis, and dissemination of all data useful in the prevention, diagnosis, and treatment of cancer. (cdc.gov)
  • Universal Screening for Lynch Syndrome: Can Tumor Sequencing Have a Larger Public Health Impact on Treatment and Prevention of Colorectal Cancer? (cdc.gov)
  • To date, gene expression in such tumors has been profiled using bulk transcriptome methods, providing a single transcriptome measure for what, in essence, represents many cell types. (medicalxpress.com)
  • The main emphasis is on supervised machine learning methods for classification and prediction of tumor gene expression profiles. (lu.se)
  • An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells. (lu.se)
  • We performed meta-analysis as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. (medpagetoday.com)
  • therefore, this systematic review and meta-analysis evaluated this association. (frontiersin.org)
  • Because this was a study-level systematic review and meta-analysis of observational studies and did not involve the collection and analysis of any individual-level data, ethical approval was not sought for this study. (frontiersin.org)
  • This systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines ( 15 ) ( Supplementary Table S1 ). (frontiersin.org)
  • Local control of extra-abdominal desmoid tumors: systematic review and meta-analysis. (dtrf.org)
  • The purpose of this study was to evaluate the occurrence of benign tumors of the jaws over a period of ten years. (bvsalud.org)
  • First described by Cooper and Travers in 1818, giant cell tumors (GCTs) of bone have been labeled the most challenging benign bone tumors. (medscape.com)
  • In the United States and Europe, GCTs represent approximately 5% of all primary bone tumors and 21% of all benign bone tumors. (medscape.com)
  • Background: Liquid biopsy has emerged as a promising, non-invasive diagnostic approach in oncology because the analysis of circulating tumor DNA (ctDNA) reflects the precise status of the disease at diagnosis, progression, and response to treatment. (upf.edu)
  • A method currently used by the Eastern Cooperative Oncology Group and the Radiation and Treatment Group to determine tumor response to treatment relies on measuring the area of tumor enhancement in a single MR section (1) . (ajnr.org)
  • However, the relationship between polymorphisms in the WDR4 gene and susceptibility to Wilms tumor remains to be fully investigated. (jcancer.org)
  • Primary tumor site, metastatic disease, younger age, higher comorbidity burden, lower socioeconomic status, and receipt of therapy within 30 days of assessment were independently associated with higher risk of elevated symptom burden. (ices.on.ca)
  • The nanoparticles possessed good biocompatibility and could generate singlet oxygen to cause remarkable photodynamic anti-tumor effects. (springer.com)
  • It has also been shown that metformin and phenformin inhibit tumor growth by disrupting mitochondrial complex. (rsc.org)
  • In this meta-analysis of clinical trials of PD-1/PD-L1-targeted agents, we evaluate the predictive value of a tumor and tumor-infiltrating immune cell PD-L1 IHC assay as a biomarker for objective response to PD-1/PD-L1 inhibitors. (medpagetoday.com)
  • Our meta-analysis shows that tumor and tumor-infiltrating immune cell PD-L1 overexpression based on IHC is associated with significantly higher response rates to PD-1/PD-L1 axis inhibitors across a range of malignant solid tumors. (medpagetoday.com)
  • Due to the low evidence level and low number of observations, the results of our meta-analysis should not be viewed as a final proof of inferiority or superiority of one approach in relation to the other. (scielo.br)
  • Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too. (the-scientist.com)
  • The surface modeling algorithm is able to quantify tumor volume reliably as well. (ajnr.org)
  • There is no method presently in widespread use to quantify tumor volume. (ajnr.org)
  • Therefore, this study aimed to conduct a bibliometric analysis to quantify and identify the status quo and trend of tumor ablation and immunity . (bvsalud.org)
  • Several scenarios are adopted to cover the plausible development of the incidence and survival rates, and the probability of an anti-tumour therapy initiation. (biomedcentral.com)
  • The overall goal of this procedure is to rapidly isolate xenotransplanted human tumor cells from mice to improve the downstream analysis of the desired target cells. (jove.com)
  • The uptake and retention in the tumor of 111 In-/ 125 I-labeled bivalent peptides ( l -a.a. peptide and d -a.a. peptide) were studied in female BALB/c athymic mice with subcutaneous SK-RC-52 RCC tumors. (snmjournals.org)
  • Tumors were pretargeted with the bispecific monoclonal antibody (bs-mAb) G250xDTIn-1 and, 72 h later, mice were injected intravenously with one of both radiolabeled peptides. (snmjournals.org)
  • The effect of bs-mAb-diDTPA-bs-mAb (DTPA is diethylenetriaminepentaacetic acid) bridging at the tumor cell surface on the internalization of the bs-mAb-diDTPA complex was investigated in SK-RC-52 tumor-bearing mice. (snmjournals.org)
  • Attach the heater to the dissociator, then click the folder symbol on the touch screen and use the up and down arrows to select the appropriate tumor dissociation mode. (jove.com)
  • As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
  • Carcinoid tumors are unusual and most reports are anecdotal or limited in number. (nih.gov)
  • A cumulative analysis of all types of carcinoid tumors in the SEER group indicates that in 45.3% metastases are already evident at the time of diagnosis. (nih.gov)
  • OBJECTIVE: This study aimed to investigate whether analysis of a selected group of biomarker mRNAs improves detection and characterization of lymph node metastases/micrometastases compared with the routine method. (lu.se)
  • Additional PET-derived parameters allowing a more complete lesion characterization include mean SUV (SUV mean ), metabolically active tumor volume (MATV, defined as the tumor volume that can be seen and delineated on a PET image), and total lesion glycolysis (defined as the product of MATV and its associated SUV mean ), although they all require an accurate delineation of the functional tumor volume. (snmjournals.org)
  • Monoclonal antibodies (mAbs) directed against tumor-associated antigens have excellent characteristics to target tumor cells selectively ( 1 - 3 ). (snmjournals.org)
  • In the process of tumor ablation, a large number of tumor cell debris is released, which can be used as a source of tumor antigens and trigger a series of immune responses . (bvsalud.org)
  • Objective response rates (primary endpoint) from all phase I to III trials investigating nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab in advanced solid tumors were collected. (medpagetoday.com)
  • Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [ 1 ]. (hindawi.com)
  • [ 1 ] In China, GCTs have been estimated to account for 20% of all primary bone tumors. (medscape.com)
  • RESULTS: The number of tumor cell-positive lymph nodes was 1.33-fold higher based on CEACAM5 mRNA levels compared with histopathological examination. (lu.se)
  • Data Bridge Market Research analyses that the global germ cell tumor treatment market which was USD 12.82 billion in 2022, is expected to reach USD 16.84 billion by 2030, and is expected to undergo a CAGR of 3.5% during the forecast period 2023-2030. (databridgemarketresearch.com)
  • Germ cell tumor can occur in the testicles, ovaries, and various other parts of the body, such as the abdomen, chest, and brain. (databridgemarketresearch.com)
  • Drugs targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway show significant clinical activity across several tumor types. (medpagetoday.com)
  • Combining single-cell genomics and computational techniques, a research team including Paul Robson, Ph.D., director of single-cell biology at The Jackson Laboratory (JAX), has defined cell-type composition of cancerous cells from 11 colorectal tumors, as well as adjacent noncancerous cells, a key to more targeted diagnosis and treatment. (medicalxpress.com)
  • Using single-cell signatures," says JAX Research Scientist Elise Courtois, Ph.D., co-first author of a study published in Nature Genetics , "colorectal cancers can be further divided into subgroups based on cell-type composition of tumors. (medicalxpress.com)
  • By employing single-cell transcriptomic technology it is now possible to deconstruct a tumor into its component cell-type parts and therefore gain a better understanding of the underlying biology. (medicalxpress.com)
  • To circumvent the bias caused by these contaminating cells during downstream analysis, we developed a method allowing for comprehensive depletion of all mouse cells by magnetic cell sorting. (jove.com)
  • The elimination of the contuminating mouse cells by this method allows the specific assessment of human tumor cell gene expression or in vitro direct responses. (jove.com)
  • Then centrifuge the cells and resuspend the human tumor mouse stromal cell pellet in five milliliters of PB buffer. (jove.com)
  • Distribution of giant cell tumors according to age and sex of patient. (medscape.com)
  • Second, we determined the whole genome profiles of tumour-reactive gd T cells and compared these to healthy donors. (muni.cz)
  • Wilms tumor is the most common embryonal renal malignancy in children. (jcancer.org)
  • Wilms tumor is the most frequently occurring embryonal renal malignancy in children, representing approximately 7% of childhood tumors [ 1 ]. (jcancer.org)
  • In addition, unconditioned logistic regression analysis was performed, odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association between WDR4 gene SNPs and Wilms tumor susceptibility as well as the strength of the associations. (jcancer.org)
  • However, tumors typically contain a variety of cancerous and noncancerous cells that all contribute to the biology of the tumor. (medicalxpress.com)
  • Human tumor xenografts are vascularized and infiltrated by cells of mouse origin during the growth phase in vivo . (jove.com)
  • The main advantage of this technique is that the human tumor cells can be quickly and easily isolated without having to identify any surface markers on the target cells. (jove.com)
  • It is well known that the rapid growth of tumor cells and distortion of tumor blood vessels often results in insufficient oxygen supply and acidification in solid tumors. (nature.com)
  • Human gd T cells are currently the subject of intensive research ana large expansions of tumour-reactive gd T cells have been observed inpatients with haematological malignancies including Multiple Myeloma (MM) and chronic leukaemias (CML, CLL) in our laboratory. (muni.cz)
  • The 131 I radiolabel generally clears rapidly from the tumor after internalization and subsequent degradation of the bivalent l -amino acid peptide ( l -a.a. peptide) in the tumor cells. (snmjournals.org)
  • Unfortunately, after internalization and degradation of the 131 I-labeled peptide in the lysosomes, the metabolite 131 I-Tyr is rapidly cleared from tumor cells ( 12 - 15 ). (snmjournals.org)
  • In this experiment, we found that apelin normalizes tumor vasculature, resulting in improvement of drug delivery and tumor immunity. (nii.ac.jp)
  • Knowledge mapping of image-guided tumor ablation and immunity: A bibliometric analysis. (bvsalud.org)
  • However, no research has systematically analyzed the intellectual landscape and emerging trends for tumor ablation and immunity using scientometric analysis . (bvsalud.org)
  • In the past decade, the neighborhood of tumor ablation domain immunity has been paid more and more attention . (bvsalud.org)
  • Here we investigated the characteristics of the residualizing iodine label in SK-RC-52 RCC tumors. (snmjournals.org)
  • It is the largest and most detailed analysis of patient‐reported symptoms for NETs. (ices.on.ca)
  • Image analysis algorithms may also be used to facilitate the planning of radiation therapy and surgery. (ajnr.org)
  • Accordingly, the radiation dose to the tumor, correlating with the therapeutic efficacy of pretargeted RCC, can be enhanced substantially. (snmjournals.org)
  • In multivariate logistic regression analysis the significant correlates of current waterpipe use for both males and females were having smokers among friends and family members, while for males, older age and educational failure were also risk factors. (who.int)
  • Fig. 4: Examples of IF staining across different brain (tumor) tissues. (nature.com)
  • On the contrary, small size NPs with a diameter of 4-20 nm easily penetrate into deep tumor tissues, but they are more prone to rapid clearance and insufficient drug retention. (nature.com)
  • Through its ability to detect contrast in soft tissues, MR imaging is well suited to monitor and evaluate cerebral tumors as they develop and respond or, as the case may be, fail to respond to therapy. (ajnr.org)
  • T polymorphism of the WDR4 gene was significantly associated with Wilms tumor. (jcancer.org)
  • In what follows we limit ourselves to the analysis of gene expression measurements obtained using microarrays with small spots of DNA fixed to glass slides. (lu.se)