Analysis of the transcriptional occur replication through transcriptional. Medical search. Frequent questions

The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
Although AmlR apparently is a local transcriptional regulator of the aml operon, the Δ amlR strain shows severe growth inhibitions on glucose and - concomitantly - differential transcription of several genes of various functional classes. (frontiersin.org)
The genome-wide phylogenetic trees were also superior to trees based on 43 SNPs in the replication, repair and recombination genes in that the latter exhibited branch collapse in this study. (sun.ac.za)
The comparative SNP analysis among the 7 sub-lineages of Beijing showed the evolution of amino acid changes occurred mostly in the genes of cell wall, cell processes, intermediary metabolism and respiration. (sun.ac.za)
We have also attempted to verify a series of differentially expressed candidate susceptibility genes to lung tumours in our previous microarray analysis with semiquantitative reverse transcriptase PCR (RT-PCR). (bmj.com)
Genes are flanked by conserved transcriptional initiation and termination (polyadenylation) sites. (ictv.global)
DNA damage leads to cellular responses that include the increased expression of DNA repair genes, repression of DNA replication and alterations in cellular metabolism. (biomedcentral.com)
Differential effects on the expression of the three transcription factor B ( tfb ) genes hint at a mechanism for the modulation of transcriptional patterns in response to DNA damage. (biomedcentral.com)
These findings suggest a scenario where collisions between DNA replication and transcription are frequent, leading to increased genetic variability, as seen by the increase SNP levels at chromosome subtelomeres and in DGF-1 genes containing putative origins. (biomedcentral.com)
Gene ontology category and KEGG analysis suggested that 216 upregulated genes in MZ-2 were annotated by 70 GO assignments, 242 upregulated genes were associated with 188 signal pathways, while 321 upregulated genes in MZ-3 were annotated by 56 GO assignments, 322 upregulated genes were associated with 168 signal pathways. (biomedcentral.com)
The molecular functions of upregulated genes in MZ-3 were mainly enriched for transcriptional activity, cell proliferation and cell differentiation. (biomedcentral.com)
In lytic infection, virus IE genes ( genes) are expressed initial, followed by expression of early genes, DNA replication, and expression of late genes. (angiotensinreceptor.com)
The maximum rate of synthesis by genes occurs three? (angiotensinreceptor.com)
However, this analysis requires accurate reference genomes to identify the specific genes from which RNA reads originate. (osti.gov)
This analysis revealed a developmental time point between 10 and 12 days after germination where FLC expression had decreased but LFY expression had not yet increased, which was characterized by a peak in the number of differentially expressed genes. (biomedcentral.com)
Gene Ontology (GO) enrichment analysis of these genes identified an overrepresentation of genes related to the cell cycle. (biomedcentral.com)
Analysis of mutants with abnormal flowering time has allowed the identification of genes controlling floral transition [ 8 ]. (biomedcentral.com)
Interferons are a broad class of cytokines elicited to defend the organism and are essential for mobilizing the immune response to pathogens, activating genes that impair their replication. (news-medical.net)
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. (cancerindex.org)
all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
Analysis of 270 families in the DKC registry found that mutations in dyskerin ( DKC1 ), TERT , and TERC only account for 64% of patients, with an additional 1% due to NOP10 , suggesting that other genes associated with this syndrome are, as yet, unidentified. (medscape.com)

Vpr stands for "Viral Protein R". Vpr, a 96 amino acid 14-kDa protein, plays an important role in regulating nuclear import of the HIV-1 pre-integration complex, and is required for virus replication and enhanced gene expression from provirus in dividing or non-dividing cells such as T cells or macrophages. (wikipedia.org)
This was shown to be due to decreased transcriptional output from the integrated HIV viral genome. (wikipedia.org)
Using mutational analysis (biochemical identification of mutational changes in a nucleotide sequence), prevention of cell cycle progression into mitosis was shown to be required for LTR-mediated viral expression. (wikipedia.org)
These findings suggest that the evolutionarily secured G2 cell cycle arrest function of Vpr (Viral Protein R) is essential for HIV-1 replication. (wikipedia.org)
Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. (nature.com)
A single amino acid substitution in SP26 was found to be responsible for altering its intracellular localization as well as its function as a post-transcriptional regulator of viral gene expression. (gla.ac.uk)
Increasing evidence has shown that KSHV infection can alter central carbon metabolic pathways to produce biomass for viral replication, as well as the survival and proliferation of infected cells. (frontiersin.org)
Increasing evidence has shown that virus infection, similar to cancer development, depends on the reprogramming of cellular metabolism to produce biomass for viral replication and virion production. (frontiersin.org)
They observed that HSV-1 swiftly induced expression of SOCS3 in a human amniotic cell line (FLcells) resulting in efficient viral replication. (angiotensinreceptor.com)
We compared the HCV anti- viral effect of the most potent SKI-1/S1P small molecule inhibitor (PF-429242) with a set of two statins on different steps of the viral life cycle, and showed that SKI-1/S1P inhibitor blocked HCVcc (strain JFH-1) RNA replication (EC50 = 5.8 lM) more efficiently than statins. (cp-673451inhibitor.com)
To evade host's innate immune response, influenza has evolved a few strategies for viral replication. (datexis.com)
We also found that viral replication was suppressed in the presence of aptamers, which suggests that the selected RNA aptamers can be developed as a useful therapeutic agent in future. (datexis.com)
The protein interferon helps inhibit replication of the virus and is an extremely important part of the response to any viral disease,' she said. (news-medical.net)
The different interactions between viral proteins and cellular host proteins are required for efficient replication of HIV-1. (biomedcentral.com)
The siRNA knockdown (KD) of PSF resulted in increased viral replication in TZM-bl cells, suggesting PSF has negative influence on viral replication. (biomedcentral.com)
In an attempt to study the host interacting protein of IN, we have identified a new interacting host protein PSF which is a splicing factor and elucidated its role in integration and viral replication. (biomedcentral.com)
Experimental as well as in silico analysis inferred that the host protein causes not only change in the integration events but also targets the incoming viral DNA or the integrase-viral DNA complex. (biomedcentral.com)
MD trajectory analyses provided a strong clue of destabilization of Integrase-viral DNA complex occurred due to PSF interaction with the conserved bases of viral DNA ends that are extremely crucial contact points with integrase and indispensable for integration. (biomedcentral.com)
Identification of these interacting host cellular protein provide better understanding of mechanism of viral replication and subsequently development of new therapeutic approaches. (biomedcentral.com)
They are involved in DNA repair during retroviral integration process as well as viral Long terminal repeat (2-LTR) formation, which occurs in the absence of viral DNA integration. (biomedcentral.com)

Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication timing of the INK4a/ARF locus during senescence. (plos.org)
Filovirus RNP complexes are composed of a genomic RNA molecule and four virion-associated structural proteins: NP (nucleoprotein), VP35 (RNA-dependent RNA polymerase cofactor), VP30 (transcriptional activator), and L (RNA-dependent RNA polymerase). (ictv.global)
There was, however, a clear transcriptional response, including repression of DNA replication and chromatin proteins. (biomedcentral.com)
A clear response to DNA damage was observed, with down-regulation of the DNA replication machinery, changes in transcriptional regulatory proteins, and up-regulation of the biosynthetic enzymes for beta-carotene, which has UV protective properties, and proteins that detoxify reactive oxygen species. (biomedcentral.com)
In general, the aim is to ensure that DNA repair proteins are activated and that DNA replication is delayed until repair can be completed. (biomedcentral.com)
When DNA damage occurs, a damage signal corresponding to the strand exchange protein RecA bound to single-stranded DNA causes the LexA repressor to be degraded, resulting in the induction of transcription of a large number of repair proteins. (biomedcentral.com)
There are no clear archaeal homologues of either bacterial LexA or of eukaryal proteins involved in the transcriptional response to DNA damage, such as p53. (biomedcentral.com)

Given the complexity of human transcriptional regulation in vivo and the multitude of potential epigenetic mechanisms cooperating to regulate transcriptional activity, questions remain about the interplay of regulatory mechanisms in patients with CMML. (nature.com)
Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. (frontiersin.org)
The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model. (spandidos-publications.com)
Moreover, DNA hypomethylation of the COX‑2 promoter region located from ‑1,522 to ‑829 bp might contribute to transcriptional regulation of COX‑2 expression and induce a pro‑inflammatory response in KIC. (spandidos-publications.com)
Polypyrimidine tract binding protein and associated splicing factor (PSF) has diverse functions inside the cell such as transcriptional regulation, DNA repair, acts as nucleic acids binding protein and regulate replication and infectivity of different viruses. (biomedcentral.com)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)

Retroviruses must integrate their genome into the host DNA as a necessary step of their replication cycle. (gla.ac.uk)
The sheep genome harbours at least twenty-seven enJSRV loci and, most likely, the process of endogenization is still occurring. (gla.ac.uk)
Finally, sequence analyses revealed that the domestic sheep has acquired, by genome amplification, several copies of the enJS56A1 provirus, reinforcing the hypothesis that this locus has provided an evolutionary advantage to the host. (gla.ac.uk)
This study aimed to further elucidate the evolutionary history of the 7 sub-lineages of the Beijing lineage of M. tuberculosis in a Cape Town suburb of South Africa using whole genome sequencing analysis. (sun.ac.za)
WGS revealed that ~ 70% of these tumors had HPV integrations within the human genome and HPV integration occurred independent of HPV copy number. (biomedcentral.com)
According to the model it is believed that the integration of HPV into the human genome is an important step in carcinogenesis as a frequent site of disruption is the HPV E2 gene which is a transcriptional repressor of the HPV-specific oncogenes: E6 and E7. (biomedcentral.com)
An examination of a large number of HPV16 and HPV18-positive cervical cancers has revealed that while most HPV18-positive cervical cancers have HPV integrated somewhere within the human genome, this only occurs in about 75% of HPV16-positive cervical cancers [ 8 ]. (biomedcentral.com)
It was also discovered that there is no preferential disruption of the HPV E2 gene as breakpoints occur throughout the HPV genome in cervical cancer [ 9 ]. (biomedcentral.com)
Whole genome sequencing has revealed the complexity of the HPV18 integration event in the HeLa cell line and this integration occurs within an HPV18-specific hot-spot near the c-MYC oncogene. (biomedcentral.com)
Here we have mapped sites of DNA replication initiation across the T. cruzi genome using Marker Frequency Analysis, which has previously only been deployed in two related trypanosomatids. (biomedcentral.com)
Genome replication is responsible for accurate transmission of genetic information through cell division cycles. (biomedcentral.com)
As originally proposed in 1963, cells rely on two genetic elements to duplicate their genome: the replicator, a DNA region where replication begins (now named the replication origin), and the initiator, a protein or a protein complex that recognizes the replicator [ 1 ]. (biomedcentral.com)
Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. (cancerindex.org)

Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M (2009) Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence. (plos.org)
To our knowledge, this is the first systematic and integrated analysis at genetic, epigenetic, transcriptomic, and functional levels of multiple single-cell-derived clones from human cancers to incorporate high-quality and comprehensive description of essentially all somatic mutations present in multiple single cells," the authors concluded. (genomeweb.com)
Several changes in histone H3 and H4 PTMs were observed, including a marked increase in H3K79me2 and H3K27me3K36me2, and a decrease in H4K16ac, highlighting likely epigenetic strategies of transcriptional activation and silencing during HCMV lytic infection. (princeton.edu)
This work documents multiple histone PTMs that occur in response to HCMV infection of fibroblasts, and provides a framework for evaluation of the role of epigenetic modifications in the virus-host interaction. (princeton.edu)

These include control of the transcriptional repertoire of the cell, activation of repair enzymes and repression of DNA replication and cell division. (biomedcentral.com)

Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic cells. (plos.org)
in an operon with an upstream PurR/LacI-type transcriptional regulator gene, named amlR ( ACSP50_2475 ), and a gene downstream ( ACSP50_2473 ) encoding a GGDEF-EAL-domain-containing protein putatively involved in c-di-GMP signaling. (frontiersin.org)
The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)

Together, these results provide a unified model that integrates replication, transcription and epigenetics at the INK4/ARF locus. (plos.org)
Whilst archaea have eukaryal-type informational pathways such as DNA replication and transcription, archaeal DNA repair pathways are still poorly understood. (biomedcentral.com)
Collision between replication and transcription is considered especially problematic, as each are catalyzed by large multiprotein machines, and can occur co-directionally, when the replication fork and transcription machinery are moving in the same direction, or on the leading strand and is head-on, when the fork and transcription are moving towards each other. (biomedcentral.com)
Splicing factor such as Serine Arginine rich splicing factor (SRSF1) [ 16 ] regulate HIV-1 transcription whereas, Small nuclear RNAs [ 17 ] inhibit HIV-1 replication through excessive RNA Splicing. (biomedcentral.com)

Here we show that in young proliferating embryonic fibroblasts (MEFs) the Polycomb Repressive Complex 2 (PRC2) member EZH2 together with PRC1 members BMI1 and M33 are strongly expressed and localized at the INK4/ARF regulatory domain (RD) identified as a DNA replication origin. (plos.org)
A novel protein call AnkA in A. phagocytophilum is translocated from the bacterium within a host vacuole into the host nucleus, where it forms complexes with heterochromatin and is largely responsible for many host transcriptional changes by directly binding to regulatory regions of the DNA. (cdc.gov)
a transcriptional cis regulatory region that when located between an enhancer and a gene's promoter prevents the enhancer from modulating the expression of the gene. (insdc.org)

Replication fork barriers are a commonly encountered problem, which can cause fork collapse and act as hotspots for replication termination. (elifesciences.org)
However, replication restart is relatively slow and, therefore, replication termination may frequently occur by an active fork converging on a collapsed fork. (elifesciences.org)
After origin firing, bidirectional replication forks travel until they reach termination sites. (biomedcentral.com)

The goal of scRNA-seq data integration is to characterize and eliminate the effect of experimental factors driving expression variation between multiple scRNA-seq datasets, so that downstream analyses such as clustering [ 9 , 10 ] and trajectory inference [ 10 , 11 , 12 ] performed on all datasets jointly are not driven by these factors. (biomedcentral.com)
Therefore, downstream analysis of integrated datasets typically involves clustering cells across datasets to find matching cell types and estimating cell type-specific differences across datasets. (biomedcentral.com)

Vpr is also immunosuppressive due to its ability to sequester a proinflammatory transcriptional activator in the cytoplasm. (wikipedia.org)

scRNA-seq dataset integration occurs in different contexts, such as the identification of cell type-specific differences in gene expression across conditions or species, or batch effect correction. (biomedcentral.com)

Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. (elifesciences.org)
Analysis of the placenta samples showed that in non-infected obese pregnant women there were no alterations in transcriptional expression of antiviral factors or expression of types I and III interferon. (news-medical.net)

The lack of an in vitro cell culture system that demonstrated a deficit in replication upon infection with viruses in the absence of Vpr has led to some mystery in the function of Vpr. (wikipedia.org)
This replication difference occurred in a single round of infection. (wikipedia.org)
Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. (nature.com)
to determine the average age of ms onset vs the age at which epstein-barr infection has previously occurred and stratify this analysis by sex and the blood level of epstein-barr nuclear antigen 1 (ebna1) antibody. (liverpool.ac.uk)
This work represents the first comprehensive quantitative analysis of global histone post-translational modifications (PTMs) from a virus infection, namely human cytomegalovirus (HCMV) infection. (princeton.edu)

During evolution, one of these enJSRV loci, enJS56A1, has acquired a defective and transdominant Gag polyprotein that blocks the late replication steps of related retroviruses, by a mechanism known as JSRV late restriction (JLR). (gla.ac.uk)
A total of 186 SNPs and 241 SNPs were discovered in the coding regions of the dwarf lines 1282 and 1303, respectively, and we discovered 33 homogeneous nonsynonymous SNPs that occurred at the same loci in each set of dwarf and normal soybean. (genominfo.org)
Association analysis identifies 65 new breast cancer risk loci. (cancerindex.org)

Intergenic SNPs unique to each sub-lineage were however identified in close proximity to previously described transcriptional start sites and thus warrant further investigations on their associated transcriptional promoter activity. (sun.ac.za)

High risk human papillomaviruses (HPV) plays important roles in the development of cervical cancer, a number of other anogenital cancer and they are increasingly found in oropharyngeal squamous cell carcinoma (OPSCC), however there has not been comprehensive analysis about the role how these viruses play in the development of OPSCC. (biomedcentral.com)

We identified the replication licencing factor CDC6 as a new partner of the Polycomb group member BMI1. (plos.org)

In the presence of functional DNA replication, RTEL1 mutations produce a large amount of extrachromosomal T-circles. (medscape.com)
In addition to the mutations that directly effect telomere length, recent studies also indicate that a DKC diagnosis should not be based solely on the length of the telomere, but also the fact that there are defects in telomere replication and protection. (medscape.com)

Western blotting was used for protein expression analysis of the collected cell masses (spheroids), and H-E staining was used for structural observation. (medsci.org)
Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)
They also found that intra-tumor diversification of DNA methylation and transcriptome states occurred, and that the alternations were cell-autonomous, stable, and followed the phylogenetic tree of each cancer. (genomeweb.com)

These infected human dendritic cells showed a slower rate of replication when deprived of the Vpr protein in HIV-1 cells. (wikipedia.org)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
In all other eukaryotes, clear consensus sequences for origins are elusive, perhaps indicating there are no cis elements to initiate replication in most of these cells and organisms. (biomedcentral.com)
According to the usage, origins have been classified as constitutive (fired at same position in different cells of a population), flexible (fired stochastically in different cells) and dormant (fired as consequence of replication stress) [ 5 ]. (biomedcentral.com)
HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. (biomedcentral.com)
In this study, we established circRNA expression profiles in FMDV-infected PK-15 cells using RNA-seq (RNA-sequencing) technology analysis. (biomedcentral.com)

We used a nanoLC-MS/MS platform to identify and quantify the dynamic histone H3 and H4 PTMs expressed during HCMV replication in primary fibroblasts. (princeton.edu)

Collapsed forks can be rescued by homologous recombination, which restarts replication. (elifesciences.org)
Eukaryotic DNA replication initiates at multiple origin sites along each chromosome and terminates when replication forks (RFs) from adjacent origins converge. (elifesciences.org)

An overlap of SNPs called by each mapping algorithm determined our set of high confidence SNPs which were subsequently used for phylogenetic and comparative SNP analysis. (sun.ac.za)
The more focused analysis of 2 closely-related members of Beijing sub-lineage 7 having contrasting virulence phenotypes had unique predicted deleterious non-synonymous SNPs which were associated with their whole proteome expression. (sun.ac.za)

DNA replication in trypanosomatids operates in a uniquely challenging environment, since most of their genomes are constitutively transcribed. (biomedcentral.com)

Histological analyses were performed on the mouse functional genomics platform RIO/Marseille-Nice Genopole with support from the INCA PROCAN program. (plos.org)
By sequence similarity analysis and functional assays from the species Streptomyces lividans TK23, S. coelicolor A3(2) and S. glaucescens GLA.O, first hints for a widespread lack of MalP and presence of AmlE in the class Actinobacteria were given. (frontiersin.org)

Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb from the INK4/ARF locus, its transcriptional activation and its replication during early S-phase. (plos.org)

Each mutational signature can be regarded as the outcome of a mutational process, which includes components of DNA damage or modification, DNA repair (or absence of it), and DNA replication, with each component potentially influencing the profile of the signature," the authors wrote. (genomeweb.com)

We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
IFN- promotes expression of SOCS1 in the transcriptional level (43). (angiotensinreceptor.com)
In obese pregnant women who contracted zika, we observed a decrease in transcriptional expression of RIG-I and IFIH1 [ the precursor gene for the protein MDA-5 ]. (news-medical.net)

Previous experimental observations revealed that KIC occurred in bladder mucosa and decreased bladder capacity, enhanced detrusor hyperactivity and thereafter induced interstitial fibrosis ( 1 ). (spandidos-publications.com)

2, 3] The software application uses quantitative analysis of nuclear medicine liver-spleen images to determine the severity of liver disease and to predict clinical outcomes. (medscape.com)

We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)

Further, their RNA-seq analysis found that diversification of methylation and transcriptome state occurred within each cancer and this was apparently heritable, stable, and independent of the tumor microenvironment, as it persisted after the organoids were cultured in vitro . (genomeweb.com)
DNMT1 preserves the methyltransferase by binding to hemi-methylated CpG sites and methylates the cytosine on the newly synthesized strand after DNA replication, whereas DNMT3a/DNMT3b are required for the de novo genomic methylation of DNA ( 15 ). (spandidos-publications.com)

Total RNA extracted from second- (MZ-2) and third-generation merozoites (MZ-3) of Eimeria necatrix was subjected to transcriptome analysis using RNA sequencing (RNA-seq) followed by qRT-PCR validation. (biomedcentral.com)

Where transplantation from another allogeneic host occurs, unless the transplant is matched with the host or the host is immunocompromised, the transplant may be attacked and destroyed by the immune system. (justia.com)
When a transplant occurs which includes lymphocytes, monocytes or progenitors thereof, particularly bone marrow, a graft may attack the host as foreign, resulting in graft-versus-host disease. (justia.com)

Hierarchical levels can also be distinguished by the rates at which processes occur-faster at finer scales, slower at coarser ones. (cdc.gov)

understanding epstein-barr virus life cycle with proteomics: a temporal analysis of ubiquitination during virus reactivation. (liverpool.ac.uk)
The study showed that these evasion strategies enabled the virus to persist in placenta, facilitating its replication and transmission to the fetus. (news-medical.net)

Understanding factors required for DNA replication will enrich our knowledge of this important process and potentially identify vulnerabilities that can be exploited in cancer therapy. (aacrjournals.org)
Integrative analyses are challenging due to several factors. (biomedcentral.com)

We proved in this study that the placenta's immune response, or rather the immune response that occurs at the maternal-fetal interface, is highly compromised in these cases. (news-medical.net)
Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)

On the other hand, analysis between this polymorphism genotype distribution and cervical cancer risk, showed that allele A of this polymorphism may be a risk factor for patients with a positive history of tobacco smoking [ 14 ]. (biomedcentral.com)

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Anatomy22

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