• The team identified 1,215 blocks of genes that consistently occur on the same chromosome in the same order across all 32 genomes. (bionity.com)
  • The scientists found nine whole chromosomes, or chromosome fragments in the mammal ancestor whose order of genes is the same in modern birds' chromosomes. (bionity.com)
  • This remarkable finding shows the evolutionary stability of the order and orientation of genes on chromosomes over an extended evolutionary timeframe of more than 320 million years," Lewin says. (bionity.com)
  • AceView: gene:him-8, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
  • The induction cascades of early morphogenesis involve numerous growth factors, homeobox genes, and paired domain genes. (medscape.com)
  • Comparative genomic hybridisation (CGH) was used to screen 76 vestibular schwannomas from 76 patients (66 sporadic and 10 NF2 related) to identify other chromosome regions that may harbour genes involved in the tumorigenesis. (bmj.com)
  • Thus, crucial genes seem to have been retained by the Y chromosome. (biomedcentral.com)
  • The chromosome encodes a complete type VI secretion system and plasmid genes encode type IV secretion proteins. (nottingham.ac.uk)
  • Identifying genes on each chromosome is an active area of genetic research. (medlineplus.gov)
  • Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
  • Chromosome 18 likely contains 200 to 300 genes that provide instructions for making proteins. (medlineplus.gov)
  • The signs and symptoms of distal 18q deletion syndrome are thought to be related to the loss of multiple genes from this part of the long arm of chromosome 18. (medlineplus.gov)
  • Correlation analysis and target prediction with genes in the gene set of IFN-α response revealed that 10 miRNA-mRNA pairs presented a significant correlation. (bvsalud.org)
  • The deletion of varying lengths of chromosomal material along the short arm of chromosome 11 is the underlying defect, and developmental abnormalities are related to the contiguous loss of neighboring genes. (medscape.com)
  • Because miRNAs may regulate approximately 60% of human genes [ 11 ], the relationship between miRNAs and human diseases has been extensively explored in the last decade. (cdc.gov)
  • 2003). A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. (umaryland.edu)
  • Genetic loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have been mapped to chromosomes 2p, 8q, 12q, 14q, and 15q. (nih.gov)
  • Therefore, in this system, current models of sex chromosome evolution predict that recombination would be selected against between the sex determining locus and linked loci involved in colouration. (nature.com)
  • This process would shrink the pseudoautosomal region in favour of expanding X- and Y-specific regions, creating a male supergene on the Y chromosome containing multiple colouration loci and thereby resolving sexually antagonistic selection. (nature.com)
  • She did not have a CASR mutation within the coding region and splice sites, and 24 members from three generations of her kindred were ascertained and investigated for serum abnormalities and cosegregation with polymorphic loci from chromosomes 3q21.1 and 19q13 using leukocyte DNA. (ox.ac.uk)
  • Use of microsatellite and single nucleotide polymorphic loci from chromosome 19q13.3 demonstrated cosegregation with FHH in the kindred, with a peak LOD score = 5.98 at 0% recombination with D19S412. (ox.ac.uk)
  • A genome-wide linkage analysis was performed to localise Quantitative trait loci influencing BMI in a large cohort collected in the PROCARDIS coronary heart disease study consisting of 1,812 informative families. (ox.ac.uk)
  • Genetic correlations between loci on different chromosomes can be high and can generate false positive linkage. (nervenet.org)
  • Short tandem repeats (STRs) compose approximately 3% of the genome, and mutations at STR loci have been linked to dozens of human diseases including amyotrophic lateral sclerosis, Friedreich ataxia, Huntington disease, and fragile X syndrome. (biomedcentral.com)
  • It is possible that each of these mechanisms contributes to the high mutation rate of STRs, but strand slippage is the mechanism proposed for generating most observed mutations in STR loci [ 19 ]. (biomedcentral.com)
  • The predicted promoter region spans 714 basepairs from 4,246,532 to 4,247,245 on the plus strand of chromosome 19. (wikipedia.org)
  • The predicted promoter region spans 1002 base pairs from 98,611,892 through 98,612,893 on the minus strand of chromosome 2. (wn.com)
  • Human Genetics 118, 245-254. (umaryland.edu)
  • Human molecular genetics. (wustl.edu)
  • American journal of human genetics. (wustl.edu)
  • Human molecular genetics , 22 (2), 408-415. (johnshopkins.edu)
  • 19 examples: We present an integrated view of the molecular genetics, physiology and… An influential adoption study of schizophrenia in 1966 by American behavioral geneticist Leonard Heston showed that children adopted away from their schizophrenic biological mothers at birth were just as likely to become schizophrenic (about 10 percent) as were children reared by their schizophrenic biological mothers. (thecoffeeparlor.com)
  • The first human behavioral genetic research on intelligence and mental illness began in the 1920s, when environmentalism (the theory that behaviour is a result of nongenetic factors such as various childhood experiences) became popular and before Nazi Germany's abuse of genetics made the notion of hereditary influence abhorrent. (thecoffeeparlor.com)
  • A team of researchers at the Max Planck Institute for Molecular Genetics and Charité - Universitätsmedizin Berlin led by human geneticists Malte Spielmann and Stefan Mundlos analyzed clinical samples from patients with genetic developmental disorders with the Hi-C method. (mpg.de)
  • As the team led by human geneticists Stefan Mundlos and Malte Spielmann describe in the current issue of The American Journal of Human Genetics , a method from basic research could improve clinical diagnostics considerably at some point in the future. (mpg.de)
  • Despite of the extraordinary importance that all new knowledge on human genetics will have in dental clinics, little efforts have been made to prepare undergraduates in relation to this new information and technology. (bvsalud.org)
  • Sequencing struggled, however, to detect a 20-kb gap that D-R mapping showed clearly in a megabase fragment that otherwise mapped well to the reference at the pericentromeric region of chromosome 4. (ox.ac.uk)
  • Pericentromeric regions are complex and show substantial sequence homology between different chromosomes, making mapping of sequence reads ambiguous. (ox.ac.uk)
  • The importance of structural variation in human disease and the difficulty of detecting structural variants larger than 50 base pairs has led to the development of several long-read sequencing technologies and optical mapping platforms. (nabsys.com)
  • The Human Genome Project (HGP) started in the United States of America aiming at sequencing and mapping the human genetic code. (bvsalud.org)
  • The goal of this study is to determine if linkage to chromosome 4q exists in our series of well-characterized families with idiopathic familial pancreatic cancer enrolled in the Pancreatic Cancer Genetic Epidemiology Consortium (PACGENE). (elsevierpure.com)
  • Methods: Parametric and nonparametric linkage analyses were performed using 21 microsatellite markers on chromosome 4 on affected individuals with pancreatic cancer from 42 familial pancreatic cancer kindreds. (elsevierpure.com)
  • We show that although the nascent Y chromosome encompasses nearly half of the linkage group, there has been no perceptible degradation of Y chromosome gene content or activity. (nature.com)
  • Quantitative trait genetic linkage analysis of body mass index in familial coronary artery disease. (ox.ac.uk)
  • METHODS: Multipoint linkage analysis for BMI was conducted using both a variance component approach and a model-free regression method, and the resulting LOD scores were compared. (ox.ac.uk)
  • RESULTS: The strongest evidence for linkage was detected on chromosomes 13 (LOD 1.6). (ox.ac.uk)
  • Genomic DNA was extracted from white blood cells, and a genome-wide linkage or a locus-specific exclusion analysis was completed with polymorphic short tandem repeats (STRs). (molvis.org)
  • In order to trace the origins and migratory patterns that may have led to the genetic isolation and autosomal clustering in some of these communities we analyzed Y-chromosome STR and SNP sample data from 6327 individuals, in addition to whole genome autosomal sample data from 609 individuals, from Mount Lebanon and other surrounding communities. (nature.com)
  • Autosomal DNA analyses suggest that the North Lebanese Mountain Maronite community possesses an ancestral Fertile Crescent genetic component distinct from other populations in the region. (nature.com)
  • The reconstruction shows that the mammal ancestor had 19 autosomal chromosomes, which control the inheritance of an organism's characteristics outside of those controlled by sex-linked chromosomes, (these are paired in most cells, making 38 in total) plus two sex chromosomes, said Joana Damas, first author on the study and a postdoctoral scientist at the UC Davis Genome Center. (bionity.com)
  • Paired-end single-cell sequencing supported this finding, revealing a region of complexity and a 50-kb deletion. (ox.ac.uk)
  • The final benchmark set contains 12,745 isolated, sequence-resolved insertion (7,281) and deletion (5,464) calls ≥50 base pairs (bp). (nabsys.com)
  • Distal 18q deletion syndrome occurs when a piece of the long (q) arm of chromosome 18 is missing. (medlineplus.gov)
  • The term "distal" means that the missing piece (deletion) occurs near one end of the chromosome arm. (medlineplus.gov)
  • The deletion that causes distal 18q deletion syndrome can occur anywhere between a region called 18q21 and the end of the chromosome. (medlineplus.gov)
  • The term "proximal" means that in this disorder the deletion occurs near the center of the chromosome, in an area between regions called 18q11.2 and 18q21.2. (medlineplus.gov)
  • Subject A has a large deletion on chromosome 11 that removes one copy of the BDNF gene. (medscape.com)
  • Analysis of markers on chromosome 19q gave a peak pairwise LOD score of 3.72 at D19S420, allowing assignment of a novel ADPHSP locus (which we have termed "SPG12") to this region. (nih.gov)
  • Haplotype construction and analysis of recombination events narrowed the SPG12 locus to a 16.1-cM region between markers D19S868 and D19S902. (nih.gov)
  • In addition, a pancreatic cancer susceptibility locus has been reported to be linked to chromosome 4q32-34 in a single family having a high penetrance of early-onset pancreatic ductal adenocarcinoma and pancreatic insufficiency. (elsevierpure.com)
  • We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10 -8 ]. (johnshopkins.edu)
  • The dominant theoretical model for the early stages of sex chromosome evolution 3 , 4 , 5 predicts that recombination will be selected against in the region between a sex determining gene and a nearby locus with alleles of sex-specific effect. (nature.com)
  • We estimate that a 95-kilobase-pair segment containing BOLA2 duplicated across the critical region approximately 282 thousand years ago (ka), one of the latest among a series of genomic changes that dramatically restructured the locus during hominid evolution. (pacb.com)
  • To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). (johnshopkins.edu)
  • Microsatellite genotyping was used for haplotype analysis. (molvis.org)
  • Silver Age of GOLD Introduces New Features The Genomes OnLine Database makes curated microbiome metadata that follows community standards freely available and enables large-scale comparative genomics analysis initiatives. (doe.gov)
  • In humans, mutations in the L1 cell adhesion molecule are associated with a neurological syndrome termed CRASH, which includes corpus callosum agenesis, mental retardation, adducted thumbs, spasticity, and hydrocephalus. (jneurosci.org)
  • By watching the timing of the cells' development, doctors could determine which cells are genetically healthy, and which have abnormal numbers of chromosomes, finds the study published today (Dec. 4) in the journal Nature Communications. (livescience.com)
  • Combining data about the abnormal timing with other signs that something has gone wrong (such as fragmented DNA and asymmetrical cell sizes within a developing embryo) could reliably show which cells have the right number of chromosomes and which don't, the researchers report. (livescience.com)
  • Tetrasomy 18p results from the presence of an abnormal extra chromosome, called an isochromosome 18p, in each cell. (medlineplus.gov)
  • The presence of endogenous bornavirus and filovirus sequences were subsequently confirmed and extended to 19 different vertebrate species. (virology.ws)
  • In situ hybridization analysis in adultmouse testis showed that tesmin is specifically expressed in spermatocytes.Quantitative RT-PCR at different stages of mouse postnatal development (days 4,8, 12, 18, and 42) revealed that tesmin is expressed as early as day 8 andcoincides with the entry of germ cells into meiosis. (embl.de)
  • The intracellular localization of CCDC94 has not yet been experimentally determined, but bioinformatic analysis using PSORT highly suggests CCDC94 resides in the nucleus due to the presence of nuclear localization signals. (wikipedia.org)
  • High-scoring segment pairs between the 15AR0984 genome and the plasmid pcjDM ware connected with gray bars to illustrate the similar shared regions except for the backbone regions, which were highly conserved across the pTet-like plasmid genomes. (cdc.gov)
  • The analysis also included the chicken and Chinese alligator genomes as comparison groups. (bionity.com)
  • Results This algorithm has been applied in a large-scale analysis of 1092 sequenced human genomes. (ucalgary.ca)
  • Bornaviral sequences were found in the genomes of humans, non-human primates, rodents, and elephants. (virology.ws)
  • Genomes of individuals strains typically incorporate 45-55 recombinations between parental chromosomes. (nervenet.org)
  • Genetic differences that specify unique aspects of human evolution have typically been identified by comparative analyses between the genomes of humans and closely related primates, including more recently the genomes of archaic hominins. (pacb.com)
  • Several attempts have been made toward identification of S/MARs in genomes of various organisms including human. (researchgate.net)
  • In each meiosis event, on average, gBGC results in replacement of 7 AT base pairs by GC base pairs, while only 6 GC pairs are replaced by AT pairs. (ucalgary.ca)
  • We demonstrate that whole genome maps, constructed from electronic detection of tagged DNA, hundreds of kilobases in length, can be used effectively to facilitate calling of structural variants ranging in size from 300 base pairs to hundreds of kilobase pairs. (nabsys.com)
  • The cyn operon is approximately 2600 base pairs and includes cynT,cynS, and cynX, which encode cyanate permease, cyanase, and a protein of unknown function, respectively. (embl.de)
  • Chromosome 18 spans about 78 million DNA building blocks (base pairs) and represents approximately 2.5 percent of the total DNA in cells. (medlineplus.gov)
  • Happening over millions of years of evolution, this bias may be a noticeable force in changing the nucleotide composition landscape along chromosomes. (ucalgary.ca)
  • Abstract Background GC-Biased Gene Conversion (gBGC) is one of the important theories put forward to explain profound long-range non-randomness in nucleotide compositions along mammalian chromosomes. (ucalgary.ca)
  • Here, we present an algorithm for analysis of millions of known SNPs that detects a subset of so-called "SNP flip-over" events representing recent gBGC nucleotide changes, which occurred in previous generations via non-crossover meiotic recombination. (ucalgary.ca)
  • Analysis of recombinants mapped FHH to a 3.46-Mbp interval flanked centromerically by single nucleotide polymorphism rs1990932 and telomerically by D19S604. (ox.ac.uk)
  • 2012). Comparative Effectiveness and Safety of Insulin Delivery and Glucose Monitoring Methods for Diabetes Mellitus: Systematic Review and Meta-analysis. (umaryland.edu)
  • The putative TSO1 protein has two cysteine-rich regions that aresimilar to the CXC domains of a variety of proteins from plants and animals,including a class of kinesins involved in chromosome segregation, and enhancer ofzeste-type proteins. (embl.de)
  • The biochemical pathways that control learning and memory in Drosophila are similar to those in other organisms, including mice and humans. (thecoffeeparlor.com)
  • Cow-Human Ortholog Pathways and Gene annot. (myexperiment.org)
  • We also performed correlation analysis and target prediction on pathways. (bvsalud.org)
  • The chromosomes of two Fhadeficient isolates included unexpected structural variation that did not appear to influence Fha production. (nabsys.com)
  • Often, DNA-containing cell fragments will fuse with other cells in the embryo, transferring extra chromosomes to those cells. (livescience.com)
  • They took 75 human embryos that had been frozen at the single-cell phase and cultured them in Petri dishes for two days, taking a microscopic snapshot of each embryo every five minutes. (livescience.com)
  • As the Cow genome is currently unfinished, the workflow subsequently maps the cow ensembl gene ids to human orthologues. (myexperiment.org)
  • The gene product is a 1,441 base pair mRNA with 8 predicted exons in the human gene. (wikipedia.org)
  • Conclusions On average, a human gamete acquires 7 SNP flip-over events, in which one allele is replaced by its complementary allele during the process of meiotic non-crossover recombination. (ucalgary.ca)
  • The human Y chromosome is male specific, constitutively haploid and largely escapes meiotic recombination. (biomedcentral.com)
  • The phenotype of the L1 mutant mouse indicates that it is a potentially valuable model for the human CRASH syndrome. (jneurosci.org)
  • Genome-wide scans localized the disease phenotype to chromosome 8q, a region harboring RP1, a gene previously implicated in the pathogenesis of RP. (molvis.org)
  • The dominant model of sex chromosome evolution posits that recombination is suppressed between emerging X and Y chromosomes in order to resolve sexual conflict. (nature.com)
  • These results provide empirical support for longstanding models of sex chromosome catalysis, and suggest an important role for sexual selection and sexual conflict in genome evolution. (nature.com)
  • Although we have a detailed understanding of the evolutionary consequences of the loss of recombination for sex chromosome evolution 1 , 2 , we still do not understand the evolutionary forces acting to halt recombination in the first place. (nature.com)
  • Recurrent copy number variation (CNV) at chromosome 16p11.2 accounts for approximately 1% of cases of autism and is mediated by a complex set of segmental duplications, many of which arose recently during human evolution. (pacb.com)
  • Many of the twentieth century archeologists and geographers who investigated the question of the inhabitants of the mountains of Lebanon and the nature of its human occupation also concluded that it was an unpopulated region during antiquity that was only visited by loggers and hunters [ 2 , 6 ]. (nature.com)
  • Multiplex ligation probe-dependent amplification analysis was performed to detect hypomethylation at the imprinting control region 1 on 11p15. (nih.gov)
  • Using replicate wild populations with differing levels of sexually antagonistic selection for colour, we also show that sexual selection leads to greater expansion of the non-recombining region and increased Y chromosome divergence. (nature.com)
  • 3.5 megabase pair region on chromosome 19q13.3. (ox.ac.uk)
  • The researchers applied a method called 'Hi-C' (High-throughput Chromosome Conformation Capture) to samples from patients with developmental disorders suspected to be caused by chromosomal rearrangements. (mpg.de)
  • Chromosomal rearrangements may alter these interaction patterns and can thus be seen in the analysis. (mpg.de)
  • The classical analysis of chromosomal defects is done by a karyogram, which is a microscopic view of stained chromosomes. (mpg.de)
  • The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 18. (medlineplus.gov)
  • [ 8 ] The 11p13 chromosomal analysis of these patients revealed that 10 of the 14 (71%) patients with WAGR syndrome had deletions (2 cryptic and 8 visible). (medscape.com)
  • WAGR syndrome is caused by the contiguous loss of chromosomal material from the short arm of chromosome 11. (medscape.com)
  • These syndromes result from the loss of chromosomal material from the short arm of chromosome 11. (medscape.com)
  • However, a comprehensive genome-wide map of human S/MARs is yet not available. (researchgate.net)
  • All humans examined carried one or more copies of the duplication, which nearly fixed early in the human lineage-a pattern unlikely to have arisen so rapidly in the absence of selection (P? (pacb.com)
  • While all DNA is stained blue, a specific sequence stained pink appears duplicated in one of the two copies of chromosome 17, but not the other. (mpg.de)
  • Two copies of chromosome 18, one copy inherited from each parent, form one of the pairs. (medlineplus.gov)
  • Cells normally have two copies of each chromosome, one inherited from each parent. (medlineplus.gov)
  • In people with tetrasomy 18p, cells have the usual two copies of chromosome 18 plus an isochromosome 18p. (medlineplus.gov)
  • As a result, each cell has four copies of the short arm of chromosome 18. (medlineplus.gov)
  • Trisomy 18 occurs when each cell in the body has three copies of chromosome 18 instead of the usual two copies, causing severe intellectual disability and multiple birth defects that are usually fatal by early childhood. (medlineplus.gov)
  • Affected individuals have two copies of chromosome 18, plus the extra material from chromosome 18 attached to another chromosome. (medlineplus.gov)
  • Previous analyses of tso1 mutants revealed a loss of control of directionalcellular expansion and coordination of growth of adjacent cells, and defects inkaryokinesis and cytokinesis. (embl.de)
  • Genome structures of the complete Campylobacter jejuni strain 15AR0984 chromosome and plasmid (15AR0984-m) isolated from humans and poultry, New Zealand, 2014-2016, compared with the closest plasmid (pcjDM) sequence found in GenBank. (cdc.gov)
  • The primary causative organisms, Campylobacter jejuni and C. coli, colonize the chicken's gastrointestinal tract and contaminated poultry meat is the primary mode of transmission to humans. (nottingham.ac.uk)
  • Analysis of the Campylobacter phage CP8 genome identified significant sequence identity of protein gp010 with the avian leukocyte receptor CD30 ligand. (nottingham.ac.uk)
  • IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans. (cdc.gov)
  • In addition to the above-mentioned rely on epidemiological data for which izing radiation should be considered reviews in the IARC Monographs , statistical significance is reached as carcinogenic to humans (Group 1). (who.int)
  • Uniparental disomy of chromosome 7 (UPD7) was analyzed by short tandem repeats typing. (nih.gov)
  • Short tandem repeats (STRs), or microsatellites, are 1-6 base pair (bp) motifs of repeating units of DNA. (biomedcentral.com)
  • Mucosal tissue was collected from four sites in the stomach of each patient as biopsy specimens for mRNA sequencing, gene set enrichment analysis, and microRNA (miRNA) sequencing. (bvsalud.org)
  • o Some data were not ready for release at the time of this publication due to continued processing of the data or analysis of laboratory specimens. (cdc.gov)
  • To create this benchmark for a broadly consented son in a Personal Genome Project trio with broadly available cells and DNA, the Genome in a Bottle Consortium integrated 19 sequence-resolved variant calling methods from diverse technologies. (nabsys.com)
  • 1979. Chemicals and industrial processes associated with cancer in humans. (cdc.gov)
  • In 1986, the NF2 gene was mapped to chromosome 22, and in 1993, two groups independently isolated the gene and named its encoding protein merlin or schwannomin. (bmj.com)
  • Phylogenetic analyses of these endogenous viral sequences reveal that both virus families are 40 to 50 million years old. (virology.ws)
  • Even though the guppy sex chromosomes are a classic model for the study of sexual conflict and sex chromosome divergence, little is actually known about the pattern of divergence between the X and Y chromosomes. (nature.com)
  • In the present study we used DYZ1, a satellite fraction present in the form of tandem arrays on the long arm of the human Y chromosome, as a tool to uncover sequence variations between the monozygotic males. (biomedcentral.com)
  • S/MARs identified in present study and their subsequent analysis also suggests that these elements act as hotspots for integration of retroviruses. (researchgate.net)
  • Galton became the first to use twins in genetic research and pioneered many of the statistical methods of analysis that are in use today. (thecoffeeparlor.com)
  • New technologies and analysis methods are enabling genomic structural variants (SVs) to be detected with ever-increasing accuracy, resolution and comprehensiveness. (nabsys.com)
  • Material and methods: Thirty-one students were interviewed by using a questionnaire with open questions, followed by qualitative and quantitative analysis through answers' grouping. (bvsalud.org)
  • Background information on the procedures, survey components, questionnaires, examination and laboratory methods, and statistical analysis guidelines is available on the NHANES III Reference Manuals and Reports (CD-ROM). (cdc.gov)
  • Promoter prediction and analysis was carried out using ElDorado. (wikipedia.org)
  • Promoter prediction and analysis was carried out using El Dorado through the Genomatix software page. (wn.com)
  • Coiled-coil domain containing 94 (CCDC94) is a protein that in humans is encoded by the CCDC94 gene. (wikipedia.org)
  • Protein interaction analysis for CCDC94 has been carried out using computational tools. (wikipedia.org)
  • Closer analysis shows very little potential for these interactions to be real, thus none should be considered actual protein-protein interactions. (wikipedia.org)
  • The protein interaction from the STRING analysis is shown. (wikipedia.org)
  • Transmembrane protein 53 , or TMEM53 , is a protein that is encoded on chromosome 1 in humans. (wn.com)
  • Transmembrane protein 131 (TMEM131) is a protein that is encoded by the TMEM131 gene in humans. (wn.com)
  • These results were mainly confirmed by the three different approaches used in the analysis. (ox.ac.uk)
  • If the quality scores are used in downstream analyses, these inaccuracies can have a significant impact on the results. (biomedcentral.com)
  • ReQON produces a new BAM file with more accurate quality scores, which can improve the results of downstream analysis, and produces several diagnostic plots showing the effectiveness of the recalibration. (biomedcentral.com)
  • The results of surveys, analyses, and studies are made known through a number of data release mechanisms including publications, mainframe computer data files, CD-ROMs (Search and Retrieval Software, Statistical Export and Tabulation System (SETS)), and the Internet. (cdc.gov)