Analyses revealed differentially expressed genes. Medical search. Frequent questions

Five of the 6 most significant gene ontology pathways involve inflammation and activation of the immune response with CD28 and CTLA signaling of Tcells. (scienceblog.com)
Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
Gene ontology analysis of the differentially expressed genes revealed the expected differences in gene expression profiles between the two tissues. (cambridge.org)
Furthermore, a functional analysis of differentially expressed genes revealed enriched gene ontology terms involved in the regulation of circadian rhythm, histone modification, meiotic nuclear division, and others. (biomedcentral.com)
Enrichment analysis was performed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. (nature.com)
Based on differentially expressed genes, we identified 22 major temporal co-expression (TCoE) patterns of gene expression and revealed enriched gene ontology biological processes. (usda.gov)
The Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment was obtained. (biomedcentral.com)
Bioinformatic analysis of the proteomes revealed shared Gene Ontology (GO) terms and signaling pathways within the clusters of co-expressed proteins (Tables 1-3 and S4. (lu.se)
Whole genome analysis of lung, sampled 24 hours after challenge, showed expression changes of not only genes belonging to several Gene Ontology groups with up-regulation of inflammatory-associated genes and those associated with lung remodeling but also genes involved in downsizing these processes. (cdc.gov)

Analysis of the functional categories of the proteins encoded by DEGs. (figshare.com)
By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. (researchsquare.com)
A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)
GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)
Our analysis revealed a higher number of differentially expressed genes (DEGs) in resistant plants (1,916) when compared with susceptible plants (1,226). (ugent.be)
For the DEGs at 2 dpi, Ingenuity Pathway Analysis predicted inhibition of multiple signaling pathways in response to NDV that regulate immune cell development and activity, neurogenesis, and angiogenesis. (escholarship.org)
STRING database and Enrichr were used for GO-term analysis, miRNA and TF analysis associated with DEGs. (degruyter.com)
Sensitivity and specificity of DEGs was assessed using receiver operating characteristic (ROC) analyses. (degruyter.com)
In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
The differentially expressed genes (DEGs) in AD were screened in GSE48350 dataset. (nature.com)
The differentially expressed oxidative stress genes (DEOSGs) were analyzed by intersection of DEGs and oxidative stress-related genes. (nature.com)
Thus, based on the differentially expressed genes (DEGs) of mitophagy-related tumor classification, we established a 13-gene signature and robust nomogram for predicting BC prognosis, which can be beneficial for the diagnosis and treatment of BC. (aging-us.com)
In our analysis, we established a stable signature, including 13 genes, based on differentially expressed genes (DEGs) in mitophagy-related tumor classification. (aging-us.com)
A prognosis model based on differentially expressed genes (DEGs) of cuproptosis patterns was constructed and validated. (figshare.com)
Differentially expressed genes (DEGs) were identified and analysed. (biomedcentral.com)
The DEGs' protein-protein interaction (PPI) network was built, and the enriched terms of the PPI network were also analysed. (biomedcentral.com)

Functional analysis revealed that there were 12 genes associated with cancer, based on the tumor‑associated gene database. (urotoday.com)
Erb‑B2 receptor tyrosine kinase 4, centrosomal protein 55 (CEP55) and vascular endothelial growth factor A are oncogenes, all of which were associated with tumor stage, whereas only CEP55 was significantly associated with survival time as determined by Gene Expression Profiling Interactive Analysis. (urotoday.com)
In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
[ 1 ] the Cancer Genome Anatomy Project index of tumor genes has classified more than 40,000 genes directly or indirectly involved in one or more cancers. (medscape.com)

The goal of the study was to compare whole-transcriptome, mucosal gene expression in Candida albicans (a parasitic fungus that can infect the mouth) associated chronic denture stomatitis to that of healthy oral mucosa and perform proteomic analyses of potential salivary biomarkers. (scienceblog.com)
By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
Investigation of hub genes for the development of potential therapeutic targets and candidate biomarkers is warranted. (nature.com)
Integrative analyses of hepatic differentially expressed genes and blood biomarkers during the peripartal period between dairy cows overfed or restricted-fed energy prepartum. (oregonstate.edu)
Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism, and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using Ingenuity Pathway Analysis (IPA). (oregonstate.edu)
Liu S, Huang Z, Deng X, Zou X, Li H, Mu S, Cao B. Identification of key candidate biomarkers for severe influenza infection by integrated bioinformatical analysis and initial clinical validation . (flu.org.cn)
3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)

80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)
Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Resistance to PWN is mediated by the induction of the jasmonic acid (JA) defense pathway, secondary metabolism pathways, lignin synthesis, oxidative stress response genes, and resistance genes. (ugent.be)
Genes in cancer-related pathways. (biomedcentral.com)
Gene enrichment analysis revealed that these lncRNA-related mRNAs are associated with cell adhesion, collagen adhesion, cell differentiation, and mainly enriched in ECM-receptor interaction and PI3K-Akt signaling pathways. (biomedcentral.com)
The bioinformatics analysis indicated that RE vs. OF cows had a liver with a greater lipid and amino acid catabolic capacity both pre- and post-partum while OF vs. RE cows had a greater activation of pathways/functions related to triglyceride synthesis. (oregonstate.edu)
This study expands our understanding of gene activity during oat seed maturation and provides plant breeders the means to change oat seed composition through targeted manipulation of key pathways. (usda.gov)
Unsensitized animals challenged with TMA exhibited also an increased number of macrophages in BAL, but gene expression in the above-mentioned gene pathways was unchanged or down-regulated. (cdc.gov)
orthogonal exPeriMental changes and pathways induced by EGE investigated the impact of aSSeSSMent of ePigenetic environmental factors in cancer causation, both current H. pylori infection and driver geneS and their link to underpinning studies of etiology e , pigenetic memory of past (eradicated) environMental carcinogenS carcinogen evaluation, and prevention. (who.int)

C1orf198 has high levels of expression in all tissues throughout the human body, but is most highly expressed in lung, brain, and spinal cord tissues. (wikipedia.org)
RNA-seq tissue data revealed high expression of C1orf198 across all tissues, but especially high expression in lung, heart, spinal cord, and brain tissues. (wikipedia.org)
In this study, we demonstrate that gDNA-based probe selection on the Affymetrix Human U133+2 GeneChip array can be used to study gene expression profiles in sheep tissues. (cambridge.org)
The transmembrane protein MCT4, the respective gene termed SLC16A3 , acts as an H + /lactate exporter in highly glycolytic tissues [ 8 , 9 ]. (hindawi.com)
In addition to less lignified cell walls, susceptibility to the pine wood nematode seems associated with the activation of the salicylic acid (SA) defense pathway at 72 hpi, as revealed by the higher SA levels in the tissues of susceptible plants. (ugent.be)
Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. (biomedcentral.com)
This thermoception may have caused the observed effects through epigenetic mechanisms, since all analysed tissues further revealed differentially expressed genes involved in histone modification. (biomedcentral.com)
This study conducted a comparative analysis of the T. wilfordii transcriptome derived from its root and leaf tissues. (techscience.com)

In addition, gene set enrichment analysis indicated that high CEP55 expression was associated with immunization, cell adhesion, inflammation, the Janus kinase/signal transducer and activator of transcription signaling pathway and cell proliferation. (urotoday.com)
Here we show that SETD2 accumulation results in a non-canonical deposition of the functionally important H3K36me3 histone mark, which includes its reduced enrichment over gene bodies and exons. (frontiersin.org)
Gene enrichment analysis was demonstrated using DAVID 6.8 tool. (biomedcentral.com)
The KEGG pathway enrichment analysis showed that the cis-target genes between RU486-XX and control-XX were concentrated in NOD - like receptor signaling pathway, Cell adhesion molecules (CAMs) and Biosynthesis of amino acids. (nih.gov)
Gene set enrichment analysis (GSEA) for single hub gene revealed that these genes had a close association with antimicrobial response and neutrophils activity. (flu.org.cn)

Genes in the 'Focal adhesion', 'Wnt signaling pathway' and 'MAPK signaling' pathway. (biomedcentral.com)

Microarray analysis of mRNA expression revealed 3034 genes-in-play differentially expressed in C. albicans stomatitis. (scienceblog.com)
Moreover, several promising candidate genes differentially expressed in gefitinib sensitive and resistant NSCLC cell lines were revealed by a global mRNA expression analyses. (uni-muenchen.de)
CXCR1 is expressed in the human IEC line Caco-2 BBE [ 3 ], which is in agreement with our own microarray data using Caco-2 BBE cell mRNA (see below). (biomedcentral.com)
The mRNA expression of diagnostic genes was determined by qRT-PCR analysis. (nature.com)
With this reference transcriptome and QuantSeq 3' mRNA sequencing, gene expression was quantified during seed development from 22 diverse lines across six time points. (usda.gov)
Because the locations of the probes are known, the intensity and pattern of the labeled mRNA can be used to measure the expression of the targeted gene. (medscape.com)

Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
These candidate genes or encoding proteins could be biomarker for clinical diagnosis and therapeutic targets for severe influenza infection. (flu.org.cn)
Defects in genes and proteins important for B cell maturation block the maturation on certain stage and cause primary immunodeficiencies ( IDbase ). (lu.se)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

The diagnostic value of hub genes was assessed by receiver operating characteristic analysis and validated in GSE1297. (nature.com)
Subsequently, Kaplan-Meier (K-M) and receiver operating characteristic (ROC) analyses were performed to demonstrate the predictive power of our gene signature. (aging-us.com)

Thus, building a novel gene signature and clarifying the potential mechanisms in BC patients are critically needed. (aging-us.com)
Taken together, this comprehensive analysis provides important, new insights into cuproptosis mechanisms associated with human HCC. (figshare.com)

We extracted gene expression profiles from mouse macrophages from the GEO dataset, GSE152795 using the GEO2R webtool. (degruyter.com)

Six extracellular protein genes up-regulated in stomatitis were confirmed within the saliva using proteomic methods. (scienceblog.com)
Chromosome 1 open reading frame 198 (C1orf198) is a protein that in humans is encoded by the C1orf198 gene. (wikipedia.org)
C1orf198 is a protein-encoding gene found on the reverse strand of chromosome 1 at the locus 1q42. (wikipedia.org)
Comparison of far-upstream element binding protein knockdowns revealed differential expression in C1orf198. (wikipedia.org)
HIF-1 is known to induce transcription of gene involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. (wikipedia.org)
This gene is a member of the protein-tyrosine kinase oncogene family. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
Bioinformatics analysis revealed that rats in the adapting groups presented growth and remodeling processes (i.e. increased protein synthesis), whereas O3x demonstrated inflammatory signaling. (cdc.gov)
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (biomedcentral.com)
two protein structures were solved, and insights into their regulation and biological roles were gained through gene expression analysis and enzymatic assays on complex biomass. (proteopedia.org)
Predicted protein sequences encoded by the assembled transcriptomes were clustered with reference proteomes from 92 other species to identify pathogenesis related gene families in P. patula, P. tecunumanii and other pine species. (biomedcentral.com)
The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, respectively. (nature.com)
In 2D-DIGE method three protein samples differentially labeled with Cy3-, Cy5- and Cy2-dyes are separated in the same gel. (lu.se)
It is mainly expressed in skeletal muscle as a monomeric multidomain protein characterized by three unique insertion sequences (NS, IS1, IS2). (lu.se)
In vitro experiments have then revealed that only PDLIM1 is cleaved directly by the protease, and that a fragment of about 8 kDa is released from the C-terminal portion of the protein. (lu.se)
ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)

To validate this assumption, we have performed genomic, transcriptomic, and proteomic analyses of recent clinical isolates from the Czech Republic obtained during 2008-2015, previously characterized vaccine strains isolated during 1954-1965 ( 22 ) (hereafter referred to as historic strains), and the reference strain Tohama I. (cdc.gov)

This genetic resource will aid in isolating the celastrol biosynthetic genes as well as engineering the celastrol biosynthesis pathway. (techscience.com)
Temporal expression patterns of oat avenanthramides and lipid biosynthetic genes were concordant with previous studies of avenanthramide biosynthetic enzyme activity and lipid accumulation. (usda.gov)

In this study, oral palatal biopsies were obtained from 17 healthy and 15 C. albicans-infected stomatitis subjects for whole-transcriptome analyses using Affymetrix arrays. (scienceblog.com)
Further, in order to capture gene-by-environment interactions through eQTL analyses, we combine whole-transcriptome RNA-Sequencing profiles with whole-genome genotyping and extensive fine-scale environmental exposure data. (nature.com)

The transcriptional profile of 11 fungal genes related to pathogenicity and virulence were evaluated by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR). (frontiersin.org)
Variations in transcriptional responses of CE15-encoding genes under different growth conditions suggest nonredundant functions for enzymes found in species with multiple CE15 genes and further illuminate the importance of GEs in native lignin-carbohydrate disassembly. (proteopedia.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)

In the transcriptomic results, genes related to thermoception were observed. (biomedcentral.com)
Subsequent RNA sequence analysis and liquid chromatography with mass tandem spectrometry analyses showed that these variations translated into discretely separated transcriptomic and proteomic profiles. (cdc.gov)

Diagnostic and prognostic value of CEP55 in clear cell renal cell carcinoma as determined by bioinformatics analysis. (urotoday.com)
Bioinformatics analysis was used to integrate the four microarray datasets to identify and analyze differentially expressed genes. (urotoday.com)

Univariate and multivariate Cox proportional hazards analyses demonstrated that CEP55 expression was an independent risk factor for poor prognosis. (urotoday.com)
Uni- and multivariate regression analyses of the expression of these genes with mean arterial pressure (MAP) revealed four genes that significantly correlated with MAP in normotensive and/or hypertensive individuals. (nih.gov)
Univariate and multivariate Cox regression analyses were performed to ascertain the independent factors impacting the prognosis of EOEC patients, while a prognostic nomogram was established. (preprints.org)

The overarching aim of the Epigenetics common cause of gastric cancer, Pan-cancer genoMe and Group (EGE) is to advance the which is the third most common cause tranScriPtoMe analySiS and understanding of the role of epigenetic of cancer-related deaths worldwide. (who.int)
Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)

In total, 962 sexually differentially expressed lncRNAs and their target genes were screened from the gonads of control and sex reversed fish. (nih.gov)
The results allow us to revise the previously generated lists of genes associated with breast cancer and also identify most promising anticancer drug-target genes. (iospress.com)

In this study, a suppression subtractive hybridization cDNA library approach was used for the identification of pathogen and plant genes that were differentially expressed during infection of the susceptible cultivar BRS Pérola of Phaseolus vulgaris L. A total of 979 unigenes (430 contigs and 549 singletons) were obtained and classified according to their functional categories. (frontiersin.org)

Generating a reference sequence for P. tecunumanii and characterizing pathogenesis related gene families in these two pine species is an important step towards unravelling the pine- F. circinatum interaction. (biomedcentral.com)

Transcriptome Analysis Reveals Inhibitory Effects of Lentogenic Newcastle Disease Virus on Cell Survival and Immune Function in Spleen of Commercial Layer Chicks. (escholarship.org)

In this study, we utilized differentially expressed genes screening incorporating weighted gene co-expression network analysis in one eligible influenza GEO data set (GSE111368) to identify hub genes associated with clinical severity. (flu.org.cn)

The majority of the top 15 differentially expressed genes for each tissue were known to either be expressed in a tissue-specific manner or relate to specific functions of that tissue. (cambridge.org)
However, it is not known if CXCR1 is expressed on the apical or basolateral poles in polarized Caco-2 BBE cells or human intestinal tissue or whether the direction of TLR signalling influences the direction of IL-8 secretion. (biomedcentral.com)
To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. (cdc.gov)
Microarrays may be used to assay gene expression within a single sample or to compare gene expression in 2 different cell types or tissue samples, such as in healthy versus diseased tissue. (medscape.com)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)

Objective: This systemic review and meta-analysis focuses on the prognostic value of p53 Abs expressed in the serum of patients with solid tumors. (stanford.edu)
Data from the TCGA-BRCA cohort were analyzed using univariate Cox regression analysis, and least absolute shrinkage and selection operator (LASSO) analysis was performed to build a stable prognostic model. (aging-us.com)
Cox regression analysis suggested that our signature was an independent prognostic factor. (aging-us.com)
9 cuproptosis-related genes showed significant, independent prognostic values. (figshare.com)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)

Yet, cells expressing EGFR kinase domain mutations tended to generally respond better to treatments with gefitinib compared to those with wild-type EGFR. (uni-muenchen.de)
This week in Nature Genetics , two studies report recurrent mutations in splicing-related genes in blood tumors. (massgenomics.org)
Limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder generated by inactivating mutations in the gene coding for the muscle specific protease calpain-3. (lu.se)
If this is the case, gene-correction presents a solution for patients with known monogenetic mutations. (lu.se)

Among these, EZH2 that mediates repressive histone H3 lysine 27 trimethylation (H3K27me3) is upregulated and binds to muscle specific genes in ERMS. (elifesciences.org)

In this report, a comprehensive analysis of cuproptosis in hepatocellular carcinoma (HCC) was conducted using multi-omics including genomics, bulk RNA-seq, single cell RNA-seq and proteomics. (figshare.com)

Our study identified 9 key genes associated with oxidative stress and immune reaction in AD pathogenesis. (nature.com)
Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
Previous in vitro and in vivo studies revealed that oxidative stress caused by the accumulation of Aβ contributed to the initiation of AD 8 . (nature.com)

In this study, we investigated gene expression changes at 2 and 6 days post inoculation (dpi) at day 21 with a lentogenic NDV in a commercial egg-laying chicken hybrid using RNA sequencing analysis. (escholarship.org)

Pearson correlation analysis was applied to evaluate the relationships between selected lncRNAs and mRNAs. (biomedcentral.com)
Statistical comparisons and contrasts were made using 2-tailed t tests, chi-square tests, and Pearson correlation analyses as appropriate. (cdc.gov)

The signature of our top screening hits is significantly correlated with gene expression data from clinical melanoma samples. (cdc.gov)

Further phylogenetic analysis suggested specific family members of CYPs that may participate in the late steps during celastrol biosynthesis. (techscience.com)

Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to validate the expression pattern of differentially expressed lncRNAs. (biomedcentral.com)
One thousand seven hundred and sixteenth differentially expressed mRNAs and 311 differentially expressed lncRNAs were screened out. (biomedcentral.com)
In conclusion, these results of the RNA-seq and bioinformatic analysis strongly suggested that the dysregulation of lncRNA is involved in the complicated process of CRC development, and providing important insight regarding the lncRNAs involved in CRC. (biomedcentral.com)

In addition, a candidate-based approach identified genes that are differentially expressed in cancer cells with primary or secondary resistance to gefitinib or cetuximab. (uni-muenchen.de)
The P. tecunumanii transcriptome is the first gene catalogue for the species, representing an important resource for studying resistance to the pitch canker pathogen, F. circinatum . (biomedcentral.com)
We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)

The span of the gene from the start of transcription to polyA site, including introns, is 32,470 bp. (wikipedia.org)
Transcription profiling by high throughput sequencing revealed similar patterns of expression. (wikipedia.org)
XCPE1 is an important transcription factor for poorly categorized TATA-less genes in the human genome, and it drives RNA polymerase II transcription. (wikipedia.org)
It functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes. (wikipedia.org)
Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
Analysis of upstream regulators indicated a pivotal role of several lipid-related transcription factors (e.g. (oregonstate.edu)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)

The introduction of complementary DNA (cDNA) microarray technology in 1995 has helped to facilitate the identification and classification of DNA sequence information and the assignment of functions to these new genes by allowing investigators to analyze expression of thousands of genes simultaneously in a single experiment. (medscape.com)

Identified genes, miRNAs, and TFs can be possible drug targets that may be used for the therapeutics. (degruyter.com)

We identified 22 major temporal expression patterns of gene expression and were able to show that these patterns associated with biological processes. (usda.gov)

C.P. tion stage, why much more detailed molecular analysis is contributed to the design of the study, discussions on statistical analysis of called for [2]. (lu.se)

Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
In addition, though statistically questionable, several biologically interesting genes that are possibly involved in determining in vitro response of NSCLC cells to cetuximab have been postulated. (uni-muenchen.de)
We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)

Albeit the great number of microarray data available on breast cancer, reliable identification of genes associated with breast cancer development remains a challenge. (iospress.com)
We developed a statistical method for identification of up- and down-regulated genes to perform meta-analysis. (iospress.com)
[ 2 , 3 ] Conventional techniques of gene investigation in cancer rely on the identification of single genetic alterations associated with disease. (medscape.com)

Using our method we performed meta-analysis of five data sets from independent cDNA-microarray experiments on breast cancer. (iospress.com)
Because of the complexity of the data sets generated by microarray experiments, the use of data-analysis software is essential. (medscape.com)

A new study reveals microglial cells, a type of immune cell in the brain, are less active in individuals with depression. (neurosciencenews.com)
We obtained 66 immune-related DEOSGs by intersecting turquoise module with the DEOSGs and identified 15 hub genes through PPI analysis. (nature.com)
Based on cuproptosis-related gene expressions, two immune patterns were found, with the cuproptosis-C1 subtype identified as a cytotoxic immune pattern, while the cuproptosis-C2 subtype was identified as a regulatory immune pattern. (figshare.com)

Learn how to use a basic Single-Cell RNA-Seq workflow to perform standard exploration on a scRNA-seq data set, investigate customized marker genes, and launch ANOVA process for Differential Gene Expression analysis. (jmp.com)
Differential gene expression analysis identified a number of root-specific CYP genes. (techscience.com)

Our meta-analysis showed that the expression of the majority of genes does not show significant differences in different subtypes of breast cancer. (iospress.com)

These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)

These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
To view the results, click on 2D-DIGE analysis of B cell maturation. (lu.se)

However, histopathological examinations have revealed weak correlations between clinical features and pulp status[6]. (researchsquare.com)
From ∼ 1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. (nature.com)
The prediction accuracy and clinical net benefit between the model, TNM stage and SEER stage were further compared by the concordance index (C-index) and decision curve analysis (DCA). (preprints.org)
We established a cuproptosis index (CPI) and further performed an analysis of its clinical relevance. (figshare.com)
These findings provide new insight into severe influenza pathogenesis and identify two significant candidate genes that were superior to the conventional clinical indicators. (flu.org.cn)

Ontology9

DEGs16

Tumor7

Biomarkers7

Pathways10

Tissues8

Enrichment5

Signaling pathway1

MRNA6

Proteins8

Receiver operating char2

Mechanisms2

Dataset1

Protein17

Proteomic analyses1

Biosynthetic genes2

Whole-transcriptome2

Transcriptional4

Transcriptomic2

Bioinformatics analysis2

Multivariate3

Epigenetic2

Target genes2

Infection1

Pathogenesis-related1

Transcriptome analysis1

Weighted gene co-expression network analysis1

Tissue5

Prognostic5

Mutations4

Histone1

Hepatocellular carcinoma1

Oxidative stress3

Investigated gene expression1

Pearson2

Significantly correlated1

Phylogenetic1

LncRNAs3

Resistance3

Transcription7

Analyze1

Targets1

Biological1

Molecular1

Vitro3

Identification3

Microarray experiments2

Immune3

Differential2

Differences1

Modulate1

Results2

Clinical5