Long acting somatostatinOctreotideNeuroendocrineInhibits the secretionReceptorsAcromegalyPeptide Receptor Radionuclide TherapySecretionPegvisomantMycapssaInhibit tumor growthSSTRsPasireotideScintigraphyTherapyCyclicHormonesPharmacologicSSTR2Clinical practiceRecombinantApoptosisPatientsProteinGlycemicWidelyUptakeGrowthPortalDrugDevelopment
Long acting somatostatin1
- The antiproliferative effect of first-line long acting somatostatin analogs (SSA) in advanced gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) was shown in the PROMID and the CLARINET trials. (enets.org)
Octreotide9
- Previous studies have shown that secretory losses in patients with end jejunostomy syndrome (EJS) on home parenteral nutrition (HPN) can be suppressed by the somatostatin analogue, octreotide, thus facilitating fluid balance. (nih.gov)
- The vasoconstrictors somatostatin and octreotide are used to treat acute bleeding in patients with portal hypertension before performing endoscopy. (medscape.com)
- Compared with somatostatin, octreotide has similar pharmacologic actions with greater potency and longer duration of action. (medscape.com)
- Octreotide, a synthetic octapeptide, acts primarily on somatostatin receptor subtypes II and V. It inhibits growth hormone secretion and has a multitude of other endocrine and nonendocrine effects, including the inhibition of glucagon, vasoactive intestinal peptide, and GI peptides. (medscape.com)
- Octreotide has greater potency and a longer duration of action than somatostatin. (medscape.com)
- Because of different somatostatin receptor subtype expression of different neuroendocrine tumors, different synthetic somatostatin analogs with different SSTRs subtype affinities have been developed such as DOTA-D-Phe1-Tyr3-octreotide (DOTATOC), DOTA- 1-Nal3-octreotide (DOTANOC) and DOTA-D-Phe1-Tyr3-Thr8-octreotide (DOTATATE) (Figure 1). (symbiosisonlinepublishing.com)
- Octreotide may be used in diazoxide-unresponsive patients but is often ineffective because of down-regulation of the somatostatin receptor, and it carries a risk of causing necrotizing enterocolitis and death. (medscape.com)
- Many human neuroendocrine and non-neuroendocrine tumors express the five known somatostatin receptors (sst1 5) in different amounts.Tachyphylaxis after prolonged treatment with octreotide (Sand. (endocrine-abstracts.org)
- Telotristat is used in combination with another medication (a somatostatin analog [SSA] such as lanreotide, octreotide, pasinreotide) to control diarrhea caused by carcinoid tumors (slow-growing tumors that release natural substances that can cause symptoms like diarrhea) in patients with diarrhea not controlled by a somatostatin analog alone. (medlineplus.gov)
Neuroendocrine9
- Soydal C (2014) Ga-68 Labeled Somatostatin Analogs Positron Emission Tomography/ Computed Tomography in Gastroenteropancreatic Neuroendocrine Tumors. (symbiosisonlinepublishing.com)
- However these anatomical methods cannot give information about somatostatin receptor expression, which is extremely important in the management of neuroendocrine tumors. (symbiosisonlinepublishing.com)
- Recently, studies about superiority of positron emission tomography/computed tomography with Ga-68 labeled somatostatin receptor analogs in the management of neuroendocrine tumors have been reported. (symbiosisonlinepublishing.com)
- The aim of this review is to search the recent literature the role of positron emission tomography/computed tomography with Ga-68 labeled somatostatin receptor analogs in the management of gastroenteropancreatic neuroendocrine tumors. (symbiosisonlinepublishing.com)
- Somatostatin is a cyclic peptide consisted of 14 amino acids and produced by neuroendocrine, immune, and inflammatory cells. (symbiosisonlinepublishing.com)
- Patients with neuroendocrine tumors that over-express the somatostatin receptor 2 have an improved prognosis. (wikipedia.org)
- Somatostatin 2 receptors have been found in concentration on the surface of tumor cells, particularly those associated with the neuroendocrine system where the overexpression of somatostatin can lead to many complications Due to this, these receptors are considered a prospective aid for the detection of tumors, especially in patients who present with conditions like hypothyroidism and Cushing's syndrome. (wikipedia.org)
- As both speakers indicated, peptide receptor radionuclide therapy (90-Y dotatate or Lu-177 dotatate ) is recommended for patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors that are progressing despite standard-dose long-acting somatostatin analog therapy and for pancreatic neuroendocrine tumors progressing after somatostatin analog therapy or everolimus (Afinitor). (ascopost.com)
- A Machine Learning Decision Support System (DSS) for Neuroendocrine Tumor Patients Treated with Somatostatin Analog (SSA) Therapy. (cdc.gov)
Inhibits the secretion1
- In the pancreas, after binding to somatostatin, it inhibits the secretion of peptide hormones from pancreatic islets. (wikipedia.org)
Receptors6
- Well/moderately differentiated NETs are generally overexpress somatostatin receptors (SSTRs) [3]. (symbiosisonlinepublishing.com)
- The lead compound showed exceptional tumor/normal tissue ratios, ranging from 9 to 90, and has potential for targeting SCLC overexpressing somatostatin receptors. (tau.ac.il)
- All somatostatin receptors including SSTR2 may have different specific functions, but all fall under the same receptor super family, the G-protein binding family and all of which are a major inhibitor for other hormones. (wikipedia.org)
- Because of which, the receptors for somatostatin type 2 impact the body's locomotor, sensory, autonomic, and cognitive functions. (wikipedia.org)
- The novel somatostatin receptor agonist SOM230 (pasireotide) binds with high affinity to somatostatin receptors sst1, sst2, sst3 and sst5. (endocrine-abstracts.org)
- We assessed the effects of pasireotide, a somatostatin analogue with high affinity for somatostatin receptors (SSTRs) −1, −2, −3 and −5, in a mouse model of MEN1. (endocrine-abstracts.org)
Acromegaly2
- They are targeted at individuals with acromegaly who are inadequately treated with the combination therapy of lanreotide autogel and pegvisomant by Ipsen and somatostatin analogs. (technavio.com)
- The call will feature presentations by Key Opinion Leader (KOL) Maria Fleseriu, MD, FACE, lead investigator of the MPOWERED study, who will discuss the topline data from Chiasma's Phase 3 MPOWERED study as well as the unmet medical need in acromegaly and the treatment burden that patients experience with monthly somatostatin analog injections. (biospace.com)
Peptide Receptor Radionuclide Therapy1
- Lu-177 dotatate , a peptide receptor radionuclide therapy, consists of the somatostatin analog octreotate connected with the beta- and gamma-emitting radiopharmaceutical lutetium-177. (ascopost.com)
Secretion1
- Somatostatin analogs inhibit the secretion of hormones involved in vasodilation. (medscape.com)
Pegvisomant1
- Pegvisomant (PEGV) is widely used, alone or with somatostatin analogs (SSA), for GH-secreting pituitary tumors poorly controlled by SSAs alone. (altmetric.com)
Mycapssa1
- In addition, Chiasma advanced its efforts to gain European approval by finalizing the design of a planned Phase 3 trial to demonstrate the non-inferiority of Mycapssa™ to injectable somatostatin analogs. (biospace.com)
Inhibit tumor growth2
- The somatostatin receptor 2 is also being looked at as a possible target in cancer treatment for its ability to inhibit tumor growth. (wikipedia.org)
- Moreover, SRIF and SRIF analogs are able to inhibit tumor growth. (endocrine-abstracts.org)
SSTRs1
- Because of the overexpression of SSTRs the radiolabeled somatostatin analogs can be used to localize the primary tumor and its metastasis. (symbiosisonlinepublishing.com)
Pasireotide1
- Pasireotide is a somatostatin analog that blocks cortisol production. (medpagetoday.com)
Scintigraphy2
- Today, planar scintigraphy or SPECT imaging with Tc-99m or In-111 labeled somatostatin analogs are widely being utilized worldwide. (symbiosisonlinepublishing.com)
- Firstly, somatostatin receptor scintigraphy with Tc-99m and In-111 labeled somatostatin analogs have been used for the evaluation of NETs [8,9]. (symbiosisonlinepublishing.com)
Therapy2
- We have reviewed the literature on current therapy of carcinoid patients with special emphasis on the use of the somatostatin analogue SMS 20-1995. (johnshopkins.edu)
- Somatostatin analogs are sometimes used as second-line therapy but their effectiveness is limited and they have significant side effects, particularly in newborns, De León said. (medscape.com)
Cyclic1
- We synthesized novel somatostatin analogs, based on backbone cyclic peptides, and conjugated them with fluorescent agents. (tau.ac.il)
Hormones2
- The somatostatin hormone itself can negatively affect the uptake of hormones in the body and may play a role in some hormonal conditions. (wikipedia.org)
- Hormones produced within the gut which can be measured in the blood - vasoactive intestinal peptide, gastrin, glucagon, somatostatin, pancreatic polypeptide. (christie.nhs.uk)
Pharmacologic1
- The table contains 42 products whose active ingredient are classified under the same pharmacologic class Somatostatin Analog [EPC]. (ndclist.com)
SSTR24
- Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene. (wikipedia.org)
- The somatostatin receptor 2 (SSTR2), which belongs to the G-protein coupled receptor family, is a protein which is most highly expressed in the pancreas (both alpha- and beta-cells), but also in other tissues such as the cerebrum and kidney and in lower amount in the jejunum, colon and liver. (wikipedia.org)
- The gene for somatostatin receptor 2, SSTR2 for short, is responsible for making a receptor for the signalling peptide, somatostatin (SST). (wikipedia.org)
- SSTR2 is a receptor for somatostatin-14 and -28 respectively. (wikipedia.org)
Clinical practice1
- For this reason, somatostatin receptor imaging with radiolabelled somatostatin analogs has an increasing clinical practice. (symbiosisonlinepublishing.com)
Recombinant1
- Insulin glargine is a recombinant human long-acting insulin analog [see CLINICAL PHARMACOLOGY ]. (rxlist.com)
Apoptosis2
- Somatostatin receptor 2 also has the ability to stimulate apoptosis in many cells including cancer cells. (wikipedia.org)
- In general, somatostatin can put a cell in cycle arrest using the phosphotyrosine phosphatase dependent regulation of nitrogen-activated protein kinase, this process can lead to a halt in the cell cycle or apoptosis of the cell and is used as a tumor suppressor in the genome. (wikipedia.org)
Patients1
- Semglee ( insulin glargine injection) is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus. (rxlist.com)
Protein2
- For all somatostatin inhibitors, somatostatin-14 and -28 work by binding to the receptor with the help of a G-protein. (wikipedia.org)
- In fact, this protein, is the dominant one out of all of the somatostatins in the pancreas. (wikipedia.org)
Glycemic1
- Participant has failed to achieve adequate glycemic control with appropriate and reasonable trials of locally accepted and available Standard of Care (SOC) medical therapies (e.g., diazoxide and somatostatin analogs (SSAs)) per the judgment of the investigator. (who.int)
Widely1
- Somatostatin receptor imaging is widely used for the diagnosis, staging and restaging of NETs [7]. (symbiosisonlinepublishing.com)
Uptake1
- This inhibition by somatostatin allows the body to uptake the maximum amount of nutrients in the digestive system. (wikipedia.org)
Growth1
- The somatostatin analogs segment will account for the highest growth in the market. (technavio.com)
Portal1
- Through vasoconstriction, somatostatin diminishes blood flow to the portal system, thus decreasing variceal bleeding. (medscape.com)
Drug1
- Somatostatin, an orphan drug, is a naturally occurring tetradecapeptide isolated from the hypothalamus and from pancreatic and enteric epithelial cells. (medscape.com)
Development1
- After development of Ga-68 labeled somatostatin analogs, in most centers in Europe positron emission tomography (PET) with Ga-68 labeled somatostatin analogs have been utilized due to higher resolution of PET imaging. (symbiosisonlinepublishing.com)