Hiddinga, HJ & Eberhardt, NL 1999, ' Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells ', American Journal of Pathology , vol. 154, no. 4, pp. 1077-1088. (elsevierpure.com)
These covalent transthyretin kinetic stabilizers exhibit superior amyloid inhibition potency compared to their noncovalent counterparts, and they prevent cytotoxicity associated with amyloidogenesis. (rcsb.org)
Increased oxysterol concentrations in the brain may promote cellular damage, cause neuron [nerve cell] dysfunction and degeneration, and could contribute to neuroinflammation [brain inflammation] and amyloidogenesis," the formation of amyloid plaques. (alzheimersweekly.com)
Transthyretin1
2005). X-ray crystallographic studies of two transthyretin variants: Further insights into amyloidogenesis . (up.pt)
Molecular1
Obviously, molecular mechanisms describing amyloidogenesis of ordered and natively unfolded proteins are different. (usf.edu)
Hippocampal2
One week after continuous, subcutaneous E2 therapy, we subjected animals to 10-min global cerebral ischemia (GCI) to assess the effect of LTED on ischemia-induced amyloidogenesis in the hippocampal CA1. (elsevierpure.com)
Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. (rochester.edu)
Protein3
Loss of DNAJB6 expression upon differentiation is confirmed in vivo, explaining why stem cells are intrinsically protected against amyloidogenesis and protein aggregates are dominantly present in neurons. (nih.gov)
The prediction of peptide amyloidogenesis is a challenging problem in the field of protein folding . (bvsalud.org)
Lysozyme amyloidogenesis is accelerated by specific nicking and fragmentation but decelerated by intact protein binding and conversion. (jnu.ac.in)
Proteins1
In this review recent findings are surveyed to illustrate some unique features of the natively unfolded proteins amyloidogenesis. (usf.edu)
Metabolic1
Our strategy is to investigate the effect of AD risk factors like stress, inflammation, metabolic changes, and amyloidogenesis, on different types of brain cells including pericytes, astrocytes, neurons, and NG2 cells. (lu.se)
Model2
AggBERT: Best in Class Prediction of Hexapeptide Amyloidogenesis with a Semi-Supervised ProtBERT Model. (bvsalud.org)
In this article, we describe the use of a semisupervised and fine-tuned ProtBERT model to predict peptide amyloidogenesis from sequences alone. (bvsalud.org)
Time1
The hIAPP-induced apoptosis was negligible at 24 and 48 hours after transfection and was maximal at 96 hours which parallels the time course of amyloidogenesis. (elsevierpure.com)
Formation1
Altogether, these results demonstrate that a single amino acid mutation can trigger the formation of high-temperature RO and concurrent amyloidogenesis. (ugr.es)
Domain2
Agitation and high ionic strength induce amyloidogenesis of a folded PDZ domain in native conditions. (harvard.edu)
Signaling pathways that activate ADAM10 or ADAM17 inhibit amyloidogenesis by cleaving APP within the Abeta domain. (bu.edu)
Neuronal amyloidogenesis2
Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis. (musc.edu)
Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts. (nih.gov)
Aggregation3
We present the effect of functionalized magnetic core-shell nanoparticles of Fe 3 O 4 (MNPs) with β-cyclodextrin (β-CD) on the aggregation/fibrillation of bovine serum albumin (BSA) under diabetic condition known as amyloidogenesis. (eurekaselect.com)
Moreover, spectrofluorimetry and spectropolarimetry were utilized to analyze the effect of β-CD/Fe 3 O 4 MNPs on the aggregation and amyloidogenesis of BSA through glycation. (eurekaselect.com)
Our results indicated that HSF1 depletion provokes proteomic chaos in cancer cells, causing proteome destabilization, aggregation, and tumor-suppressive amyloidogenesis. (nih.gov)
Insights1
The study of solid condensates A-bodies will offer unique perspectives on cellular assembly of membrane-less compartments and provide alternative insights on pathological amyloidogenesis involved in neurological disorders. (preprints.org)
Studies1
Our recent studies have revealed a previously unappreciated phenomenon-tumor-suppressive amyloidogenesis. (nih.gov)