Amyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAmyloidAmyloid beta-PeptidesReceptors, NotchAlzheimer DiseaseAspartic Acid EndopeptidasesPresenilin-1Receptor, Notch2Plaque, AmyloidEndopeptidasesProtein PrecursorsMice, TransgenicProtease NexinsSerum Amyloid A ProteinPeptide FragmentsBrainPresenilin-2NeuronsProtein Processing, Post-TranslationalPresenilinsAmyloidosisCerebral Amyloid AngiopathyMembrane ProteinsMolecular Sequence DataAmino Acid SequenceProtein Structure, TertiaryMutationtau ProteinsNerve Tissue ProteinsDisease Models, AnimalAmyloidogenic ProteinsCell LineAmyloid NeuropathiesHippocampusCells, CulturedIslet Amyloid PolypeptideMice, Inbred C57BLProtein BindingProtein TransportCerebral CortexLDL-Receptor Related ProteinsTransfectionSignal TransductionImmunohistochemistryProteolysisMaze LearningBlotting, WesternCHO CellsBase SequenceCricetinaeADAM ProteinsGene Expression RegulationMice, KnockoutNeurofibrillary TanglesAxonal TransportPC12 CellsNerve DegenerationRecombinant ProteinsConvolvulusSerum Amyloid P-ComponentRNA, MessengerNeuroblastomaPrionsDipeptidesProtease InhibitorsInsulysinCell MembraneCell Line, TumorEnzyme-Linked Immunosorbent AssayModels, BiologicalCricetulusNeuritesAgingBrain ChemistryAxonsCongo RedEndosomesRecombinant Fusion ProteinsNeprilysinReceptors, Cell SurfaceBinding SitesImmunoprecipitationHEK293 CellsGene ExpressionMemory DisordersCOS CellsGliosisPeptidesMicrogliaAstrocytesClioquinolCell DifferentiationApolipoproteins EAlzheimer VaccinesHistory, Early Modern 1451-1600KineticsEnzyme PrecursorsTime FactorsBiotinylation