Amyloid fibrillization. Medical search. Frequent questions

To investigate whether small molecules can modulate aggregation to achieve selective inhibition of neurotoxic amyloid oligomers, Aβ aggregation was assayed in vitro in the presence of methylene blue, using immunoreactivity with the prefibrillar oligomer-specific antibody A11, transmission electron microscopy, and turbidity assays. (utmb.edu)
We demonstrate the effectiveness of this approach by identifying drug-like, head-to-tail cyclic peptides that modulate the aggregation of the Alzheimer's disease-associated amyloid β peptide. (nature.com)
The viral protein corona directs viral pathogenesis and amyloid aggregation. (alzforum.org)
Moreover, the C-terminal region regulates the amyloid aggregation and fibril formation of α-Syn. (biomedcentral.com)
Amyloid aggregation of tau protein is implicated in neurodegenerative diseases, yet its facilitating factors are poorly understood. (biorxiv.org)
LLPS was shown to facilitate tau amyloid aggregation in certain cases, while independent of aggregation in other cases. (biorxiv.org)
We report on a model system of hydrophobically driven LLPS induced by high salt concentration (LLPS-HS), and compare it to electrostatically driven LLPS represented by tau-RNA/heparin complex coacervation (LLPS-ED). We show that LLPS-HS promotes tau protein dehydration, undergoes maturation and directly leads to canonical tau fibrils, while LLPS-ED is reversible, remains hydrated and does not promote amyloid aggregation. (biorxiv.org)
However, direct real-time imaging of protein aggregation, including oligomerization and fibrillization, has never been achieved. (elsevierpure.com)
Alzheimer's disease (AD) is characterized by the abnormal aggregation of amyloid ß (Aß) peptide into insoluble fibrils called amyloid plaques. (ijpsr.com)
Aggregation results in both amorphous aggregates and amyloid fibrils, with the presence of the nanopatterns leading to retarded fibrillization and stronger amorphous aggregation. (uni-paderborn.de)
Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer's Amyloid Beta", a joint work by Clemson, Monash University, Ningbo University, and Southwest University, is now accepted for publication in Nano Today. (clemson.edu)
Amyloid Aggregation under the Lens of Liquid-Liquid Phase Separation", first authored by Yanting, is now in press in The Journal of Physical Chemistry Letter. (clemson.edu)
The work "Amphiphilic Surface Chemistry of Fullerenols Is Necessary for Inhibiting the Amyloid Aggregation of Alpha-Synuclein NACore" first authored by Yunxiang Sun is now accepted for publication in Nanoscale. (clemson.edu)

The International Society of Amyloidosis classifies amyloid fibrils and their associated diseases based upon associated proteins (for example ATTR is the group of diseases and associated fibrils formed by TTR). (wikipedia.org)
Functional amyloid in Homo sapiens: Intralumenal domain of melanocyte protein PMEL Peptide/protein hormones stored as amyloids within endocrine secretory granules Receptor-interacting serine/threonine-protein kinase 1/3 (RIP1/RIP3) Fragments of prostatic acid phosphatase and semenogelins Functional amyloid in other organisms: Curli fibrils produced by E. coli, Salmonella, and a few other members of the Enterobacteriales (Csg). (wikipedia.org)
GvpA, forming the walls of particular Gas vesicles, i.e. the buoyancy organelles of aquatic archaea and eubacteria Fap fibrils in various species of Pseudomonas Chaplins from Streptomyces coelicolor Spidroin from Trichonephila edulis (spider) (Spider silk) Hydrophobins from Neurospora crassa and other fungi Fungal cell adhesion proteins forming cell surface amyloid regions with greatly increased binding strength Environmental biofilms according to staining with amyloid specific dyes and antibodies. (wikipedia.org)
However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., "molten globular"), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). (tau.ac.il)
Several in vitro studies have shown the propensity of α-Syn to aggregate into amyloid fibrils, a process that is accelerated by the truncation of its C-terminal. (biomedcentral.com)
Title: Probing and trapping a sensitive conformation: amyloid-β fibrils, oligomers, and dimers. (aablocks.com)
Characterization of the properties of formed aggregates confirmed the development of amyloid-like fibrils, which are in cross-β-pattern and possibly in anti-parallel β-sheet arrangement. (aku.edu)
2010). On the other hand, filamentous aggregates made up of one proteins may straight cross-seed additional amyloidogenic proteins due to possibly shared structural top features of amyloid fibrils (Kayed et al. (sdfca.org)

Amyloids are aggregates of proteins characterised by a fibrillar morphology of typically 7-13 nm in diameter, a β-sheet secondary structure (known as cross-β) and ability to be stained by particular dyes, such as Congo red. (wikipedia.org)
Biochemical, biophysical and biological assays using isolated amyloid β peptide, primary neurons and various established Alzheimer's disease nematode models showed that the selected macrocycles potently inhibit the formation of neurotoxic amyloid β peptide aggregates. (nature.com)
The generation of Aβ amyloid aggregates in the form of senile plaques in the brain is one of the pathological hallmarks of Alzheimer's disease (AD). (biofullerene.com)
The pathology Alzheimer's disease (AD) is associated with the self-assembly of amyloid-β (Aβ) peptides into β-sheet enriched fibrillar aggregates. (biofullerene.com)
The neuropathologic hallmarks of AD are senile plaques composed of extracellular deposits of amyloid-β (Aβ) and neurofibrillary tangles composed of intracellular aggregates of tau protein with multiple post-translational modifications including phosphorylation. (biomedcentral.com)
This is attributed to structural differences in the amorphous aggregates formed at the nanopatterned surface, which result in a lower propensity for nucleating amyloid fibrillization. (uni-paderborn.de)
2011). Furthermore, cell-to-cell transmission of the amyloid proteins aggregates may underlie the stereotypical spatiotemporal development of both Advertisement and PD pathologies (evaluated by Jucker and Walker, 2011). (sdfca.org)

Title: Inhibition of glycosaminoglycan-mediated amyloid formation by islet amyloid polypeptide and proIAPP processing intermediates. (aablocks.com)
Amylin, or islet amyloid polypeptide ( IAPP ), is a 37-residue peptide hormone . (wikidoc.org)
Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide", coauthored by Yunxiang, is now accepted for publication in Nano Research. (clemson.edu)
Single-molecular hetero-amyloidosis of human islet amyloid polypeptide", co-authored by Yanting and Yunxiang, is now accepted for publication in Nano Letter. (clemson.edu)

A hallmark of Alzheimer's disease (AD) brain is the amyloid β (Aβ) plaque, which is comprised of Aβ peptides. (jneurosci.org)
Bourgade K, Garneau H, Giroux G, Le Page AY, Bocti C, Dupuis G, Frost EH, Fülöp T Jr . β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1 . (alzforum.org)

Amyloid plaques are hallmark neuropathological lesions in Alzheimer's disease, which consist of abnormally aggregated Aβ protein. (utmb.edu)
This thesis demonstrates that amyloid ß-peptide (Aß)-induced peroxynitrite contributes to the switch of the Aβ42/Aβ40 ratio that occurs in Alzheimer's disease (AD). (upf.edu)
Catafau AM, Bullich S. Amyloid PET imaging: applications beyond Alzheimer's disease. (eurekaselect.com)
Amyloid beta (Aβ) deposits are implicated in the pathogenesis of debilitating neurodegenerative disorders such as Alzheimer's disease. (biofullerene.com)
Title: Alzheimer's disease and the amyloid cascade hypothesis: a critical review. (aablocks.com)
Abnormal processing and extracellular deposition of Aβ (1-42), a proteolytic derivative of the larger amyloid precursor protein (APP) is a key step in the pathogenesis of Alzheimer's disease 2 . (ijpsr.com)
Heparan sulfate proteoglycan in Alzheimer's disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism. (uu.se)
Oligomerization, fibrillization and neurotoxicity of native Aβ associated with Alzheimer's disease (AD) type has been compared with E32Q Aβ (amyloid β-protein containing residues 1-40 with the native Glu at residue 22 changed to Gln) implicated in Dutch cerebral haemorrhage disease. (uaeu.ac.ae)

Our results demonstrate that PQQ inhibits the amyloid fibril formation and cytotoxicity of the C-truncated alpha-synuclein variants. (biomedcentral.com)

Inhibition of Aβ oligomerization was achieved concomitant with promotion of fibrillization, suggesting that oligomer and fibril formation are distinct and competing pathways. (utmb.edu)
There is no cure for AD and one of the recent treatment strategies is focused on the inhibition of amyloid fibrillization of Aβ peptide. (biofullerene.com)
A promising treatment strategy is focused on the inhibition of amyloid fibrillization of Aβ peptide. (biofullerene.com)
Featuring small sizes, caged structures, low cytotoxicity and the capability to cross biological barriers, fullerene hydroxy derivatives named fullerenols have been explored as nanomedicinal candidates for amyloid inhibition. (biofullerene.com)
Our collaborative work, "Inhibition of Amyloid Beta Toxicity in Zebrafish with A Chaperone-Gold Nanoparticle Dual Strategy", is now accepted for publication in Nature Communications. (clemson.edu)

A major plaque component, β amyloid peptide (Aβ), derives from the amyloid precursor protein (APP). (jneurosci.org)
This peptide exhibited the greatest retardation of fibrillization rate among many of the most important clinically relevant amyloid beta-protein alloforms. (peptide.com)
It is also known that defects in mitochondrial functions, which are responsible for energy production in the cell, occur before the accumulation of amyloid b (Ab) that causes AD and are closely related to the accumulation of tau protein. (journalmeddbu.com)
Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin. (wikidoc.org)
Induces fibrillization of microtubule-associated protein tau. (abcam.com)
UV-B induced fibrillization of crystallin protein mixtures" by Sibel Cetinel, Valentyna Semenchenko et al. (aku.edu)
A recent cryo-EM study involving four individuals with FTLD-TDP types A-D in the absence of ALS did not find amyloid filaments of TDP-43 and reported that filaments of transmembrane protein 106B (TMEM106B) characterize FTLD-TDP instead21. (lafurnitura.com)
Certainly, we showed previously that recombinant -syn and tau protein synergistically promote the fibrillization of every additional in vitro (Giasson et al. (sdfca.org)

An unusual secondary structure named α sheet has been proposed as the toxic constituent of amyloid precursor proteins, but this idea is not widely accepted at present. (wikipedia.org)

Previously, we showed full-length TDP-43 forms spherical oligomers and perturbs amyloid-β (Aβ) fibrillization. (ox.ac.uk)
Addition of methylene blue to preformed oligomers resulted in oligomer loss and promotion of fibrillization. (utmb.edu)
Many attempts have been made to develop such a diagnostic tool by measuring amyloid-β oligomers (AβOs) in the blood, but none have been successful in terms of method reliability. (biomedcentral.com)
In this study, A10E could prevent cognitive impairments in APP/PS1 transgenic mice and beta-amyloid (Abeta) oligomers-treated mice, with higher potency than tacrine and huperzine A. Moreover, A10E could effectively inhibit Abeta production and deposition, alleviate neuroinflammation, enhance BDNF expression, and elevate cholinergic neurotransmission in vivo. (inrae.fr)

We conclude that TDP-43 inhibits Aβ fibrillization through its interaction with Aβ and exacerbates AD pathology. (ox.ac.uk)

Conclusions/Significance: These data demonstrate that QDAβ is a novel nanoprobe for studying Aβ oligomerization and fibrillization in multiple modalities and may be applicable for high-throughput drug screening systems. (elsevierpure.com)
Furthermore, Abeta oligomerization and fibrillization could be directly disrupted by A10E. (inrae.fr)

Pathogenic amyloids form when previously healthy proteins lose their normal structure and physiological functions (misfolding) and form fibrous deposits within and around cells. (wikipedia.org)
Amyloids have been known to arise from many different proteins. (wikipedia.org)
To date, 37 human proteins have been found to form amyloid in pathology and be associated with well-defined diseases. (wikipedia.org)
This thesis shows the Aß-induced peroxynitrite, and the consequent nitrotyrosination of proteins, promotes tau fibrillization. (upf.edu)
Beta-amyloid is one of the proteins involved in neurodegenerative disorders, which is currently suitable to be imaged by means of PET. (eurekaselect.com)

On the therapeutic ground, attempts of developing anti-amyloid, anti-inflammatory, anti-tau therapies are on peak, having APP and tau as putative targets. (benthamscience.com)

The classical, histopathological definition of amyloid is an extracellular, proteinaceous fibrillar deposit exhibiting β-sheet secondary structure and identified by apple-green birefringence when stained with congo red under polarized light. (wikipedia.org)
AD brain has two characteristic neuropathological features i.e., extracellular amyloid ß (Aß) plaques and intra-neuronal neurofibrillary tangles 1 . (ijpsr.com)

Here, the fibrillization and toxicity effect of SERF1a on Htt-exon1 are examined. (bvsalud.org)

For example, when tau becomes hyperphosphorylated or, as a result of other mechanisms, disengages from MTs, higher concentrations of cytosolic tau lead to tau fibrillization and the formation amyloid-like paired helical filaments that aggregate to form neurofibrillary tangles (NFTs). (alzforum.org)

Tubular sheaths encasing Methanosaeta thermophila filaments Functional amyloid acting as prions Several yeast prions are based on an infectious amyloid, e.g. (wikipedia.org)
We previously showed, using cryo-electron microscopy, that TDP-43 assembles into amyloid filaments in ALS and type B FTLD-TDP9. (lafurnitura.com)
Here we report the cryo-electron microscopy structures of assembled TDP-43 from the brains of three individuals with the most common type of FTLD-TDP, type A. TDP-43 formed amyloid filaments with a new fold that was the same across individuals, indicating that this fold may characterize type A FTLD-TDP. (lafurnitura.com)
Cryo-electron microscopy (cryo-EM) structures of assembled TDP-43 from the prefrontal and motor cortices of two individuals with amyotrophic lateral sclerosis (ALS) and type B frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) have shown amyloid filaments with an identical double-spiral-shaped fold (double-spiral fold)9. (lafurnitura.com)
Here, we use cryo-EM to determine the structures of assembled TDP-43 from the brains of individuals with the most common type of FTLD-TDP, type A. We show that TDP-43 does in fact form amyloid filaments, which are present in addition to TMEM106B filaments. (lafurnitura.com)

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer disease: Phase 3 study. (eurekaselect.com)
Senile plaques are complicated and heterogeneous lesions that contain not only amyloid deposits and tau positive neurites, but also neurites with degenerating pre- and post-synaptic elements (so-called dystrophic neurites), as well as activated microglia and reactive astrocytes [ 1 ]. (biomedcentral.com)

The authors present data showing Aβ binds HSV1 and RSV, and that the binding induces fibrillization of the peptide. (alzforum.org)

We found TDP-43 inhibited Aβ fibrillization at initial and oligomeric stages. (ox.ac.uk)

In this review, we summarize that the representative dimers, such as B3C, provide neuroprotection against a variety of neurotoxins via multiple targets, including the inhibitions of N-methyl-d-aspartic acid receptor with pathological-activated potential, neuronal nitric oxide synthase, and beta-amyloid cascades synergistically. (inrae.fr)

SERF1a enhances the fibrillization of and interacts with mutant thioredoxin (Trx)-fused Httex1. (bvsalud.org)

Such amyloids have been associated with (but not necessarily as the cause of) more than 50 human diseases, known as amyloidosis, and may play a role in some neurodegenerative diseases. (wikipedia.org)
The structures reveal that unlike TMEM106B, TDP-43 forms distinct amyloid filament folds in different neurodegenerative conditions and detail their structural basis. (lafurnitura.com)

Methylene blue-mediated promotion of fiber formation occurred via a dose-dependent decrease in the lag time and an increase in the fibrillization rate, consistent with promotion of both filament nucleation and elongation. (utmb.edu)

These may be termed as functional or physiological or native amyloid. (wikipedia.org)

We respectfully point out that a central finding of our previous study is that HSV1 (and other pathogens) directly seed amyloid deposition as a mechanism to trap and neutralize invading microbes. (alzforum.org)

however, identical polypeptides can fold into multiple distinct amyloid conformations. (wikipedia.org)

Abnormal polyglutamine (polyQ) expansion and fibrillization occur in Huntington's disease (HD). (bvsalud.org)

For a period, the scientific community debated whether or not amyloid deposits are fatty deposits or carbohydrate deposits until it was finally found (in 1859) that they are, in fact, deposits of albumoid proteinaceous material. (wikipedia.org)
These deposits often recruit various sugars and other components such as serum amyloid P component, resulting in complex, and sometimes inhomogeneous structures. (wikipedia.org)
Aβ deposits within the walls of blood vessels in the form of amyloid angiopathy are found in many patients with AD, but it is also found in other neurologic disorders [ 2 ]. (biomedcentral.com)

Research efforts are currently ongoing in order to identify new PET tracers targeting non-amyloid PET tracers for neurodegeneration. (eurekaselect.com)

Amyloid modifier SERF enhances amyloid formation, but the underlying mechanism is not revealed. (bvsalud.org)
Nous démontrons l'efficacité de l'approche BSW en suivant en temps réel les premières étapes cruciales de formation des oligomères toxiques du peptide Aβ42. (unine.ch)
Par ailleurs, nous apportons des nouvelles notions sur le mécanisme complexe d'agrégation du peptide Aβ42 en présence de petites sondes moléculaires qui sont capables d'interférer avec la dynamique de formation amyloïde. (unine.ch)

A molecular recycling mechanism has been observed by a combination of NMR spectroscopy and mass spectroscopy for an amyloid fibril formed from an SH3 domain. (uzh.ch)

Among these, bacosides from B acopa monniera extract have been shown to reduce the amyloid plaque levels in PSAPP mice 8 . (ijpsr.com)

Recently this definition has come into question as some classic, amyloid species have been observed in distinctly intracellular locations. (wikipedia.org)

Prions are an infectious form of amyloids that can act as a template to convert other non-infectious forms. (wikipedia.org)

Fibrillization is a classical AMP mechanism, not something unique to Aβ. (alzforum.org)

In the human body, amyloids have been linked to the development of various diseases. (wikipedia.org)
Many examples of non-pathological amyloid with a well-defined physiological role have been identified in various organisms, including human. (wikipedia.org)

evidence of a direct role of HSV-1 in the process of amyloid nucleation and subsequent fibril growth is currently lacking" (p. 7, 2nd last para). (alzforum.org)
Preventing this process of fibrillization may offer effective therapy for treatment of AD. (ijpsr.com)

Oligomerization, fibrillization and neurotoxicity of native Aβ associated. (silverchair.com)

Anatomy6

Organisms1

Diseases11

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology1

Phenomena and Processes15

Disciplines and Occupations1

Information Science2

Health Care1

Aggregation13

Fibrils8

Aggregates7

Islet amyloid pol4

Peptides2

Alzheimer's8

Alpha-Synuclein1

Inhibition5

Protein8

Precursor1

Oligomers4

Inhibits1

Oligomerization and fibrillization2

Proteins5

Anti-amyloid1

Extracellular2

Toxicity1

Neurofibrillary tangles1

Filaments5

Plaques2

Induces1

Oligomeric1

Synergistically1

Interacts1

Neurodegenerative2

Nucleation and elongation1

Functional1

Deposition1

Distinct1

Abnormal1

Deposits3

Neurodegeneration1

Formation3

Molecular1

Plaque1

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Native1