• I would like to use Roy's (2009) tactic for parcellating the amygdala with resting state data into superficial, centromedial, and basolateral subdivisions. (nih.gov)
  • A relatively large body of evidence supports the view that the amygdala (and in particular the basolateral area) contributes to conditioned reinforcement by maintaining a representation of the affective value of conditioned stimuli. (jneurosci.org)
  • The basolateral amygdala (BLA), a brain center of emotional expression, contributes to acoustic communication by first interpreting the meaning of social sounds in the context of the listener's internal state, then organizing the appropriate behavioral responses. (elifesciences.org)
  • The basolateral amygdala (BLA), a brain center of emotional expression, contributes to this analysis. (elifesciences.org)
  • This is not surprising considering that the amygdala, and the basolateral nucleus of the amygdala (BLA) in particular, plays a central role in anxiety, and this structure suffers severe damage by nerve agent-induced seizures. (nih.gov)
  • Whole-cell in vitro recordings in the rat basolateral amygdala (BLA) showed that RDX reduces the frequency and amplitude of spontaneous GABA A receptor-mediated inhibitory postsynaptic currents and the amplitude of GABA-evoked postsynaptic currents. (nih.gov)
  • Changes in lateral/basolateral amygdala (BLA) neurotransmission could directly influence anxiety-like behaviors after chronic ethanol exposure and withdrawal. (aspetjournals.org)
  • Using in vitro and in vivo data we develop the first large-scale biophysically and anatomically realistic model of the basolateral amygdala nucleus (BL), which reproduces the dynamics of the in vivo local field potential (LFP). (yale.edu)
  • The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections. (elifesciences.org)
  • Basolateral Amygdala and Morphine-Induced Taste Avoidance in the Rat" by Jamie Lovaglio, Jian-You Lin et al. (butler.edu)
  • The present experiment examined the influence of excitotoxic lesions of the basolateral amygdala (BLA) on morphine-induced saccharin avoidance. (butler.edu)
  • The central nucleus (CeA) serves major amygdala output functions and receives nociceptive and affected-related information from the spino-parabrachial and lateral-basolateral amygdala (LA-BLA) networks. (scienceopen.com)
  • Previous studies indicate that neuronal activity within the basolateral amygdala (BLA) during the stressful event is necessary for the impaired performance in females (Waddell et al. (rutgers.edu)
  • Given the prominent role of the basolateral amygdala (BLA) in emotional processing and valence coding, understanding the functional relationship between the CLA and the BLA may provide important insights into claustral function. (ntu.edu.sg)
  • Previous studies using pharmacological inactivations have shown that the basolateral amygdala (BLA) to nucleus accumbens (NAc) pathway promotes choice towards larger/riskier rewards. (eneuro.org)
  • To inject KA , an injection cannula (Plastics One Inc) connected to a syringe pump is inserted into the guide cannula and slowly lowered into the basolateral amygdala at a depth of 3.7 mm below the dura and 0.39 µg of KA dissolved in 0.26 µL 0.9% saline is delivered at a rate of 50 nL/second. (nih.gov)
  • In one study, electrical stimulations of the right amygdala induced negative emotions, especially fear and sadness. (wikipedia.org)
  • When an individual is presented with a conditioned, aversive stimulus, it is processed within the right amygdala, producing an unpleasant or fearful response. (wikipedia.org)
  • The right amygdala plays a role in the association of time and places with emotional properties. (wikipedia.org)
  • The left amygdala reaches its developmental peak approximately 1.5-2 years prior to the right amygdala. (wikipedia.org)
  • The right amygdala is associated with response to fearful stimuli as well as face recognition. (wikipedia.org)
  • Therefore, we developed a task that trained participants to down-regulate activity of the right amygdala while being confronted with amygdala stimulation, i.e. negative emotional faces. (uzh.ch)
  • Over a period of four training sessions, participants significantly increased down-regulation of the right amygdala compared to a passive viewing condition to control for habilitation effects. (uzh.ch)
  • The main findings were that the right amygdala directly predicts (unmediated) the right orbitofrontal volume, but in the left hemisphere the role of mediation by the uncinate fasciculus was more complex and cross hemispheric. (bvsalud.org)
  • The hypothesis was if the uncinate connectivity was a mediator of the influence of the size of the amygdala on the size of the orbitofrontal cortex. (bvsalud.org)
  • Using a computational model of the monkey's choices, the researchers were able to characterize the different types of information conveyed by groups of neurons in the amygdala and ventral striatum. (ohsu.edu)
  • There were more neurons in the amygdala that signaled the value of exploring a new opportunity than in the ventral striatum. (ohsu.edu)
  • In fact, our response to a particular event is triggered by the neurons in the amygdala. (targetwoman.com)
  • The amygdala is one of the best-understood brain regions with regard to differences between the sexes. (wikipedia.org)
  • Our working hypothesis is that amygdala activation does not itself produce affective experience, but may set the neural preconditions (i.e. enhanced perceptual sensitivity for negative objects) for negative feelings to arise by influencing how sensory information from evocative stimuli is processed in the brain. (medscape.com)
  • The amygdala - a brain structure enlarged in two-year-old children diagnosed with autism spectrum disorder (ASD) - begins its accelerated growth between 6 and 12 months of age, suggests a study funded by the National Institutes of Health. (nih.gov)
  • They had no differences in amygdala growth but enlargement of another brain structure, the caudate, which was linked to increased repetitive behaviors. (nih.gov)
  • By examining the post-seizure phase in individuals with uncontrollable epilepsy, researchers identified a correlation between the amygdala, a brain region associated with emotion processing, and postictal apnea, a perilous pause in breathing following a seizure. (neurosciencenews.com)
  • They found that seizures that originate in the amygdala, a brain region primarily involved in processing emotion and fear, can cause postictal apnea and identified the amygdala subregion involved in prolonged breathing loss. (neurosciencenews.com)
  • Our amygdala, when over activated, acts as a 'short-cut' and can override our rational thinking brain. (health-local.com)
  • While important, the amygdala can hijack the more rational brain processes to keep us feeling anxious, unsafe and uncomfortable. (health-local.com)
  • Caption: Implanted deep brain stimulation with one lead (blue) in the amygdala, and the other lead (red) in the ventral capsule/ventral striatum. (nih.gov)
  • I've been thinking a lot about the amygdala, the part of the brain that's involved with the experiencing of emotions, especially the experiencing of fear and anxiety - the fight or flight response. (rishi.io)
  • Neuroscientists have now discovered that the amygdala, a walnut-sized structure deep within the brain and typically viewed as controlling our emotions, plays a key role in deciding whether we should shoot for the moon or stick to the world as we know it. (ohsu.edu)
  • Their findings, published today in the journal Neuron , reveal that two interconnected brain regions, the amygdala and ventral striatum, are important in determining when we should seek new opportunities to achieve a brighter future. (ohsu.edu)
  • The amygdala and ventral striatum are key components in the neural circuits in our brain that help us to learn from past experiences what in our environment is harmful or rewarding. (ohsu.edu)
  • The memory of the anxious event is retained in the brain and the neural synapses store the information of the anxious condition in which fear was the response created by the amygdala. (targetwoman.com)
  • A new study conducted in mice explores the previously unknown role of the central amygdala (region of the brain associated with emotional processes) in upgrading and downgrading pain signals in the brain. (nih.gov)
  • The amygdala and orbitofrontal cortex are brain structures that are closely related in emotional processing. (bvsalud.org)
  • In our ongoing studies, we have discovered that the TLR4 system plays a critical role in the ethanol-induced potentiation of GABAergic transmission in the central amygdala (CeA), a key brain area underlying stress reactions and alcohol dependence. (nih.gov)
  • Current models of reinforcement learning-which hold that this process is dependent on the ventral striatum's ability to process dopaminergic signals in order to associate particular choices with outcomes-fail to take into account that, in Pavlovian conditioned learning, dopamine also goes to the amygdala and that this region of the brain also affects choice behaviors and learning. (nih.gov)
  • Shown to perform a primary role in the processing of memory, decision making, and emotional responses (including fear, anxiety, and aggression), the amygdalae are considered part of the limbic system. (wikipedia.org)
  • Amygdala rethinks techno as a psychedelic journey filled with jarring tunes only to later segue to more relaxing melodies, all anchored in emotional aural storytelling. (juiceonline.com)
  • The amygdala is uniquely sensitive to emotional events. (biorxiv.org)
  • However, it is not understood whether and how the amygdala uses such emotional signals to control behavior, especially eye movements. (biorxiv.org)
  • These findings suggest that CeA controls spatially selective gaze and attention in emotional contexts, and provide a new framework for understanding psychiatric disorders related to amygdala dysfunction. (biorxiv.org)
  • The amygdala thus controls goal-directed behavior based on emotional contexts. (biorxiv.org)
  • We investigated the feasibility of training healthy humans to self-regulate the hemodynamic activity of the amygdala, which plays major roles in emotional processing. (dericbownds.net)
  • Title : Low versus high level of response to alcohol affect amygdala functional connectivity during processing of emotional stimuli Personal Author(s) : McKenna, Benjamin S.;Anthenelli, Robert M.;Smith, Tom L.;Schuckit, Marc A. (cdc.gov)
  • Collectively, our study provides new insight into serotonergic mechanisms in amygdala function and in emotional behaviors that are aberrant in psychiatric illnesses. (nih.gov)
  • The amygdala is an important neural substrate for the emotional-affective dimension of pain and modulation of pain. (scienceopen.com)
  • The amygdala plays a major role in processing our memories, in particular those that have emotional impact. (targetwoman.com)
  • In contrast, stimulation of the left amygdala was able to induce either pleasant (happiness) or unpleasant (fear, anxiety, sadness) emotions. (wikipedia.org)
  • Other evidence suggests that the left amygdala plays a role in the brain's reward system. (wikipedia.org)
  • There are observable developmental differences between the right and left amygdala. (wikipedia.org)
  • Despite the early growth of the left amygdala, the right increases in volume for a longer period of time. (wikipedia.org)
  • It is inferred that the early development of the left amygdala functions to provide infants the ability to detect danger. (wikipedia.org)
  • Participants in the experimental group were provided with ongoing information about the blood oxygen level dependent (BOLD) activity in the left amygdala (LA) and were instructed to raise the BOLD rtfMRI signal by contemplating positive autobiographical memories. (dericbownds.net)
  • The regions described as amygdala nuclei encompass several structures of the cerebrum with distinct connectional and functional characteristics in humans and other animals. (wikipedia.org)
  • Anatomically, the amygdala and more particularly its central and medial nuclei, have sometimes been classified as a part of the basal ganglia. (wikipedia.org)
  • Using data from a neuroimaging follow-up of the ELSPAC prenatal birth cohort (n=129, 47% men, 23-24 years old), we studied the impact of prenatal stress during the first and second half of pregnancy on the volume of the amygdala and its nuclei in young adult offspring. (muni.cz)
  • Amygdala nuclei were parcellated using FreeSurfer's automated segmentation pipeline. (muni.cz)
  • We found that nicotine injection drives opposite functional responses of two distinct populations of VTA DA neurons with anatomically segregated projections: it activates neurons that project to the nucleus accumbens (NAc), whereas it inhibits neurons that project to the amygdala nuclei (Amg). (pasteur.fr)
  • Emotions arise from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala, ventral striatum, putamen, caudate nucleus, and ventral tegmental area. (nih.gov)
  • New research suggests that the amygdala (shown) and ventral striatum, may play a key role in letting you know whether to explore or exploit what you already know. (ohsu.edu)
  • To demonstrate the role of the amygdala and ventral striatum in exploratory decision-making, Costa and his colleagues with NIMH listened in on the activity of individual neurons in the brains of rhesus monkeys as they performed a task where they had to choose between exploring a new opportunity whose value was uncertain, versus repeating choices they already knew were valuable or not. (ohsu.edu)
  • By demonstrating that the amygdala is as important as the ventral striatum in reinforcement learning, and that the two areas work together through dopamine signaling, this study has advanced our understanding of how primates learn, and could inform our understanding of how some neurological disorders impact learning and decision-making. (nih.gov)
  • 2016). Amygdala and Ventral Striatum Make Distinct Contributions to Reinforcement Learning . (nih.gov)
  • The current study examined the hypothesis that amygdala activation serves as a neural precondition for negative affective experience. (medscape.com)
  • With recent technological advances that allow for causal investigations of specific neural circuit elements, we can now begin to map the complex anatomical connections of the amygdala onto behavioural function. (scienceopen.com)
  • Amygdala projections to the nucleus accumbens (NAc) form a neural circuit that has been implicated in guiding risk-related decision making, and dysfunction in this circuitry is thought to underlie aberrant decision making observed in a variety of psychiatric illnesses. (eneuro.org)
  • What is exciting about these results is that they chip away at the false dichotomy that we use to characterize neural circuits, particularly the amygdala, as contributing to emotion or decision making. (ohsu.edu)
  • hippocampus (orange), amygdala (pink), putamen (magenta), caudate nucleus (purple), and nucleus accumbens (green). (nih.gov)
  • In the present study, excitotoxic lesions of the amygdala in a new world primate, the common marmoset, resulted in a progressive impairment in responding under a second-order schedule of food reinforcement. (jneurosci.org)
  • This important study advances our understanding of the ways in which different types of communication signals differentially affect mouse behaviors and amygdala cholinergic/dopaminergic neuromodulation. (elifesciences.org)
  • Here we explored the effects of modulating amygdala neurons on nociceptive processing in the spinal cord and on pain-like behaviors, using optogenetic activation or silencing of BLA to CeA projections and CeA-CRF neurons under normal conditions and in an acute pain model. (scienceopen.com)
  • These findings suggest that the amygdala can drive the activity of spinal cord neurons and pain-like behaviors under normal conditions and in a pain model. (scienceopen.com)
  • The results are consistent with the interpretation that the amygdala contributes to negative affective experience by increasing perceptual sensitivity for negative stimuli. (medscape.com)
  • Understanding how the amygdala contributes to a wide array of behaviours requires the study of distinct amygdala circuits. (scienceopen.com)
  • Since amygdala is the structure associated with the limbic system, its functions are predominantly associated with emotions pertaining to the survival of the individual. (targetwoman.com)
  • Negative affect, as measured during the experience-sampling procedure 1-year prior, was positively correlated with amygdala activation in response to these brief presentations of fear depictions. (medscape.com)
  • Employing a pioneering method that melds electrical stimulation and functional MRI, researchers spotlighted previously unidentified connections between the amygdala and brainstem, opening new avenues in understanding and potentially mitigating post-seizure breathing suppression. (neurosciencenews.com)
  • The scientists then used a technique combining electrical stimulation with functional MRI to identify novel connections between the amygdala site and the brainstem region critical for sensing changes in blood CO 2 levels and controlling breathing. (neurosciencenews.com)
  • Microinjection of the chemoconvulsant kainic acid (KA) into unilateral amygdala induces a prolong status epilepticus, following which the majority of mice develop spontaneous recurrent seizures with relatively stable average frequency after a short latent period. (nih.gov)
  • Central amygdala facilitates contralateral saccades selectively. (biorxiv.org)
  • The response of the amygdala facilitates into a condition called conditioned stress response, in which various conditions such as muscle fatigue, neurotransmitter and stress hormone release, sympathetic arousal, sleep deprivation, immune reactivation etc occurs. (targetwoman.com)
  • Metoprolol decreases retention of fear memory and facilitates long-term depression in lateral amygdala. (bvsalud.org)
  • Cano, Jose Carlos, "Shining Light On An Amygdala -- Brainstem Connection Important For Attention Processing" (2019). (utep.edu)
  • The amygdala and striatum seem to play a key role in letting you know whether to explore or exploit what you already know," said Costa, a member of the Division of Neuroscience at the Oregon National Primate Research Center. (ohsu.edu)
  • The findings indicate that therapies to reduce the symptoms of ASD might have the greatest chance of success if they begin in the first year of life, before the amygdala begins its accelerated growth. (nih.gov)
  • Moreover, the faster the rate of amygdala overgrowth, the greater the severity of ASD symptoms at 24 months. (nih.gov)
  • We conclude that exposure to stress during the first half of pregnancy might have long-term implications for amygdala anatomy, which may in turn predict the experience of depressive symptoms in young adulthood. (muni.cz)
  • It is overactive and dysregulated in affective and anxiety disorders and amygdala activity normalizes with successful therapy of the symptoms. (uzh.ch)
  • Basal amygdala (BA) circuits are a locus of fear learning and receive dense 5-HT input from the dorsal raphe (DR). To understand the involvement of 5-HT signaling and to optimize the efficacy of 5-HT-targeting drugs, characterizing the mechanisms of 5-HT modulation during fear behavior is essential. (nih.gov)
  • From circuits to behaviour in the amygdala. (scienceopen.com)
  • Two types of cholinergic projections to the rat amygdala. (atsbio.com)
  • The CeA is a major site of extra-hypothalamic expression of corticotropin releasing factor (CRF, also known as corticotropin releasing hormone, CRH), and amygdala CRF neurons form widespread projections to target regions involved in behavioral and descending pain modulation. (scienceopen.com)
  • In this study, we investigated the action of ß1- adrenergic receptor antagonist- metoprolol and ß2- adrenergic receptor antagonist- butoxamine on the retention of conditioned fear memory and synaptic adaptation in the lateral amygdala of rats . (bvsalud.org)
  • Evidence from lesion patients suggests that the amygdala is not necessary for the experience of affect (Anderson and Phelps, 2001, 2002). (medscape.com)
  • using a second-order visual discrimination task, suggests that the amygdala is not critical for the conditioned reinforcement process. (jneurosci.org)
  • The right and left portions of the amygdala have independent memory systems, but work together to store, encode, and interpret emotion. (wikipedia.org)
  • The right hemisphere of the amygdala is associated with negative emotion. (wikipedia.org)
  • Yet, the amygdala often shows robust activation in imaging studies of emotion experience. (medscape.com)
  • Of the 102 imaging studies that have imaged experiences of emotion or affect (i.e. participants were either asked to rate their experience in the scanner, undergo a mood induction or were shown evocative scenes or images), 42 reported significant amygdala activation over baseline. (medscape.com)
  • The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. (muni.cz)
  • The amygdala is a central target of emotion regulation. (uzh.ch)
  • The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli. (scienceopen.com)
  • Specifically, negative affective experiences are associated with sensitivity to negative stimuli, and this sensitivity appears to be instantiated, in part, by increases in amygdala activity. (medscape.com)
  • These data confirm that the amygdala is critical for the conditioned reinforcement process in primates, and taken together with other recent work in monkeys, these results suggest that the contribution of the amygdala is to provide the affective value of specific reinforcers as accessed by associated conditioned stimuli. (jneurosci.org)
  • the investigators suggested that the amygdala is either involved only in the acquisition, but not performance, of conditioned reinforcement, or instead is specifically involved in acquiring an association between environmental stimuli and the value of one particular foodstuff compared with another, and not the association between environmental stimuli and food reward as opposed to no reward. (jneurosci.org)
  • All the social stimuli we get are assimilated by the amygdala thereby making us responsive to a gaze, face or voice. (targetwoman.com)
  • The current study begins to address that question by investigating the association between affective experience and activation in the amygdala. (medscape.com)
  • There is currently mixed evidence regarding the importance of the amygdala to affective experience. (medscape.com)
  • Taken together, these findings can be reconciled by hypothesizing that amygdala activation might serve to cause affective experience via its influence on perception and memory, but it does not directly entail or instantiate experience itself. (medscape.com)
  • We therefore injected muscimol (GABA A agonist) into the central nucleus of amygdala (CeA) in monkeys. (biorxiv.org)
  • Here, using a tastant (sucrose/quinine)-reinforced "go/no-go" task in male and female mice, we examined the anatomical and functional connectivity of the circuit linking the insular cortex (IC) to the central amygdala (CeA) and the role of this circuit in the establishment of appropriate behavioral responses. (nih.gov)
  • Central amygdala neurons expressing protein kinase C-delta (CeA-PKCδ) are sensitized following nerve injury and promote pain-related responses in mice. (nih.gov)
  • In mice, we first characterized the neuroanatomy and neurochemistry of a connection from the central nucleus of the amygdala (CeA) to the caudal pontine reticular nucleus (PnC), at the core of the sensorimotor gating circuit. (utep.edu)
  • The central amygdala (CeA) functions as a pain rheostat in the forebrain, enhancing or attenuating pain. (nih.gov)
  • The researchers found that there is a "switch" in the central amygdala that can both turn up or turn down pain signals. (nih.gov)
  • During the experiments, researchers were able to take advantage of molecular genetic approaches that allow them to fluorescently label and manipulate the activity of these two central amygdala cell-types. (nih.gov)
  • The involvement of the amygdala in conditioned reinforcement has been, until recently, unequivocal. (jneurosci.org)
  • IRP researchers led by Bruno B. Averbeck, Ph.D. , used computational modeling and behavioral experiments to confirm the existence of an essential role for the amygdala in reinforcement learning, which is distinct from that of the ventrial striatum. (nih.gov)
  • The amygdala is involved in processing emotions, such as interpreting facial expressions or feeling afraid when exposed to a threat. (nih.gov)
  • you may be asking.The amygdala is found nestled in the midbrain, two small almond shaped clusters who's primary role is to process emotions and memories associated with fear. (health-local.com)
  • We further evaluated the relationship between amygdala anatomy and offspring depressive symptomatology. (muni.cz)
  • There is considerable growth within the first few years of structural development in both male and female amygdalae. (wikipedia.org)
  • The structural development of the male amygdala occurs over a longer period than in women. (wikipedia.org)
  • A new study reports prolonged exposure to stress can result in structural changes to the amygdala in mice. (neurosciencenews.com)
  • Additional studies are needed to confirm the role of the amygdala in breathing suppression and its involvement in SUDEP. (neurosciencenews.com)
  • Corticotropin-releasing factor (CRF), which is highly abundant in the amygdala as well as in the paraventricular nucleus of the hypothalamus, plays an important role in regulating anxiety-like behavior [ 14 ]. (biomedcentral.com)
  • Expression of corticotropin-releasing factor (CRF), which is important for the regulation of anxiety-like behavior, is increased in the amygdala of the knock-in mice. (biomedcentral.com)
  • The amygdala is larger in males than females, in children aged 7 to 11, adult humans, and adult rats. (wikipedia.org)
  • At this point I'm rambling but I think it's a shame that I'm so driven by anxiety avoidance and my amygdala in my life. (rishi.io)
  • Taken together, the findings suggest that seizure activity in a subregion of the amygdala can suppress breathing and air hunger for prolonged periods of time following seizure. (neurosciencenews.com)
  • The findings demonstrate that healthy subjects can learn to regulate their amygdala activation using rtfMRI neurofeedback, suggesting possible applications of rtfMRI neurofeedback training in the treatment of patients with neuropsychiatric disorders. (dericbownds.net)
  • The present study used temporally-discrete optogenetic inhibition to identify how activity in amygdala inputs to the accumbens, during different phases of the decision process, promotes optimal decision making. (eneuro.org)
  • Gross ablation of the amygdala in rhesus monkeys, which also causes nonspecific damage to fibers of passage and to the adjacent rhinal cortex, produced impairments on a task requiring subjects to solve a series of visual discriminations in which the only feedback that the monkey received after each response was the presentation of a conditioned positive or negative auditory stimulus. (jneurosci.org)
  • One year later, participants viewed backwardly masked depictions of fear while functional magnetic resonance imaging was used to measure their amygdala and fusiform gyrus activation. (medscape.com)
  • Lesion studies demonstrate intact 5-HT fibers in the amygdala are necessary for normal fear behavior. (nih.gov)
  • Amygdala is associated with the fear factor that is generated in a person. (targetwoman.com)
  • This is because the amygdala provides an autonomic response when associated with fear. (targetwoman.com)
  • In our previous study, we found propranolol efficaciously reduced fear retention induced by reactivation via ß- adrenergic receptors in lateral amygdala . (bvsalud.org)
  • We found metoprolol not butoxamine attenuated the reactivation-induced strengthening of fear retention and restored the impaired long-term depression in lateral amygdala . (bvsalud.org)
  • Intra- amygdala infusion of metoprolol not butoxamine attenuated reactivation-induced enhancement of fear retention. (bvsalud.org)
  • We compared amygdala degree centrality, a measure of hubness, between those exposed to high vs. low (median split) prenatal stress, defined by maternal reports of stressful life events during the first (n = 93, 57% female) and second (n = 125, 54% female) half of pregnancy. (muni.cz)
  • Conclusion: Unlike childhood trauma, prenatal stress may shift SCN towards a less amygdala-centric SCN pattern, particularly in men. (muni.cz)
  • 1 Furthermore, participants with various mood disorders involving enhanced negative affect also show significantly higher amygdala activation (Drevets et al . (medscape.com)
  • Results: The high-stress during the first half of pregnancy ELSPAC group showed lower amygdala degree particularly in men, who demonstrated this difference at 10 consecutive thresholds, with no significant differences in global network properties. (muni.cz)
  • Sex differences in amygdala expression of selected genes. (nih.gov)
  • The study elucidates how seizures originating in specific amygdala subregions might suppress both breathing and the crucial alarm signal of "air hunger," potentially through novel connections to the brainstem, which regulates responses to blood CO2 alterations. (neurosciencenews.com)
  • Seizures originating in the amygdala subregions can suppress breathing and the vital "air hunger" alarm after the event, potentially elucidating a key mechanism in SUDEP. (neurosciencenews.com)
  • These results suggest that binding to the GABA A receptor convulsant site is the primary mechanism of seizure induction by RDX and that reduction of GABAergic inhibitory transmission in the amygdala is involved in the generation of RDX-induced seizures. (nih.gov)