Following remission, 1,017 patients were randomly assigned to a third course, MACE (amsacrine, etoposide, and Ara-C), plus a fourth course of MidAc (mitoxantrone and Ara-C) and following an amendment to one or two courses of high-dose Ara-C. Primary end points were cumulative incidence of relapse (CIR), relapse-free survival (RFS), and overall survival (OS). (ox.ac.uk)
Topoisomerase1
Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. (wikipedia.org)
Induction1
this consisted of 2 cycles of induction therapy with infusions of daunomycin, cytosine arabinoside, etoposide (ADE therapy). (medscape.com)
Drugs2
1 With some variations, most centers apply treatment schedules based on these drugs, sometimes supplemented with etoposide. (ashpublications.org)
Visual compatibility of amsacrine with selected drugs during simulated Y-site injection. (stabilis.org)
C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C67162 ABVE Regimen DVBE A regimen containing doxorubicin hydrochloride, bleomycin sulfate, vincristine sulfate and etoposide used in combination with radiation therapy for the treatment of low-risk, childhood Hodgkin lymphoma. (nih.gov)
Daunorubicin1
C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C9579 ADE Regimen ADE A regimen consisting of cytarabine (Ara-C), daunorubicin and etoposide, that is used as an induction treatment for pediatric acute myeloid leukemia (AML). (nih.gov)
Cytosine arabinoside2
this consisted of 2 cycles of induction therapy with infusions of daunomycin, cytosine arabinoside, etoposide (ADE therapy). (medscape.com)
High dose BEAM (BCNU, cytosine-arabinoside, etoposide, melphalan) chemotherapy followed after the 4th cycle with autologous stem cell transplantation. (muni.cz)
Cyclophosphamide1
Therefore, the treatment started with an application of stimulation regime (cyclophosphamide 2 g/m2 day 1 and etoposide 200 mg/m2 days 1-3) followed by collection of peripheral blood haematopoietic stem cells. (muni.cz)
VP161
AT5BIVA cells are sensitive to the topo II inhibitors etoposide (VP16) and amsacrine (m-AMSA), compared to normal human fibroblasts (MRC5-V1 and VA13). (ox.ac.uk)
Dexamethasone2
Etoposide (100 mg i.v.) was added to lenalidomide and dexamethasone on days 22, 23 and 24 of the above mentioned 28-day cycle. (muni.cz)
Four cycles have led to partial remission and treatment response was furthered with the combination of lenalidomide, dexamethasone and etoposide to complete remission. (muni.cz)
Azacitidine1
C167080 SEER Rx Interactive Antineoplastic Drugs Database-Regimen C9675 Amsacrine/Azacitidine/Etoposide Regimen MAZE A chemotherapy regimen consisting of amsacrine, azacitidine, and etoposide that may be used in the treatment of induction-resistant or relapsed childhood acute myeloid leukemia (AML). (nih.gov)
Bone marrow transpla1
The achieved remission was consolidated using allogeneic bone marrow transplantation after FLAMSA reduced density conditioning without amsacrine. (muni.cz)
Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. (wikipedia.org)
5. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing. (nih.gov)
Treatment1
Very rarely, LCH involves multiple systems (multiple organ LCH) and is difficult to manage either with the traditional first line treatment (vinblastine, mercaptopurine, prednisone or etoposide) or with 2-chlorodeoxyadenosine. (muni.cz)