• Amphotericin B Deoxycholate is available under the following different brand names: Amphotericin B (conventional), AmBisome . (rxlist.com)
  • AmBisome (LAMB) is a liposomal formulation of amphotericin B for injection and consists of a mixture of phosphatidylcholine, cholesterol and distearoyl phosphatidylglycerol that in aqueous media spontaneously arrange into unilamellar vesicles that contain amphotericin B. It was developed by NeXstar Pharmaceuticals (acquired by Gilead Sciences in 1999). (wikipedia.org)
  • There is a risk of under-dose if AmBisome is administered at a dose recommended for amphotericin B deoxycholate. (medicines.org.uk)
  • However, a cumulative dose of 1.0 - 3.0 g of amphotericin B as AmBisome over 3 - 4 weeks has been typical. (medicines.org.uk)
  • Dosage of amphotericin B as AmBisome must be adjusted to the specific requirements of each patient. (medicines.org.uk)
  • Liposomal amphotericin B (AmBisome) was given to our patient as an inpatient for seven daily doses of 3 mg kg(-1) day(-1) and then as an outpatient at 3 mg kg(-1) twice weekly for a further three weeks, a total of 40 mg kg(-1). (unboundmedicine.com)
  • Per ID consultation, the patient was switched from posaconazole to intravenous (IV) liposomal amphotericin B (Ambisome) for presumed posaconazole treatment failure. (ahrq.gov)
  • He wrote for "amphotericin B" in his note, while the attending ID note specified "Ambisome" at 5 mg/kg. (ahrq.gov)
  • The original formulation uses sodium deoxycholate to improve solubility. (wikipedia.org)
  • Biodistribution and histopathology studies of amphotericin B sodium deoxycholate sulfate formulation following intratracheal instillation in rat models. (olmdiagnostics.com)
  • We report aerosol formulation of AmB using sodium deoxycholate sulfate (SDCS), a lipid carrier synthesized in-house using natural precursor deoxycholic acid. (olmdiagnostics.com)
  • Different amphotericin products (sodium deoxycholate, liposomal, lipid complex) are not equivalent in terms of pharmacodynamics, pharmacokinetics and dosing and so the products should not be used interchangeably without accounting for these differences. (medicines.org.uk)
  • The 2 main classes of antifungal medications used to treat mucormycosis are the polyenes (amphotericin formulations) and triazoles (isavuconazole and posaconazole). (medscape.com)
  • Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. (wikipedia.org)
  • Amphotericin B (AMB) is a polyene antibiotic with broad spectrum antifungal activity, but its clinical toxicities and poor solubility limit the wide application of AMB in clinical practice. (dovepress.com)
  • Planktonic and sessile antifungal susceptibilities of each isolate were determined for amphotericin B deoxycholate, caspofungin, and voriconazole. (who.int)
  • She was discharged home with a PICC line for prolonged IV caspofungin therapy (a suboptimal antifungal agent for treating aspergillosis), due to her fear of receiving more amphotericin. (ahrq.gov)
  • Traditionally, the mainstay of systemic antifungal therapy has been amphotericin B deoxycholate (conventional amphotericin B). Newer agents have been developed to fulfill special niches and to compete with conventional amphotericin B by virtue of having more favourable toxicity profiles. (hindawi.com)
  • Owing to decreased risk of nephrotoxicity at this dose, it can be used in the setting of preexisting renal dysfunction and when nephrotoxicity develops during amphotericin B deoxycholate therapy. (medscape.com)
  • amphotericin B deoxycholate and tobramycin both increase nephrotoxicity and/or ototoxicity. (medscape.com)
  • 1 ) Nephrotoxicity is also common, occurring in up to 53% in patients during amphotericin treatment of Aspergillus infections. (ahrq.gov)
  • Lipid preparations are often preferred because they are better tolerated and associated with less nephrotoxicity than amphotericin B deoxycholate (AII*) . (hiv.gov)
  • Lipid-based formulations of amphotericin B are no more effective than conventional formulations, although there is some evidence that lipid-based formulations may be better tolerated by patients and may have fewer adverse effects. (wikipedia.org)
  • In order to improve the tolerability of amphotericin and reduce toxicity, several lipid formulations have been developed. (wikipedia.org)
  • Liposomal formulations have been found to have less renal toxicity than deoxycholate, and fewer infusion-related reactions. (wikipedia.org)
  • Alternative treatments include voriconazole and amphotericin B formulations. (cdc.gov)
  • First, the resident on the consulting ID team, unfamiliar with the different formulations of amphotericin B, did not distinguish between the two preparations in his progress note. (ahrq.gov)
  • Third, the pharmacist filling the prescription was also unfamiliar with the different amphotericin formulations and did not recognize the toxic dose, either while compounding the medication or sending it to the floor. (ahrq.gov)
  • The lipid formulations of amphotericin B are licensed for use in patients whose infection is intolerant or refractory to amphotericin B deoxycholate treatment. (drfungus.org)
  • Liposomal and Deoxycholate Amphotericin B Formulations: Effectiveness against Biofilm Infections of Candida spp. (rodriguescf.pt)
  • As the original formulation of amphotericin, it is often referred to as "conventional" amphotericin. (wikipedia.org)
  • The next morning, it was discovered that she had been given conventional amphotericin B (Fungizone) at the intended 5 mg/kg liposomal amphotericin B dose. (ahrq.gov)
  • When treating aspergillosis, conventional amphotericin is dosed at a maximum of 1-1.5 mg/kg. (ahrq.gov)
  • The primary service (thoracic surgery) inadvertently prescribed conventional amphotericin B (Fungizone) at the ID consult-recommended dose of 5 mg/kg. (ahrq.gov)
  • Second, the electronic prescribing system lacked an alert for the conventional amphotericin formulation that would have notified the prescribing physician that the dose was out of the recommended range. (ahrq.gov)
  • Some agents have displaced conventional amphotericin B for the treatment of specific fungal diseases. (hindawi.com)
  • This notwithstanding, conventional amphotericin B remains a useful agent for the treatment of paediatric fungal infections. (hindawi.com)
  • Most of the territories reported access to medications such as trimethoprim-sulfamethoxazole, itraconazole, voriconazole and amphotericin B (AMB) deoxycholate. (duke.edu)
  • Posaconazole can be used off-label for salvage treatment in patients intolerant to amphotericin B. It has also been used as step-down therapy after initial control of the disease with amphotericin. (medscape.com)
  • Amphotericin B deoxycholate (AmBD) and amphotericin B colloidal dispersion (AmBCD) are the two most commonly used antifungals for invasive fungal infections (IFI) among paediatric patients. (setpublisher.com)
  • However, recently novel nanoparticulate drug delivery systems such as AmbiOnp, nanosuspensions, lipid-based drug delivery systems including cochleates, self-emulsifying drug delivery systems, solid lipid nanoparticles and polymeric nanoparticles-such as Amphotericin B in pegylated polylactide coglycolide copolymer nanoparticles-have demonstrated potential for oral formulation of amphotericin B. Amphotericin B is well known for its severe and potentially lethal side effects. (wikipedia.org)
  • Safety and efficacy of amphotericin-B deoxycholate inhalation in critically ill patients with respiratory Candida spp. (biomedcentral.com)
  • Most intensivists start amphotericin-B deoxycholate (ABDC) inhalation therapy to eradicate Candida spp. (biomedcentral.com)
  • 1,2 ) Infusion-related adverse events, including fever, chills, and rigors, occur in 30%-72% of patients treated with amphotericin B deoxycholate (Fungizone). (ahrq.gov)
  • Consists of a mixture of phosphatidylcholine, cholesterol, and distearoyl phosphatidylglycerol that arrange into amphotericin B-containing unilamellar vesicles in aqueous media. (medscape.com)
  • Amphotericin B Deoxycholate is a prescription medication used to treat the symptoms of Systemic Fungal Infections. (rxlist.com)
  • One of the main uses of amphotericin B is treating a wide range of systemic fungal infections. (wikipedia.org)
  • Liposomal amphotericin offers a well-tolerated alternative to pentavalent antimony or amphotericin B deoxycholate for the systemic treatment of New World CL. (unboundmedicine.com)
  • Using a well-validated pharmacodynamic murine model of invasive candidiasis, we defined the effect of the combination of amphotericin B deoxycholate (AmB) and 5-fluorocytosine (5FC) by use of the Greco model of drug interaction. (manchester.ac.uk)
  • There is no current evidence-based recommendation for the addition of an echinocandin to amphotericin B or isavuconazole for the treatment of mucormycosis. (medscape.com)
  • Aerosol inhalation of amphotericin B (AmB) can be a clinically compliant way to administer the drug directly to the pulmonary route for treatment as well as prophylaxis of invasive pulmonary aspergillosis (IPA). (olmdiagnostics.com)
  • Liposomal amphotericin B has been used extensively for the treatment of visceral leishmaniasis, but in few cases of CL, and an appropriate regimen for CL has not been described. (unboundmedicine.com)
  • There is no evidence that lipid preparations of amphotericin are more effective than amphotericin B deoxycholate for the treatment of coccidioidomycosis. (hiv.gov)
  • Amphotericin B (AmB) is commonly used in patients with a human immunodeficiency virus (HIV)-positive diagnosis for the treatment of disseminated fungal infections such as Histoplasma spp. (okstate.edu)
  • What Are Warnings and Precautions for Amphotericin B Deoxycholate? (rxlist.com)
  • Amphotec is a complex of amphotericin and sodium cholesteryl sulfate in a 1:1 ratio. (wikipedia.org)
  • 256, and 0.5 and 2 microg/mL for amphotericin, voriconazole, and caspofungin, respectively. (who.int)
  • Amphotericin B is used for life-threatening protozoan infections such as visceral leishmaniasis and primary amoebic meningoencephalitis. (wikipedia.org)
  • Amphotericin B is often used as fungicidal therapy for various invasive fungal infections. (firstline.org)
  • We report the case of an HIV-seropositive patient who inadvertently received five times the dose of AmB deoxycholate for disseminated Histoplasma capsulatum and died. (okstate.edu)
  • Amphotericin B was isolated from Streptomyces nodosus in 1955 at the Squibb For Medical Research Institute from cultures isolated from the streptomycete obtained from the river bed of Orinoco in that region of Venezuela and came into medical use in 1958. (wikipedia.org)
  • Am B isome is contraindicated in those patients who have demonstrated or have a known hypersensitivity to amphotericin B deoxycholate or any other constituents of the product, unless benefit of therapy outweighs the risk. (ambisome.com)
  • Below are a few examples of reports where side effects / adverse reactions may be related to Amphotericin B. For a complete list or a specific selection of reports, please use the links above. (druglib.com)
  • What Are Dosages of Amphotericin B Deoxycholate? (rxlist.com)
  • What Other Drugs Interact with Amphotericin B Deoxycholate? (rxlist.com)
  • Amphotericin B Deoxycholate has mild interactions with at least 31 other drugs. (rxlist.com)
  • What Are Side Effects Associated with Using Amphotericin B Deoxycholate? (rxlist.com)