FungusHistoplasmaBlastomycosisFluconazolePneumoniaFlucytosineInfectionsSoilDiseaseSevereItraconazoleTreated with intravenous amphotericinInfectionIntravenousCoccidioidesLiposomalDeoxycholateThrivesEndemicAntibioticCandidaPoorly understoodSpecimensYeastFungiSpeciesPatientsClinicalGrowsPulmonaryCultureSelf-limitedCaseDrug
Fungus6
- Blastomycosis is a pulmonary disease caused by inhaling spores of the dimorphic fungus Blastomyces dermatitidis . (msdmanuals.com)
- Blastomycosis is caused by the dimorphic fungus Blastomyces . (cdc.gov)
- Blastomycosis is an infection caused by breathing in the Blastomyces dermatitidis fungus. (medlineplus.gov)
- Blastomyces dermatitidis is a fungus that is found primarily in endemic areas of the midwestern and southcentral USA. (biomedcentral.com)
- Blastomyces dermatitidis, a fungus that is endemic to the midwestern and southcentral USA, is a relatively common cause of pulmonary and cutaneous mycosis in these areas. (biomedcentral.com)
- Blastomycosis, hereafter called blasto, is an infection caused by the fungus Blastomyces dermatitidis (B. dermatitidis). (mushing.com)
Histoplasma1
- The results of a molecular analysis indicate that Coccidioides is related to ascomycetes such as Histoplasma capsulatum and Blastomyces dermatitidis. (microbiologynote.com)
Blastomycosis2
- In disseminated blastomycosis, the large Blastomyces yeast cells translocate from the lungs and are trapped in capillary beds elsewhere in the body, where they cause lesions. (wikipedia.org)
- Most blastomycosis infections in the United States are caused by B. dermatitidis or B. gilchristii . (cdc.gov)
Fluconazole2
- Separate in vitro laboratory testing evaluating Brilacidin in combination with other conventional antifungals - including caspofungin, fluconazole, posaconazole, amphotericin B and micafungin - demonstrated additive or synergistic inhibition of fungal growth. (stockdaymedia.com)
- Intrathecal amphotericin B has long been the standard therapy for meningeal disease [ 309 , 1277 ], but fluconazole is increasingly found to be an effective and better tolerated option [ 795 ]. (drfungus.org)
Pneumonia4
- We describe an immunocompetent patient with Horner syndrome secondary to invasive Blastomyces pneumonia and provide a review of the rare infectious etiologies of this syndrome. (acpjournals.org)
- To our knowledge, this is the first published human case report of Horner syndrome secondary to Blastomyces pneumonia. (acpjournals.org)
- Blastomyces pneumonia is a commonly diagnosed infection in several parts of the United States. (acpjournals.org)
- This patient case presents the rarely encountered infectious Horner syndrome in an immunocompetent patient secondary to Blastomyces pneumonia and reviews the infectious causes of the syndrome. (acpjournals.org)
Flucytosine1
- Flucytosine is usually used with amphotericin B for serious Candida and cryptococcal infections. (msdmanuals.com)
Infections1
- Amphotericin B may be used for severe infections. (medlineplus.gov)
Soil2
- Blastomyces dermatitidis is found in the soil and decaying organic matter like wood or leaves. (wikipedia.org)
- B. dermatitidis grows as a mold at ambient temperature in soil enriched with animal excreta and in moist, decaying, acidic organic material, often near rivers. (msdmanuals.com)
Disease2
Severe1
- In severe cases, patients are treated with amphotericin B before azole treatment. (wikipedia.org)
Itraconazole6
- Treatment is with itraconazole, fluconazole, or amphotericin B. (msdmanuals.com)
- The patient was treated with intravenous amphotericin B followed by oral itraconazole for 6 months. (wisc.edu)
- Oral azoles, usually itraconazole or amphotericin B, are first-line treatment for blastomycosis depending on the severity of the disease, its clinical form, and the host's immune status. (medscape.com)
- In general, mild to moderate disease is typically treated with oral itraconazole-except in pregnant women and those with CNS disease, all of whom should always receive amphotericin B. Patients with moderately severe to severe disseminated disease should receive amphotericin B followed by a long-term oral azole when they clinically improve. (medscape.com)
- Acute pulmonary histoplasmosis in a domestic cat treated with amphotericin B and itraconazole. (cabi.org)
- This paper reports on a case of acute pulmonary histoplasmosis in a domestic cat treated with oral itraconazole associated with amphotericin B administered subcutaneously. (cabi.org)
Treated with intravenous amphotericin1
- All patients were treated with intravenous amphotericin B (0.7 to 1.0 mg per kilogram per day). (nih.gov)
Infection5
- Overwhelming infection with B. dermatitidis can cause diffuse pneumonitis and the adult respiratory distress syndrome, even in immunocompetent hosts. (nih.gov)
- Infection with Blastomyces occurs when a cat or dog inhales the fungal spores into the lungs. (vin.com)
- RESULTS Histopathologic examination of the nerve specimen showed B. dermatitidis infection. (wisc.edu)
- Medical treatment for aspergillosis infection includes voriconazole , caspofungin , or amphotericin B . An aspergilloma , on the other hand, must be surgically removed. (amboss.com)
- Endemic fungal pathogens (eg, Histoplasma capsulatum , Coccidioides immitis , Blastomyces dermatitidis , Paracoccidioides brasiliensis , Sporothrix schenckii , Cryptococcus neoformans ) cause infection in healthy hosts and in immunocompromised persons, in defined geographic locations of the Americas and around the world. (medscape.com)
Intravenous3
- Amphotericin B liposome for injection is a sterile, non-pyrogenic, pale yellow to yellow lyophilized product for intravenous infusion. (nih.gov)
- Amphotericin B liposome for injection is a sterile, non-pyrogenic lyophilized product for intravenous infusion. (nih.gov)
- Despite its limiting toxic potential, amphotericin B is the only intravenous antifungal available to treat severe sporotrichosis. (cabi.org)
Coccidioides2
- Histoplasma capsulatum , Coccidioides immitis , Candida species , Blastomyces dermatitidis , Rhodotorula , Cryptococcus neoformans , Sporothrix schenckii , Mucor mucedo , and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro . (pharmacycode.com)
- Fluconazole also exhibits activity in vitro against Cryptococcus neoformans and Cryptococcus gattii as well as the endemic moulds Blastomyces dermatitidis , Coccidioides immitis , Histoplasma capsulatum and Paracoccidioides brasiliensis . (mims.com)
Liposomal6
- Amphotericin B liposome for injection is a true single bilayer liposomal drug delivery system. (nih.gov)
- Amphotericin B liposome for injection, the liposomal preparation of amphotericin B, has been shown to penetrate the cell wall of both extracellular and intracellular forms of susceptible fungi. (nih.gov)
- To compare amphotericin B with liposomal amphotericin B for induction therapy of moderate to severe disseminated histoplasmosis in patients with AIDS. (nih.gov)
- Three patients treated with amphotericin B and one treated with liposomal amphotericin B died during induction (P = 0.04). (nih.gov)
- Johns Hopkins Guides , www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540022/8/Amphotericin_B_liposomal. (hopkinsguides.com)
- Amphotericin B is less frequently used and, when used, is often given as a liposomal formulation to decrease toxicity. (medscape.com)
Deoxycholate1
- In patients with moderate to severe histoplasmosis associated with AIDS, the preferred treatment has been the deoxycholate formulation of amphotericin B. However, serious side effects are associated with use of amphotericin B. (nih.gov)
Thrives1
- B dermatitidis thrives in moist, acidic soil, rich with organic debris. (patientcareonline.com)
Endemic1
- Severe sporotrichosis treated with amphotericin B: a 20-year cohort study in an endemic area of zoonotic transmission. (cabi.org)
Antibiotic1
- are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses. (pharmacycode.com)
Candida1
- While Candida albicans is generally quite susceptible to amphotericin B, non- albicans species may be less susceptible. (pharmacycode.com)
Poorly understood1
- The ecological niche of Blastomyces in the wild is poorly understood, and it is unknown if there are any significant host animals. (wikipedia.org)
Specimens2
- The culture specimens obtained by bronchoscopy grew Blastomyces dermatitidis, and results were confirmed by DNA probe. (patientcareonline.com)
- More recently, molecular DNA probes have been developed to facilitate the rapid identification of B dermatitidis from clinical specimens. (medscape.com)
Yeast1
- Blastomyces yeast in budding stage, as seen through a microscope. (vin.com)
Fungi2
- Amphotericin B, the active ingredient of amphotericin B liposome for injection, acts by binding to the sterol component, ergosterol, of the cell membrane of susceptible fungi. (nih.gov)
- Amphotericin B shows a high order of in vitro activity against many species of fungi. (pharmacycode.com)
Species1
- Mutants with decreased susceptibility to amphotericin B have been isolated from several fungal species after serial passage in culture media containing the drug, and from some patients receiving prolonged therapy. (nih.gov)
Patients1
- Six of the patients had no underlying disease associated with altered immunity, and two had no recent exposure to environmental reservoirs of Blastomyces dermatitidis. (nih.gov)
Clinical1
- Drug combination studies in vitro and in vivo suggest that imidazoles may induce resistance to amphotericin B. However, the clinical relevance of drug resistance has not been established. (nih.gov)
Grows1
- B. dermatitidis grows as a mold at ambient temperature in soil enriched with animal excreta and in moist, decaying, acidic organic material, often near rivers. (msdmanuals.com)
Pulmonary1
- With prompt diagnosis by microscopical examination of tracheal secretions, intensive therapy with amphotericin B, and ventilatory support, good recovery of pulmonary function is possible. (nih.gov)
Culture1
- Needle biopsy and culture results of a suspicious lung scar were positive for Blastomyces. (wisc.edu)
Self-limited1
- During epidemics, most persons exposed to B dermatitidis have a self-limited illness. (patientcareonline.com)
Case1
- Unilateral Blastomyces dermatitidis optic neuropathy case report and systematic literature review. (wisc.edu)
Drug1
- Due to the nature and quantity of amphophilic substances used, and the lipophilic moiety in the amphotericin B molecule, the drug is an integral part of the overall structure of the amphotericin B liposome for injection liposomes. (nih.gov)