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  • chronic
  • Toxins, including ifosfamide (more commonly causing pRTA than dRTA), toluene, lithium carbonate and amphotericin B. Chronic urinary tract obstruction. (wikipedia.org)
  • solubility
  • The amphipathic nature of amphotericin along with its low solubility and permeability has posed major hurdles for oral administration given its low bioavailability. (wikipedia.org)
  • conventional
  • Severe infusion-related side effects have been associated with conventional amphotericin B administration, and may be lessened by treatment with corticosteroids, acetaminophen , antihistamines , and meperidine . (drugs.com)
  • slowly
  • Avid binding to serum proteins, probably coupled at least in part by cholesterol, makes amphotericin B equilibrate slowly with infected exudates and penetrate poorly into cerebrospinal fluid, urine and hemodialysis baths. (springer.com)
  • Amphotericin B liposomal must be given slowly, and the IV infusion can take 1 or more hours to complete. (rexhealth.com)