Amphiphilic graft copolymer. Medical search. Frequent questions

Herein, we present such a smart nanoparticle platform based on self-assembled, reduction-responsive amphiphilic graft copolymers, which were successfully synthesized through thiol-disulfide exchange reaction between thiolated hydrophilic block and pyridyl disulfide functionalized hydrophobic block. (rsc.org)
These amphiphilic graft copolymers self-assembled into nanoparticles with mean diameters of about 30-50 nm and readily incorporated hydrophobic guest molecules. (rsc.org)
These responsive copolymer-based nanoparticles represent a promising candidate as smart nanocarrier platform for various drugs to be applied to different diseases, due to the biocompatibility and biodegradability of the hydrophobic block, and the protein-repellent hydrophilic block. (rsc.org)
Successful synthesis of the graft copolymer was confirmed using 1HNMRand FT-IR spectroscopy.TEMand DSC analysis revealed the welldefined microphase-separated structure of the graft copolymer into hydrophobic PVC and hydrophilic POEM domains. (elsevierpure.com)
Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which itself was prepared by enzymatic polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol. (fu-berlin.de)
Amphiphilic graft-copolymers with poly(dimethylsiloxane) (PDMS) and methoxy poly(ethylene glycol) (MPEG)-grafts as the hydrophobic and hydrophilic constituents, respectively, were prepared via a grafted-through approach. (ntnu.no)
With this in mind, I focused to the synthesis of amphiphilic materials that possess hydrophilic and hydrophobic parts, therefore affinity with inorganic materials, or water based, and organic materials. (unimib.it)
Hence, hydrophilic polyoxazoline (POx) graft arms are located on hydrophobic polysulfone backbone via "grafting from" method in which the modified PSU act as a macroinitiator. (itu.edu.tr)
Lipids are amphiphilic molecules with both hydrophilic and hydrophobic functional groups, which enable a possible self-assembly in an aqueous medium to form structures as liposomes. (univapollonia.ro)

In polymer chemistry, graft polymers are segmented copolymers with a linear backbone of one composite and randomly distributed branches of another composite. (wikipedia.org)
Graft polymers have been synthesized for many decades and are especially used as impact resistant materials, thermoplastic elastomers, compatibilizers, or emulsifiers for the preparation of stable blends or alloys. (wikipedia.org)
Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. (fu-berlin.de)
RAFT polymerization offers substantial versatility when it comes to the synthesis of block copolymers, star polymers, polymer brushes, and other complex polymer systems. (unimib.it)
Similar to other living radical polymerization techniques, block copolymers, star and comb polymers, as well as graft polymers are accessible by attaching the controlling moiety to a (multi)functional core linking moiety. (unimib.it)
Electrically conductive polymers capable of being covalently grafted on by light, method for obtaining same and uses as supports in probes for specific identification in electronic biosensors. (univ-grenoble-alpes.fr)

Self-assembled nanoparticles of amphiphilic cellulose derivatives carrying a single pyrene group at the reducing-end. (springer.com)
Improvement of poly(amphiphilic pyrrole) enzyme electrodes via the incorporation of synthetic laponite-clay-nanoparticles. (univ-grenoble-alpes.fr)

Amphiphilic anionic and cationic graft copolymers possessing poly(2-hydroxyethyl methacrylate) (PHEMA) backbone and poly(methacrylic acid), poly(2-methoxyethyl acrylate-co-methacrylic acid), and poly(2-methoxyethyl acrylate-co-2-(dimethylamino)ethyl methacrylate) grafts are constructed by merging reversible addition-fragmentation chain transfer (RAFT) polymerization, copper-mediated atom transfer radical polymerization (ATRP), and a selective deprotection reaction. (dtu.dk)
The graft copolymers showed effective surface adsorption and lubrication for self-mated poly(dimethylsiloxane) (PDMS) contacts in physiological salt concentration. (dtu.dk)
Amphiphilic graft copolymers comprising poly(vinyl chloride) (PVC) main chains and poly(oxyethylene methacrylate) (POEM) side chains, i.e. (elsevierpure.com)
Specifically, conjugated polymer poly(fluorene- alt -(4,7-bis(hexylthien)-2,1,3-benzothiadiazole)) (PFTB) was utilized as a fluorescent backbone and a macroinitiator for grafting with polycaprolactone (PCL) and poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) blocks via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) successively, resulting in highly fluorescent polymer bottlebrushes, PFTB- g -(PCL- b -POEGMA). (rsc.org)
However, the promising results for the copolymerization's employing RITP were further explored in the preparation of poly(MMA-co-PDMSMA-co-MPEGMA) graft-type amphiphilic copolymers. (ntnu.no)
Glycerol 1,3-diglycerolate diacrylate (GDD) was graft copolymerized onto poly(3-hydroxyoctanoate-co-3-hydroxyhexanoate) P(3HO-co-3HHX) to render the latter more hydrophilic. (um.edu.my)
In this article, poly(styrene-alt-maleic anhydride) copolymers were first prepared by RAFT polymerization and characterized by different analytical techniques. (ibmmpolymerbiomaterials.com)
For the amphiphilic graft copolymers based on poly(ethylene glycol), aggregation behavior in water was investigated. (ibmmpolymerbiomaterials.com)
Chen D (2013) Crystal behavior of semicrystalline polystyrene-block-poly(L-lactide) diblock copolymer in thin films with various structures. (springer.com)
In this work, copolymers based on poly(dimethylsiloxane) and poly(ethylene oxide) with different molar masses and architectures (graft, triblock) were associated with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). (cnrs.fr)
Reversible self-organization of poly(ethylene glycol)-based hybrid block copolymers mediated by a De Novo four-stranded α-helical coiled coil motif. (mpg.de)
Small-angle neutron scattering from diblock copolymer poly(styrene-d 8 )-b-poly(γ-benzyl L-glutamate) solutions: Rod-coil to coil-coil transition. (mpg.de)
From supramolecular polymersomes to stimuli-responsive nano- capsules based on poly(diene-b-peptide) diblock copolymers. (mpg.de)
Hierarchical self-assembly of poly(γ-benzyl-L-glutamate)-poly(ethylene glycol)-poly(γ-benzyl-L-glutamate) rod-coil-rod triblock copolymers. (mpg.de)
Poly(ethylene glycol) block copolymers containing protein folding motifs. (mpg.de)
We have developed a series of NPs based on (bio)degradable and biocompatible poly(malic acid) derivatives, poly(benzyl malate) (PMLABe), with its PEG-grafted stealth analog and target-specific biotin-PEG- b -PMLABe one. (frontiersin.org)

One of the better-known examples of a graft polymer is a component used in high impact polystyrene, consisting of a polystyrene backbone with polybutadiene grafted chains. (wikipedia.org)
The grafting to method involves the use of a backbone chain with functional groups A that are distributed randomly along the chain. (wikipedia.org)
The formation of the graft copolymer originates from the coupling reaction between the functional backbone and the end-groups of the branches that are reactive. (wikipedia.org)
In the grafting-from method, the macromolecular backbone is chemically modified in order to introduce active sites capable of initiating functionality. (wikipedia.org)
If the number of active sites along the backbone participates in the formation of one branch, then the number of chains grafted to the macromolecule can be controlled by the number of active sites. (wikipedia.org)
Grafting of P(3HO-co-3HHX) backbone was performed using benzoyl peroxide as free radical initiator in homogenous acetone solution. (um.edu.my)
The combination of the properties of both backbone PSU and side chain POx imply that these graft copolymers are promising biomaterials and may find many applications in various areas. (itu.edu.tr)
After polymerization and ultimate deprotection of the silylated dextran backbone, amphiphilic polyester-grafted dextrans were readily recovered. (univ-lorraine.fr)

All the membranes exhibited amorphous structures and the intersegmental d-spacing were increased with the grafting degree, as characterized by XRD analysis. (elsevierpure.com)
The present work deals with the preparation of ultrafiltration (UF) and microfiltration (MF) membranes with enhanced fouling resistant ability by using two different methods, liquid- induced phase separation (LIPS) and vapor-induced phase separation (VIPS), after in-situ modification of the PVDF solution using amphiphilic PS-b-PEGMA block copolymers as additive. (ncl.edu.tw)
The ability of amphiphilic copolymers and phospholipids to self-assemble into hybrid membranes has been studied until now on the submicrometer scale using optical microscopy on giant hybrid unilamellar vesicles (GHUVs), but limited information is available on large hybrid unilamellar vesicles (LHUVs). (cnrs.fr)

Small angle neutron scattering of diblock copolymer PS-PBLG: rod-coil to coil-coil transition. (mpg.de)

Ceresa RJ (1961) The synthesis of block and graft copolymer of cellulose and its derivatives. (springer.com)

Improved lubricating properties of the graft copolymers compared to the block copolymer counterparts further support superior stability of graft copolymers on surfaces. (dtu.dk)
IUPAC definitions graft macromolecule: A macromolecule with one or more species of block connected to the main chain as side-chains, these side-chains having constitutional or configurational features that differ from those in the main chain. (wikipedia.org)
We report the molecular design, synthesis and characterization of multifunctional unimolecular micelles formed by amphiphilic bottlebrush-like grafted block copolymers with theranostic functions of bright far red/near infrared (FR/NIR) fluorescence and anticancer drug delivery. (rsc.org)
The amphiphilic and branched nature of these grafted block copolymers enabled the formation of unimolecular micelles (UMs) that were well dispersible in aqueous media. (rsc.org)
The first aspect analyzed was the self-assembly of amphiphilic block copolymers into complex architectures. (unimib.it)
Fully conjugated block copolymers, where a conjugated donor and acceptor block are covalently linked with each other, have an ability to attain a defined morphology by manipulating the Flory-Huggins segment-segment interaction parameter. (edu.au)
Moreover, developing a fully conjugated block copolymer with a specific molecular weight, block ratio, and high purity is lacking behind due to the unavailability of the synthetic approach. (edu.au)
For industrial adoption of OSCs, we have developed a strategy to control the synthesis of an amphiphilic di-block copolymer containing high performing push-pull donor and acceptor blocks to achieve a clean phase separation and solubility in non-chlorinated solvents. (edu.au)
In order to obtain control synthesis of a block copolymer, firstly, we have developed a strategy to control the molecular weight/ end-group functionality of homopolymers. (edu.au)
Two fully conjugated amphiphilic di-block copolymers with a specific molecular weight and block ratio (1:1) were synthesised via a stepwise or one-pot procedure. (edu.au)
Student of the doctorate in 'Ciencia y Tecnología Química', has been working on the synthesis and application of linear-dendritic block copolymers (supervisors: M. Lazzari and M. Torneiro), defending his PhD thesis in May 2018. (fun-nanotech.org)
Over the past few decades, the advancement of controlled/living polymerization techniques has facilitated the synthesis of well-defined block copolymers with precisely controlled composition, topology, and functionality. (mdpi.com)
This behavior, also known as block copolymer self-assembly, in turn, results in the formation of nanostructured materials with unique properties. (mdpi.com)
In a similar manner, amphiphilic block copolymers self-assemble in solution into nano-sized formulations with distinct solvophilic and solvophobic domains, such as core-shell spherical and worm-like micelles, bilayer lamellae, polymersomes, and other more complex morphologies, owing to strong attraction forces and aggregation between the associating blocks. (mdpi.com)
Caillol S, Lecommandoux S, Mingotaud A-F, Schappacher M, Soum A, Bryson N, Meyrueix R (2003) Synthesis and self-assembly properties of peptide-polylactide block copolymers. (springer.com)
Block-copolymers with cellulose propionate. (springer.com)
Supramolecular Materials via Block Copolymer Self-Assembly. (mpg.de)
Advanced Drug Delivery Devices via Self-Assembly of Amphiphilic Block Copolymers. (mpg.de)
PEG 42 - b -PMLABe 73 and Biot-PEG 66 - b -PMLABe 73 block copolymers were obtained by anionic ring-opening polymerization of benzyl malolactonate in presence of α-methoxy-ω-carboxy-PEG 42 and α-biotin-ω-carboxy-PEG 66 as initiators. (frontiersin.org)

These hyperbranched cores are used as macroinitiators for 'grafting-from' polymerisation using controlled radical polymerisation leading to amphiphilic copolymers which can subsequently be self-assembled into spherical core-shell micelles. (birmingham.ac.uk)

In the second part of the thesis, amphiphilic polysulfone graft copolymers was developed with a new approach in which chemical modification of PSU followed by living cationic ring opening reaction of oxazolines. (itu.edu.tr)

Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers. (mpg.de)

This is indebted from "dilution" of the charges along the grafted chains by balancing neutral/charged repeating units to minimize the accumulated charge repulsion on neutral surface. (dtu.dk)
The picture labeled "graft polymer" shows how grafted chains of species B are covalently bonded to polymer species A. Although the side chains are structurally distinct from the main chain, the individual grafted chains may be homopolymers or copolymers. (wikipedia.org)
Graft copolymers containing a larger quantity of side chains are capable of wormlike conformation, compact molecular dimension, and notable chain end effects due to their confined and tight fit structures. (wikipedia.org)
Even though the number of grafted chains can be controlled, there may be a difference in the lengths of each grafted chain due to kinetic and steric hindrance effects. (wikipedia.org)

The study of the release profile of encapsulated curcumin incubated with/without a hydrolase enzyme Candida antarctica lipase (CAL-B) suggested that the drug is better stabilized in perfluoroalkyl chain grafted polymeric nanostructures in the absence of enzyme for up to 12 days as compared to its alkyl chain analogs. (fu-berlin.de)
This project focuses on the synthesis of novel polymeric structures that have amphiphilic properties and are potentially useful in ice release coatings. (ntnu.no)

Thermal stability of grafted copolymer reduced with increased grafting yield. (um.edu.my)

Recipient of a Banco Santander-USC fellowship for predoctoral stays of Latin America researchers, he has been working in the CIQUS lab in 2012-2014, finally defending his thesis on the modification and self-assembly in aqueous solution of amphiphilic graft copolymers based on oxidized carboxymethylcellulose in December 2014 (supervisor M. Lazzari). (fun-nanotech.org)

Common reaction mechanisms used to synthesize these copolymers include free-radical polymerization, anionic polymerization, atom-transfer radical-polymerization, and living polymerization techniques. (wikipedia.org)
Copolymers that are prepared with the grafting-to method often utilize anionic polymerization techniques. (wikipedia.org)

In a second part, azido-functionalized polystyrene copolymers were used to prepare a new protein-polymer bioconjugate by copper-free click chemistry reaction. (ibmmpolymerbiomaterials.com)

A high yield chemical reaction called atom transfer nitroxide radical coupling chemistry is for the grafting-to method for polymerization. (wikipedia.org)

The activation energy, Ea, for the graft copolymerization was calculated at ∼ 51 kJ mol−1. (um.edu.my)
Scaffolds of P(3HO-co-3HHX)-g-GDD/HA were successfully fabricated via graft copolymerization and physical blend in order to improve the hydrophilicity of the mcl-PHA. (um.edu.my)

Using small-angle neutron scattering (SANS), time-resolved Förster resonance energy transfer (TR-FRET), and cryo-transmission electron microscopy (cryo-TEM), we show that copolymer architecture and molar mass have direct influences on the formation of hybrid nanostructures that can range from wormlike hybrid micelles to hybrid vesicles presenting small lipid nanodomains. (cnrs.fr)

Graft copolymers are a branched copolymer where the components of the side chain are structurally different than that of the main chain. (wikipedia.org)

This resulted in a library of amphiphilic graft-copolymers with a wide range of monomer compositions. (ntnu.no)
The presence of GDD monomer in the grafted P(3HO-co-3HHX) materials linked through covalent bond was indicated by spectroscopic analyses. (um.edu.my)

Chalker, J. M., Processes for coating surfaces with a copolymer made from sulfur and dicyclopentadiene. (jia-lab.com)
There are several promising approaches to design low ice adhesion materials ranging from surface structured surfaces, freezing point depression, lubricated surfaces, soft elastomeric materials, and amphiphilic coatings. (ntnu.no)

Mechanism of grafting reaction was also proposed. (um.edu.my)
The silylation reaction of dextran with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) in DMSO was studied as the ®rst step of the synthesis of new amphiphilic polyester-grafted dextrans. (univ-lorraine.fr)

Generally, grafting methods for copolymer synthesis results in materials that are more thermostable than their homopolymer counterparts. (wikipedia.org)

Importantly, the preparation of copolymers comprising discrete blocks that differ significantly in their solvophilicity leads to microphase separation between the incompatible domains either in bulk or in solution in the system's effort to minimize unfavorable polymer-polymer and polymer-solvent interactions. (mdpi.com)

Introduction of hydroxyl groups via grafted GDD monomers improved the wettability and imparted amphiphilicity to the graft copolymer, thus potentially improving their facility for cellular interaction. (um.edu.my)

The preparation of graft copolymers has been around for decades. (wikipedia.org)
Electrically conductive copolymers containing biotin and their preparation. (univ-grenoble-alpes.fr)

Permeation experimental results using a CO 2 /N 2 (50/50) mixture indicated that as an amount of POEM in a copolymer increased, CO 2 permeability increased dramatically without the sacrifice of selectivity. (elsevierpure.com)

Hereto, an amphiphilic polymer with pendant benzene-1,3,5-tri-carboxamide (BTA) units is mixed with a free BTA that contains a functional group, either a fluorescent naphthalimide or a catalytically active L-proline. (stanford.edu)
Our team is also working on drugs' encapsulation and grafting of a fluorescent probe. (frontiersin.org)

All synthesis methods can be employed to create general physical properties of graft copolymers. (wikipedia.org)
The composition and structure of the amphiphilic graft-copolymers were correlated to the ice shear adhesion and wetting properties of the coatings. (ntnu.no)
It is hypothesized that the liquid-like nature of the PDMS-grafts is responsible for the lubricating nature of these coating and the resulting low ice adhesion properties. (ntnu.no)
The graft-copolymers with demonstrated ice shear adhesion reduction in a polyurethane coating were also probed as an additive that can enhance ice release properties of commercially available wind turbine blade coatings. (ntnu.no)
The structure, morphology and surface properties of the graft copolymers were characterized. (itu.edu.tr)

The synthesized copolymers revealed no intrinsic cellular toxicity up to 1 mg mL −1 . (rsc.org)

There are many different approaches to synthesizing graft copolymers. (wikipedia.org)

Enomoto Y, Kamitakahara H, Takano T, Nakatsubo F (2006) Synthesis of diblock copolymers with cellulose derivatives. (springer.com)
Enomoto-Rogers Y, Kamitakahara H, Yoshinaga A, Takano T (2011) Synthesis of diblock copolymers with cellulose derivatives 4. (springer.com)

Soluplus® (SOL), a unique water-soluble graft copolymer introduced by BASF Corporation, is constructed from hydrophilic and lipophilic portions. (pharmaexcipients.com)

This amphiphilic polymer can be used above the critical micelle concentration (CMC) to dissolve certain drugs via micelle formation. (pharmaexcipients.com)

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