Loading...
  • reaction
  • In mammalian liver, the reaction catalysed by AMP-deaminase constitutes a rate-limiting step in adenine nucleotide catabolism [ PMID: 18493842 ]. (ebi.ac.uk)
  • The first committed step is the reaction of PRPP, glutamine and water to 5'-phosphoribosylamine (PRA), glutamate , and pyrophosphate - catalyzed by amidophosphoribosyltransferase , which is activated by PRPP and inhibited by AMP , GMP and IMP . (rug.nl)