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  • regulator
  • It also increases the expression of uncoupling proteins and the transcriptional regulator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC1alpha), which could possibly increase energy expenditure. (garvan.org.au)
  • The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-gated Cl - channel that regulates other epithelial transport proteins by uncharacterized mechanisms. (jci.org)
  • Diabetes
  • Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice," Circulation , vol. 126, no. 10, pp. 1267-1277, 2012. (hindawi.com)
  • genes
  • Real-time PCR and Western blotting were used to confirm genes and proteins of interest, respectively. (nih.gov)
  • intestinal
  • Asn supplementation also increased the ratios of RNA:DNA and protein:DNA as well as disaccharidase activities in intestinal mucosa. (cambridge.org)
  • In addition, Asn supplementation attenuated bacterial LPS-induced intestinal energy deficits, indicated by increased ATP and adenylate energy charge levels, and decreased AMP:ATP ratio. (cambridge.org)
  • mutations
  • Mutations of two protein trafficking motifs within the 38-amino acid region in CFTR each disrupted the interaction. (jci.org)
  • binds
  • For example, lipopolysaccharide (LPS), a well-known PAMP expressed on Gram-negative bacteria, binds to and activates toll-like receptor 4 leading to the upregulation of critical inflammasome components (e.g. (frontiersin.org)
  • the β subunits provide a structural link between the other subunits and also contain a specialized sequence that binds to glycogen, whereas the γ subunits contain the binding sites that enable AMP to activate the complex. (ahajournals.org)
  • yeast
  • We employed a yeast two-hybrid screen using the COOH-terminal 70 residues of CFTR to identify proteins that might be involved in such interactions. (jci.org)
  • gene
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)