Regimen prior to allogeneic hematopoietic progenitorTransplantationHematopoietic stem cellPancreatic islet cellular therapyComplicating allogeneic transfusionUmbilicalGraft-versus-Stem CellsHSCTAutologous bloodDonorTransplantMSCsInvestigationalCellsBone MarrowMesenchymalIntravenousRecipients2021IntraoperativePediatricLiving cellTumorCardiacInfusionPatientsDoseTherapeuticComplicationsPhysicianVastInsulinTypeTherapyPatientHemoglobinDonorsRiskSurgicalEarlyWhole bloodHumanTimeControl groupTotalGroupPlatform
Regimen prior to allogeneic hematopoietic progenitor1
- The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
Transplantation17
- citation needed] The transplantation may be autologous (an individual's own blood cells), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
- We used real-time PCR to test for these and 12 respiratory viruses in 2,732 nasal wash samples collected during the first year after allogeneic hematopoietic cell transplantation from 222 patients. (cdc.gov)
- It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. (nih.gov)
- The objective of this study was to examine the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with T1D. (biomedcentral.com)
- Here, we present a case of an over 60-years old male patient with AML, and the possibility for him to receive an allogeneic hematopoietic stem cell transplantation (allo-HSCT). (pensoft.net)
- Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
- This Institute is the only place in the Republic of Croatia where allogeneic bone marrow transplantation is performed (i.e. the donor and the recipient are different persons), and over the years the need for this form of treatment has more and more increased. (ina.hr)
- The Allogeneic bone-marrow transplantation represents the only curative treatment and requires a compatible donor HLA. (longdom.org)
- Since then, allogeneic hematopoietic stem cell transplantation (HSCT) has evolved to become a frequently used and effective therapy for many hematologic malignancies. (longdom.org)
- Allogeneic bone marrow transplantation, as we understood it, allows saving lives, but cannot take place without donors. (longdom.org)
- If one of the brothers and sisters is compatible, we speak about geno-identical allogeneic transplantation having the advantage of reducing the complications post-transplantation. (longdom.org)
- In this case we will speak about pheno-identical allogeneic transplantation. (longdom.org)
- The efficacy of Omisirge was based on the amount of time needed for recovery of the subject's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (fda.gov)
- Prospective Clinical Trial of BUSULFEX: The prospective trial was a single-arm, open-label study in 61 patients who received BUSULFEX as part of a conditioning regimen for allogeneic hematopoietic stem cell transplantation. (clustermed.info)
- Warnings and precautions associated with Jemperli include immune-mediated adverse reactions, infusion-related reactions, complications of allogeneic hematopoietic stem cell transplantation, and embryo-fetal toxicity. (drugs.com)
- After undergoing an allogeneic haematopoietic stem cell transplantation (alloHCT), patients need intensive physiological and psychological rehabilitation. (mdpi.com)
- Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)
Hematopoietic stem cell2
- Vanderbilt was the lead site for an NIH-funded, phase 2, multicenter influenza vaccine study in pediatric allogeneic hematopoietic stem cell transplant (HCT) recipients that may lead to a change in the current flu vaccine recommendations in this vulnerable population. (vicc.org)
- Patients receive fructooligosaccharides (FOS) orally (PO) twice daily (BID) for 21 days starting at 7 days before allogeneic hematopoietic stem cell transplant in the absence of disease progression or unexpected toxicity. (bioseek.eu)
Pancreatic islet cellular therapy1
- Today, the U.S. Food and Drug Administration approved Lantidra, the first allogeneic (donor) pancreatic islet cellular therapy made from deceased donor pancreatic cells for the treatment of type 1 diabetes. (fda.gov)
Complicating allogeneic transfusion1
- In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
Umbilical4
- The aim of the study was to evaluate the efficacy and safety of allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) for complex perianal fistula in patients with Crohn's disease (CD). (biomedcentral.com)
- We conducted a single-arm, pilot study to evaluate the safety and effects of TH-SC01, an investigational, allogeneic, umbilical cord-derived, off-the-shelf MSC product candidate, to treat patients with pfCD that was refractory to conventional and/or biological treatments. (biomedcentral.com)
- Omisirge, administered as a single intravenous dose, is composed of human allogeneic stem cells from umbilical cord blood that are processed and cultured with nicotinamide (a form of vitamin B3). (fda.gov)
- Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
Graft-versus-2
- Our lead shRNA-based allogeneic candidate, CYAD-211, which is currently being evaluated in the Phase 1 IMMUNICY-1 trial for the treatment of multiple myeloma, has shown no safety concerns nor evidence of Graft-versus-Host Disease (GvHD) at dose level 1. (pharmiweb.com)
- Extracorporeal photopheresis (ECP) is an established therapy for the treatment of graft-versus-host-disease (GVHD) following an allogeneic stem cell transplant. (bvsalud.org)
Stem Cells4
- In March 2018, allogeneic, expanded, adipose-derived stem cells (Darvadstrocel) were approved by the European Medicines Agency for the treatment of complex perianal fistulas in adult patients with non-active/mildly active luminal CD [ 10 ]. (biomedcentral.com)
- The aim of this pre-clinical study was to investigate the effects of intradermal injections of MSC in experimental cutaneous wound repair comparing allogeneic and autologous adipose stem cells (ASCs) and autologous bone marrow-mesenchymal stromal cells (BM-MSCs). (biomedcentral.com)
- Each dose is patient-specific, containing healthy stem cells from an allogeneic pre-screened donor, meaning it comes from a different individual rather than using the patient's own cells. (fda.gov)
- A bone marrow transplant may be autologous (using a patient's own stem cells that were collected from the marrow and saved before treatment), allogeneic (using stem cells donated by someone who is not an identical twin), or syngeneic (using stem cells donated by an identical twin). (cancer101.org)
HSCT2
- In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (longdom.org)
- I. Conduct a dose escalation trial to determine the tolerability of the fructo-oligosaccharides prebiotic in allogeneic hematopoeitic stem cell transplant (HSCT) patients. (bioseek.eu)
Autologous blood2
- When blood loss is more than the amount of autologous blood storage, allogeneic blood transfusion should be done to save the lives of mother and child. (scirp.org)
- Strategies to decrease the use of allogeneic blood transfusion include preoperative autologous blood donation and intraoperative hypotensive anesthesia. (researchsquare.com)
Donor5
- For example, calculations must be made to ensure consistency in the amount of total blood volume between the donor and recipient. (wikipedia.org)
- Health care providers must exercise careful precaution when considering donor-recipient matching in allogeneic PBSCT. (wikipedia.org)
- Currently, there are two types of CAR T cell therapy: autologous, which uses the patient's own white blood cells, and allogeneic, which uses white blood cells from a healthy donor. (healthiestalternative.com)
- Today, the U.S. Food and Drug Administration approved Omisirge (omidubicel-onlv), a substantially modified allogeneic (donor) cord blood-based cell therapy to quicken the recovery of neutrophils (a subset of white blood cells) in the body and reduce the risk of infection. (fda.gov)
- Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
Transplant3
- In the month after discharge from the hospital, caregivers traveled a median distance of 450 miles or 560 miles, depending on whether the patient received an autologous transplant or an allogeneic transplant, respectively. (bvsalud.org)
- Allogeneic transplant is recommended to those patients who have a high risk of relapse even after successful treatment with chemotherapy. (emergenresearch.com)
- Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
MSCs4
- Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
- Twenty-seven subjects (MSC-treated group) received an initial systemic infusion of allogeneic UC-MSCs, followed by a repeat course at 3 months, whereas the control group ( n = 26) only received standard care based on intensive insulin therapy. (biomedcentral.com)
- One repeated intravenous dose of allogeneic UC-MSCs is safe in people with recent-onset T1D and may result in better islet β cell preservation during the first year after diagnosis compared to standard treatment alone. (biomedcentral.com)
- The intradermal inoculation included autologous or allogeneic ASCs or autologous BM-MSCs. (biomedcentral.com)
Investigational1
- CYAD-211 is an investigational, shRNA-based allogeneic CAR T candidate engineered to co-express a BCMA-targeting chimeric antigen receptor and a single shRNA, which interferes with the expression of the CD3ζ component of the T-cell receptor (TCR) complex. (pharmiweb.com)
Cells12
- This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. (biospace.com)
- Because white blood cells can be harvested and genetically engineered ahead of time, then stored for future use, allogeneic therapy is available right off the shelf for patients who have too few healthy cells of their own to contribute. (healthiestalternative.com)
- Allogeneic CAR T cell therapy is fast becoming the standard for this type of non-invasive, revolutionary treatment, and it has only one drawback in that allogeneic T cells run a higher risk of rejection than cells taken from a patient's own body. (healthiestalternative.com)
- The primary mechanism of action of Lantidra is believed to be the secretion of insulin by the infused allogeneic islet beta cells. (fda.gov)
- When considering therapeutic application to human, autologous cells may be preferable to avoid host reactions to allogeneic or xenogeneic components in the vaccine. (kinasepathway.com)
- However, preparation of a considerable amount of tumor vascular endothelial cells from an individual patient is almost impossible. (kinasepathway.com)
- With cells from another individual (allogeneic) or another species (xenogeneic), encapsulation in semipermeable barriers improves immune acceptance, as it inhibits passage of antibodies and excludes cytotoxic cells of the host. (confex.com)
- Non-pancreatic cells from the same patient (autologous), targeted by gene transfer vectors or retrieved surgically and genetically engineered ex vivo before being returned to the patient, may relax the immune acceptance problems but pose challenges regarding the amount and kinetics of insulin secretion in response to physiologic stimuli. (confex.com)
- These cells are potentially autologous, however, they pose challenges regarding the amount and kinetics of secreted insulin. (confex.com)
- After one rest day, allogeneic hematopoietic progenitor cells were infused. (clustermed.info)
- Allogeneic transfusions are associated with worse short- and long-term outcomes, that are dose-dependent, with patients receiving even 1 unit of red blood cells (RBCs) having a 77% increased adjusted odds of mortality compared with those not receiving transfusions [3]. (mathewsopenaccess.com)
- WHEREAS, Institute has conducted certain research and development, and possesses certain expertise relating to the research and development of, among other things, allogeneic and autologous cytotoxic T-lymphocytes ("CTL"), including in relation to the development of novel therapies targeting tumor and other cells infected with certain viruses, for use in oncology and autoimmune indications. (justia.com)
Bone Marrow1
- Biological/Vaccine, Stem Cell, Procedure/Surgery : After measuring the patient s wound size at the initial visit, the amount of bone marrow collected is 30cc if less than 10cm2, 60cc if less than 20cm2, and 120cc if more than 20cm2, depending on the wound size. (who.int)
Mesenchymal1
- Immediate Intervention Following Tooth Extraction Using Allogeneic Adipose-Derived Mesenchymal Stem Cell Therapy for Cats with Chronic Gingivostomatitis: A Randomized, Controlled and Blinded Study. (everycat.org)
Intravenous2
- 2 Although PFCs can carry a substantial amount of oxygen, intravenous injection results in a liquid embolus that can arrest the circulation. (asahq.org)
- Previous studies have reported the efficacy and safety of intravenous (IV) iron therapy during perioperative period as an alternative and adjunct to allogeneic blood transfusion. (researchsquare.com)
Recipients2
- Caregivers of allogeneic recipients had out-of-pocket expenses of $110 in 4 weeks, or a total of $610 when lost wages were included. (bvsalud.org)
- The cohort included consecutive allogeneic stem cell recipients with GVHD. (bvsalud.org)
20211
- Net cash burn during the first quarter of 2021 amounted to €5.1 million ($5.9 million), in line with expectations. (pharmiweb.com)
Intraoperative3
- The purpose of this prospective non-randomised study was to determine the impact of intraoperative cell salvage on postoperative allogeneic blood products transfusion in infant patients undergoing cardiac surgery with cardiopulmonary bypass. (doctime.es)
- Results: Additional intraoperative cell salvage significantly enhanced the amount of cell saving product available for transfusion (183+/-56ml vs 152+/-57ml, p=0.003) and significantly more patients in this group received the cell saving product postoperatively. (doctime.es)
- Conclusion: Intraoperative cell salvage, employed as an adjuvant technique to the residual volume salvage in infants undergoing first time cardiac surgery with cardiopulmonary bypass, was a safe and effective method to reduce postoperative allogeneic blood transfusion. (doctime.es)
Pediatric2
- Rethymic ( allogeneic processed thymus tissue-agdc) is processed thymus tissue indicated for immune reconstitution in pediatric patients with congenital athymia. (rxlist.com)
- INA's donation in the amount of HRK 150 thousand will enable the University Hospital Centre Zagreb to procure necessary medical equipment intended for better care for the patients of the Department of Pediatric Hematology and Oncology, and the visit of the members of Croatian national football team, Dario Srna and Ivan Rakitić especially cheered up the young patients, who were also presented with gifts. (ina.hr)
Living cell1
- Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. (biospace.com)
Tumor2
- MSI-high (MSI-H) means that there is a high amount of instability in a tumor. (drugs.com)
- In return for an upfront payment and the promise of potential future milestones for various programs-the dollar amounts of which Editas would not disclose to Fierce Biotech-Shoreline will acquire Editas' allogeneic natural killer (iNK) cell franchise including preclinical solid tumor therapy EDIT-202. (biotech-insider.com)
Cardiac1
- Mortality in cardiac surgery increases by 0.5% for every unit of blood infused and allogeneic transfusions are also associated with an overall increase in the length of hospital stays [18] [4]. (mathewsopenaccess.com)
Infusion1
- INA's donation will allow the University Hospital Centre Zagreb to procure medical devices, which enable simultaneous administration of different medication, while being able to accurately calculate the amount and rate of the medication infusion at the same time, which is crucial in the process of treating oncological and hematological patients. (ina.hr)
Patients5
- Both forms of treatment have proven effective at improving the prognosis for cancer patients, but allogeneic CAR-T therapy has the capability to help more patients in a shorter timeframe. (healthiestalternative.com)
- The aim of this study was to generate a score based on preoperative characteristics and predictive of the individual probability of allogeneic erythrocyte transfusion in patients undergoing elective thoracolumbar spine surgery. (silverchair.com)
- 4 Therefore, predicting the need for allogeneic erythrocyte transfusion based on patient preoperative characteristics would be helpful (1) to identify the patient subpopulations undergoing spine surgery at risk of massive perioperative transfusion and encourage erythrocyte-saving strategies in these patients, (2) to improve patient information on their perioperative erythrocyte requirements, and (3) to properly allocate blood and mobilize donors. (silverchair.com)
- Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
- En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
Dose2
- the amount of product provided is adjusted at the manufacturing facility to ensure the maximum dose for the patient cannot be exceeded. (rxlist.com)
- Natasha Halasa, MD, MPH and colleagues recently published in the New England Journal of Medicine, that two doses of high-dose trivalent flu vaccine resulted in higher amounts of influenza-specific antibodies than two doses of standard dose quadrivalent vaccine. (vicc.org)
Therapeutic1
- The acquisition of our allogeneic iNK franchise by Shoreline is highly aligned with our strategic portfolio reprioritization, as it allows us to sharpen our efforts on advancing current clinical stage trials and focus our resources on in vivo fit-for-purpose therapeutic construction and development," Editas CEO Gilmore O'Neill said in this morning's release. (biotech-insider.com)
Complications1
- Since allogeneic PBSCT involves transformation of blood between different individuals, this naturally carries more complications than autologous PBSCT. (wikipedia.org)
Physician1
- Allogeneic blood is a scarce and expensive resource and its use continues to raise concerns, including but not limited to latent viral or transfusion-transmitted infectious disease, for both the patient and physician [1,2]. (mathewsopenaccess.com)
Vast1
- Development of advanced genomic analysis techniques, the introduction of effective guidelines for cell therapy manufacturing, a vast amount of research by cancer societies, and the proven effectiveness of transplants are some of the primary growth stimulants for the market. (emergenresearch.com)
Insulin1
- Some people with type 1 diabetes have trouble managing the amount of insulin needed every day to prevent hyperglycemia (high blood sugar) without causing hypoglycemia. (fda.gov)
Type1
- Allogeneic Stem Cell Therapy dominated the segment of stem cell therapy by type. (emergenresearch.com)
Therapy1
- At the same time, the design of a medical cleanroom can be complex, as the production process, size and amount of equipment required can affect the overall cost, so whether you want to build an autologous or allogeneic facility, all cell and gene therapy cleanrooms need to be CGMP compliant. (cleanroomsdoors.com)
Patient1
- Following anesthesia induction and prior to heparinization, a specific amount of whole blood volume is removed from the patient and stored at the bedside. (mathewsopenaccess.com)
Hemoglobin2
- On POD 2, the hemoglobin level became lower in the iron group, which eventually led to greater requirement of allogeneic blood transfusion compared to the whole blood group. (researchsquare.com)
- Clinical features of thalassemias are similar but vary in severity depending on the amount of normal hemoglobin present. (msdmanuals.com)
Donors1
- However, in whole blood donation studies [ 7 , 8 ], donors have been reported to have lost large amounts of iron on harvesting of a unit of whole blood (500 mL, plus 25 mL for testing), and it requires more than 6 months to restore the iron to the level before donation with a standard diet. (researchsquare.com)
Risk1
- A 0-4 score (0 = no risk, 4 = maximum risk) predictive of allogeneic transfusion was derived by weighting estimate parameters for each variable in a multivariable logistic regression model. (silverchair.com)
Surgical2
- Our Rethymic (allogeneic processed thymus tissue-agdc) for Surgical Implantation Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
- RETHYMIC consists of yellow to brown slices of allogeneic processed thymus tissue for administration by surgical implantation. (rxlist.com)
Early1
- However, the iron group did not require allogeneic blood transfusion during or early after surgery, and the whole blood group showed continuously higher incidence of overt iron deficiency compared to the iron group. (researchsquare.com)
Whole blood1
- Allogeneic transfusion of whole blood and fractionated blood components remains a controversial topic with respect to transfusion triggers and practices. (medscape.com)
Human1
- Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)
Time1
- In the normal healing process, all of the above stages function sequentially and for a specific amount of time. (biomedcentral.com)
Control group1
- In the case of the control group, the cut allogeneic dermal matrix was similarly dressed over the wound at a thickness of 1 mm per 1 cm2, and a polyurethane foam dressing was placed on top to provide a fixed dressing. (who.int)
Total1
- It was possible to detect amounts of BMP-2 in six of nine total samples tested. (bvsalud.org)
Group1
- In the case of the intervention group, cell concentrate was injected subcutaneously into the wound, a cut allogeneic dermal matrix was applied to a thickness of 1 mm per cm2, and a polyurethane foam dressing was placed on top to provide a fixed dressing. (who.int)
Platform1
- Lastly, we are planning an R&D day for this summer that will provide an opportunity for our broader team to offer an in-depth overview of our clinical programs and strategy for advancing our next-generation shRNA platform and allogeneic pipeline. (pharmiweb.com)