GalactoseGlycoconjugatesGlycoproteinsGlycansEssential fattyOligosaccharidesFatty AcidsGangliosidesNeuraminic acidProteinMannoseEnzymeNine-carbonOligosaccharideNeu5GcBacteriaNeu5AcEnzymesSynthesisCellularMoleculeGlycanInteractionsCompoundSecretionMolecularPrecipitateCompositionAminoCellsChemicalFormFoundSuccessfullyPresenceCellTraceResultSurfaceRichPlayRoleReleaseResultsWaterMilk
Galactose3
- HMOs are produced in the mammary gland from the monosaccharides galactose, glucose, N-acetylglucosamine, fucose, and sialic acid, forming unconjugated complex glycans consisting of both short chain as well as long chain structures (in 9:1 ratio), that range from 10 to 15 g/L in mature milk ( 2 ). (frontiersin.org)
- α-2,6-Linked sialic acids on galactose drive cancer development and metastasis, immunological recognition, and microglial phagocytosis. (medicineinnovates.com)
- Adherent mucus was assessed by the alcian blue binding technique while erosion of the surface gel was assessed from the appearance of sialic acids and galactose in the gastric juice. (internationalscholarsjournals.com)
Glycoconjugates4
- Sialic acid-rich oligosaccharides on the glycoconjugates (glycolipids, glycoproteins, proteoglycans) found on surface membranes help keep water at the surface of cells[citation needed]. (wikipedia.org)
- Description: This 1RNM44N monoclonal antibody recognizes mouse CD170, also known as Siglec F. Siglec F is a cell surface lectin belonging to the Ig superfamily that binds glycoconjugates containing sialic acids that are commonly found on various cell types. (fishersci.com)
- The increased sialic acids and low protein contents were observed in plasma, possibly as a result of decreased sialic acid cycling crucial for formation of new glycoconjugates in tissues, caused by decreased protein synthesis due to microsomal degranulation. (niscpr.res.in)
- While the glycoconjugates on the basolateral surface are of acid characteristic, glycoconjugates on the apical surface are neutral [ 10 , 11 ]. (hindawi.com)
Glycoproteins6
- Sialic acids are commonly part of glycoproteins, glycolipids or gangliosides, where they decorate the end of sugar chains at the surface of cells or soluble proteins. (wikipedia.org)
- Sialic acid containing glycoproteins (sialoglycoproteins) bind selectin in humans and other organisms. (wikipedia.org)
- Metastatic cancer cells often express a high density of sialic acid-rich glycoproteins. (wikipedia.org)
- Sialic acid residues are present in the mucin glycoproteins of mucus. (wikipedia.org)
- The glandular cells in the surface epithelia secrete mucus that is rich in glycans, glycoproteins, and sialic acid residues [ 5 - 7 ]. (hindawi.com)
- O-Glycoprotease (IMPa) cleaves a variety of glycoproteins and glycopeptides containing mucin-type O-glycans with or without sialic acid, including Tn-antigen (GalNAc-α-Ser/Thr). (neb.com)
Glycans1
- The alpha-anomer is the form that is found when sialic acid is bound to glycans. (wikipedia.org)
Essential fatty1
- Various production of edible oils, olive oil, walnut oil, flax oil, China Bama flax oil, the original growth in the South American Andes (Andres) mountain range in the rainforest region of South America oil vine star oil vine oil contains essential fatty acids a-linolenic acid, ω3 at most, ω3 in the body can be derived from DHA in trace quantities. (easynetworld.com)
Oligosaccharides2
- The secretor and the Lewis blood group status direct the amount and type of oligosaccharides present in the milk ( 4 ). (frontiersin.org)
- Furthermore, feces containing different bifidobacterial species possessed differing amounts of oligosaccharides, suggesting differential consumption in situ . (biomedcentral.com)
Fatty Acids4
- On days 8 and 16 of life the morphometry, intestinal architecture, and cytokine release, mesenteric lymph nodes cell composition, plasma immunoglobulin concentrations, fecal microbiota composition, cecal short-chain fatty acids content, and the urinary metabolic profile were assessed. (frontiersin.org)
- These two groups are both involved in the production of short-chain fatty acids and lactate, which alter the pH of the environment, modulate the microbiota, and have other systemic properties [ 19 ]. (biomedcentral.com)
- Sea cucumber contains two kinds of omega-polyunsaturated fatty acids (EPA and DHA). (easynetworld.com)
- The light brown powder, prepared by enzymatic hydrolysis of fresh snail meat, consists of 9.3% protein (Bradford method), 3.3% fatty acids and 13.6% carbohydrates. (grenboel.eu)
Gangliosides2
- The defining characteristic of gangliosides is the sialic acid moiety of the oligosaccharide head group. (matreya.com)
- This mixture contains gangliosides having two sialic acids. (matreya.com)
Neuraminic acid3
- More than 50 kinds of sialic acid are known, all of which can be obtained from a molecule of neuraminic acid by substituting its amino group or one of its hydroxyl groups. (wikipedia.org)
- The sialic acid family includes many derivatives of the nine-carbon sugar neuraminic acid, but these acids rarely appear free in nature. (wikipedia.org)
- The neuramininc acid synthase responsible for the reaction that synthesises neuraminic acid from ManNAc and PEP have been successfully cloned and expressed in two constructs NHis and CHis which coded for a TEV cleavable His-tag and a non-cleavable His-tag. (uit.no)
Protein6
- This protein binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. (fishersci.com)
- The researchers developed a fluorescence assay that can analyze how miRNAs interact with their targets, and whether they increase or decrease the amount of protein produced. (medicineinnovates.com)
- The product also contains a significant amount of protein-related trace elements - calcium, phosphorus, magnesium and selenium. (grenboel.eu)
- Based on immunological and mass spectrometric analysis, SALSA was estimated to constitute up to 4-10% of the total protein amount in meconium, making it one of the most abundant proteins. (researchgate.net)
- The NHis construct was found to precipitate during purification preparations and only a low amount of the protein was obtained. (uit.no)
- CHis was found to give high amounts of protein. (uit.no)
Mannose2
- This enzyme uses for example a mannose derivative as a substrate, inserting three carbons from pyruvate into the resulting sialic acid structure. (wikipedia.org)
- Sialic acid can "hide" mannose antigens on the surface of host cells or bacteria from mannose-binding lectin. (wikipedia.org)
Enzyme1
- A bacterial enzyme with sialic acid mutarotase activity, NanM, that is able to rapidly equilibrate solutions of sialic acid to the resting equilibrium position of around 90% beta/10% alpha has been discovered. (wikipedia.org)
Nine-carbon2
- Sialic acids are a class of alpha-keto acid sugars with a nine-carbon backbone. (wikipedia.org)
- Sialic acids are family of nine carbon α-keto acids found to have important roles mammals and bacteria. (uit.no)
Oligosaccharide2
- For it to become active to enter in the oligosaccharide biosynthesis process of the cell, a monophosphate nucleoside is added, which comes from a cytidine triphosphate, turning sialic acid into cytidine monophosphate-sialic acid (CMP-sialic acid). (wikipedia.org)
- Infant feces with high levels of bifidobacteria had lower milk oligosaccharide levels in the feces and higher amounts of lactate. (biomedcentral.com)
Neu5Gc5
- In contrast to other animals, humans are genetically unable to produce the sialic acid variant N-glycolylneuraminic acid (Neu5Gc). (wikipedia.org)
- Small amounts of Neu5Gc detected in human tissue however may be incorporated from exogenous (nutrient) sources. (wikipedia.org)
- The N-glycoylneuraminic acid (NGNA) standard is a quantitative standard of NIST-F and USP traceable Neu5Gc monosaccharide. (qa-bio.com)
- The occurrence of N-glycolylneuraminic acid (Neu5Gc) in cancerous tissue and inflammatory diseases, conditions associated with increased oxidative stress suggests the participation of reactive oxygen radicals in Neu5Gc generation, where an oxygen atom is transferred. (niscpr.res.in)
- The presence of Neu5Gc and apparent absence of Neu5Ac hydroxylase activity in liver of chicken treated with GTA indicate that free radicals might be involved in the non-enzymatic hydroxylation of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc in liver, which normally does not express this sialic acid. (niscpr.res.in)
Bacteria2
- Sialic acids are found widely distributed in animal tissues and related forms are found to a lesser extent in other organisms like in some micro-algae, bacteria and archaea. (wikipedia.org)
- This bacteria have been found to have the genes necessary to synthesise sialic acids. (uit.no)
Neu5Ac3
- The most common member of this group is N-acetylneuraminic acid (Neu5Ac or NANA) found in animals and some prokaryotes. (wikipedia.org)
- The N-acetylneuraminic acid (NANA) standard is a quantitative standard of NIST-F and USP traceable Neu5Ac monosaccharide. (qa-bio.com)
- We have developed novel methods for large-scale production of N -acetylneuraminic acid (Neu5Ac) and N -acetyl-D-mannosamine (ManNAc). (go.jp)
Enzymes3
- These enzymes can be used for chemoenzymatic synthesis of sialic acid derivatives. (wikipedia.org)
- Although this modification is critical in both health and disease, the regulation and dysregulation of these enzymes and thus α-2,6-linked sialic acid are poorly understood. (medicineinnovates.com)
- They applied the new assay to analyze the regulation of ST6GAL1 and ST6GAL2, the enzymes underlying α-2,6-sialic acid. (medicineinnovates.com)
Synthesis1
- Finally we prepared the synthesis of dextran derivative possessing disialic acids via polymer reactions. (nii.ac.jp)
Cellular1
- 14. Cormack 1971 Paul C. Adenovirus type nigreian uses sialic acid as a cellular receptor. (forextrading-madeeasy.com)
Molecule1
- SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. (fishersci.com)
Glycan1
- In many cancers, α-2,6-linked sialic acids are overexpressed, and dysregulation of this glycan is emerging as a crucial part of cancer formation, metastasis, and immune recognition. (medicineinnovates.com)
Interactions2
- Lamin C adheres to the nuclear membrane primarily through its interactions nigeriqn other lamins, namely lamin A. Enter the amount of money that you will invest in your binary option. (forextrading-madeeasy.com)
- The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. (fishersci.com)
Compound1
- To study this possibility, we treated two groups of domesticated birds and rabbits with different dosages of gallotannic acid (GTA), a compound known to cause generation of reactive oxygen species (ROS). (niscpr.res.in)
Secretion1
- Adrenalectomy produces many changes in gastric functional parameters including gastric acid secretion, gastric motility and mucosal blood flow. (internationalscholarsjournals.com)
Molecular1
- 3A molecular sieve is the type A sialic acids potassium salt. (hiphopgalaxy.com)
Precipitate1
- It is a weak acid sodium, so it can precipitate siliconic acid in the presence hydrochloric acid and sulfuric acid. (hiphopgalaxy.com)
Composition1
- However, the amount of DHA in the mother's milk depends on the food composition of the three meals. (easynetworld.com)
Amino6
- The amount of free amino acids and polyamines is also relatively low compared to other snail products. (grenboel.eu)
- The product is rich in free amino acids (2.56 g / 100g) and polyamines (0.26 g / 100g). (grenboel.eu)
- Among the essential amino acids, lysine dominates with a value of about 45% of all essential amino acids. (grenboel.eu)
- The product is rich in cationic and anionic amino acids, such as aspartic acid, ornithine, glutamine, lysine and especially glutamic acid. (grenboel.eu)
- The material was found to contain a relatively large amount of sulfur-containing amino acids (methionine, homocysteine and cysteine) and glutathione. (grenboel.eu)
- The branched-chain amino acids - leucine, isoleucine and valine are the main ingredients with application. (grenboel.eu)
Cells2
- The sialic acid-rich regions contribute to creating a negative charge on the cells' surfaces. (wikipedia.org)
- Mammalian cells express sialic acids to confer self to the immune system, a trait being exploited by some pathogens that use sialic acid on their cell surface to hide themselves from the hosts immune system. (uit.no)
Chemical2
- Chemical biology tools have increasingly revealed the importance of sialic acids as a major signal in physiology and disease. (medicineinnovates.com)
- There are two types sodium silicates: the chemical formula Na2SiO3, and the formula amount 122.00 is sodium metasilicate. (hiphopgalaxy.com)
Form2
- Sialic acid in the form of polysialic acid is an unusual posttranslational modification that occurs on the neural cell adhesion molecules (NCAMs). (wikipedia.org)
- The antioxidant status and leukocyte capacity, as well as amount and form of sialic acids were assessed in plasma and liver. (niscpr.res.in)
Found1
- Small amounts of sulfonated and sialic acid-containing polysaccharides have been found. (grenboel.eu)
Successfully1
- Next we successfully prepared Glycopolymers possessing disialic acids with a narrow with narrow polydisparities from glycosylated monomers via π-allyl nickel catalyzed coordinating polymerization. (nii.ac.jp)
Presence2
- Recent experiments have demonstrated the presence of sialic acid in the cancer-secreted extracellular matrix. (wikipedia.org)
- The presence of fucose and sialic acid renders the HMOs resistant to digestion, thus allowing them to reach the large intestine of an infant unaltered ( 2 , 3 ). (frontiersin.org)
Cell2
- This overexpression of sialic acid on surfaces creates a negative charge on cell membranes. (wikipedia.org)
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. (fishersci.com)
Trace1
- 1988. Spectrophotometric determination of trace amounts of hydrazine in polluted water. (cdc.gov)
Result1
- Large quantities of smaller amounts will result in a lower price. (hiphopgalaxy.com)
Surface1
- The cement foaming agent (also known as foaming concrete agent) is an admixture which can lower the surface tension and produce large amounts of stable, uniform foam for the production concrete. (hiphopgalaxy.com)
Rich1
- Although dry fruits such as walnuts, almonds, peanuts and sesame seeds do not directly contain DHA, the rich alpha-linolenic acid contained therein can be converted into DHA in the human body, so dry fruits are also an important food source for babies to obtain DHA. (easynetworld.com)
Play1
- In humans the brain has the highest sialic acid content, where these acids play an important role in neural transmission and ganglioside structure in synaptogenesis. (wikipedia.org)
Role1
- miRNA are major regulators of the glycome, but their role in controlling α-2,6-linked sialic acid has not been well-studied. (medicineinnovates.com)
Release1
- This quantitative glycopeptide standard was developed for use during the sialic acid or monosaccharide release and labeling process. (qa-bio.com)
Results1
- Using HPLC-MSMS to detect sialic acids in Moritella viscosa gave positive results for several compounds. (uit.no)
Water1
- The generated silicic Acid gel is in an expansion state due to the soil's absorption of water. (hiphopgalaxy.com)
Milk1
- If the mother eats more fish, then the corresponding amount of DHA in breast milk is much higher. (easynetworld.com)