Amount of cyclin. Medical search. Frequent questions

Cyclin A, along with the other members of the cyclin family, regulates cell cycle progression through physically interacting with cyclin-dependent kinases (CDKs), which thereby activates the enzymatic activity of its CDK partner. (wikipedia.org)
An orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. (ncats.io)
Flavopiridol is a synthetic flavone that has been postulated to be an inhibitor of cyclin-dependent kinases (CDKs) (Schmerwitz et al. (researchsquare.com)
Proteins called cyclins and cylcin-dependent kinases (Cdks) are considered positive cell cycle regulators and act by phosphorylating other proteins. (byui.edu)
This became paralleled through inhibition from the expression of cyclin-dependent kinases 1 and 2 mRNA. (vegfrsignaling.com)

The model is based on a bicyclic phosphorylation-dephosphorylation cascade involving cyclin and cdc2 kinase. (ebi.ac.uk)
This is thought to occur through the phosphorylation of particular DNA replication machinery components, such as CDC6, by the cyclin A/CDK2 complex. (wikipedia.org)
In mammals, Cyclin B1 associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at amino acids Thr-14 and Tyr-15. (nsjbio.com)
These "LP" type docking motifs determine cyclin specificity, promote phosphorylation of suboptimal CDK sites and multi-site phosphorylation of substrates both in vivo and in vitro. (umassmed.edu)
Studies with Mcl-1 phosphorylation mutants show that cyclin E/Cdk2-dependent phosphorylation of Mcl-1 residues on its PEST domain resulted in increased Mcl-1 stability (Thr92, and Thr163) and Bim binding (Ser64). (oncotarget.com)
As cyclin concentrations fluctuate according to timing events in the cell cycle, different complexes of cyclin/Cdk complexes form which result in different phosphorylation activities. (byui.edu)

Cyclin A can regulate multiple cell cycle steps because it associates with, and thereby activates, two distinct CDKs - CDK2 and CDK1. (wikipedia.org)
Association of cyclin A with CDK2 is required for passage into S phase while association with CDK1 is required for entry into M phase. (wikipedia.org)
As the cell passes from G1 into S phase, cyclin A associates with CDK2, replacing cyclin E. Cyclin E is responsible for initiating the assembly of the pre-replication complex. (wikipedia.org)
When the amount of cyclin A/CDK2 complex reaches a threshold level, it terminates the assembly of the pre-replication complex made by cyclin E/CDK2. (wikipedia.org)
As the amount of Cyclin A/CDK2 complex increases, the complex initiates DNA replication. (wikipedia.org)
Since the action of cyclin A/CDK2 inhibits that of cyclin E/CDK2, the sequential activation of cyclin E followed by the activation of cyclin A is important and tightly regulated in S phase. (wikipedia.org)
Cyclin A/CDK2 complex was thought to be restricted to the nucleus and thus exclusively involved in S phase progression. (wikipedia.org)
New research has since debunked this assumption, shedding light on cyclin A/CDK2 migration to the centrosomes in late G2. (wikipedia.org)
It is suspected that the presence of cyclin A/CDK2 at the centrosomes may confer a means of regulating the movement of cyclin B/CDK1 to the centrosome and thus the timing of mitotic events. (wikipedia.org)
A study in 2008 provided further evidence of cyclin A/CDK2 complex's role in mitosis. (wikipedia.org)
Cells were modified so their CDK2 was inhibited and their cyclin A2 gene was knocked out. (wikipedia.org)
Coupling of microtubule nucleation in the centrosome with mitotic events in the nucleus was lost in the cyclin A knockout/CDK2 inhibited mutant cells. (wikipedia.org)
CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. (ncats.io)
Multiple rounds of centrosome reproduction were blocked by selective inactivation of cyclin-dependent kinase 2-cyclin E (Cdk2-E) and were restored by addition of purified Cdk2-E. Confocal immunomicroscopy revealed that cyclin E was localized at the centrosome. (umassmed.edu)
Treatment with honey stops the tumour cells cycle by regulating some genes (cyclin D1, CDK2, p27Kip. (agenciasinc.es)
Cyclin E/Cdk2 kinase activity is frequently deregulated in human cancers, resulting in impaired apoptosis. (oncotarget.com)
Here, we show that cyclin E/Cdk2 phosphorylates and stabilizes the pro-survival Bcl-2 family protein Mcl-1, a key cell death resistance determinant to the small molecule Bcl-2 family inhibitors ABT-199 and ABT-737, mimetics of the Bcl-2 homology domain 3 (BH3). (oncotarget.com)
Cyclin E levels were elevated and there was increased association of cyclin E/Cdk2 with Mcl-1 in ABT-737-resistant compared to parental cells. (oncotarget.com)

Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor. (ncats.io)
Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model: evaluation by multimodality imaging. (ncats.io)
The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound. (ncats.io)
The selective suppression of HIV-1 transcription by the cyclin-dependent kinase inhibitor, flavopiridol, abrogated cyclin D 1 expression, underlying the requirement for HIV-1 encoded products to induce cyclin D 1 . (biomedcentral.com)

Cyclin A remains associated with CDK1 from late S into late G2 phase when it is replaced by cyclin B. Cyclin A/CDK1 is thought to be involved in the activation and stabilization of cyclin B/CDK1 complex. (wikipedia.org)
HIV-1-infected podocytes showed markedly elevated cyclin D 1 mRNA and cyclin D 1 protein, the latter of which did not down-regulate during cell-cell contact or differentiation, suggesting post-transcriptional stabilization of cyclin D 1 protein levels by HIV-1. (biomedcentral.com)

Mice that were vaccinated to boost their immune response against this cell cycle protein, called cyclin B1, were able to reject a tumor challenge in which they were exposed to a cancer cell line that overproduced it, explained senior author Olivera Finn, Ph.D., Distinguished Professor and chair of the Department of Immunology at the Pitt School of Medicine. (scienceblog.com)
Because cyclin B1 is a 'self' protein, there have been concerns that boosting the immune response against it would produce autoimmunity and create new problems," Dr. Finn said. (scienceblog.com)
This antibody recognizes a protein of 55-62kDa, identified as Cyclin B1. (nsjbio.com)
The inactive Cyclin B1-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates amino acids Thr-14 and Tyr-15 of p34cdc2 rendering the complex active at the G2/M boundary. (nsjbio.com)
Hamster protein was used as the immunogen for this Cyclin B1 antibody. (nsjbio.com)
Mechanistically, p100 inhibited Cyclin D1 protein translation by activating the transcription of LARP7 and its hosted miR-302d, which could directly bind to 3′-UTR of cyclin d1 mRNA and inhibited its protein translation. (oncotarget.com)
However, changes in regulation that reduce the amount or function of the p27 protein in the nucleus are found in many types of cancer. (medlineplus.gov)
ST caused G0/G1 cell cycle arrest which was accompanied by a decrease in CDK4 and cyclin D1, and an increase in p21/Cip1and p27/Kip1 protein levels. (biomedcentral.com)
Cyclin E depletion in various human tumor cell-lines and cyclin E -/- mouse embryo fibroblasts showed decreased levels of Mcl-1 protein, with no change in Mcl-1 mRNA levels. (oncotarget.com)
In the absence of cyclin E, Mcl-1 ubiquitination was enhanced, leading to decreased protein stability. (oncotarget.com)
In addition, NS5A significantly increases the expression of inducible nitric oxide synthase, cyclin D1 and nuclear factor-κB, but decreases p53 protein expression in HepG2 cells ( 6 ). (spandidos-publications.com)

Indeed, HIV-1 virus deleted of nef failed to induce cyclin D 1 mRNA to the level of other single gene mutant viruses. (biomedcentral.com)

These mutants entered mitosis late due to a delayed activation of the cyclin B/CDK1 complex. (wikipedia.org)

The cyclin-dependent kinase (Cdk) inhibitor p21Cip1 (p21) plays a crucial role in restraining cellular proliferation and maintaining cellular quiescence. (blogspot.com)
Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)

One such regulatory component is cyclin A which plays a role in the regulation of two different cell cycle stages. (wikipedia.org)
Collectively, our findings identify a novel mechanism of cyclin E-mediated Mcl-1 regulation that provides a rationale for clinical use of Bcl-2 family and Cdk inhibitors for Mcl-1-dependent tumors. (oncotarget.com)
The primary form of regulation occurs by altering the concentration of the cyclin/Cdk ratios. (byui.edu)

The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro (PubMed:21127351). (wuxibiortus.com)

In addition to initiating DNA synthesis, Cyclin A ensures that DNA is replicated once per cell cycle by preventing the assembly of additional replication complexes. (wikipedia.org)
Several cell cycle events require specific forms of the cyclin-CDK complexes. (umassmed.edu)
As the levels of p53 increase, p21 becomes triggered which reinforces the stopping of the cell cycle by inhibiting cyclin/Cdk complexes. (byui.edu)

In late S phase, cyclin A can also associate with CDK1. (wikipedia.org)
Degradation of cyclin A/CDK1 induces mitotic exit. (wikipedia.org)

Here, we ask whether the expression of HIV-1 genes in infected podocytes induces cyclin D 1 and phospho-pRb (Ser780) expression, hallmarks of cyclin D1-mediated G 1 → S phase progression. (biomedcentral.com)
HIV-1 expression induces cyclin D 1 and phospho-pRb (Ser780) expression in infected podocytes, suggesting that HIV-1 activates cyclin D1-dependent cell-cycle mechanisms to promote proliferation of infected renal epithelium. (biomedcentral.com)

Transcription of cyclin A is tightly regulated and synchronized with cell cycle progression. (wikipedia.org)
Initiation of transcription of cyclin A is coordinated with passage of the R point, a critical transition point that is required for progression from G1 into S phase. (wikipedia.org)
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). (wuxibiortus.com)

Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. (wikipedia.org)
Cyclin B1 and MUC1 are part of a big family of self-proteins that become over-produced during cancer development, so they have great potential as targets in prevention vaccines. (scienceblog.com)
Concomitantly, downregulation of estrogen receptor (ER alpha), the estrogen-responsive gene - vascular endothelial growth factor (VEGF), and G1 cell cycle proteins, cyclin D1 and CDK4, was also observed. (biomedcentral.com)
To determine that the C2C12 cell line underwent myogenesis, two proteins PCNA and cyclin D1 whose expression are linked to the cell cycle were utilized. (smith.edu)

Compared to controls, cultured podocytes expressing HIV-1 genes, and podocytes and tubular epithelium from hyperplastic nephrons in Tg26 kidneys, had increased levels of phospho-pRb (Ser780), a target of active cyclin D 1 /cyclin-dependent kinase-4/6 known to promote G 1 → S phase progression. (biomedcentral.com)

A single cyclin A gene has been identified in Drosophila while Xenopus, mice and humans contain two distinct types of cyclin A: A1, the embryonic-specific form, and A2, the somatic form. (wikipedia.org)
Duplication of CCND1 gene was attributed to some of the cases with cyclin D1 expression. (biomedcentral.com)
The underlying mechanism for cyclin D1 expression was due to an abnormal gene rearrangement involving BCL-6 and CCND1, which was different from most reported cases. (biomedcentral.com)
In this study we aimed to investigate the association of FLT3 -ITD gene mutation with bone marrow blast cell count, CD34 expression as malignant cell burden, cyclin D1 and Bcl-xL expressions as indexes of cell proliferation and anti-apoptosis and human equilibrative nucleoside transporter 1 (hENT1) expression as cytarabine transporter during AML treatment. (iranpath.org)
A significant association was found between FLT3 -ITD gene mutations in AML patients with bone marrow blast cell count, CD34, cyclin D1 and hENT1 expressions, however no association was obtained with Bcl-xL expression. (iranpath.org)
ncifcrf.gov) (version 6.8) can integrate substantial amounts of biological data and connected analysis tools to supply systematic and extensive biological function annotation info for high-throughput gene expression (Huang et al. (trpv1inhibitor.com)
In comparison to the two general alternative mechanisms utilized by known transforming viruses to promote cell-cycle progression, namely, by activating or bypassing endogenous D-type cyclins (herein, referred to as "cyclin D"), it has not been established whether HIV-1 gene products trigger either cyclin D-dependent or cyclin D-independent proliferation in non-lymphoid tissues [ 15 ]. (biomedcentral.com)

Cells infected with chicken pox virus, for example, look very much like tumor cells because they, too, overproduce cyclin B1. (scienceblog.com)
Cyclin E knock-down restored ABT-737 sensitivity to acquired and inherently resistant Mcl-1-dependent tumor cells. (oncotarget.com)
Increasing amounts of evidence indicate that autophagy is induced by a number of stressors in tumor cells, such as starvation, growth factor deprivation, hypoxia, damage stimulation and therapeutic drugs, and is an important survival mechanism in response to cellular stress ( 9 ). (spandidos-publications.com)
8%. As the amount of tumor nodules greater, the actuarial RFS showed a significant reduce. (rafinhibitors.com)
To explore the complete molecular system by which the metformin/nelfinavir mixture prevents human being cervical tumor, we utilized confocal microscopy and American mark studies to determine if mitochondrial ROS amounts had been modified pursuing treatment with metformin only or in mixture with nelfinavir. (insulin-receptor.info)

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders. (elsevierpure.com)
Induced-seizures in wild-type animals led to elevated amounts of p25, the Cdk5-activating cofactor. (elsevierpure.com)

She is working with collaborators to open, by the end of the year, a clinical trial of a cyclin B1 treatment vaccine in lung cancer patients, and she plans to assess it in the future as a prevention strategy in patients with pre-malignant lung lesions. (scienceblog.com)

Finally, by studying many fungal cyclins exogenously expressed in budding yeast, we discovered that some have the ability to make the CDK hyper-potent, which suggests that these cyclins confer special properties to the CDK. (umassmed.edu)

A one-cell embryo from a CYB-3 offers essential and unique buy SNS-032 functions from cyclin B1 and NOS3 B2 in the early embryo. (healthy-nutrition-plan.com)

Since its initial discovery, homologues of cyclin A have been identified in numerous eukaryotes including Drosophila, Xenopus, mice, and in humans but has not been found in lower eukaryotes like yeast. (wikipedia.org)
Cyclin A has been shown to play a crucial role in the G2/M transition in Drosophila and Xenopus embryos. (wikipedia.org)

Cyclin A binds to the mitotic spindle poles in the centrosome however, the mechanism by which the complex is shuttled to the centrosome is not well understood. (wikipedia.org)

All of these mutations reduce the amount of functional p27 that is available in the nucleus to regulate the cell cycle. (medlineplus.gov)
Like the mutations that cause multiple endocrine neoplasia type 4, these genetic changes reduce the amount of functional p27 available to control cell division. (medlineplus.gov)
We investigated FLT3 -ITD mutations, bone marrow blast cell count, CD34, cyclin D1, Bcl-xL and hENT1 expression in bone marrow aspirates from 22 de novo AML patients in a cross sectional study. (iranpath.org)
In patients with FLT3 -ITD mutations, CD34 and cyclin D1 expressions were higher (MFI 328.80 vs 25.78, p =0.003 and MFI 74.51 vs 57.15 p =0.005) than the patients without mutations. (iranpath.org)

A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. (biomedcentral.com)
We report a case of diffuse large B-cell lymphoma with cyclin D1 expression. (biomedcentral.com)
However, rare DLBCLs may show cyclin D1 expression in absence of t (11,14)(q13;q23) or SOX11 expression. (biomedcentral.com)
Herein, we report a case of DLBCL with cyclin D1 expression and unusual genetic rearrangement involving CCND1 and BCL-6. (biomedcentral.com)
The expression of CEP55 was positively correlated using the Fn amount in Fn-infected CRC sufferers, and these individuals with 5-HT Receptor Antagonist Species higher CEP55 expression had an of course poorer differentiation, worse metastasis and decreased cumulative survival price.Identification of DEGsGEO2R was utilized to determine the DEGs amongst Fn-infected and Fn-non-infected Caco-2 samples. (trpv1inhibitor.com)
We assessed cyclin D 1 and phospho-pRb (Ser780) expression in two well-characterized models of HIV-associated nephropathy pathogenesis: HIV-1 infection of cultured podocytes and HIV-1 transgenic mice (Tg26). (biomedcentral.com)

Depending on which CDK partner cyclin A binds, the cell will continue through the S phase or it will transition from G2 to the M phase. (wikipedia.org)
This mitotic kinase complex remains active until the metaphase/anaphase transition when Cyclin B1 is degraded. (nsjbio.com)
Cyclin B1-p34cdc2 plays a critical role in G2 to M transition. (nsjbio.com)

The relationships among hippocampal neurogenesis, depression and the mechanism of action of antidepressant drugs have generated a considerable amount of controversy. (blogspot.com)

Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)

The phenotype and genetic abnormalities of DLBCL with cyclin D1 overexpression can be complex and may be difficult to differentiate from blastoid and pleomorphic variants of mantle cell lymphoma. (biomedcentral.com)

The lymphocytes showed moderate amount of cytoplasm and round nuclei with prominent nucleoli. (biomedcentral.com)

Cyclin A is the only cyclin that regulates multiple steps of the cell cycle. (wikipedia.org)
Such interactions were not known for the G1 class of cyclins, which are instrumental in helping the cell decide whether or not to commit to a new cell cycle, a function that is non-redundant with B-type cylins in budding yeast. (umassmed.edu)
the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage (PubMed:20493174). (wuxibiortus.com)
Cyclins are activated in a very predictable manner throughout the cell cycle. (byui.edu)

Cyclin A resides in the nucleus during S phase where it is involved in the initiation and completion of DNA replication. (wikipedia.org)

As myoblasts progressed to myotubes there was a significant decrease in the amount of both PCNA and cyclin D1. (smith.edu)

If painful blood no amount and shape those uterus a is AIDS. (1000journals.com)

It is the amount and activity of the cyclin/Cdk activities that signal the cell to continue to different phases. (byui.edu)

The interaction between the cyclin box, a region conserved across cyclins, and a region of the CDK, called the PSTAIRE, confers the foundation of the cyclin-CDK complex. (wikipedia.org)

Cyclin A2 is expressed in dividing somatic cells. (wikipedia.org)
Immunofluorescent staining of PFA-fixed human HeLa cells with Cyclin B1 antibody (clone V92.1). (nsjbio.com)
T-bet, therefore reducing the amount of pathogenic IL-17+IFN-+Compact disc4+ T cells in the spleen during experimental autoimmune encephalomyelitis (EAE). (globaltechbiz.com)
Range club: 1 m. (0.45 MB TIF) pgen.1001218.s005.tif (439K) GUID:?27A226BD-C3BC-4993-8B41-DA338CAF1EFB Amount S6: DNC-1/p150(glued) is sequestered at chromosomes in CYB-3 depleted cells and embryos were set and stained with DAPI (blue) and antibodies recognizing -tubulin (green) and DNC-1 (crimson). (healthy-nutrition-plan.com)

The cytotoxicity and anti-tumour effects of strawberry tree honey in relation to colon cancer lines increased with the amount and time of treatment. (agenciasinc.es)

SDS-PAGE analysis of purified, BSA-free Cyclin B1 antibody (clone V92.1) as confirmation of integrity and purity. (nsjbio.com)

In this dissertation, I have presented evidence that some G1 cyclins in budding yeast, Cln1/2, specifically identify substrates by interacting with a leucine-proline rich sequence different from the ones used by B-type cyclins. (umassmed.edu)

Cyclin A1 is prevalently expressed during meiosis and early on in embryogenesis. (wikipedia.org)
Pregnancy have the cyclin in sperm, the early safe tree try be pollution with to have chest, and take from. (1000journals.com)

[ 12 ] Commercially freeze-dried products such as pan masala, guthka, and mawa have higher concentrations of areca nut per chew and appear to cause oral submucous fibrosis more rapidly than self-prepared conventional betel quid, which contains smaller amounts of areca nut. (medscape.com)

Cyclin A has a second function in S phase. (wikipedia.org)
Subsequently, we have discovered the substrate-binding region in Cln2 and further showed that this region is highly conserved amongst a variety of fungal G1 cyclins from budding yeasts to molds and mushrooms, thus suggesting a conserved function across fungal evolution. (umassmed.edu)

Anatomy21

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