Among inbred mice. Medical search. Frequent questions

Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Mice, Inbred C57BL" by people in this website by year, and whether "Mice, Inbred C57BL" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Mice, Inbred C57BL" by people in Profiles. (uchicago.edu)
Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. (uchicago.edu)
Specifically, inheritance patterns derived from low-responsive C3H/HeJ (C3) and high-responsive C57BL/6J (B6) mouse strains suggest that differential hypercapnic ventilatory sensitivity (HCVS) is controlled by two independent genes. (johnshopkins.edu)
The inbred C57BL/6J-mice (B6) and hybrid B6D2F1-mice demonstrated extensive permanent threshold shift and subsequent onset of AHL. (cdc.gov)
Common inbred strains include BALB/c, C3H, C57BL/6 and DBA. (uwm.edu)
C57BL/6 mice received 10 5 red blood cells infected with Plasmodium berghei ANKA intraperitoneally. (hindawi.com)
Inbred male C57BL/6 mice (8 weeks old) were used. (hindawi.com)

BALB/cCrl mice were, however, found to have a mean heterozygosity of only 0.8% in their genome, and selection of breeders with a high similarity in the gut microbiota for three generations did not change the overall gut microbiota similarity, which was 66% in the P generation and 66%, 64% and 63% in the F1, F2 and F3 generations, respectively. (ku.dk)
Dams from two inbred strains of mice (C57BR and BALB/c) were treated with caffeine in solution in their drinking water during gestation. (elsevierpure.com)
and CBA and A/J. Very similar frequencies are found for lipoprotein-reactive B cells in BALB/c, BALB/c ν/ν, C3H/Tif, and C3H/HeJ mice. (silverchair.com)

Recombinant inbred strains derived from crosses between high and low activity strains exhibit segregation characteristic of a single allele difference. (jci.org)
Southern analyses using a 5'DI probe identified a restriction fragment length variant that segregated with 5'DI activity in 33 of 35 recombinant inbred strains derived from four different pairs of high and low activity parental strains. (jci.org)

What are the unique advantages of using inbred mice in genetic and genomic research? (jax.org)
The findings demonstrated the advantages of using inbred and F1 hybrid strains of mice which are genetically well defined, numerous and readily available. (cdc.gov)

Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
FVB is an albino, inbred laboratory mouse strain that is named after its susceptibility to Friend leukemia virus B. This strain was produced from mice established at the National Institutes of Health in 1935. (wikipedia.org)
These mice have greater susceptibility to an asthma-like phenotype than wild-type animals. (wikipedia.org)
Genotype is an important determinant factor of host susceptibility to periodontitis in the Collaborative Cross and inbred mouse populations. (bvsalud.org)
At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice. (jax.org)
Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. (cdc.gov)
These mice provided some of the first evidence that susceptibility to cancer can be inherited, just like hair color. (mentalfloss.com)

Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)
We expect the colony of mice to have less variation and be able to supply the research groups at IEMR with mice optimized for gender, age and genetics. (mattilsynet.no)
Genetics of age-related hearing loss in mice. (cdc.gov)

In addition, powerful databases like the Mouse Genome Informatics (MGI) database, the JAX® Mice database and the Mouse Phenome Database - all maintained at The Jackson Laboratory - are constantly improving to facilitate QTL mapping in the mouse. (jax.org)
The Mouse Phenome Database (MPD) is particularly useful for helping investigators select the most appropriate strains to cross in a QTL mapping project. (jax.org)
To determine the breadth and underpinning of changes in immunocyte gene expression due to genetic variation in mice, we performed, as part of the Immunological Genome Project, gene expression profiling for CD4(+) T cells and neutrophils purified from 39 inbred strains of the Mouse Phenome Database. (ox.ac.uk)

Learn about breeding schemes that generate coisogenic, recombinant inbred, consomic and congenic mice. (jax.org)

That similarity has become all the more evident in the past 15 years as comparative genomics has demonstrated that the location of mouse and other model animal QTL can predict the location of homologous QTL in humans. (jax.org)
Because of cross-species concordance, QTL and their underlying candidate genes can first be identified, cost-effectively, in mice and then the genes can be tested relatively easily in humans and verified in mice. (jax.org)
Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. (ouhsc.edu)
It's made studying the prevalence of inbreeding in humans, and dealing with the consequences, difficult. (discovermagazine.com)
How Common Is Inbreeding in Humans? (discovermagazine.com)
The researchers found that inbreeding in humans causes physical and mental problems, though the severity of those effects was somewhat limited. (discovermagazine.com)
For studies of inbreeding in humans, as well as other areas where it's tough to gather reliable data, the work is just getting started. (discovermagazine.com)
In the early 1980s, researchers began genetically manipulating mice by inserting genes from other species (including humans) during the earliest stages of embryonic cell division. (mentalfloss.com)

A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. (uchicago.edu)
Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)

The MPDt systematically characterizes biochemical and behavioral phenotypes of 40 commonly used and genetically diverse inbred mouse strains. (jax.org)
This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)
Inbred children commonly displayed decreased cognitive abilities and muscular function, reduced height and lung function, and are at greater risk from diseases in general, they found. (discovermagazine.com)
Mild inborn errors of metabolism in commonly used inbred mouse strains. (nih.gov)
The most commonly used methods for catching and picking up mice are grasping the animal near the tip of the tail, between thumb and forefinger, or by grasping the tail near the base or the neck between the ends of a smooth tipped forceps. (uwm.edu)

Generations of inbreeding left him infertile, in addition to numerous additional health problems. (discovermagazine.com)
Inbred strains are the result of at least 20 generations of brother-sister mating. (uwm.edu)

Most QTL have been mapped in model organisms such as the mouse and the rat. (jax.org)

In 1966, mice from this founding population were bred for sensitivity or resistance to challenge with histamine following pertussis vaccination. (wikipedia.org)

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. (jefferson.edu)
In 1970, of the sensitive mice from that breeding, some were found to be susceptible to Friend leukaemia virus. (wikipedia.org)
These results strongly support the possibility of using the Collaborative Cross, as well as developing dedicated F2 (resistant x susceptible inbred strains ) resource populations , for future dissection of genetic factors in periodontitis . (bvsalud.org)
The purpose of this study was to test the hypothesis that putative genotypes for age related hearing loss (AHL) may make mice more susceptible to noise induced hearing loss (NIHL). (cdc.gov)

Timed mated rats and mice are determined by observation of a vaginal plug. (inotivco.com)
For models fulfilled from Envigo Affiliates in Europe, the last stage of gestation for mice is over 17 days and for rats is over 18 days, each at shipping. (inotivco.com)
To avoid charges, cancellations for timed mated rats, mice, guinea pigs, and hamsters must be received one week prior to mating date, however, cancelled orders for timed mated rabbits will be charged at full price regardless of the amount of notice supplied. (inotivco.com)
If customer's research project requires such litters, Envigo recommends ordering timed mated pregnant rats and mice which can litter at customer's facility. (inotivco.com)
In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
The production of female mice with pseudopregnancy induced using sonic vibration was as efficient as rats. (nature.com)

Using the inbred mouse as a model organism, QTL mapping has become a very important tool for finding the genes that regulate complex human diseases, including atherosclerosis, diabetes, obesity, asthma and hypertension. (jax.org)
We all have homozygous genes, but finding many of them in a row is a hallmark of inbreeding. (discovermagazine.com)
Scientists also began turning off specific genes during early development, creating 'knockout mice. (mentalfloss.com)

The average for the seven traits that inbreeding negatively impacted in the study was between 0.3 and 0.7 standard deviations below the mean. (discovermagazine.com)
Between 1909 and 1914, C.C. Little toiled in the biology labs of Harvard's Bussey Institute, using mice to learn how mammals inherit traits from their parents. (mentalfloss.com)
Sometimes, the traits that Little and his team found most useful were the ones that produced the least healthy mice. (mentalfloss.com)

The result was 'transgenic mice. (mentalfloss.com)

The aim of this study was to determine the phenotypic response of inbred and Collaborative Cross (CC) mouse populations to periodontal bacterial challenge, using an experimental periodontitis model. (bvsalud.org)

The analysis was possible owing to the fact that the C-band on chromosomes 14 of the CBA/Kw strain and that of chromosome 18 of the KE strain show size polymorphism: while the CBA/Kw mice have a small sized C-band on chromosome 14, the KE mice show small C-bands on chromosome 18. (edu.pl)

Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. (ox.ac.uk)
Considering both cell types, a large number of transcripts showed significant variation across the inbred strains, with 22% of the transcriptome varying by 2-fold or more. (ox.ac.uk)
Genetic determinants confer variation between inbred mouse strains with respect to the magnitude and pattern of ventilation during hypercapnic challenge. (johnshopkins.edu)

We profiled individual differences in alcohol consumption upon initial exposure and during 5 weeks of voluntary alcohol intake in female mice from 39 BXD recombinant inbred strains and parents using the drinking in the dark (DID) method. (northumbria.ac.uk)
These results demonstrate an essential role for Jak2 signaling in GnRH neurons for normal reproductive development and fertility in female mice. (jneurosci.org)
and report here a role for the Jak2 signaling molecule in the regulation of reproductive development and function in female mice. (jneurosci.org)

Mice, Inbred DBA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. (jci.org)
1991). FVB/N: an inbred mouse strain preferable for transgenic analyses. (wikipedia.org)

By this point, approximately 60% of surviving mice show tumors/lesions. (wikipedia.org)
He discovered, for instance, that you can breed strains of mice with bodies that readily accept transplanted cancer tumors. (mentalfloss.com)

This project encompasses i) core breeding and ii) genetic background control of research mice in use at IEMR, all already being FOTS-approved for housing, breeding and experiments at KPM US. (mattilsynet.no)
First, the genetic background integrity for all genetically modified (GM) mouse strains at the institute needs to be verified. (mattilsynet.no)
This breeding is not expected to alter the phenotypes of the GM mice, but is a measure done to secure the proper genetic background and avoid genetic background drifting which could cause a change in phenotype. (mattilsynet.no)
Most of the experimental laboratory studies by virus-hunters have been based on the use of inbred mice, inbred implying a totally unnatural genetic background. (ratical.org)

Inbred mouse strains differ in their capacity to deiodinate iododioxin and iodothyronines, with strains segregating into high or low activity groups. (jci.org)

This MicroLesson is designed to meet the needs of people who are new to utilizing laboratory mice for genetic and genomic research projects, including graduate and postdoctoral students, research assistants, early career scientists, lab technicians and advanced undergraduates with a background in biology. (jax.org)
More laboratory mice are used in research every year than any other animal species. (uwm.edu)
Strains of laboratory mice that are inbred for higher metabolic rates show stronger immune responses to immune challenge with stronger antigen-specific IgM production than strains bred for lower metabolic rates. (cdc.gov)

The investment in training should be outweighed by the benefits observed with more reliable behavioral and physiological responses in the mice. (uwm.edu)

Recombination frequencies using previously mapped loci allowed assignment of the 5'DI gene to mouse chromosome 4 and identified its approximate chromosomal position. (jci.org)
Conserved linkage between this segment of mouse chromosome 4 and human HSA1p predicts this location for human Dio1. (jci.org)

Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
A genetically diverse mouse population model in combination with a systems biology approach was utilized to identify transcriptional changes, INH-responsive metabolites, and gene variants that contribute to the liver response in genetically sensitive individuals. (nih.gov)
This mouse population segregates millions of variants from eight inbred founders, enabling precision genetic mapping with extensive genotypic and phenotypic diversity. (elifesciences.org)

Cytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice. (edu.au)
Mice were culled on day 7 after infection and blood and spleen cell phenotype and activation were evaluated. (hindawi.com)

4 and, most importantly, the biology of the mouse is very similar to ours. (jax.org)

FVB mice show elevated aggressive behavior towards newly intruding FVB mice shortly after the new mouse's introduction, potentially due to chronically disrupted circadian rhythms. (wikipedia.org)
So he began to dream of mice strains that were identical and docile, 'like newly minted coins. (mentalfloss.com)

Gut microbiota modulates bleomycin-induced acute lung injury response in mice. (uchicago.edu)
Inflammatory diseases in mouse models are under strong impact from the gut microbiota. (ku.dk)
Therefore increased interindividual gut microbiota similarity may be seen as a way to reduce group sizes in mouse experiments. (ku.dk)
We therefore hypothesized that selective breeding of mice aiming at a high similarity in the gut microbiota would increase the interindividual similarity of the gut microbiota. (ku.dk)
Increased gut microbiota similarity in closely related mice in inbred mouse colonies is, therefore, more likely to be caused by other factors, such as imprinting or different intrauterine conditions, rather than by residual heterozygosity. (ku.dk)

Spontaneous Lesions in Aging FVB/N Mice. (wikipedia.org)

Inbreeding, or mating between two closely-related people, is a strong taboo across the world. (discovermagazine.com)

The segregation pattern of chromosomes 14 and 18 were analysed in recombinant inbred strains of mice developed from KE and CBA/Kw strains. (edu.pl)

SJL mice had significantly lower frequencies of LPS- and of lipoprotein-reactive B cells (1 in approximately 30 B cells). (silverchair.com)
Secretion of GnRH is also reduced as basal serum luteinizing hormone (LH) levels were significantly lower in female Jak2 G −/− mice while the pituitary responded normally to exogenous GnRH. (jneurosci.org)
Female Jak2 G −/− mice exhibited significantly delayed puberty and first estrus, abnormal estrous cyclicity, and impaired fertility. (jneurosci.org)
Compared with wild-type (WT) mice, P-deficient (P(-/-)) mice had markedly reduced total and eosinophil cell counts in BAL and significantly attenuated airway hyperresponsiveness to methacholine. (nih.gov)
Notably, C3a levels in the BAL of OVA-challenged P(-/-) mice were significantly lower than in wild-type mice, and intranasal coadministration of an anti-C3a mAb with P to P(-/-) mice prevented restoration of airway inflammation. (nih.gov)

And scientists have few good sources of data on the issue, as there are a number of difficulties in getting data on human inbreeding. (discovermagazine.com)

Plastic restraint devices can be used to hold mice and other rodents for longer periods of time. (uwm.edu)

These days, when geneticists want to create a new strain of mice, they often take a more hands-on approach. (mentalfloss.com)

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. (broadinstitute.org)

This work also highlights the value of using a mouse diversity panel to investigate drug-induced responses across a diverse population. (nih.gov)
LPS-reactive B cells yielding IgM- and IgG-PFC responses could be found in mesenteric lymph nodes, bone marrow, thymus, thoracic duct, and peripheral blood of 6- to 8-wk old mice. (silverchair.com)

These mice were bred into the modern FVB strain at the Jackson Laboratory, with no subsequent selection for histamine sensitivity. (wikipedia.org)
In addition to albinism and Friend leukemia virus sensitivity, these mice become blind by weaning age due to being homozygous for a retinal deterioration allele on the PDE6B gene. (wikipedia.org)

In this model, mice are co-infected with Porphyromonas gingivalis and Fusobacterium nucleatum , bacterial strains associated with human periodontal disease . (bvsalud.org)

These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)

She and co-researchers found significant concordance among mouse, human and rat hypertension QTL, 4 between mouse and human HDL cholesterol QTL, 6 between rat and human kidney disease QTL, 7 between mouse and human atherosclerosis QTL, 8 and among various species for osteoporosis, inflammatory bowel disease, type II diabetes and asthma QTL. (jax.org)
Two years is a common life expectancy in wild-type house mice. (wikipedia.org)
Conversely, intranasal reconstitution of P to P(-/-) mice at the challenge phase restored airway inflammation to wild-type levels. (nih.gov)

North America has consistently been a key region in terms of demand for mice models. (prnewswire.com)

The global market for mice models is expected to be evaluated at US$1.79 bn by the end of 2023. (prnewswire.com)
Meanwhile, the demand for mice models is expected to expand at a CAGR of 11.1% in Asia Pacific , from 2015 to 2023. (prnewswire.com)
The information presented in this review is based on a Transparency Market Research report, titled, "Mice Model Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023. (prnewswire.com)
Genetically engineered mice is expected to be the leading service by 2023. (prnewswire.com)
By 2023, North America will generated a revenue of US$785.4 mn in mice models. (prnewswire.com)

Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. (ouhsc.edu)

Anatomy26

Organisms32

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C57BL10

BALB3

Recombinant inbred strains derived2

Advantages of using2

Susceptibility7

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Commonly5

Generations2

Organisms1

19661

Susceptible4

Rats6

Genes3

Traits3

Transgenic Mice1

Populations1

Polymorphism1

Variation3

Female mice3

MeSH1

Analyses2

Tumors2

Genetic background4

Differ1

Laboratory mice3

Physiological1

Chromosome2

Variants3

Infection2

Biology1

Newly2

Microbiota5

Spontaneous1

Closely1

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Significantly5

Scientists1

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20235

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