Among genetic anticancer drugs or radiation. Medical search. Frequent questions

Indeed, some chemotherapeutic drugs selectively killed cells with specific genetic mutations. (nature.com)
As a direct result of this work, in 2014, the PARP inhibitor olaparib became the first targeted therapy for the treatment of patients with ovarian cancer with germline BRCA1 / 2 mutations to be approved by the European Medicines Agency (EMA) and US Food and Drug Administration (FDA). (nature.com)
Beyond associations with specific genetic mutations, drugs may synergize, such that treatment with one cancer drug exposes a vulnerability to a second drug. (nature.com)
Some people inherit genetic mutations that increase their cancer risk, but most mutations are spontaneous. (healthline.com)
Technically, all cancer is genetic, since it results from DNA damage that causes genetic mutations. (healthline.com)
The rest were due to genetic factors - inherited mutations or spontaneous errors in DNA replication. (healthline.com)
The latest anti-cancer targeted therapies and immunotherapies are directed at the genetic DNA mutations that underlie the development and progression of brain cancer. (businesswire.com)
The fast implementation of these targeted therapies into routine clinical practice has been constrained by a lack of comprehensive genetic screening for these DNA mutations at diagnosis. (businesswire.com)
Oncologica's Next generation sequencing platform captures 764 of the leading anti-cancer targeted medicine drug combinations and immunotherapies via analysis of actionable genomic mutations across 505 genes. (businesswire.com)
BC comprises of variant subtypes and those subtypes arise from basal progenitor or luminal progenitor cells undergoing different genetic mutations[ 2 ]. (ijpsonline.com)
Genetic predisposition: Certain genetic mutations inherited from family members can make individuals more susceptible to lung cancer. (drbobmmj.com)
Targeted therapy: Drugs that specifically target genetic mutations or proteins unique to cancer cells. (drbobmmj.com)
Our research shows how certain genetic mutations can impact a patient's response to certain drugs, enabling novel treatment options for patients with metastatic bladder cancer that developed resistance to the other first-line treatments. (uchicagomedicine.org)
The U.S. Food and Drug Administration today expanded the indication for Symdeko (a combination of tezacaftor/ivacaftor) tablets for treatment of pediatric patients ages 6 years and older with cystic fibrosis who have certain genetic mutations. (news-medical.net)
Cancer is characterised by the excessive and uncontrolled proliferation of cells whose DNA, the carrier of genetic information, has certain mutations. (universite-paris-saclay.fr)
They also involve therapies that focus on specific genetic mutations or alterations in cancer cells and stimulate the immune system to fight against the disease. (imarcgroup.com)
Molecular testing and genetic profiling enable the identification of specific mutations and biomarkers in lung cancer cells. (imarcgroup.com)

There is a high need for personalization of the drug-based cancer treatment of tumors in order to administer the adequate and successful individual medication for each cancer patient. (bosch.com)
Radiation therapy: The targeted use of high-energy radiation to destroy cancer cells and shrink tumors. (drbobmmj.com)
Recurrent tumors are highly aggressive, potentially cross-drug resistant, highly metastatic, and have a poor prognosis. (hindawi.com)
Radiation therapy may cause solid tumors and leukemia. (angelsofcourage.com)
By studying the biology of patients' tumors, genomic information and genetic abnormalities, our physician-scientists develop more targeted treatment plans by selecting drugs that will complement an individual's genome. (uchicagomedicine.org)
Medical College of Georgia at Georgia Regents University) It's a fairly common genetic condition that can surface as a series of dark skin spots and result in a host of maladies from tumors to premature cardiovascular disease. (medworm.com)
Treatment with antiangiogenesis drugs may improve the effectiveness of radiation treatment of nervous system tumors that interfere with the hearing of patients with the genetic disorder neurofibromatosis 2, investigators report. (medworm.com)
All of these pathogens cause genetic damage which lead to disease, from the common cold to the formation of tumors. (dremilykane.com)
These compounds do not destroy growing tumors, but prevent the genetic damage that leads to the initiation of cancerous growth. (dremilykane.com)
The genetic characteristics of tumors. (msdmanuals.com)

I. Determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D) of olaparib in combination with durvalumab and radiation therapy (RT). (drugtrialsformoney.com)
I. Evaluate the genetic and clinicopathologic markers of response and resistance including prior receipt of platinum therapy. (drugtrialsformoney.com)
OUTLINE: This is a dose-escalation study of olaparib in combination with fixed dose durvalumab and radiation therapy. (drugtrialsformoney.com)
Beginning cycle 2, patients also undergo radiation therapy daily on weekdays for 3 weeks. (drugtrialsformoney.com)
New study of genetic brain cancer biomarkers empowers patients and doctors with DNA blueprints for better targeted therapy decisions. (businesswire.com)
However, a newly published study from the research team at Oncologica the world-leading genetic cancer testing laboratory based in Cambridge UK, explains how their genetic sequencing research into predictive glioblastoma biomarkers can empower patients and doctors with DNA blueprints to make better targeted therapy decisions. (businesswire.com)
Gene therapy is a therapeutic method that reduces genetic abnormalities that cause cancer. (or.jp)
Other characteristics include almost no resistance (treatment becomes ineffective), and treatment is possible even if immunity is weakened by anticancer drugs or radiation therapy. (or.jp)
The process uses high doses of chemotherapy and sometimes radiation therapy and transfusion of bone marrow from a compatible donor. (medlineplus.gov)
Is it possible to improve the treatment of a cancer patient by selecting an appropriate individualized drug therapy? (bosch.com)
A commonly used form of drug therapy is chemotherapy, which uses agents that inhibit the rapid growth of cancer cells or destroy them. (bosch.com)
Despite great efforts in the development and clinical application of anti-cancer drugs, the individual response of a patient to a specific pharmacological cancer therapy can unfortunately vary strongly. (bosch.com)
Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
Treatments for NSCLC include surgery , chemotherapy , radiation therapy and targeted therapy. (yalemedicine.org)
Risk of second cancers after radiation therapy is increased if alkylating agents were also used and if the patient is female, was younger at the time of diagnosis, or had Hodgkin lymphoma or soft tissue cancer. (angelsofcourage.com)
Advancements using a person's unique genetic makeup to deliver individualized drug therapy not only improve a patient's response to the medication, thereby improving their health, but can also prevent potentially fatal drug toxicities. (uchicagomedicine.org)
Treatment for acute myeloid leukemia includes: Blood and platelet transfusions, anticancer drugs to kill cancer cells, followed by radiation therapy» Treatment for acute myeloid leukemia refers to when there is no evidence of cancer cells in the blood and bone marrow. (clinific.com)
At GenesisCare, we offer various drug therapies and a wide range of the latest anti-cancer drugs for liver cancer treatment, including chemotherapy and targeted therapy. (genesiscare.com)
Radiation therapy: It utilizes high-energy rays to destroy cancer cells. (ndtv.com)
Targeted therapy: This therapy uses drugs that target only cancer cells without harming normal cells and is most commonly used to treat leukaemia. (ndtv.com)
Radiation Therapy to kill cancer cells by exposure to high-energy radiation. (bestcancerhospitalindia.com)
Stem Cell Transplantation (SCT) to enable treatment with high doses of chemotherapy and radiation therapy surgery to remove an enlarged spleen or to install a venous access device (large plastic tube) to give medications and withdraw blood samples. (bestcancerhospitalindia.com)
Documented, external risk factors include radiation (especially at a young age), hormone replacement therapy (the "Pill" and estrogen for post-menopausal women), and diet, especially fat, alcohol and refined sugars. (dremilykane.com)
The poor solubility of anticancer drugs is one of the major problems in cancer therapy because the drugs require the addition of solvents in order to be easily absorbed into cancer cells. (spiritindia.com)
Classical Hodgkin lymphoma (cHL) is a highly curable disease (70-80%), even though long-term toxicities, drug resistance, and predicting clinical responses to therapy are major challenges in cHL treatment. (preprints.org)
These hormonal therapy drugs do not cure prostate cancer, but they can slow the growth and spread of prostate cancer. (msdmanuals.com)
2. Prior chemotherapy, immunotherapy (tumour vaccine, cytokine or growth factor given to control the cancer) or other anti-cancer therapy within less than 2 weeks before study drug administration, or any persistent unresolved toxicity from such previous therapy that, according to the judgement of the investigator, may pose a risk for the subject if taking part in the study. (who.int)
3. Prior definitive radiation therapy within less than 4 weeks and prior palliative radiotherapy within less than 2 weeks before study drug administration. (who.int)
For chemotherapy, two-drug cytotoxic regimens that include a platinum agent are generally preferred for first-line therapy. (medscape.com)
Radiation therapy is often given with chemotherapy. (medscape.com)
External beam radiation therapy (EBRT) is used. (medscape.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)

Our molecular testing capabilities now cover cancer screening, tumour DNA sequencing, Covid -19 mutation profiling and allergen testing, with over 5 million genetic health tests performed during the last two years. (businesswire.com)
Analyzing the genetic basis of each individual tumour allows scientists to understand key genetic changes that drive cancer development, progression and resistance to treatment. (bcgsc.ca)
An international team of scientists led by Hana Hanzlíková from the Institute of Molecular Genetics of the Czech Academy of Sciences and Keith Caldecott from the University of Sussex in the United Kingdom discovered which sites in the DNA molecule inside tumour cells represent the basis of the effect of anticancer drugs (so-called PARP inhibitors). (cas.cz)

Environmental factors, like UV radiation or chemical exposure, can damage your DNA. (healthline.com)
Exposure to high doses of ionizing radiation has been associated with the development of all types of leukemia except CLL. (bloodhealthadvice.com)
however, senescent cells become "toxic" as they accumulate after exposure to radiation and with age. (appliedradiationoncology.com)
Other risk factors include second-hand smoke, exposure to workplace carcinogens, radiation exposure, environmental pollution, family history of lung cancer and previous infection of HIV. (yalemedicine.org)
Exposure to radiation or hazardous chemicals: Exposure to certain types of radiation-electromagnetic fields or chemicals including pesticides can also lead to the growth of cancerous cells. (ndtv.com)
Exposure to very high levels of radiation increases acute leukemia risk. (bestcancerhospitalindia.com)

It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. (wikipedia.org)
We are continually researching new ways to improve the genetic test options at initial diagnosis to provide valuable personalised data to aid targeted cancer treatments" said Dr Marco Loddo, Co-Founder and Scientific Director of Oncologica. (businesswire.com)
Ultimately, virtually all new drugs and treatments must be tested on animals serving as surrogates for us as well as their own or other species of animals. (nyu.edu)
Chemotherapy: The use of anticancer drugs to kill cancer cells throughout the body, either alone or in combination with other treatments. (drbobmmj.com)
Research applications should focus on mitigation/management of adverse effects associated with anti-cancer treatments including: cytotoxic chemotherapies, targeted agents, immunomodulatory therapies and radiation (that occur during cancer treatment and/or long-term survivorship) as defined by cardiac and/or vascular specific common terminology criteria for adverse events (CTCAE). (nih.gov)
These two treatments rely on the use of ionizing radiation and the administration of various active ingredients respectively in order to destroy cancer cells. (universite-paris-saclay.fr)
These treatments target specific genetic characteristics of the tumor cells. (msdmanuals.com)

Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC. (wikipedia.org)
Genetic changes to the inherited genome can influence cancer development, progression and response to treatment. (bcgsc.ca)
BC is both histopathologically as well as genetically heterogeneous, thus underlying mechanisms of developing BC still remains uncertain[ 3 ], which cause hurdles in BC diagnosis as well as treatment, owing to this conventional treatment for BC like surgery, radiation and chemotherapy does not hold good efficiency. (ijpsonline.com)
We are investigating and developing innovative technological solutions for the personalization of cancer treatment by using a patient tumor sample to perform drug screening and determine the appropriate medication for the cancer patient. (bosch.com)
The post will also give you some insights into the background and targeted novel approach to improving the efficacy of anti-cancer drug treatment. (bosch.com)
Other drug-based treatment approaches are targeted therapies, immunotherapies, and hormonal therapies. (bosch.com)
Currently, the accurate prediction of an individual patient's response to established or novel anti-cancer drugs is an unsolved challenge in cancer treatment. (bosch.com)
The administration of anticancer drugs is one crucial approach that is employed for the treatment of cancer, although its therapeutic status is not presently satisfactory. (mdpi.com)
Drugs for the treatment of acute myeloid leukemia: »Blood transfusions» Anticancer drugs »Corticosteroids» Painkillers »Antibiotics to fight infections» Uric acid-enhancing drugs to prevent the accumulation of uric acid, which is one of the possible side effects of anticancer drugs. (clinific.com)
People who have had treatment with particular chemotherapy drugs in the past. (bestcancerhospitalindia.com)
These attributes enhance the delivery of multiple therapeutic agents directly to the tumor microenvironment (TME), resulting in reversal of LC resistance to anticancer treatment. (preprints.org)
Along with this, ongoing research and technological advancements in novel treatment modalities, drug delivery systems, and diagnostic tools for lung cancer are expected to stimulate market growth. (imarcgroup.com)
Chemotherapy is a form of systemic treatment that uses drugs to kill cancer cells or to stop them from growing. (msdmanuals.com)

And most of them are also hydrophobic, which results in a subcutaneous stagnation of the drug. (universite-paris-saclay.fr)
Tamanoi and Zink devised a method for incorporating the representative hydrophobic anticancer drug camptothecin into the pores of fluorescent mesoporous silica nanoparticles and delivering the particles into a variety of human cancer cells to induce cell death. (spiritindia.com)
We have successfully loaded hydrophobic anticancer drugs into mesoporous nanoparticles and delivered them into human cancer cells to induce cell death. (spiritindia.com)

In a paper scheduled to be published in the nanoscience journal Small in June, researchers from UCLA?s California NanoSystems Institute and Jonsson Cancer Center report a novel approach using silica-based nanoparticles to deliver the anticancer drug camptothecin and other water-insoluble drugs into human cancer cells. (spiritindia.com)
The results suggest that the mesoporous silica nanoparticles might be used as a vehicle to overcome the insolubility problem of many anticancer drugs. (spiritindia.com)
To overcome these problems, drug delivery systems using pegylated polymers, liposomal particles or albumin-based nanoparticles have been developed. (spiritindia.com)

Based on the agreement with the U.S. Food and Drug Administration (FDA) on Special Protocol Assessments for two phase 3 studies with ceftobiprole - one in Staphylococcus aureus bacteremia (SAB) and one in acute bacterial skin and skin structure infections (ABSSSI) - Basilea is in preparation to initiate these studies. (basilea.com)
Carcinogens in the etiology of acute myeloid leukemia include gasoline, cigarette smoke, and ionizing radiation. (clinific.com)

The standard therapies of surgery, radiation and chemotherapy have proven extremely successful in a variety of cancers, such as Hodgkin's disease, some childhood leukemias, early-stage leukemias and early-stage colorectal cancer. (bcgsc.ca)
Because senescent cells are believed to play a role in the late effects of radiation on normal tissues and certain age-related diseases, this study has broad implications for future therapies targeting the common biological mechanism that contributes to late tissue injury caused by radiation and aging. (appliedradiationoncology.com)
Our physicians partner with basic science researchers across the institution to better understand the molecular, genetic and biochemical make up of bladder cancer in order to discover new therapies that allow us to deliver personalize medicine to each individual patient. (uchicagomedicine.org)
Moreover, strategic collaborations between pharmaceutical companies, research institutions, and healthcare providers to develop innovative therapies and drugs are propelling market growth. (imarcgroup.com)

They are used depending on the specific genetic make up of your cancer. (genesiscare.com)

is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)

Rapidly dividing cells had long been known to be susceptible to drug-induced DNA damage, suggesting that DNA-repair inhibitors might selectively kill cancer cells. (nature.com)
One of the latest trials can be viewed here: Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism. (dna-biopharm-sa.com)
Anti-cancer: Extensive published research shows pure honokiol works on critical cell signaling and genetic pathways to halt cancer growth, promote apoptosis in cancer cells, and disable the metastatic process. (dna-biopharm-sa.com)
In conclusion, the current investigation regarding anticancer effects of piperine against breast cancer revealed remarkable suppression of cancer cells. (ijpsonline.com)
A team of scientists from the Institute of Molecular Genetics of the Czech Academy of Sciences has discovered which places in the DNA molecule inside cancer cells are the basis of the effect of anticancer drugs. (cas.cz)
Chemotherapy refers to drugs that destroy cancer cells. (genesiscare.com)

Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. (mdpi.com)
In line with this, the increasing use of nanomedicine to increase the efficient delivery of the anticancer drug to the affected tissues by enhancing the efficacy and reducing the side effects. (imarcgroup.com)

Medical professionals rely on a combination of diagnostic tests, including imaging scans, biopsies, and genetic testing, to determine the presence of lung cancer and its specific subtypes. (drbobmmj.com)
This review article is based on the therapeutic outcomes of polymer-drug conjugates against breast and lung cancer. (mdpi.com)

Then, in a seminal 1997 article, Leland Hartwell, Stephen Friend and colleagues suggested that synthetic-lethality relationships could lead to new anticancer drug targets, and genetics might therefore offer a rational approach to drug discovery. (nature.com)

Glioblastoma, the most aggressive form of brain cancer is commonly treated with surgery, radiation, and chemotherapy. (businesswire.com)
Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)

Mechanisms underlying synthetic lethality are now known to include genetic and non-genetic redundancies, buffers and adaptation. (nature.com)

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. (wikipedia.org)

[ 2 , 3 ] Conventional techniques of gene investigation in cancer rely on the identification of single genetic alterations associated with disease. (medscape.com)

Therefore, the current investigation was designed to unveil the anticancer effects of piperine molecule against human breast carcinoma. (ijpsonline.com)
We are investigating next-generation small-molecule drugs that are optimized to clear senescent cells without drug-induced toxicity," Zhou said. (appliedradiationoncology.com)

Certain anticancer drugs, such as alkylating agents or platinum drugs, may cause leukemia and myelodysplastic syndrome. (angelsofcourage.com)
Such data chal enge the "ca- and in experimental animals, with The four anticancer agents dis- nonical" site-specificity of carcino- reference to the possible underlying cussed here were first used in clin- ical practice in the 1960s, but since genesis. (who.int)
Since many effective anticancer agents have poor water solubility, the development of novel delivery systems for these molecules without the use of organic solvents has received significant attention. (spiritindia.com)

Grapefruit juice is already listed as a substance to avoid when taking QT-prolonging medications because it increases the toxicity of many drugs. (news-medical.net)
Unfortunately, these solvents not only dilute the potency of the drugs but create toxicity as well. (spiritindia.com)

Women tested at high risk for breast cancer using non-clinical genetic tests overlooking family history may decide to undergo unnecessary breast surgery. (medindia.net)
7. Major surgery within 4 weeks before the first dose of the study drug or minor surgery within 1 week (subject must also have recovered from any surgery-related toxicities to less than CTCAE Grade 2). (who.int)

It is also shown to enhance certain conventional cancer protocols -including synergy with chemotherapy and radiation- and prevent multi-drug resistance. (dna-biopharm-sa.com)
Due to various factors including socioeconomic factors, compliance is poor to anti-tuberculosis drugs, leading to resistance. (preprints.org)
Conclusion Multi-drug resistance tuberculosis is very prevalent in Pakistan, which may increase burden on health care system and may lead to various complications of tuberculosis. (preprints.org)
Drug resistance (DR) is a complex process that occurs due to a variety of genetic and acquired factors. (preprints.org)
Both HDLM-2 and HDLM-2dx cells had an intrinsic resistance to BV but not to the drug MMAE. (preprints.org)

People treated with certain types of anti-cancer drugs are at greater risk for getting leukemia. (bloodhealthadvice.com)
Chemotherapy: It involves the administration of anti-cancer drugs into the body via injection or through a pill to target cancerous cells and destroy them. (ndtv.com)
Chemotherapy - to kill leukemia cells using strong anti-cancer drugs. (bestcancerhospitalindia.com)

This insight focused attention on development of drugs and procedures that would suppress the immune system and permit transplantation between genetically dissimilar individuals. (nyu.edu)
Having a weakened immune system, such as in individuals with HIV (human immunodeficiency virus) or those who have undergone organ transplantation and take immunosuppressive drugs, increases the risk of vulval cancer. (docvatsa.com)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)

Cancer starts when a healthy cell undergoes one or more genetic or epigenetic changes within specific regions of the genome that are involved in the regulation of cell growth and metabolism. (bcgsc.ca)

This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)

1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)
Since chronic inflammation and oxidative stress are thought to be the root cause of some late effects of radiation and many age-related diseases, including radiation-induced long-term bone marrow injury and age-related osteoarthritis and atherosclerosis, eliminating senescent cells has the potential to mitigate radiation-induced late tissue injury and treat many age-related diseases. (appliedradiationoncology.com)

Letter: On drugs and therapeutics 44(1121):1-4. (cdc.gov)

Tia Leigh, 14, from Cwmbran, Wales, was diagnosed with the genetic disorder neurofibromatosis type 1 as a baby. (medworm.com)

Through projects like the 1200 Patients Project , we are using this genetic information identify the best medication for each patient to maximize effectiveness while reducing unwanted negative side effects. (uchicagomedicine.org)

In addition, undesired serious side effects can occur because of the administered drug (see Figure 1A). (bosch.com)
The anticancer drugs are limited pharmacologically, resulting from the serious side effects, which could be life-threatening. (mdpi.com)

Professor Vincent Marks was the Head of the Department of Biochemistry and Nutrition, and there was a strong focus on liver metabolism, drugs and toxins. (surrey.ac.uk)

These new genomic targeted drugs have greater specificity and reduce toxic effects for patients compared to conventional chemotherapy. (businesswire.com)

Understanding the exact genetic changes at each of these stages is the focus of genome sequencing in cancer research. (bcgsc.ca)

The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs. (medindia.net)

Further studies with pharmacological and genetic approaches revealed that TIGAR regulated the phosphorylation of ATM, a key protein in DDR, through Cdk5. (nature.com)

Researchers from the University of Arkansas for Medical Sciences (UAMS) and other institutions are reporting the discovery of the first broad spectrum drug that can potently kill senescent (or aging) cells in culture and effectively clear the cells in animals by specifically targeting a pathway that is critical for the survival of senescent cells. (appliedradiationoncology.com)
A Nature 2011 publication showed that genetic clearance of senescent cells from a progeroid animal is beneficial, leading to delayed onset of age-related phenotypes. (appliedradiationoncology.com)
DNA, or deoxyribonucleic acid, carries genetic information and determines the proper division of cells and survival of the whole organism. (cas.cz)
Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
In HRSdx cells, less sensitive to DNA damage and oxidative stress, the efflux drug transporters MDR1 and MRP1 were not up-regulated, and doxorubicin accumulated in cytoplasm rather than in nucleus. (preprints.org)

If you have a family history of leukemia, consider genetic counseling before starting a family. (clinific.com)

The FDA awarded orphan drug status in November 2016 for NSCLC. (wikipedia.org)

Anatomy14

Organisms5

Diseases26

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes54

Disciplines and Occupations8

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture8

Information Science5

Health Care23

Mutations17

Tumors10

Therapy32

Tumour3

Exposure6

Treatments7

Treatment13

Hydrophobic3

Nanoparticles3

Acute2

Therapies4

Specific genetic1

Immunotherapy1

Cancer cells6

Tissues2

Lung cancer2

Genetics1

Commonly2

Mechanisms1

PARP1

Alterations1

Molecule2

Agents3

Toxicity2

Surgery2

Resistance5

Anti-cancer3

Immune3

Epigenetic1

Tumor cells1

Bone marrow2

Therapeutics1

Neurofibromatosis1

Effectiveness1

Side effects2

Metabolism1

Genomic1

Understanding1

Validate1

Approaches1

Cells5

Leukemia1

NSCLC1