• As a doctoral candidate at Oxford University, Dr. Bramah Singh determined that amiodarone and sotalol had antiarrhythmic properties and belonged to a new class of antiarrhythmic agents (what would become the class III antiarrhythmic agents). (chemeurope.com)
  • [3] Today the mechanisms of action of amiodarone and sotalol remain unknown. (chemeurope.com)
  • [6] This makes amiodarone one of the few drugs approved by the FDA without rigorous randomized clinical trials. (chemeurope.com)
  • Amiodarone hydrochloride injection is a class III antiarrhythmic drug. (druglib.com)
  • Efficacy and Safety of Celivarone, With Amiodarone as Calibrator, in Patients With an Implantable Cardioverter-Defibrillator for Prevention of Implantable Cardioverter-Defibrillator Interventions or Death: The ALPHEE Study. (druglib.com)
  • A randomized active-controlled study comparing the efficacy and safety of vernakalant to amiodarone in recent-onset atrial fibrillation. (druglib.com)
  • OBJECTIVES: This randomized double-blind study compared the efficacy and safety of intravenous vernakalant and amiodarone for the acute conversion of recent-onset atrial fibrillation (AF). (druglib.com)
  • CONCLUSIONS: Vernakalant demonstrated efficacy superior to amiodarone for acute conversion of recent-onset AF. (druglib.com)
  • Related newer compounds, such as dronedarone , may have similar efficacy but a reduced rate of side-effects. (chemeurope.com)
  • Amiodarone HCl injection is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. (druglib.com)
  • Amiodarone injection should be used for acute treatment until the patient's ventricular arrhythmias are stabilized. (druglib.com)
  • Amiodarone is an antiarrhythmic agent (medication used for irregular heart beat) used for various types of tachyarrhythmias (fast forms of irregular heart beat), both ventricular and supraventricular (atrial) arrhythmias. (chemeurope.com)
  • Based on Singh's work, the Argentinian physician Dr. Mauricio Rosenbaum began using amiodarone to treat his patients who suffered from supraventricular and ventricular arrhythmias, with impressive results. (chemeurope.com)
  • Chest radiographs should also be obtained in patients taking amiodarone or dronedarone and presenting with pulmonary symptoms. (medscape.com)
  • Amiodarone-induced loculated pleural effusion without pulmonary parenchymal involvement: A case report and literature review. (pneumotox.com)
  • Amiodarone pulmonary toxicity presenting as bilateral exudative pleural effusions. (pneumotox.com)
  • The FDA was reluctant to officially approve the use of amiodarone, since initial reports had shown increased incidence of serious pulmonary side-effects of the drug. (chemeurope.com)
  • The non-iodinated nature of celivarone means that the harmful side-effects on the thyroid commonly seen with amiodarone therapy are eliminated, making the drug an attractive alternative. (wikipedia.org)
  • Thyroid function tests should be obtained in patients taking amiodarone or dronedarone who present with signs and symptoms of hypothyroidism or hyperthyroidism. (medscape.com)
  • Celivarone is a non-iodinated benzofuran derivative, structurally related to amiodarone, a drug commonly used to treat arrhythmias. (wikipedia.org)
  • During or after treatment with intravenous amiodarone injection patients may be transferred to oral amiodarone therapy (see DOSAGE AND ADMINISTRATION ). (druglib.com)
  • Pharmacokinetics of intravenous amiodarone and its electrocardiographic effects on healthy Japanese subjects. (druglib.com)
  • The aim of this phase I, dose-escalating study was to evaluate the pharmacokinetics, electrocardiographic effect and safety of amiodarone after a single intravenous administration in Japanese subjects. (druglib.com)
  • Amiodarone is available in oral and intravenous formulations. (chemeurope.com)
  • The dose of amiodarone administered is tailored to the individual and the dysrhythmia that is being treated. (chemeurope.com)
  • [4] [5] By 1980, amiodarone was commonly prescribed throughout Europe for the treatment of arrhythmias, but in the U.S. amiodarone remained unapproved by the Food and Drug Administration , and physicians were forced to directly obtain amiodarone from pharmaceutical companies in Canada and Europe. (chemeurope.com)
  • In the mid 1980s, the European pharmaceutical companies began putting pressure on the FDA to approve amiodarone by threatening to cut the supply to American physicians if it were not approved. (chemeurope.com)
  • Based on papers written by Dr. Rosenbaum developing Singh's theories, physicians in the United States began prescribing amiodarone to their patients with potentially life-threatening arrhythmias in the late 1970s. (chemeurope.com)
  • Amiodarone injection also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. (druglib.com)
  • Most patients will require this therapy for 48 to 96 hours, but amiodarone injection may be safely administered for longer periods if necessary. (druglib.com)
  • Amiodarone is the drug of choice to treat POAF. (druglib.com)
  • Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet amiodarone therapy. (pneumotox.com)
  • and amiodarone or dronedarone for those with coronary heart disease, heart failure with preserved ejection fraction, or severe valvular disease. (stopafib.org)
  • If these drugs don't work, then dofetilide and amiodarone can be considered. (a-fib.com)
  • Only dofetilide and amiodarone have been demonstrated to be safe in randomized trials. (a-fib.com)
  • Amiodarone or dofetilide combined with a beta blocker can also be used. (a-fib.com)
  • Dronedarone is an amiodarone-like antiarrhythmic drug associated with severe liver injury. (unibas.ch)
  • Severe amiodarone induced pulmonary toxicity. (pneumotox.com)
  • Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity. (pneumotox.com)
  • An unintended consequence: fatal amiodarone pulmonary toxicity in an older woman. (pneumotox.com)
  • Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone. (pneumotox.com)
  • Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry. (pneumotox.com)
  • Amiodarone-induced pulmonary toxicity. (pneumotox.com)
  • Amiodarone pulmonary toxicity: clinical and subclinical features. (pneumotox.com)
  • Electron microscopic demonstration of lysosomal inclusion bodies in lung, liver, lymph nodes, and blood leukocytes of patients with amiodarone pulmonary toxicity. (pneumotox.com)
  • Amiodarone pulmonary toxicity. (pneumotox.com)
  • Eosinophilic pneumonia: A rare manifestation of amiodarone toxicity diagnosed using traditional bronchoscopy. (pneumotox.com)
  • Since dronedarone inhibits mitochondrial respiration and β-oxidation in vitro, mitochondrial toxicity may also explain dronedarone-associated hepatotoxicity in vivo. (unibas.ch)
  • Treatment with dronedarone 200mg/kg/day had no effect on body weight, serum transaminases and bilirubin, and hepatic mitochondrial function in both wild-type and jvs(+/-) mice. (unibas.ch)
  • However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving amiodarone injection. (drugs.com)
  • A likely explanation for these findings was a reduced activity of carnitine palmitoyltransferase 1a in liver mitochondria from dronedarone-treated mice. (unibas.ch)
  • In contrast, dronedarone did not affect the activity of the respiratory chain ex vivo. (unibas.ch)
  • We conclude that dronedarone inhibits mitochondrial β-oxidation in and ex vivo, but not the respiratory chain. (unibas.ch)
  • Celivarone is a non-iodinated benzofuran derivative, structurally related to amiodarone, a drug commonly used to treat arrhythmias. (wikipedia.org)
  • A non-iodinated derivative of amiodarone that is used for the treatment of ARRHYTHMIA . (bvsalud.org)
  • Also, "only one of the four amiodarone trials and none of the dronedarone trials enrolled patients with highly symptomatic AF. (medscape.com)
  • But that has to be balanced against the fact that dronedarone is associated with fewer adverse events that cause the drug to be discontinued. (medscape.com)
  • The results suggest that inhibition of mitochondrial β-oxidation is an important mechanism of hepatotoxicity associated with dronedarone. (unibas.ch)
  • In vivo probe-based confocal laser endomicroscopy in amiodarone-related pneumonia. (pneumotox.com)
  • In vivo metabolism of intraperitoneal (14)C-palmitate was impaired in wild-type, and, more accentuated, in jvs(+/-) mice treated with 400mg/kg/day dronedarone compared to vehicle-treated mice. (unibas.ch)
  • If they're tolerating amiodarone and have not developed any adverse effects, and they've received a good rhythm response, the available evidence suggests that dronedarone is not as good as amiodarone at maintaining sinus rhythm. (medscape.com)
  • Appropriate studies have not been performed on the relationship of age to the effects of amiodarone injection in the pediatric population. (drugs.com)
  • 14. Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids. (nih.gov)
  • Amiodarone injection is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. (drugs.com)
  • But there was a trend: an increased all-cause mortality risk with amiodarone, at an OR of 1.61 (95% CI 0.97-2.68), fell short of significance (p=0.066). (medscape.com)
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amiodarone injection in the elderly. (drugs.com)
  • In contrast, dronedarone 400mg/kg/day was associated with a 10-15% drop in body weight, and a 3-5-fold increase in transaminases and bilirubin in wild-type mice and, more accentuated, in jvs(+/-) mice. (unibas.ch)
  • desflurane and dronedarone both increase QTc interval. (medscape.com)
  • We therefore studied hepatotoxicity of dronedarone (200mg/kg/day for 2 weeks or 400mg/kg/day for 1 week by intragastric gavage) in heterozygous juvenile visceral steatosis (jvs(+/-)) and wild-type mice. (unibas.ch)
  • Amiodarone injection belongs to the group of medicines known as antiarrhythmics. (drugs.com)