• Fass environmental information for Cordarone (amiodarone) from Sanofi AB (downloaded 2023-10-04). (janusinfo.se)
  • Cordarone, a heart drug that contains the active ingredient amiodarone, has been linked to a wide range of serious complications, including lung problems, liver damage and death. (rxinjuryhelp.com)
  • In April 2015, the daughter of University of Alabama athletic director Mal Moor filed a wrongful death suite against Wyeth Pharmaceuticals, Inc., the manufacturer of Cordarone, and Par Pharmaceutical Companies, which markets a generic version of amiodarone. (rxinjuryhelp.com)
  • Cordarone and other forms of amiodarone are not approved to treat atrial fibrillation, and are only indicated as "a drug of last resort for patients suffering from documented recurrent life-threatening ventricular fibrillation and ventricular tachycardia. (rxinjuryhelp.com)
  • But the Moor lawsuit claims that the drugs' manufacturers aggressively marketed Cordarone and amiodarone as a first line treatment for such patients. (rxinjuryhelp.com)
  • While it's not clear how Cordarone works, it is thought that amiodarone affects a portion of the heart's electrical activity. (rxinjuryhelp.com)
  • Teach your students the complex skills related to the use of the cardiovascular drug, Amiodarone Hydrochloride (Cordarone) with Practi-Amiodarone HCL. (becksonmedical.com)
  • This 3 mL clear amp accurately simulates the drug Amiodarone Hydrochloride (Cordarone) an anti-arrhythmic agent for frequently recurring ventricular fibrillation (VF) and ventricular tachycardia (VT. (becksonmedical.com)
  • In the ARCH trial, intravenous amiodarone (2 g administered over 2 d) has been shown to reduce the incidence of atrial fibrillation after open heart surgery when compared to placebo. (wikipedia.org)
  • citation needed] So-called 'acute onset atrial fibrillation', defined by the North American Society of Pacing and Electrophysiology (NASPE) in 2003, responds well to short duration treatment with amiodarone. (wikipedia.org)
  • citation needed] The benefit of amiodarone in the treatment of atrial fibrillation in the critical care population has yet to be determined but it may prove to be the agent of choice where the patient is hemodynamically unstable and unsuitable for DC cardioversion. (wikipedia.org)
  • Amiodarone significantly decreases atrial fibrillation in patients undergoing surgery for lung cancer. (druglib.com)
  • A randomized active-controlled study comparing the efficacy and safety of vernakalant to amiodarone in recent-onset atrial fibrillation. (druglib.com)
  • OBJECTIVES: This randomized double-blind study compared the efficacy and safety of intravenous vernakalant and amiodarone for the acute conversion of recent-onset atrial fibrillation (AF). (druglib.com)
  • Older adults with atrial fibrillation who were treated with amiodarone during apixaban or rivaroxaban use had a greater risk for bleeding-related hospitalizations compared to those taking flecainide or sotalol, a study found. (acpinternist.org)
  • The goal of the trial was to evaluate catheter ablation compared with amiodarone among patients with persistent atrial fibrillation and heart failure. (acc.org)
  • Contribution to the Literature: The AATAC trial showed that catheter ablation led to a higher procedural success rate (freedom from atrial fibrillation) than amiodarone therapy. (acc.org)
  • Patients with persistent atrial fibrillation and heart failure were randomized to catheter ablation (n = 102) versus amiodarone (n = 101). (acc.org)
  • Among patients with persistent atrial fibrillation and heart failure, catheter ablation was superior to amiodarone therapy. (acc.org)
  • Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device: results from the AATAC multicenter randomized trial. (acc.org)
  • Amiodarone is an antiarrhythmic agent (medication used for irregular heart beat) used for various types of tachyarrhythmias (fast forms of irregular heart beat), both ventricular and supraventricular (atrial) arrhythmias. (chemeurope.com)
  • Amiodarone is a medication primarily used to treat certain types of irregular heart rhythms, such as atrial fibrillation and ventricular tachycardia. (healthylifepharma.com)
  • [ 6 ] With respect to irregular WCT, amiodarone is contraindicated when there is concern for atrial fibrillation with pre-excitation. (medscape.com)
  • The patient initially presented with atrial flutter, which was controlled with beta blockers but was switched to amiodarone after 2 weeks when he developed atrial fibrillation with the rapid ventricular response. (journalmc.org)
  • Amiodarone is the most effective antiarrhythmic drug for atrial and ventricular arrhythmias and the drug of choice for ventricular arrhythmias in an unstable patient. (journalmc.org)
  • Amiodarone is in a class of medications called antiarrhythmics. (medlineplus.gov)
  • A retrospective analysis of Medicare patients who started an anticoagulant and then amiodarone found that they had a 44% increased risk for bleeding-related hospitalization compared to those on other antiarrhythmics and that this risk was higher with rivaroxaban than apixaban. (acpinternist.org)
  • Amiodarone belongs to the family of medications known as antiarrhythmics . (rxhealthmed.ca)
  • Like other antiarrhythmics, amiodarone can exacerbate the arrhythmia, e.g., by making the arrhythmia less well tolerated or more difficult to reverse. (druglib.com)
  • Because of its life-threatening side effects and the substantial management difficulties associated with amiodarone use (see "WARNINGS" below), Pacerone ® (Amiodarone HCl) Tablets are indicated only for the treatment of the following documented, life-threatening recurrent ventricular arrhythmias when these have not responded to documented adequate doses of other available antiarrhythmics or when alternative agents could not be tolerated. (druglib.com)
  • As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias. (wikipedia.org)
  • Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the long term suppression of arrhythmias. (wikipedia.org)
  • Amiodarone may cause your arrhythmia (irregular heart rhythm) to worsen or may cause you to develop new arrhythmias. (medlineplus.gov)
  • Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm when other medications did not help or could not be tolerated. (medlineplus.gov)
  • Amiodarone injection should be used for acute treatment until the patient's ventricular arrhythmias are stabilized. (druglib.com)
  • Based on Singh's work, the Argentinian physician Dr. Mauricio Rosenbaum began using amiodarone to treat his patients who suffered from supraventricular and ventricular arrhythmias, with impressive results. (chemeurope.com)
  • Based on papers written by Dr. Rosenbaum developing Singh's theories, physicians in the United States began prescribing amiodarone to their patients with potentially life-threatening arrhythmias in the late 1970s. (chemeurope.com)
  • [4] [5] By 1980, amiodarone was commonly prescribed throughout Europe for the treatment of arrhythmias, but in the U.S. amiodarone remained unapproved by the Food and Drug Administration , and physicians were forced to directly obtain amiodarone from pharmaceutical companies in Canada and Europe. (chemeurope.com)
  • In December of 1985, amiodarone was approved by the FDA for the treatment of arrhythmias. (chemeurope.com)
  • Arrhythmias are controlled by medication of several drugs, such as amiodarone, an antiarrhythmic agent that helps to stabilise the normal rhythm of the heart. (recipe.de)
  • Amiodarone has several potentially fatal toxicities, the most important of which is pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 10 to 17% in some series of patients with ventricular arrhythmias given doses around 400 mg/day, and as abnormal diffusion capacity without symptoms in a much higher percentage of patients. (druglib.com)
  • Pacerone ® (Amiodarone HCl) Tablets should be used only by physicians familiar with and with access to (directly or through referral) the use of all available modalities for treating recurrent life-threatening ventricular arrhythmias, and who have access to appropriate monitoring facilities, including in-hospital and ambulatory continuous electrocardiographic monitoring and electrophysiologic techniques. (druglib.com)
  • Because of the life-threatening nature of the arrhythmias treated, potential interactions with prior therapy and potential exacerbation of the arrhythmia, initiation of therapy with Pacerone ® (Amiodarone HCl) Tablets should be carried out in the hospital. (druglib.com)
  • Amiodarone 200mg Tablets, produced and exported by Aetos Pharma in Latin America, represent a crucial therapeutic option for patients afflicted with cardiac arrhythmias. (aetospharma.com)
  • Amiodarone has been widely used for the treatment of various arrhythmias. (journalmc.org)
  • If you require a Manufacturer and Supplier of Amiodarone 200mg Tablets? (aetospharma.com)
  • What is the most important information I should know about amiodarone injection? (cigna.com)
  • Amiodarone injection is for use only in life-threatening situations. (cigna.com)
  • What is amiodarone injection? (cigna.com)
  • What should I discuss with my healthcare provider before using amiodarone injection? (cigna.com)
  • In an emergency situation, it may not be possible before you are treated with amiodarone injection to tell your caregivers if you are pregnant or breast-feeding. (cigna.com)
  • How is amiodarone injection given? (cigna.com)
  • Amiodarone injection is often given directly into a large vein in the upper chest (central IV line). (cigna.com)
  • If you need surgery (including laser eye surgery), tell the surgeon ahead of time that you have received amiodarone injection. (cigna.com)
  • After treatment with amiodarone injection, your doctor may switch you to an oral form of amiodarone to take by mouth. (cigna.com)
  • Because you will receive amiodarone injection in a clinical setting, you are not likely to miss a dose. (cigna.com)
  • What should I avoid while using amiodarone injection? (cigna.com)
  • Amiodarone hydrochloride injection is a class III antiarrhythmic drug. (druglib.com)
  • Amiodarone HCl injection is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. (druglib.com)
  • Amiodarone injection also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. (druglib.com)
  • During or after treatment with intravenous amiodarone injection patients may be transferred to oral amiodarone therapy (see DOSAGE AND ADMINISTRATION ). (druglib.com)
  • Most patients will require this therapy for 48 to 96 hours, but amiodarone injection may be safely administered for longer periods if necessary. (druglib.com)
  • Amiodarone Hydrochloride Injection by Mylan is no longer being manufactured for sale in Canada. (rxhealthmed.ca)
  • Women who are pregnant or may become pregnant are strongly advised to not take amiodarone. (wikipedia.org)
  • Your doctor will monitor you carefully during this time and for as long as you continue to take amiodarone. (medlineplus.gov)
  • Your doctor will order certain tests, such as blood tests, X-rays, and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take amiodarone and to check your body's response to the medication. (medlineplus.gov)
  • You may take amiodarone tablets either with or without food, but make sure to take it each time in same manner. (healthylifepharma.com)
  • The effects range from abnormal thyroid function test findings to overt thyroid dysfunction, which may be either amiodarone-induced thyrotoxicosis (AIT) or amiodarone-induced hypothyroidism (AIH). (medscape.com)
  • Is the thyrotoxicosis related to the Amiodarone? (thyroidmanager.org)
  • Amiodarone may indeed cause thyrotoxicosis. (thyroidmanager.org)
  • Further answers to your questions: Amiodarone really has very many different side effects and I would not be surprised as the ones you mention are also due to the drug and/or the thyrotoxicosis itself. (thyroidmanager.org)
  • We describe a case of amiodarone-induced thyrotoxicosis and thyroid storm leading to refractory ventricular tachycardias treated with plasmapheresis when anti-arrhythmic therapy became contraindicated. (journalmc.org)
  • The injectable form of amiodarone may be used in hospitals under specific circumstances. (rxhealthmed.ca)
  • CONCLUSIONS: Vernakalant demonstrated efficacy superior to amiodarone for acute conversion of recent-onset AF. (druglib.com)
  • You should not receive this medicine if you are allergic to amiodarone or iodine, or if you have a serious heart condition such as 'AV block' (unless you have a pacemaker), a history of slow heart beats, or if your heart cannot pump blood properly. (cigna.com)
  • Amiodarone can worsen the cardiac arrhythmia brought on by digitalis toxicity. (wikipedia.org)
  • At oral doses of 400 mg per day or higher, amiodarone can have serious, varied side effects, including toxicity to thyroid, liver, lung, and retinal functions, requiring clinical surveillance and regular laboratory testing. (wikipedia.org)
  • Amiodarone has high chronic toxicity. (janusinfo.se)
  • Amiodarone lung refers to the various manifestations of amiodarone toxicity in the lung including acute lung injury , fibrosis, nodules, hemorrhage and pleural disease. (radiopaedia.org)
  • The reported prevalence of pulmonary toxicity in patients receiving amiodarone is ~10% (range 2-18%) 8 . (radiopaedia.org)
  • Foamy alveolar macrophages and cytoplasmic lamellar bodies containing surfactant-like material are typical of amiodarone exposure and do not necessarily indicate clinically significant toxicity. (radiopaedia.org)
  • Amiodarone pulmonary toxicity presenting as bilateral exudative pleural effusions. (pneumotox.com)
  • Warning that amiodarone may cause liver toxicity, hepatic (liver) injury, and worsened arrhythmia. (rxinjuryhelp.com)
  • 52.5% women) beginning anticoagulants and antiarrhythmic drugs, 54,977 took amiodarone and 36,613 took flecainide or sotalol. (acpinternist.org)
  • As a doctoral candidate at Oxford University, Dr. Bramah Singh determined that amiodarone and sotalol had antiarrhythmic properties and belonged to a new class of antiarrhythmic agents (what would become the class III antiarrhythmic agents). (chemeurope.com)
  • [3] Today the mechanisms of action of amiodarone and sotalol remain unknown. (chemeurope.com)
  • Patients with ongoing proarrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents. (cdc.gov)
  • For patients with no evidence of structural heart disease, flecainide, propafenone and sotalol should be considered first-line agents, and amiodarone and dofetilide can be considered as alternative agents. (medscape.com)
  • Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. (wikipedia.org)
  • Your doctor will probably start you on a high dose of amiodarone and gradually decrease your dose as the medication begins to work. (medlineplus.gov)
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amiodarone and each time you refill your prescription. (medlineplus.gov)
  • Amiodarone may also be used for purposes not listed in this medication guide. (cigna.com)
  • Be sure to read all medication guides or instruction sheets for oral amiodarone. (cigna.com)
  • The FDA advised that Zocor (simvastatin) dosage should not exceed 20 mg when the statin medication is being used in combination with amiodarone. (rxinjuryhelp.com)
  • Amiodarone Tablet also have some common side effects when you start medication, if any of your symptoms please consult your doctor immediately. (healthylifepharma.com)
  • The aim of this phase I, dose-escalating study was to evaluate the pharmacokinetics, electrocardiographic effect and safety of amiodarone after a single intravenous administration in Japanese subjects. (druglib.com)
  • The dose of amiodarone administered is tailored to the individual and the dysrhythmia that is being treated. (chemeurope.com)
  • For maintenance dose, a 540 mg amiodarone must be run with 18 hours. (rnspeak.com)
  • In case of treatment with digoxin its dose should be decreased by 50% when amiodarone is taken. (med-d.com)
  • Individuals with hemodynamically unstable ventricular tachycardia should not initially receive amiodarone. (wikipedia.org)
  • Pharmacokinetics of intravenous amiodarone and its electrocardiographic effects on healthy Japanese subjects. (druglib.com)
  • Intravenous amiodarone was introduced to mainstream acute care providers in the resuscitation guidelines released in 2000. (medscape.com)
  • Mild AIT subsides spontaneously in up to 20% of cases upon discontinuation of amiodarone therapy. (medscape.com)
  • Effects of dronedarone started rapidly after amiodarone discontinuation. (druglib.com)
  • The patient's absolute neutrophil count recovered 3 days after discontinuation of amiodarone. (journalmc.org)
  • High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in small tissue samples after enzymatic digestion. (bmj.com)
  • A method is described for the measurement of amiodarone and desethylamiodarone in small tissue samples. (bmj.com)
  • The RECIPE ClinRep® Complete Kit allows a quick, sensitive and reliable determination of amiodarone and the main metabolite desethylamiodarone. (recipe.de)
  • Some of the well-documented side effects of amiodarone are thyroid gland dysregulation, pulmonary fibrosis, and acute liver failure [ 3 ]. (journalmc.org)
  • Amiodarone contains approximately 37% iodine by weight. (medscape.com)
  • Amiodarone hydrochloride is a tri-iodinated antiarrhythmic, comprised of 37% iodine by weight and structurally similar to thyroxine, which is widely distributed in adipose tissue, liver, spleen and lung. (radiopaedia.org)
  • The use of amiodarone (sales data Sweden 2021) has been considered to result in insignificant environmental risk. (janusinfo.se)
  • Amiodarone does not appear to improve survival or positive outcomes in those who had a cardiac arrest. (wikipedia.org)
  • In this randomized, double-blind trial, we compared parenteral amiodarone, lidocaine, and saline placebo, along with standard care, in adults who had nontraumatic out-of-hospital cardiac arrest, shock-refractory ventricular fibrillation or pulseless ventricular tachycardia after at least one shock, and vascular access. (nih.gov)
  • Overall, neither amiodarone nor lidocaine resulted in a significantly higher rate of survival or favorable neurologic outcome than the rate with placebo among patients with out-of-hospital cardiac arrest due to initial shock-refractory ventricular fibrillation or pulseless ventricular tachycardia. (nih.gov)
  • The recommendation was based reports of nine severe cases of symptomatic bradycardia (slow heart rate) and one fatal cardiac arrest in individuals caused by amiodarone and Harvoni or amiodarone and Sovaldi plus another direct-acting antiviral. (rxinjuryhelp.com)
  • A daily Amiodarone dosage between 200 and 600 mg releases a 50 to 100 fold iodine excess compared to the optimal iodine intake between 150 to 200 µg per day. (thyroidmanager.org)
  • The specific dosage and frequency of amiodarone tablets depend on the individual patient's condition, as well as the doctor's recommendations. (healthylifepharma.com)
  • The most recent study [ 2 ] of amiodarone vs the older drug procainamide has perhaps added one more nail in amiodarone's coffin. (medscape.com)
  • Ortiz and colleagues [ 2 ] sought to compare the efficacy of amiodarone vs procainamide in patients with hemodynamically stable, regular WCT. (medscape.com)
  • The authors performed a multicenter, randomized, open-label study in which a total of 29 patients received amiodarone (5 mg/kg over 20 minutes) and 33 patients received procainamide (10 mg/kg over 20 minutes). (medscape.com)
  • The primary endpoint occurred in 12/29 (41%) in the amiodarone group vs 3/33 (9%) in the procainamide group. (medscape.com)
  • Tachycardia termination occurred in 11 (38%) in the amiodarone group and 22 (67%) in the procainamide group. (medscape.com)
  • In the following 24 hours, adverse events occurred in 31% of the amiodarone group vs 18% of the procainamide group. (medscape.com)
  • This study demonstrated that procainamide was more effective and safer than amiodarone for patients with WCT, including those with structural heart disease. (medscape.com)
  • Although this is the first controlled prospective trial comparing procainamide vs amiodarone, this is not the first study that has cast doubt on the effectiveness of amiodarone in WCTs. (medscape.com)
  • It's time to let amiodarone rest in peace and, if available to you, get reacquainted with an old friend, procainamide. (medscape.com)
  • Healthy Incorporation and Healthy life pharma Pvt ltd are one of the leading manufacturer,supplier, and exporter of Amiodarone Tablet 100 mg, Amiodarone Tablet 200 mg in India and serving the world with the best quality of pharmaceutical products. (healthylifepharma.com)
  • We are committed to provide a stock of highly effective Amiodarone Tablet to our innumerable clients with the help of our well-experienced pharmaceutical specialists. (healthylifepharma.com)
  • Pacerone ® (Amiodarone HCl) Tablets are a member of a class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects, available for oral administration in 100 mg and 200 mg strengths of amiodarone hydrochloride. (druglib.com)
  • Efficacy and Safety of Celivarone, With Amiodarone as Calibrator, in Patients With an Implantable Cardioverter-Defibrillator for Prevention of Implantable Cardioverter-Defibrillator Interventions or Death: The ALPHEE Study. (druglib.com)
  • Amiodarone has been found to have higher efficacy and lower relapse rates compared to placebo and rate-control medications [ 1 ]. (journalmc.org)
  • Other antiarrhythmic agents, such as amiodarone, are used in an off-label fashion with great clinical efficacy. (medscape.com)
  • Amiodarone is potentially persistent. (janusinfo.se)
  • Amiodarone is known for its effectiveness in controlling abnormal heart rhythms, but it can also have potentially serious side effects. (healthylifepharma.com)
  • Prior to the ablation I ceased taking Amiodarone which had been administered for two years. (thyroidmanager.org)
  • Amiodarone with beta blockers, calcium channel blockers: May depress the cardiac functioning thus it should be used with caution. (rnspeak.com)
  • Amiodarone is available in oral and intravenous formulations. (chemeurope.com)
  • The FDA was reluctant to officially approve the use of amiodarone, since initial reports had shown increased incidence of serious pulmonary side-effects of the drug. (chemeurope.com)
  • Do not take grapefruit juice during amiodarone treatment because blood levels of amiodarone may increase, causing an increase in side effects. (rxhealthmed.ca)
  • Amiodarone is a potent antiarrhythmic drug that is used to treat ventricular and supraventricular tachyarrhythmias. (medscape.com)
  • Amiodarone is the drug of choice to treat POAF. (druglib.com)
  • Amiodarone Tablets is known as an anti-arrhythmic drug. (healthylifepharma.com)
  • Teva-Amiodarone is a preferred generic drug on the Reformulary. (drugfinder.ca)
  • More than 35% of patients on long-term amiodarone discontinue the drug due to adverse effects [ 2 ]. (journalmc.org)
  • Furthermore, amiodarone can induce immunological manifestations such as anti-amiodarone antibodies, lupus-like syndrome, immune-mediated thrombocytopenia, Coombs-positive hemolytic anemia (in canines), and vasculitis [ 12 - 17 ]. (journalmc.org)
  • [6] This makes amiodarone one of the few drugs approved by the FDA without rigorous randomized clinical trials. (chemeurope.com)
  • Practi-Amiodarone™ HCL 3mL Amp for clinical training. (becksonmedical.com)
  • In the mid 1980s, the European pharmaceutical companies began putting pressure on the FDA to approve amiodarone by threatening to cut the supply to American physicians if it were not approved. (chemeurope.com)
  • With Amiodarone 200 mg Tablets from Aetos Pharma, we endeavor to contribute to the improved health and well-being of our communities while maintaining the highest standards of pharmaceutical regulatory compliance. (aetospharma.com)
  • According to the lawsuit, Moor took amiodarone for 90 days in 2008 to treat an irregular heartbeat. (rxinjuryhelp.com)
  • The FDA recommended that the hepatitis C medications Harvoni and Sovaldi not be co-administered with amiodarone. (rxinjuryhelp.com)
  • Many medications have been implicated as causal agents of neutropenia, but only one case has been reported describing isolated neutropenia induced by amiodarone [ 18 ]. (journalmc.org)
  • Amiodarone was first made in 1961 and came into medical use in 1962 for chest pain believed to be related to the heart. (wikipedia.org)
  • Amiodarone was initially developed in 1961 at the Labaz company, Belgium, by chemists Tondeur and Binon. (chemeurope.com)
  • Amiodarone-induced loculated pleural effusion without pulmonary parenchymal involvement: A case report and literature review. (pneumotox.com)
  • Amiodarone-induced pleural fluid is not always accompanied by a risk factor. (pneumotox.com)
  • Amiodarone-induced loculated pleural effusion: case report and review of the literature. (pneumotox.com)
  • The initial management of AIT involves deciding whether to discontinue amiodarone therapy. (medscape.com)
  • Amiodarone causes direct cytotoxic effects, indirect immunological damage and causes phospholipid accumulation. (radiopaedia.org)
  • Amiodarone accumulation increases tissue attenuation due to the iodine content. (radiopaedia.org)