The spin-trap nitrosobenzene strongly inhibited not only the cumene hydroperoxide-supported oxidation of aminopyrine and its metabolite, but also the oxygen utilization of microsomes stimulated by this hydroperoxide. (aspetjournals.org)
Antipyrine3
Spectral changes observed during the microsomal oxidation of aminopyrine by cumene hydroperoxide have demonstrated the formation of the aminopyrine radical prior to, and concomitant with, the formation of antipyrine red. (aspetjournals.org)
The 5-HT-induced increase in permeability was very markedly inhibited by chlorpromazine (1-25 mg/kg) and to a lesser extent by aminopyrine and Tofranil (50 mg/kg), and was moderately inhibited by aspirin, antipyrine, LSD (100 mcg/kg) and Tofranil (5 mg/kg). (erowid.org)
Antiinflammatory action could also be Antipyrine (phenazone) and amidopyrine (aminopyrine) exerted by other mechanisms as nicely [url=https://aghgol.com/docs/order-cheap-prednisone/] allergy medicine 4 year old buy discount prednisone 20mg[/url]. (tmshelp.com)
Hydrolase activities1
no significant changes were noted in liver aminopyrine - N - demethylase or aniline hydrolase activities. (cdc.gov)
Microsomal2
1964). In vitro metabolism by hepatic microsomal enzymes from rats treated 8 days previously with single i.p. doses of 10 or 100 mg/kg of chlordane in corn oil was increased for the 3 drugs reported (hexobarbital, aminopyrine and chlorpromazine). (inchem.org)
The phenobarbital-induced increase in the microsomal content of CO-binding pigment and in the activities of TPNH-cytochrome c reductase and the oxidative demethylation of aminopyrine is proportional, within certain limits, to the amount of phenobarbital injected. (rupress.org)
Metamizole1
In the pharmaceutical industry, it is applied to produce intermediates of metamizole and aminopyrine. (choice-chem.com)
Activity2
The effects on aminopyrine-demethylase and acetanilide-hydroxylase activity were evaluated. (cdc.gov)
Isooctane did not inhibit aminopyrine-demethylase or acetanilide-hydroxylase activity. (cdc.gov)
Activities1
Although S. baicalensis inhibited the lipid peroxidation in rat liver microsomes and red blood cells, the extract showed inhibitory actions on aminopyrine N-demethylase and xanthine oxidase activities as well as an pro-oxidant effect observed in the Fe3+-EDTA-H2O2 system. (nih.gov)
Demethylase4
However, there was no change in activities of either hepatic microsomal aminopyrine demethylase or glucose-6-phosphatase. (nih.gov)
no significant changes were noted in liver aminopyrine - N - demethylase or aniline hydrolase activities. (cdc.gov)
total cytochrome P450 (CYP) contents, aminopyrine N-demethylase activity and delta-aminolevulinic acid synthetase activity also decreased significantly in the CRF rats. (nih.gov)
Aminopyrine demethylase activity in normal and vitamin E-deficient male rats. (illinois.edu)
Antipyrine3
The rates of oxidative metabolism of antipyrine, aminopyrine, ethylmorphine, aniline, and benzo(a)pyrene were all increased by more than 45% in the petrol-exposed rats. (bmj.com)
Brodie and Axelrod continued to collaborate on a number of projects related to the metabolism of analgesic drugs including phenacetin, antipyrine, aminopyrine, and dicoumerol. (nih.gov)
1. It is mainly used in the production of antipyrine, aminopyrine and analgin. (huatengsci.com)
Accumulation6
G17 and carboxyl terminal octapeptide of cholecystokinin (26-33) were equipotent in displacing tracer binding and in stimulating parietal cell function ( [14C]aminopyrine accumulation), whereas the tetrapeptide of gastrin (14-17) had a much lower potency. (jci.org)
Accumulation of the weak base aminopyrine was used as an index of acid secretory activity in rat isolated parietal cells. (port.ac.uk)
The nitric oxide (NO) donor, S-nitroso-N-acetyl-penicillamine (SNAP) caused a dose-dependent inhibition of aminopyrine accumulation (half-maximally effective concentration 247 μM) which was accompanied by an increase in guanosine 3',5'-cyclic monophosphate (cGMP) but no decrease in cell viability (trypan blue), glucose oxidation or adenosine 3',5'-cyclic monophosphate (cAMP) content. (port.ac.uk)
Prior exposure of intact cells to SNAP also reduced aminopyrine accumulation in response to ATP in permeabilised cells, an effect prevented by Rp-8-bromoguanosine 3',5'-monophosphorothioate, which inhibits activation of cGMP-dependent protein kinase, but not by the Sp-isomer. (port.ac.uk)
METHODS: We adopted and extensively characterised the mouse gastric gland preparation and its secretory capacity, which was measured using (14)C-aminopyrine accumulation. (mcmaster.ca)
RESULTS: (14)C-aminopyrine accumulation in mouse gastric glands was shown to be a very sensitive "in vitro" method of testing classical secretagogues and antisecretory compounds, and provided pharmacological data on acid secretion in the mouse. (mcmaster.ca)
Breath9
The aminopyrine breath test has been shown to be a sensitive noninvasive indicator of liver cell dysfunction. (nih.gov)
In a search for a noninvasive method of monitoring the effects of methotrexate therapy, we have investigated the use of the aminopyrine breath test in patients receiving methotrexate for the treatment of severe psoriasis. (nih.gov)
The [14C]-aminopyrine breath test was performed in 20 normal control subjects, 32 patients with psoriasis receiving methotrexate therapy, and 8 patients with histologically confirmed cirrhosis of differing etiology. (nih.gov)
The aminopyrine breath test was only able to detect the later severe stages of methotrexate hepatotoxicity, grade III, when fibrosis occurs, before established cirrhosis was present. (nih.gov)
Our data suggests that the aminopyrine breath test is not a sensitive indicator for the detection of early methotrexate-induced hepatotoxicity, (stages I and II), but will detect the precirrhotic stage III change. (nih.gov)
Consequently, we recommend that a liver biopsy should be performed annually in all psoriatic patients receiving methotrexate, to detect histological damage, especially when the aminopyrine breath test score falls below the 95% confidence limits of normal. (nih.gov)
Aminopyrine breath test in the prognostic evaluation of patients with cirrhosis. (bmj.com)
22. Aminopyrine breath test predicts liver-related events and death in HCV-related cirrhosis on SVR after DAA therapy. (nih.gov)
A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS . (nih.gov)