• Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick aorta : a mongraphic study by Susan Averill Taylor. (musc.edu)
  • Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica. (musc.edu)
  • Acrylonitrile and ammonia react in a solution of diphenylamine and t-butanol to create beta-aminopropionitrile, which is then alkalized to obtain beta-aminopropionic acid. (lookchem.com)
  • It is caused by a different toxin (beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues. (wikipedia.org)
  • Another type of lathyrism is angiolathyrism, which is similar to osteolathyrism in its effects on connective tissue by means of the toxin beta-aminopropionitrile. (wikipedia.org)
  • It is caused by the toxin beta-aminopropionitrile which inhibits the copper-containing enzyme lysyl oxidase, responsible for cross-linking procollagen and proelastin. (wikipedia.org)
  • It is also caused by the toxin beta-aminopropionitrile. (wikipedia.org)
  • Weanling Sprague-Dawley rats received beta-aminopropionitrile (BAPN) and/or hypertensive treatment, namely, heminephrectomy and administration of deoxycorticosterone acetate-NaCl. (researchmap.jp)
  • LOX inhibition with beta-aminopropionitrile reduces PDGFR-BB binding to cells and downstream signaling, as well as its proliferative effect on the MK lineage. (luriechildrens.org)
  • Importantly, treatment of GATA-1(low) mice with beta-aminopropionitrile significantly improves the bone marrow fibrotic phenotype, and MK number in the spleen. (luriechildrens.org)
  • Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells. (scienceopen.com)
  • In this study, we used genipin or beta-Aminopropionitrile (BAPN) agents to induce or inhibit matrix cross-linking, respectively, to investigate the effects on outflow resistance and ECM remodeling. (elsevier.com)
  • For example, Riley et al have prevented fibrosis in animal models by administering either proline analogues, which interfere with proper folding of collagen, or beta-aminopropionitrile, which interferes with collagen crosslinking. (cdc.gov)
  • Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional groups. (wikipedia.org)
  • Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of isoproterenol, and the response of various tissues to IPR in synthesizing DNA was analyzed. (aacrjournals.org)
  • To examine the role of LOX, some rats were fed food containing 0.12% β-aminopropionitrile (BAPN) (Tokyo Chemicals), a LOX inhibitor. (ahajournals.org)
  • However, treatment of mice with β-aminopropionitrile (BAPN), an inhibitor of matrix cross-linking enzymes, induced subclinical POP. (jci.org)
  • In parallel, RRECs were grown in HG medium and transfected with LOX small interfering RNA (siRNA), scrambled siRNA as control, or exposed to β-aminopropionitrile (BAPN), a LOX inhibitor. (arvojournals.org)
  • Using 3-aminopropionitrile fumarate (BAPN)- and angiotensin II (Ang II)-induced AAD animal models, inhibition of ALDH2 was found to retard development of AAD. (onmedica.com)
  • Female Sprague-Dawley rats (n=6, age 87 days) were injected twice daily for 43 days with #-aminopropionitrile (BAPN, 333 mg/kg/day i.p.), an inhibitor of lysyl oxidase, which is responsible for the production of collagen cross-links. (cdc.gov)
  • Disruption of the ECM by preventing collagen deposition using the lathrytic agent β-aminopropionitrile (BAPN) inhibits LpS1 gene transcription. (elsevier.com)
  • The PET experiments were carried out in the presence or absence of β-aminopropionitrile (BAPN), an irreversible inhibitor of LOX. (biomedcentral.com)
  • Similarly, cells grown in normal or HG medium were subjected to both LOX inhibition with β-aminopropionitrile (BAPN) and by small interfering RNA knockdown, and respectively examined for cell monolayer permeability. (nih.gov)
  • Treatment with the LOX inhibitor β-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I, III, and LOX was inhibited by interleukin-1β (IL-1β) in cultured rat aortic smooth muscle cells (RASMCs) in vitro. (ahajournals.org)
  • A. Sampath Narayanan, R. C. Siegel, and G. R. Martin, "On the inhibition of lysyl oxidase by β -aminopropionitrile," Biochemical and Biophysical Research Communications , vol. 46, no. 2, pp. 745-751, 1972. (hindawi.com)
  • Parmi ces gènes, je me suis intéressée à un membre de la famille des lysyl oxydases, LOXL4, qui joue un rôle clé dans la dynamique de la matrice extracellulaire en régulant la réticulation du collagène. (archives-ouvertes.fr)
  • All of the haplotype variants of LOXL1 (141R-153G, 141R-153D, 141L-153G, and 141L-153D) showed β-aminopropionitrile-inhibitable amine oxidase activity toward elastin, type I collagen, and cadaverine, indicating that each LOXL1 variant functions as an amine oxidase. (molvis.org)
  • We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. (utmb.edu)
  • The research team identified a compound, 3-aminopropionitrile, that inhibits the enzyme that causes graft contraction and combined it with a biocompatible polymer gel invented by chemist Steve Armes, also at Sheffield. (cosmeticsandtoiletries.com)
  • Then, the inhibition of the LOXL4 protein in scratch assay experiments (using β-aminopropionitrile or a specific siRNA) allowed us to demonstrate that the pro-healing effect of atRA was mediated, at least in part, by the retinoid-induction of this gene. (archives-ouvertes.fr)
  • 5. The method defined in claim 1 wherein the lathyrogenic agent is B-aminopropionitrile fumarate. (google.com)
  • Tritiated ß-aminopropionitrile was diffusely distributed throughout bone and was completely removed by saline extraction. (rupress.org)
  • Available data included measurements of tissue volume, biochemical composition, and tensile modulus for bovine calf articular cartilage (AC) explants harvested at three depths and incubated for 13 days in 20% fetal borine serum (FBS) and 20% FBS+ ß-aminopropionitrile. (calpoly.edu)
  • Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile. (wikipedia.org)