• Smoke contains ethylene, and once this was realized the smoke was replaced with ethephon or naphthalene acetic acid, which induce ethylene production. (wikipedia.org)
  • ACC synthesis increases with high levels of auxins, especially indole acetic acid (IAA) and cytokinins. (wikipedia.org)
  • Aminooxyacetic acid can also inhibit 1-aminocyclopropane-1-carboxylate synthase preventing ethylene synthesis, which can increase the vase life of cut flowers. (wikipedia.org)
  • SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) by the enzyme ACC synthase (ACS). (wikipedia.org)
  • Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. (wikipedia.org)
  • At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. (wikipedia.org)
  • Aminooxyacetic acid is a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes. (wikipedia.org)
  • Aminooxyacetic acid was previously used in a clinical trial to reduce symptoms of Huntington's disease by increasing GABA levels in the brain. (wikipedia.org)
  • Aminooxyacetic acid inhibits aspartate aminotransferase, another PLP-dependent enzyme, which is an essential part of the malate-aspartate shuttle. (wikipedia.org)
  • Ethylene is biosynthesized from the amino acid methionine to S-adenosyl-L-methionine (SAM, also called Adomet) by the enzyme Met adenosyltransferase. (wikipedia.org)
  • Also, the inhibition of aspartate aminotransferase by aminooxyacetic acid has clinical implications for the treatment of breast cancer, since a decrease in glycolysis disrupts breast adenocarcinoma cells more than normal cells. (wikipedia.org)
  • Moreover, selective inhibition of aspartate aminotransferase with aminooxyacetic acid ameliorated experimental autoimmune encephalomyelitis in a therapeutic mouse model by reprograming the differentiation of pro-inflammatory T helper 17 cells, that boost the immune system, towards induced anti-inflammatory regulatory T cells. (wikipedia.org)
  • It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with. (drugbank.ca)
  • Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway. (drugbank.ca)
  • Bis(Boc-aminooxy)acetic acid employed as a protecting reagent and intermediate pharmaceuticals and chemical research. (fishersci.dk)
  • In this study, experiments were conducted both in vitro (using cell cultures) and in vivo (using mice) to test the effect of a chemical compound called " (aminooxy)acetic acid " (AOA). (medicalnewstoday.com)
  • The phytotoxicity of acifluorfen and oxyfluorfen [2-chloro-l-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene] to spinach is counteracted by appropriate treatments with (aminooxy)acetic acid, L-2-(aminooxy)-3-phenylpropionic acid, or silver nitrate and by heat shock. (elsevier.com)
  • Under certain conditions soybean injury is ameliorated by combining (aminooxy)acetic acid with acifluorfen and silver nitrate with oxyfluorfen. (elsevier.com)
  • Complete submergence of rice plants under water for 10 days in presence of an ethylene-biosynthetic inhibitor, aminooxy acetic acid (AOA), resulted in appreciable lowering of lodging during post-submergence period when compared with plants submerged without AOA. (bdsbmb.org)
  • Aminooxy acetic acid (AOA) - chilling-chlorophyll-ethylene- gibberellic acid (GA) - germination-lodging - submergence. (bdsbmb.org)
  • Various nonproteinogenic β-amino acids occur naturally as free metabolites and as components of biosynthetic products ( 1 ). (asm.org)
  • quinolinic acid (QUIN)] and neuroprotective [kynurenic acid (KYNA)] KP metabolites. (pnas.org)
  • Because of this, cancer cells can then secrete extra glycolytic metabolites in the from of lactic acid. (wikibooks.org)
  • In addition, the histopathological result was consistent with that of the serum metabolomic analysis, and the changes in serum metabolites in each sausage diet group and the NDMA group were consistently associated with disorders of lipids, amino acid, and energy metabolism. (foodandnutritionresearch.net)
  • The mitochondrial tricarboxylic acid cycle (TCA cycle) provides additional metabolites that funnel into lipid, amino acid and nucleotide synthesis. (biomedcentral.com)
  • This compound belongs to the class of organic compounds known as carboxylic acids. (drugbank.ca)
  • ureidooxy carboxylic acids (3) and their derivatives as plant growth regulators and herbicides. (justia.com)
  • In organic chemistry , Acyclic Acids (Ethanoic Acids) , as organic compounds are 2 carbon straight-chain saturated carboxylic acids , that have an open-chain molecular structures as opposed to ring-shaped structures. (wellnessadvocate.com)
  • Expression of CsHA1 , CsFRO1 , and CsIRT1 is diminished in Fe-deficient roots by treatment with ethylene inhibitors, such as Co (cobalt) or AOA (aminooxyacetic acid). (unl.edu)
  • The addition of specific DAAO inhibitors, such as 3-methylpyrazole-5-carboxylic acid and 4 H -thieno [3, 2-b] pyrrole-5-carboxylic acid (Compound 8), significantly attenuated the fluorescence intensity of KYNA, suggesting that DAAO present in the rat brain homogenates was responsible for the production of KYNA. (go.jp)
  • However relaxation responses were reduced by L-NNA (100 µM) an inhibitor of nitric oxide (NO) synthesis (40-50% reduction), zinc protoprophyrin IX (10 µM) an inhibitor of carbon monoxide (CO) synthesis (20-40% reduction) and also propargylglycine (30 µM) and aminooxyacetic acid (30 µM), inhibitors of hydrogen sulphide (H2S) synthesis (15-20% reduction). (edu.au)
  • The protective activity against cisplatin-induced cytotoxicity and ROS generation was blocked by aminooxyacetic acid, a selective inhibitor of pyridoxal 5′-phosphate-dependent cysteine conjugate β-lyases, further supporting the role of β-lyase in the observed chemoprotection. (aspetjournals.org)
  • Aminooxyacetic acid can also inhibit 1-aminocyclopropane-1-carboxylate synthase preventing ethylene synthesis, which can increase the vase life of cut flowers. (wikipedia.org)
  • Kuhse, J., Schmieden, V. & Betz, H. A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit. (nature.com)
  • Schmieden, V., Kuhse, J. & Betz, H. Agonist pharmacology of neonatal and adult glycine receptor α subunits: identification of amino acid residues involved in taurine activation. (nature.com)
  • Balcar, V.J., 2002, Molecular pharmacology of the Na + -dependent transport of acidic amino acids in the mammalian central nervous system. (springer.com)
  • 2019 ) Effects of aminooxyacetic acid on hippocampal mitochondria in rats with chronic alcoholism: the analysis of learning and memory-related genes. (academictree.org)
  • An easy fluorimetric assay for measuring D-amino acid oxidase (DAAO) activity by using one of the D-amino acids - D-kynurenine (D-KYN) - as a substrate was applied to assess DAAO activity in the cerebrum, cerebellum, and brainstem of Sprague-Dawley (SD) male rats. (go.jp)
  • Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats. (cookleave.info)
  • The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori, to a method of producing chondroitin oligosaccharides from chondroitin sulphates, and a method for production of amidated glucuronic acid comprising oligosaccharides and monosaccharides from glucuronic acid comprising polysaccharides. (sumobrain.com)
  • Aminooxyacetic acid inhibits aspartate aminotransferase, another PLP-dependent enzyme, which is an essential part of the malate-aspartate shuttle. (wikipedia.org)
  • Some examples of α-ketoacids include pyruvate, oxaloacetate, or gamma-semialdehyde which are also used to synthesize nonessential acids such as alanine, serine or aspartate. (wikibooks.org)
  • It has been clearly demonstrated that dormancy is induced by abscisic acid (ABA) during seed development on the mother plant. (frontiersin.org)
  • Plant senescence is regulated by a coordinated genetic program mediated in part by changes in ethylene, abscisic acid (ABA), and cytokinin content. (plantphysiol.org)
  • Senescence is accompanied by changes in endogenous ethylene, abscisic acid (ABA), and cytokinins, and these changes are believed to mediate signaling events that control the process. (plantphysiol.org)
  • The plant growth regulator abscisic acid (ABA) can cause physiological responses that protect plants against CI or LTI. (core.ac.uk)
  • Kynurenic acid (KYNA), an astrocyte-derived, endogenous antagonist of α7 nicotinic acetylcholine and excitatory amino acid receptors, regulates glutamatergic, GABAergic, cholinergic and dopaminergic neurotransmission in several regions of the rodent brain. (frontiersin.org)
  • In this assay, DAAO produces kynurenic acid (KYNA) from D-KYN, and the fluorescence originating from KYNA can then be used to evaluate DAAO activity. (go.jp)
  • The crystal structure was used to rationalize the stereo- and regioselectivity of V. paradoxus aminotransferase and to define a sequence motif with which new aromatic β-amino acid-converting aminotransferases may be identified. (asm.org)
  • Bixel, M.G., Hutson, S.M. and Hamprecht, B., 1997, Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture. (springer.com)
  • In contrast, an inhibitor of aminotransferase (AT), aminooxyacetic acid, did not decrease KYNA production from D-KYN, meaning that AT could not metabolize D-KYN to KYNA under the present conditions. (go.jp)
  • L-type Ca2+ channels mediate joint modulation by gamma-amino-butyric acid and glutamate of [Ca2+]i and neuropeptide secretion in immortalized gonadodropin-releasing hormone. (naver.com)
  • This invention specifically relates to amino thioxomethyl amino oxyacetic acid derivatives that elevate HDL cholesterol concentration and which may be useful for the treatment of atherosclerotic conditions such as, coronary heart disease. (justia.com)
  • Aminooxyacetic acid has been shown to cause excitotoxic lesions of the striatum, similar to Huntington's disease, potentially due to its impairment of mitochondrial energy metabolism. (wikipedia.org)
  • This is particularly serious for aminooxyacetic acid, which at high concentrations will inhibit all pyridoxal phosphate-dependent enzymes. (sigmaaldrich.com)
  • Various amino acids were found to inhibit both brain and liver AspD. (nus.edu.sg)
  • The perception of this gaseous two-carbon hormone is achieved by a group of membrane-associated dimeric ethylene receptors that resemble bacterial two-component signaling systems and are composed of hybrid histidine (or aspartic acid) kinases, a histidine-containing phosphor-transfer domain, and response regulators ( 2 ). (mcponline.org)
  • The present study was undertaken to investigate the effect of established anticonvulsants, such as valproic acid, carbamazepine, gabapentin, diazepam, lacosamide and pregabalin against pentylenetetrazole (6 mM) seizures in adult zebrafish. (ijpsonline.com)
  • Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. (drugbank.ca)
  • It was found that preliminary treatment before self-pollination of stigmas of petunia self-incompatible line with aminooxyacetic acid (AOA), inhibitor of ACC synthesis, led to stimulation of pollen tubes growth when the latter did not exhibit any hallmarks of PCD. (springer.com)
  • ACC synthesis increases with high levels of auxins, especially indole acetic acid (IAA) and cytokinins. (wikipedia.org)
  • 3 R )-3-[(1 R )-1-( tert -Butyldimethylsilyl)oxy-1-(2-methoxy-4,5-methylenedioxyphenyl)methyl]-2-methylene-4-butanolide, which is a key intermediate for the synthesis of 1,2-oxidized furofuran lignan, was stereoselectively synthesized from L -glutamic acid by applying direct methylenation to butanolide. (go.jp)
  • However, alternative routes, including KYNA formation from D-kynurenine (D-KYN) by D-amino acid oxidase (DAAO) and the direct transformation of kynurenine to KYNA by reactive oxygen species (ROS), have been demonstrated in the rat brain. (frontiersin.org)
  • By grafting the amino acid sequence -GSECG to the C-terminal of our model-protein, a HER2-binding Affibody molecule, we enabled site specific labeling with both trivalent radiometals and with 99m Tc. (diva-portal.org)
  • Also in the nerve terminals, aminooxyacetic acid prevents the mitochondria from utilizing pyruvate generated from glycolysis, thus leading to a bioenergetic state similar to that of hypoglycemia. (wikipedia.org)
  • mTORC1 is typically a major regulator of cell growth and activates protein translation but inhibits the response of macrophages to excess amino acid production. (wikibooks.org)
  • Glutamate is derived from and can be converted to glutamine, and oxidation of glutamate feeds into the energy-providing TCA (tricarboxylic acid) cycle. (sciencemag.org)
  • Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. (nih.gov)
  • These are compounds containing a carboxylic acid group with the formula -C(=O)OH. (drugbank.ca)
  • Among the compounds disclosed is 5-chloro-2-methylphenyl thioureido acetic acid (2). (justia.com)
  • Other β-amino acids occur as building blocks in β-lactam antibiotics ( 4 , 7 ) and in antifungal compounds, such as jasplakinolide ( 8 ). (asm.org)
  • In view of the growing importance of pharmaceutical compounds containing β-amino acid groups, there is demand for new tools for their production in enantiopure form. (asm.org)
  • Typically these compounds are in the form of nucleotides and essential amino acids. (wikibooks.org)
  • Mice lacking the neuronal NOS (nNOS) isoform have a phenotype that could be explained by decreased availability of glutamate, an amino acid that is also an excitatory neurotransmitter. (sciencemag.org)
  • γ-Hydroxybutyric acid ( GHB ), also known as 4-hydroxybutanoic acid , is a naturally occurring neurotransmitter and a psychoactive drug . (ipfs.io)
  • Additionally, glutamine serves as an important nitrogen donor for assembly of amino acids, nucleotides and nicotinamide. (biomedcentral.com)
  • Interestingly, aminooxyacetic acid acts as a convulsant at treble doses while at trim doses it is an anticonvulsant (Tapia 1975). (telemetrica.ru)
  • The objective of this study was to investigate the effects of amino acid compositions and their concentration on the Bt toxin content in Bt cotton to gain a better physiological understanding of the observed phenomenon. (usda.gov)
  • Other β-amino acids are present in bioactive peptides, such as the protease inhibitor bestatin, which contains a (2 S ,3 R )-3-amino-2-hydroxy-4-phenylbutanoyl group, and microcystin, a cyclic nonribosomal peptide that acts as a phosphatase inhibitor and contains both an aliphatic and an aromatic β-amino acid moiety ( 2 - 4 ). (asm.org)
  • When cleaved with acid it produces peptides with amide group on C-terminus. (biodiscovery.eu)
  • It has been studied by Otto Warburg, a notable German physiologist and Nobel Laureate, that cancer cells seem to uptake more glucose and produce more lactic acid than regular cells or tissues. (wikibooks.org)
  • Also in 1936, Kitagawa and Takani described the preparation of aminooxyacetic acid by the condensation of benzhydroxamic acid and ethyl bromoacetate, followed by hydrolysis by hydrochloric acid. (wikipedia.org)
  • In protein science , an Imino Acid (Secondary Amino Acid) is a molecule, related to amino acids (differing in the bonding to the nitrogen), that contains both an imino (>C=NH) and a carboxyl (-C(=O)-OH) functional group, which occurs as either an acyclic acid or a cyclic imino acid . (wellnessadvocate.com)
  • In carbohydrate science , Sugar Acids , as an acyclic acid , are acidic sugars. (wellnessadvocate.com)
  • As shown in the structure of glutamic acid, there is a free amino group containing an available nitrogen for donation. (wikibooks.org)
  • Glutamic acid becomes the primary donor of nitrogen for synthesizing nonessential amino acids. (wikibooks.org)
  • Glutamic acid as a form of glutamine, donates its carbon skeleton and nitrogen to proline, another nonessential amino acid, as well. (wikibooks.org)
  • Glutamine donates an amide group and is then converted to glutamic acid. (wikibooks.org)
  • The influence of aminooxyacetic acid on amidopyrine-N-demethylation by 9000xg liver supernatant. (erythromycin2020.site)
  • However, the patients who received the aminooxyacetic acid treatment failed to show clinical improvement and suffered from side effects such as drowsiness, ataxia, seizures, and psychotic behavior when the dosage was increased beyond 2 mg per kilogram per day. (wikipedia.org)