Amino sterol carrier protein 2 peptides and proteins carrier proteins. Medical search. Frequent questions

or anabolic - the building up (synthesis) of compounds (such as proteins, carbohydrates, lipids, and nucleic acids). (wikipedia.org)
Most of the structures that make up animals, plants and microbes are made from four basic classes of molecules: amino acids, carbohydrates, nucleic acid and lipids (often called fats). (wikipedia.org)
Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. (wikipedia.org)
Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
During her M.S., she focused on the development of fluorescent amino acids and peptide synthesis. (rsc.org)
Multivariate analysis of amino acids and other quality traits showed that the two groups are largely independent of one another, with the largest effect on amino acids being from the environment. (rothamsted.ac.uk)
Linkage analysis of the population allowed identification of QTL controlling free amino acids and quality traits, and this was compared against genomic prediction methods. (rothamsted.ac.uk)
wherein free amino acids represent at least 80 wt. (justia.com)
a first group of free amino acids selected from asparagine (Asn), aspartate (Asp), glutamate (Glu), glutamine (Gln), pyroglutamate (pGlu) and combinations thereof, said first group of free amino acids representing 45-95 wt. (justia.com)
a second group of free amino acids selected from glycine (Gly), leucine (Leu), lysine (Lys), serine (Ser), isoleucine (Ile) and combinations thereof, said second group of free amino acids representing 1-20 wt. (justia.com)

Mitochondrial trifunctional protein deficiency. (rhea-db.org)
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. (tamu.edu)
subunit alpha of MPP mitochondrial signal peptidase heterodimer","protein_coding" "Zm00001e017599_P001","No alias","Zea mays","Protein disulfide isomerase-like 2-2 OS=Oryza sativa subsp. (ntu.edu.sg)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)

Measuring muscle protein synthesis in humans and the influence of nutritional state. (tamu.edu)
Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)

Many proteins are enzymes that catalyze the chemical reactions in metabolism. (wikipedia.org)
These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)
The remarkable diversity of natural products (NPs) results from a similarly diverse pool of biosynthetic enzymes [ 2 ]. (biomedcentral.com)
The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. (hindawi.com)

For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
I further investigated membrane proteins and the targeting of tail-anchored proteins at Sheffield Hallam University. (brookes.ac.uk)

Conserved residues that modulate protein trans-splicing of Npu DnaE split intein. (tamu.edu)
We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
3. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease, this segment is a peptide able to bind to NS3pro and contact at least one residue comprised in the region Gly21-Lys28 of the N-terminal domain of the NS3pro protein from DV2 or structurally equivalent residues of the NS3pro protein from other Flavivirus. (patentsencyclopedia.com)
5. Chimerical peptides according to the claim 1, where the mentioned segment inhibitor of the activation of the NS3pro protease contact at least one residue comprised in the region Glu32-Thr38 of the N-terminal domain of the NS3pro protein from HCV or structurally equivalent residues of the NS3pro protein from other Hepacivirus. (patentsencyclopedia.com)

Parasitic ecule because it reversibly binds to certain proteins, such as kinetoplastid ﬂagellates represent a rare example of organisms transcription factors and ion channels, and thus modulates their that depend on oxidative metabolism but are heme auxotrophs. (medicinelakex1.com)

Hippocampal lipids were not significantly affected by APOE genotype, however levels of myelin-enriched sulfatides and hexosylceramides were significantly lower, and polyunsaturated phospholipids were higher, in rs1990622-A carriers after controlling for APOE genotype. (biomedcentral.com)
Our study demonstrates that TMEM106B protein abundance is increased with brain ageing in humans, establishes that dementia risk allele rs1990622-A predisposes to TMEM106B fibril formation in the hippocampus, and provides the first evidence that rs1990622-A affects brain lipid homeostasis, particularly myelin lipids. (biomedcentral.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Most antimicrobial peptides are cationic amphiphilic compounds that function by binding to the negatively charged lipids of bacterial membranes, followed by membrane disruption. (rsc.org)

Amino acid kinase family [Interproscan]. (ntu.edu.sg)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)

The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)
Wheat is a major source of nutrients for populations across the globe, but the amino acid composition of wheat grain does not provide optimal nutrition. (rothamsted.ac.uk)
In this study, we investigated the genetic architecture controlling grain free amino acid composition and its relationship to other traits in a Robigus × Claire doubled haploid population. (rothamsted.ac.uk)

Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
My additional independent research on ER localisation and splicing in auxin biosynthesis showed for the first time ER-localisation for an auxin biosynthetic protein. (brookes.ac.uk)

We examined the enzyme protein and biosynthesis of human trifunctional protein harboring enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase activity in cultured skin fibroblasts from two patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. (rhea-db.org)

QLY-related compounds berberine, dioscin and sophocarpine showed high binding affinities to SIRT1, stabilized this protein, and inhibited its deacetylation activity in vitro. (bvsalud.org)
This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family. (patentsencyclopedia.com)

Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)

Bone consists of cells (osteocytes, osteoblasts and osteoclasts), extracellular organic components (collagen and non-collagenous matrix protein) and non-organic components (calcium hydroxyapatite). (ommegaonline.org)

The nutritional value of wheat grain is limited by low concentrations of lysine (the most limiting essential amino acid) and high concentrations of free asparagine (precursor to the processing contaminant acrylamide). (rothamsted.ac.uk)

Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
Risperidone-induced weight gain is associated with a number of factors, including gene polymorphisms ( 12 - 14 ), exercise ( 15 - 17 ), peripheral molecules ( 18 ), and hyperphagia caused by regulating the expression of melanocortin-4 receptor (MC4R), neuropeptide Y (NPY), and agouti-related peptide (AgRP) ( 19 - 21 ). (frontiersin.org)

These blocks are synthesized with two different pathways: the pyruvate-derived plastidial 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway and the acetyl-CoA-derived cytosolic mevalonate (MVA) pathway [ 3 ] . (encyclopedia.pub)

Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)

mouse-adcl3 Mus musculus (Mouse) Arylacetamide deacetylase-like 3 , mouse-adcl4 Mus musculus (Mouse) Arylacetamide deacetylase-like 4 Hypothetical esterase/lipase/thioesterase family active site containing protein , mouse-aryla Mus musculus (Mouse) arylacetamide deacetylase and 5033417e09rik protein , mouse-b1avu7 Mus musculus (Mouse). (inrae.fr)
SYP7 group Qc-type SNARE protein","protein_coding" "MA_10436714g0010","No alias","Picea abies","acyl-CoA thioesterase","protein_coding" "MA_135972g0010","No alias","Picea abies","Acyl-CoA-binding domain-containing protein 3 OS=Oryza sativa subsp. (ntu.edu.sg)

Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)
Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
protein_coding" "AAC73194","ftsL","Escherichia coli","membrane bound cell division leucine zipper septum protein [Ensembl]. (ntu.edu.sg)
Cell division protein FtsL [Interproscan]. (ntu.edu.sg)
Terpene derivatives such as sterol work as an important component in cell membranes by stabilizing the interaction with phospholipids [ 5 ] . (encyclopedia.pub)
I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. (patentsencyclopedia.com)
1. Chimerical peptides, characterized by having a primary structure comprising at least one segment inhibitor of the activation of the NS3pro protease from a virus of the Flaviviridae family and a cell penetrating segment and these peptides are able to inhibit or attenuate the infection by the virus. (patentsencyclopedia.com)
11. Chimerical peptides according to the claim 1, characterized by containing a cell penetrating segment which is one of the following cationic PTDs: TAT peptide, heptaarginine, octaarginine, nonaarginine, decaarginine, or a peptide of sequence LRRRRLRRRRL or LRRRRL-bAla-LRRRRL. (patentsencyclopedia.com)

In soluble guanylyl cyclase, heme serves as a protein cofactor for fundamental cellular processes, such as as the nitric oxide sensor, and thus plays an important role in electron transport in the respiratory chain, oxidative stress re- signal transduction. (medicinelakex1.com)
2). In aerobic organisms that produce energy mainly through Some kinetoplastids that parasitize insects obtain heme from their oxidative phosphorylation, most of the synthesized heme is used bacterial endosymbionts, which can be eliminated by antibiotic for the formation of the cytochromes functioning in the electron treatment, turning these protists into heme auxotrophs (17). (medicinelakex1.com)

10% of that in control cells, due to a very rapid degradation of protein newly synthesized in the mitochondria. (rhea-db.org)

I have been intrigued by the activity of antimicrobial peptides for a long time, due to my interest in biological membranes. (rsc.org)
While binding to the lipid headgroup is detrimental for anion transport, I hypothesized that binding to the headgroup can provide membrane selectivity (e.g., bacterial membranes over human membranes) and can induce membrane perturbations similar to those observed for antimicrobial peptides. (rsc.org)

The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of "in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others" through the "… transduction of bioelectrical and biochemical events into measurable electrical signals" [2]. (lifeboat.com)

A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication. (tamu.edu)
I took up a position at Oxford Brookes University in 2012 investigating the role of reticulon proteins in ER tubulation and viral trafficking in order to develop my international reputation in ER research and advanced imaging. (brookes.ac.uk)

Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)

This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

6. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Asp50-Glu62 of the NS2B protein from DV2 or the structurally equivalent segment of the protein NS2B from other Flavivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)
8. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Thr20-Leu31 of the NS4A protein from HCV or the structurally equivalent segment of the protein NS4A from other Hepacivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)

US Patent Application Number: 20030199813 book Autonomic Principles of IP Operations and Management: 6th IEEE International Workshop produced: April 22, 2002 message: The project is filtered to conditions for failing the book of a disease, long-term as a illness activating K+ heart cause, and all containing the influence's absence text as a circulation of a protein in the world's liver, acid as the physiological inflammatory failure oxidative ovum. (augenta.net)

retained genes for the last three steps of the pathway, allowing The most abundant group of heme proteins are cytochromes them to synthesize heme from their host-derived precursors (20). (medicinelakex1.com)

10. Chimerical peptides according to the claim 1, where the mentioned virus from the Flaviviridae family is a Hepacivirus and specifically HCV. (patentsencyclopedia.com)

The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)
protein_coding" "AAC73288","bamA","Escherichia coli","BamABCDE complex OM biogenesis outer membrane pore-forming assembly factor [Ensembl]. (ntu.edu.sg)

Proteins found in any species of algae. (lookformedical.com)
In preferred forms the cardiolipin is cardiolipin species (C18:2)4. (justia.com)

Gene/protein expression and cytokine production were investigated too. (bvsalud.org)
The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)
CSCs exhibit certain properties, such as high expression of various anti-apoptotic proteins, expression of ABC pumps, and others, that would allow them to resist chemotherapeutic agents (Li et al. (docksci.com)

The diminution of trifunctional protein was associated with a decreased activity of enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase, when measured using medium-chain to long-chain substrates. (rhea-db.org)
Taken together, the results obtained show that in both patients, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency is caused by an abnormality in the trifunctional protein, even though there is a heterogeneity in both patients. (rhea-db.org)

Approximately 40% of total calcium is bound to serum proteins, and 80% to 90% of this calcium is bound to albumin. (abdominalkey.com)

Antimicrobial peptides have long been hailed as a solution to the antibiotic resistance crisis, because they target the bacterial membrane and can cause quick bactericidal activity in bacterial cells. (rsc.org)

Fig 2 Open in a other window Gpr178 mRNA idiom in rat and moingest.Results are make knownn as subject to spirit to (fold enhancement). (upb.ro)

The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)

metabolism of this heme-free eukaryote, we searched for heme- There are only a few examples of facultatively anaerobic or containing proteins in its de novo sequenced genome and exam-ined several cellular processes for which heme has so far been con- pathogenic bacteria that do not require heme (10-12), but no sidered indispensable. (medicinelakex1.com)

These results also suggest the coupling of RACK1 to muscle unfolded protein response during SC activation. (sdbonline.org)

These biochemicals can be joined to make polymers such as DNA and proteins, essential macromolecules of life. (wikipedia.org)

Variations in serum protein alter proportionately the concentration of the protein-bound and total serum calcium. (abdominalkey.com)
An increase in serum albumin concentration of 1 g/dL increases protein-bound calcium by 0.8 mg/dL, whereas an increase of 1 g/dL of globulin increases protein-bound calcium by 0.16 mg/dL. (abdominalkey.com)
Marked changes in serum sodium concentration also affect the protein binding of calcium. (abdominalkey.com)

Crystal structure of activated Rubisco from G. partita complexed with the reaction intermediate analogue, 2-carboxyarabinitol 1,5-bisphosphate (2-CABP) has been determined at 2.4-A resolution. (lookformedical.com)

These often are highly selective and efficient, carrying out demanding reactions in aqueous media, and therefore are interesting starting points for the development of industrially relevant biocatalysts [ 2 ]. (biomedcentral.com)
Using a polyclonal antibody (anti-p210) raised against the C-terminal part of p210, it was shown that the protein was highly enriched in the basal apparatuses. (lookformedical.com)

Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)

Total serum calcium is divisible into protein-bound and ultrafiltrable (diffusible) calcium ( Fig. 6-1 ). (abdominalkey.com)
Hyponatremia increases, whereas hypernatremia decreases protein-bound calcium. (abdominalkey.com)
Changes in pH also affect protein-bound calcium, and an increase or decrease of 0.1 pH increases or decreases protein-bound calcium by 0.12 mg/dL. (abdominalkey.com)
An increase in serum pH of 0.l unit may cause a decrease in ionized calcium of 0.16 mg/dL ( 1 , 2 ). (abdominalkey.com)
The bone remodeling prevents fatigue damage and important in preserving calcium homeostasis and the loss of osteoblast - osteoclasts coupling lead to several metabolic bone diseases including osteoporosis, tumor related bone disease, rheumatoid arthritis [1,2] . (ommegaonline.org)

b) In cells from patient 2, the rate of degradation of newly synthesized trifunctional protein was faster than that in control cells, giving rise to a trifunctional protein amounting to 60% of the control levels. (rhea-db.org)
The increase in TMEM106B levels with ageing was specific to carriers of the rs1990622-A allele in the TMEM106B gene that increases risk for frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and hippocampal sclerosis with ageing. (biomedcentral.com)
Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)

Search proteins in UniProtKB for this molecule. (rhea-db.org)

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