• Carbohydrate-binding module family 1 (CBM1) consists of 36 amino acids. (wikipedia.org)
  • Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. (the-scientist.com)
  • We report the observation of intermediate structures in the self-assembly of the peptide KFE8 (FKFEFKFE), designed with alternating polar and nonpolar amino acids. (acs.org)
  • Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)
  • The B-Raf protein has 766 amino acids in three conserved domains. (news-medical.net)
  • We have discovered that erythrocyte frataxin is in fact a novel isoform of frataxin (isoform E) with 135-amino acids and an N-terminally acetylated methionine residue. (nih.gov)
  • Moreover, as the word 'coding' refers to the relationship between nucleic acids and proteins, rather than the mere transcription of DNA into RNA, it is logical to call the strand with the mRNA sequence the coding strand, as in the first example. (genomicglossaries.com)
  • It does this by binding to a sequence of molecules called amino acids, which are then attached together to make a protein. (vetinfo.com)
  • When a clindamycin molecule binds to a bacteria's RNA, that RNA molecule cannot bond to the proper sequence of amino acids, so it will not make the protein it was designed to for. (vetinfo.com)
  • Pumby adapts naturally occurring proteins called Pumilio homology domains (PumHDs), which consist of amino acids that bind to each of the four different ribonucleotide bases that make up RNA sequences. (genengnews.com)
  • Ultimately, the researchers found a particular set of amino acids that will bind each of the four bases at any position in the target sequence. (genengnews.com)
  • These are identical through amino acid 727, but then diverge, with hGRα having an additional 50 amino acids and hGRβ having an additional, nonhomologous 15 amino acids. (medscape.com)
  • The NTD of the hGRα contains a major transactivation domain, termed activation function (AF)-1, which is located between amino acids 77 and 262 of the hGRα and is ligand-independent. (medscape.com)
  • The DNA-binding domain (DBD) of the hGRα corresponds to amino acids 420-480 and contains 2 zinc finger motifs through which the hGRα binds to specific DNA sequences, the glucocorticoid-response elements (GREs) in the promoter region(s) of target genes. (medscape.com)
  • For example, in an environment rich in amino acids, cells do not expend energy for making amino acid biosynthetic enzymes. (go.jp)
  • However, if the environment becomes depleted of amino acids (nutritional downshift), cells will be exposed to a lack of both the amino acid biosynthetic enzymes and the amino acids required to make these enzymes. (go.jp)
  • To solve this dilemma, cells must use their own proteins as sources of amino acids in response to the nutritional downshift. (go.jp)
  • Once amino acid biosynthetic enzymes start to accumulate, the cell is able to produce its own amino acids, and a new growth phase begins. (go.jp)
  • AGT is a high molecular weight molecule (49.548), made up of 453 amino acids (aa) synthesized in the liver. (hindawi.com)
  • somewhat similar sequences of about 110 amino acids each. (wikipedia.org)
  • Cleavage sites are serotype-specific, with the exception of BoNT/F5, which cleaves between amino acids 54 L and 55 E, four amino acids different from the standard BoNT/F cleavage site of 58 Q and 59 K 13 . (cdc.gov)
  • they are called variable because the amino acids they contain are different in different antibodies. (msdmanuals.com)
  • The protein is ~90 amino acids long and contains 10 cycteines forming five disulfide bonds. (lu.se)
  • In addition to the 10 cysteines there are only 16 identical amino acids in the proteins from human, rhesus monkey, baboon, pig, rat and mouse. (lu.se)
  • The protein consists of some 1217 amino acid residues and a 28-residue signal peptide. (unifi.it)
  • Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)
  • Glycosylation sites, modified residues and lipid moiety-binding regions. (ucsc.edu)
  • In Escherichia coli , amino acid starvation leads to the accumulation of an unusual molecule, polyphosphate (polyP), a linear polymer of many hundreds of orthophosphate residues. (go.jp)
  • The fine specificity, as determined by the requirement of particular amino acid residues in the epitope, is shifted in these new antibody fragments. (lu.se)
  • The anaerobic bacterial dockerins are homologous to EF hands (calcium-binding motifs) and require calcium for activity whereas the fungal dockerin does not require calcium. (wikipedia.org)
  • a Domain organization of the four subunits of human Pol δ and amino acid sequence of PCNA-interacting (PIP-box) motifs. (nature.com)
  • The predicted structures of the Gimap proteins show common sequences and motifs, such as GTP-binding domains in the N-terminal half, but with differing C-terminal ends [ 2 , 3 ]. (hindawi.com)
  • Regions of repeated sequence motifs or repeated domains. (ucsc.edu)
  • Known as "destabilising motifs", these sequences attract the attention of a group of proteins called Ccr4-Not. (elifesciences.org)
  • A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)
  • The clindamycin molecule does this by entering the bacteria cell and binding to the bacteria's RNA. (vetinfo.com)
  • Furthermore, the team discovered that each time an mRNA molecule is translated, the GFP gets knocked off, and when translation is finished, another GFP binds to it, enhancing the overall fluorescent signal. (genengnews.com)
  • These RNA-binding proteins could also be used to build molecular assembly lines that would bring together enzymes needed to perform a series of reactions that produce a drug or another molecule of interest. (genengnews.com)
  • To see whether this was possible, Paulson and colleagues cultured hemagglutanin in an experimental cell line, identifying and propagating amino acid mutations in the process. (cosmosmagazine.com)
  • This experiment was conducted to study hybridization between CL rice and red rice using simple sequence repeats (SSR) markers, identify mutations in the ALS gene of imazethapyr-resistant red rice, and to detect the introgression of the ALS-resistant gene from CL rice into red rice. (weedscience.com)
  • Finally, the interaction between cohesin and dockerin appears to be species specific in bacteria, there is almost no species specificity of binding within fungal species and no identified sites that distinguish different species. (wikipedia.org)
  • In contrast to mouse FcRn, which binds to IgGs from multiple different species, human FcRn is surprisingly stringent in binding specificity. (nih.gov)
  • Here, we have used site-directed mutagenesis in combination with interaction (surface plasmon resonance) studies, with the goal of generating human FcRn variants that more closely resemble mouse FcRn in binding specificity. (nih.gov)
  • These studies define the molecular basis for the marked difference in binding specificity between human and rodent FcRn, and give insight into how human FcRn recognizes IgGs. (nih.gov)
  • They discovered several different combinations of three amino acid changes that altered the hemagglutanin's specificity from bird to human cells. (cosmosmagazine.com)
  • RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood. (elifesciences.org)
  • The whole amino acid sequence of nidogen was deduced from cDNA clones isolated from expression libraries and confirmed to approximately 50% by Edman degradation of peptides. (unifi.it)
  • Binding Mechanisms of Amyloid-like Peptides to Lipid Bilayers and Effects of Divalent Cations. (acs.org)
  • As this motif is different in the two CBR subtypes, we mutated lysine 402 of CB(1)R into glycine, to obtain a cholesterol recognition/interaction amino acid sequence and consensus similar to that of CB(2)R. Both mutated and wild-type receptors were transiently expressed in human neuronal SH-SY5Y cells, and their localization and functioning were investigated using biochemical assays and immunofluorescence labelling. (unboundmedicine.com)
  • Each has a specific amino acid sequence that allows it to bind to receptors on particular types of cells. (cosmosmagazine.com)
  • Nucleotide sequence analysis of five representative isolates confirmed that all isolates possessed one type of amino acid motif (R-S-S-R/GL) at cleavage site of HA, Deduced amino acid sequences showed the presence of L226 (234 in H9 numbering) in all five Iranian isolates which indicates a preference to binding of α (2-6) sialic acid receptors. (scialert.net)
  • Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
  • Two recently published human COMT cDNA sequences differed in the position of S-COMT amino acid 108, the residue being either Val-108 [Lundstrom et al. (lu.se)
  • Synthetic antisense DNAs are used to hybridize to complementary sequences in target RNAs or DNAs to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
  • The article described how Pumby modules can be "concatenated in chains of varying composition and length to bind desired target RNAs. (genengnews.com)
  • Using a two-color assay to simultaneously monitor poly(A) tail removal from different RNAs, we demonstrate that Puf3 can distinguish between RNAs of very similar sequence. (elifesciences.org)
  • All models were trained, tested, and evaluated on 145 SAM binding protein chains where no two chains have more than 40\% sequence similarity. (edu.in)
  • CBMs are classified into numerous families, based on amino acid sequence similarity. (wikipedia.org)
  • How to Measure the Similarity Between Protein Ligand-binding Sites. (uni-marburg.de)
  • Efficient Similarity Retrieval for Protein Binding Sites based on Histogram Comparison. (uni-marburg.de)
  • Furthermore, there is no sequence similarity between MSP and any other known protein. (lu.se)
  • In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes (for example glycoside hydrolases). (wikipedia.org)
  • Molecular biologists describing DNA sequences or referring to one of the two strands of double- stranded DNA frequently use complementary pairs of terms, such as coding/ non- coding, sense/ nonsense or transcribing/ non- transcribing. (genomicglossaries.com)
  • We demonstrate that the precise molecular mechanisms and biological outcomes underlying the Taf14 interactions depend on the accessibility of binding interfaces, the ability to recognize other ligands, and a degree of sensitivity to temperature and chemical and osmotic stresses. (bvsalud.org)
  • Many putative CBMs have been identified by amino acid sequence alignments but only a few representatives have been shown experimentally to have a carbohydrate-binding function. (wikipedia.org)
  • The first two subtracks below - one for SwissProt, one for TrEMBL - show the alignments of protein sequences to the genome, all other tracks below are the protein annotations mapped through these alignments to the genome. (ucsc.edu)
  • Using the fluorogenic substrate succinyl-Ala-Ala-Ala-4-methylcoumaryl-7-amide (Suc-Ala-Ala-Ala-MCA), containing the sequence similar to the cleavage sites for proTGF-alpha processing, we identified a putative candidate proTGF-alpha-converting enzyme in the membrane fractions of Chinese hamster ovary (CHO) cells. (nih.gov)
  • In the cell-free reconstitution system, the membrane-bound Suc-Ala-Ala-Ala-MCA-hydrolyzing enzyme from CHO cells was also activated by phorbol ester in the presence of the soluble fraction, ATP, and vanadate. (nih.gov)
  • The MHC class I-related receptor, FcRn, is involved in binding and transporting immunoglobulin G (IgG) within and across cells. (nih.gov)
  • Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells. (unifi.it)
  • Isoform E lacks a mitochondrial targeting sequence and so is distributed to both cytosol and the nucleus when expressed in cultured cells. (nih.gov)
  • In contrast, avian flu viruses have sequences that bind primarily to bird cells. (cosmosmagazine.com)
  • We further demonstrate a new use of such RNA-binding proteins, measurement of RNA translation in living cells. (genengnews.com)
  • CRTH-2 binds Prostaglandin D2 and induces chemotaxis of these cells in allergic and inflammatory immune responses. (rndsystems.com)
  • After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
  • Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at sufficiently high levels in Escherichia coil and in baculovirus-infected insect cells to allow kinetic characterization of the enzyme forms. (lu.se)
  • These programs are utilized to screen entire libraries of molecules for a possible ligand of a binding site and to furthermore estimate in which conformation the ligand will most likely bind. (uni-marburg.de)
  • When both proteins find their target sequence, the GFP molecules join and become fluorescent-a signal to the researchers that the target RNA is present. (genengnews.com)
  • The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
  • In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. (nature.com)
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Mutagenesis sites and sequence variants. (ucsc.edu)
  • Carbohydrate-binding module family 6 (CBM6) is unusual in that it contains two substrate-binding sites, cleft A and cleft B. Cellvibrio mixtus endoglucanase 5A contains two CBM6 domains, the CBM6 domain at the C-terminus displays distinct ligand binding specificities in each of the substrate-binding clefts. (wikipedia.org)
  • In the present work, accelerated methods for the comparison of protein binding sites as well as an extended procedure for the assessment of ligand poses in protein binding sites are presented. (uni-marburg.de)
  • Methods for the assessment of ligand poses in protein binding sites are also used in the early phase of drug development within docking programs. (uni-marburg.de)
  • The Automatic Search for Ligand Binding Sites in Proteins of Known Three-dimensional Structure Using only Geometric Criteria. (uni-marburg.de)
  • Pocketome via Comprehensive Identification and Classification of Ligand Binding Envelopes. (uni-marburg.de)
  • A simple and fuzzy method to align and compare druggable ligand-binding sites. (uni-marburg.de)
  • The human GR is a modular protein composed of distinct regions illustrated in panel B in the image below, as follows: (1) The amino-terminal A/B region, also called immunogenic or N-terminal domain (NTD) and (2) the C, D, and E regions, which correspond to the DNA-binding domain, the hinge region, and the ligand-binding domain, respectively. (medscape.com)
  • Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is an intracellular pattern recognition receptor that recognizes bacterial peptidoglycan (PG) containing meso-diaminopimelic acid (mesoDAP) and activates the innate immune system. (amrita.edu)
  • Nucleotide sequences of the ALS gene from the rice cultivars were identical. (weedscience.com)
  • While the genomic sequence of DcAOX2a was previously described, we characterize here the complete genomic sequence of DcAOX1 . (frontiersin.org)
  • We delineated the genomes, receptor binding profile and HB sites of NA gene of these field isolates and we also established their phylogenetic relationship to the other Asian H9N2 lineages. (scialert.net)
  • Hybridization was confirmed using SSR markers, and introgression of the resistant ALS gene from CL rice to red rice was detected by ALS gene sequencing. (weedscience.com)
  • The ALS gene sequences of U.S. rice cultivars 'Bengal' and 'Cypress', SH red rice, CL rice (CL161), and imazethapyr-resistant red rice/CL rice hybrids were compared. (weedscience.com)
  • [ 2 ] The product of the WT1 gene has zinc finger arrays that bind to specific DNA sequences, whereas the amino terminus appears to regulate transcription. (medscape.com)
  • The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
  • Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
  • Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
  • Here, we investigate the association of Taf14 with the consensus sequence present in other subunits of these complexes and describe the mechanistic features that affect this association. (bvsalud.org)
  • Even protein sequences without a single curated annotation (splice isoforms) are visible in this track. (ucsc.edu)
  • Alternative isoforms are sequences that do not have annotations on them and are colored in light-blue. (ucsc.edu)
  • These homologous CBMs are distinct in their selectivity for binding amorphous and not crystalline cellulose. (wikipedia.org)
  • The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. (nih.gov)
  • The smaller polypeptide of M(r) ~73 kDa yielded an N-terminal amino-acid sequence that was homologous to laccase-like polyphenol oxidases (E.C. 1.10.3.2) from loblolly pine (Pinus taeda L.), poplar (Populus euramericana (Dode) Guinier) and Arabidopsis. (who.int)
  • The larger polypeptide (M(r) ~77 kDa) yielded an N-terminal amino-acid sequence that was homologous with a range of plant subtilisin-like serine proteinases. (who.int)
  • Two more EGF-like repeats interrupt the N-terminal and terminate the C-terminal sequences. (unifi.it)
  • Nidogen contains two consensus sequences for tyrosine sulfation and for asparagine beta-hydroxylation, two N-linked carbohydrate acceptor sites and, within one of the EGF-like repeats an Arg-Gly-Asp sequence. (unifi.it)
  • The details appeared online the week of April 25 in PNAS, in an article entitled, "A Programmable RNA Binding Protein Composed of Repeats of a Single Modular Unit. (genengnews.com)
  • Here, we identified in the transmembrane helix 7 of human CBRs a consensus sequence already known in other proteins as cholesterol recognition/interaction amino acid sequence and consensus pattern. (unboundmedicine.com)
  • Predicted to enable L-amino acid transmembrane transporter activity. (nih.gov)
  • Predicted to be involved in amino acid transmembrane transport and sodium ion transport. (nih.gov)
  • Result: This manuscript describes a method SAMbinder, developed for predicting SAM interacting residue in a protein from its primary sequence. (edu.in)
  • Terrestrial animals such as reptiles and mammals predominantly use DPHK sequences in both IRF3 and 7. (cdc.gov)
  • Here, we demonstrate that βSyn and γSyn have a reduced affinity towards membranes compared to αSyn, and that direct interaction of βSyn or γSyn with αSyn results in reduced membrane binding of αSyn. (biorxiv.org)
  • Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. (nih.gov)
  • It was also evident that the VH/Vkappa pairing was not promiscuous, since antibody fragments selected by phage display retained light chain sequences very similar to the original hybridoma-derived light chain, proving that a high affinity interaction was very dependent on a co-operativity between both variable domains. (lu.se)
  • The hemadsorbing site of neuraminidase had up to 3 amino acid substitutions and is different from those of earlier Iranian viruses. (scialert.net)
  • Even though the function of MSP is not known it has been found that it binds very strongly to CRISP-3, another protein with an unknown function. (lu.se)
  • Weak sequence homologies (25%) were detected between some regions of nidogen, the LDL receptor, thyroglobulin and the EGF precursor. (unifi.it)
  • We find that the fission yeast homologues of Tristetraprolin/TTP and Pumilio/Puf (Zfs1 and Puf3) interact with Ccr4-Not via multiple regions within low-complexity sequences, suggestive of a multipartite interface that extends beyond previously defined interactions. (elifesciences.org)
  • For example, human FcRn does not bind to mouse IgG1 or IgG2a and interacts only weakly with mouse IgG2b. (nih.gov)
  • Human influenza viruses, for instance, have so far all been found to have hemagglutanin sequences H1, H2 and H3. (cosmosmagazine.com)
  • Some avian H9 viruses have acquired receptor binding characteristics typical of human strains, increasing the potential for reassortment in both human and pig respiratory tracts ( Suzuki, 2005 ). (scialert.net)
  • The tree-dimensional structure of human and porcine MSP are very similar in spite of only a 50 % identity in the amino acid sequences of the two proteins. (lu.se)
  • We show here that the reactivity of a high affinity, virus-neutralizing human antibody against the AD-2 epitope of cytomegalovirus gB can be modified by introducing other Vkappa sequences together with the original VH sequence. (lu.se)
  • The use of tight-binding inhibitors such as entacapone enabled the estimation of actual enzyme concentrations and, thereby, comparison of velocity parameters, substrate selectivity, and regioselectivity of the methylation of both enzyme forms. (lu.se)
  • Here, we demonstrate that the triple PHD finger cassette of MLL4, harboring its fourth, fifth and sixth PHD fingers (MLL4PHD456) forms an integrated module, maintains the binding selectivity of the PHD6 finger toward acetylated lysine 16 of histone H4 (H4K16ac), and is capable of binding to DNA. (bvsalud.org)
  • In anaerobic bacteria that degrade plant cell walls, exemplified by Clostridium thermocellum, the dockerin domains of the catalytic polypeptides can bind equally well to any cohesin from the same organism. (wikipedia.org)
  • Two polypeptides that could have been responsible for the bound oxidase activity were enriched by this procedure. (who.int)
  • The mRNAs can carry short sequences of genetic letters that can trigger their own destruction. (elifesciences.org)
  • CBMs of microbial glycoside hydrolases play a central role in the recycling of photosynthetically fixed carbon through their binding to specific plant structural polysaccharides. (wikipedia.org)
  • RNP-CS proteins display binding preferences for specific RNA sequences, and several have been shown to interact with pre-mRNA sequences important for pre-mRNA processing. (the-scientist.com)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • It phosphorylates a specific sequence on protein targets. (news-medical.net)
  • The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. (nih.gov)
  • Oligonucleotide which displays specific binding to a protein or other target, often selected by an iterative cycle of affinity- based enrichment. (genomicglossaries.com)
  • [2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
  • The variation in this preference along the length of nucleosomal DNA and the intrinsic sequence-dependent bendability of DNA implies that strong translational settings can also occur. (nature.com)
  • There is a need to develop a method for predicting SAM binding sites in a protein for designing drugs against SAM associated disease. (edu.in)
  • Binding sites for laminin and collagen IV are present on the C-terminal globule but not yet precisely localized. (unifi.it)
  • The lackof uniformity between multiple histone/DNA-binding sites causesthe DNA to deviate from ideal superhelix geometry. (nature.com)
  • Binding sites of other proteins which are similar to the binding site of the target protein can offer hints for possible side effects of a new drug prior to clinical studies. (uni-marburg.de)
  • These findings show that phage display technology might modify the binding properties of pre-existing, high affinity antibodies. (lu.se)
  • Analysis of binding kinetics reveals that this is primarily due to differences in dissociation rate constants. (elifesciences.org)
  • Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. (nature.com)
  • Hoping to make the assembly of RNA-binding proteins less of a trial-and-error and more programmable task, the MIT researchers tested many amino acid combinations. (genengnews.com)
  • The majority of these domains have carbohydrate-binding activity. (wikipedia.org)
  • CBMs were previously known as cellulose-binding domains. (wikipedia.org)
  • Carbohydrate-binding module family 4 (CBM4) includes the two cellulose-binding domains, CBD(N1) and CBD(N2), arranged in tandem at the N terminus of the 1,4-beta-glucanase, CenC, from Cellulomonas fimi. (wikipedia.org)
  • but in anaerobic fungi they are protein binding domains, referred to as dockerin domains. (wikipedia.org)
  • however, not all C2 domains bind calcium. (bvsalud.org)
  • Here we show that BIRC2 accumulates in the nucleus via binding of its second and third BIR domains, BIRC2BIR2 and BIRC2BIR3, to the histone H3 tail and report the structure of the BIRC2BIR3-H3 complex. (bvsalud.org)
  • This changes its conformation, revealing the ATP binding site and enabling enzymatic activity. (news-medical.net)
  • To the best of our knowledge, there is no method that can predict the binding site of SAM in a given protein sequence. (edu.in)
  • a small section of the protein sequence, resulting in an abnormal protein. (medlineplus.gov)
  • For example, the fungal enzymes contain one, two or three copies of the dockerin sequence in tandem within the catalytic polypeptide. (wikipedia.org)
  • The catalytic subunit (p125) harbours the polymerase and exonuclease activities, and a metal-binding C-terminal domain (CTD). (nature.com)
  • This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)