Trovafloxacin mesylate differs from other quinolone derivatives by having a 1,8-naphthyridine nucleus. (nih.gov)
Four 1,8-naphthyridine derivatives (1a-1d) with different organelle targeting abilities were obtained using the Knoevenagel condensation reaction of 1,8-naphthyridine with 4-(N,N-diethylamino)benzaldehyde (2a), 4-(N,N-diphenylamino)benzaldehyde (2b), 4-(piperazin-1-yl)benzaldehyde (2c) and 4-(ethyl(4-formylphenyl)amino)-N-(2-((4-methylphenyl)sulfonamido)ethyl)butanamide (2d), respectively. (bvsalud.org)
4. Synthesis and antitumor evaluation of novel derivatives of 6-amino-2-phenylbenzothiazoles. (nih.gov)
There are many kinds of 1,8-naphthyridine derivatives, and they are widely used. (chemenu.com)
2006. 4-Amino derivatives of the Hsp90 inhibitor CCT018159 . (ub.edu)
Synthesis and Characterization of Naphtho Fused [1,8]Naphthyridine Derivatives. (ajrconline.org)
Ethyl1
ITH12246 (ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8] naphthyridine-3-carboxylate) is a 1,8-naphthyridine described to feature an interesting neuroprotective profile in in vitro models of Alzheimer's disease. (uaeu.ac.ae)
Acid5
Title: Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. (aablocks.com)
Chemically, trovafloxacin mesylate, a fluoronaphthyridone related to the fluoroquinolone antibacterials, is (1α, 5α, 6α)-7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, monomethanesulfonate. (nih.gov)
Specifically, probes 1a-d were obtained by introducing four amines (6-amino-2H-chromen-2-one, N-(2-aminoethyl)-4-methylbenzenesulfonamide, dodecan-1-amine and N,N diphenylbenzene-1,4-diamine) into the indole hemicyanine dye of the carboxylic acid with a D-π-A structure. (bvsalud.org)
Replacing 32 proline residues by a noncanonical amino acid results in a highly active DNA polymerase. (neb.com)
1. Antitumor efficiency of novel fluoro-substituted 6-amino-2-phenylbenzothiazole hydrochloride salts in vitro and in vivo. (nih.gov)
Synthesis3
6. Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. (nih.gov)
13. Substituted 6-amino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-ones: synthesis, structure-activity relationships, and cytotoxic activity on selected human cancer cell lines. (nih.gov)
2014. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies . (ub.edu)
Acids1
PMID- 5157697 TI - [Free amino acids in plasma in kwashiorkor]. (nih.gov)
Selective1
Selective recognition of unnatural imidazopyridopyrimidine:naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment. (neb.com)
Reaction1
Reaction of 2-amino-7-chloro-1,8-naphthyridine with phthalic anhydride leads to the corresponding phthalimide. (wikipedia.org)
PMID1
PMID- 5157720 TI - 1-Hydroxy-3-amino-pyrrolidone-2(HA-966): a new GABA-like compound, with potential use in extrapyramidal diseases. (nih.gov)
Chemical1
Naphthyridine is a class of aromatic heterocyclic compounds whose chemical formula is C8H6N2. (chemenu.com)