Amino lipid transfer proteins. Medical search. Frequent questions

During sulfur starvation, genes involved in nitrogen metabolism, such as amino acid and nucleic acid metabolic pathways, along with genes encoding proteases and nucleases that are necessary for scavenging nitrogen, were activated. (escholarship.org)
The anaerobic decomposition of plant and animal polymers including polysaccharides, proteins, nucleic acids and lipids to CO 2 , H 2 O and methane requires syntrophic metabolism as an essential step. (ucla.edu)
Produced by a variety of cell types, extracellular vesicles (EVs) are able to transfer lipids, nucleic acids and proteins to recipient cells. (nature.com)
A series of studies have revealed that exosomes-mediated intercellular transfer of proteins, nucleic acids, and metabolites plays a crucial role in the initiation and progression of HCC, hypoxia and angiogenesis, chemotherapy sensitivity, and cell death mode and regulates the immune microenvironment. (hindawi.com)
Regardless of the type or the physiological or pathological state of the originating cell, exosomes share common features as enriched with nucleic acids, lipids, and proteins [ 4 ]. (hindawi.com)
The four main classes of organic compounds (carbohydrates, lipids, proteins, and nucleic acids) that are essential to the proper functioning of all living things are known as polymers or macromolecules. (baahkast.com)
Nucleic acids: Stores and transfers info. (baahkast.com)
Proteins, carbohydrates, nucleic acids, and lipids are the four major classes of biological macromolecules-large molecules necessary for life that are built from smaller organic molecules. (baahkast.com)
Carbohydrates, nucleic acids, and proteins are often found as long polymers in nature. (baahkast.com)
Macromolecules - proteins, nucleic acids, and polysaccharides - are formed by the polymerization of hundreds of their low-molecular-weight precursors - amino acids, nucleotides, and simple sugars. (baahkast.com)

The remainder could be made available by a decrease in female activity that would free protein from metabolism for reproduction. (gla.ac.uk)
Translation of RNA: The Genetic Code and Protein Metabolism. (netlify.app)
Metabolism of Fatty Acids and Lipids. (netlify.app)
Metabolism of Amino Acids and Other Nitrogenous Compounds. (netlify.app)
Along with genes involved in sulfur metabolism, this transcription factor regulated a number of uncharacterized transporter genes and genes involved in mitochondrial electron transfer. (escholarship.org)
There were abundance differences in proteins associated with stress, photosynthesis, carbohydrate and lipid metabolism proteins. (biomedcentral.com)
Overall, in this study we have identified markers, putative candidate genes and predicted putative interacting protein partners significantly associated with iron and zinc metabolism that could be utilized in future breeding studies of lentil for nutrient biofortification. (bvsalud.org)
Metabolism of carbohydrates, lipids, amino acids nucleotides and vitamins. (syllabusguru.com)
This battery of measurements are used in the diagnosis and treatment of certain liver, heart, and kidney diseases, acid-base imbalance in the respiratory and metabolic systems, other diseases involving lipid metabolism and various endocrine disorders as well as other metabolic or nutritional disorders. (cdc.gov)
Hooper AJ, van Bockxmeer FM, Burnett JR. Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism. (medlineplus.gov)
Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism. (medlineplus.gov)

Research expertise in the group includes amino acid and peptide synthesis, liposome technology and techniques for studying biological membranes, including surface tensiometry, calorimetry, x-ray scattering, optical microscopy and mass spectrometry. (dur.ac.uk)
Current work is directed towards the study of protein-membrane interactions over all timescales and the preparation of asymmetric lipid membranes for biophysical studies of membrane activity (funded by an EPSRC programme grant). (dur.ac.uk)
Work encompasses the design of peptides that have the potential to form stable pores in lipid membranes, the characterisation of peptide interactions with membrane lipids and the physical organic chemistry of peptide reactions in membranes. (dur.ac.uk)
The behaviour of membrane proteins in membranes is being examined using a range of analytical approaches. (dur.ac.uk)
Current work is examining the chemistry exhibited by drug molecules after their adsorbtion to lipid membranes. (dur.ac.uk)
Association of EcPOX to the lipid bilayer is conferred by the last 23 amino acids of the C-terminal part which form an amphipathic helix in the presence of membranes. (uni-goettingen.de)
Lipid peroxidation is a major cause of secondary nerve damage because the phospholipid membranes of neurons become oxidized and rupture ( Kavanagh & Kam 2001 ). (scireproject.com)
The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. (unl.edu)
The ABC superfamily of genes encodes proteins that transport a number of substrates across cell membranes. (medscape.com)

Recent work has begun to establish the factors that control the innate reactivity of peptides towards acyl transfer from membrane lipids (intrinsic lipidation). (dur.ac.uk)
Amino Acids, Peptides, and Proteins. (netlify.app)

Sulfur is an important nutrient source found in a number of biological macromolecules, including proteins and lipids. (escholarship.org)
Lipids are not usually polymers and are smaller than the other three, so they are not considered macromolecules by some sources 1,2start superscript, 1, comma, 2, end superscript. (baahkast.com)

Particular interests include the kinetics of peptide rearrangements following membrane binding 1 and the chemical stability of peptide-lipid systems. (dur.ac.uk)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
1995), the molecular mechanism and the peptide group, suggesting that urea-peptide inter- whereby urea unfolds proteins has not been established. (lu.se)
Solvent denaturation is a result of altered protein-solvent vorably with water-peptide interactions. (lu.se)

A particular challenge is the synthesis of oligosaccharyltransferases (OSTs), which catalyze the attachment of glycans to specific amino acid residues in target proteins. (biorxiv.org)
Here, we address this challenge by establishing a bacterial cell-free protein synthesis platform that enables rapid production of a variety of OSTs in their active conformations. (biorxiv.org)
Current work centres around the synthesis and exploitation of labelled lipids and sterols. (dur.ac.uk)
Sulphur is essential in forming plant protein as it is present in cysteine and methionine, two vital amino acids involved in protein synthesis. (dickiedirect.co.nz)
Key component of coenzymes and vitamins, involved in energy transfer and lipid synthesis. (dickiedirect.co.nz)
Required for storage lipid synthesis. (ymdb.ca)

The cavity was free of any visible electron density for lipid molecules at room temperature, suggesting that only dynamic interactions exist with the protein. (rcsb.org)
All the venomous species have a venom gland that synthesizes, stores and secretes a complex mixture of biological molecules including proteins. (nature.com)
This protein helps produce beta-lipoproteins, which are molecules that are made up of proteins (including one called apolipoprotein B), cholesterol, and particular types of fats called phospholipids and triglycerides. (medlineplus.gov)

EcPOX was used as well-suited model system to analyze the impact of multiple amino acids on an enzymes activation mechanism and eventual bilayer association. (uni-goettingen.de)
The influx of calcium activates a series of destructive enzymes, including phospholipases that go on to damage the phospholipid cell membrane and proteases thereby destroying proteins. (scireproject.com)
Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. (unl.edu)
The extruded lipids are arranged into lamellae in the intercellular space with the help of concomitantly released hydrolytic enzymes. (medscape.com)
Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)

Binding to the lipid bilayer is not only mandatory for feeding the reducing equivalents into the electron transport chain, but also leads to enhancement of the catalytic activity of the enzyme. (uni-goettingen.de)
And thanks to the lipid bilayer structure of exosomes, cargos contained in them are not easily degraded so as to convey cargos stably [ 7 - 9 ]. (hindawi.com)
A) lipids can move and diffuse laterally through the bilayer. (flashcardmachine.com)
B) proteins can span the bilayer. (flashcardmachine.com)
C) some lipids can rotate within the bilayer. (flashcardmachine.com)

The intact n-terminus was verified by Edman-degradation verifying the first 6 amino acid residues. (biomedcentral.com)
The isoforms, which contain 299 residues, differ only by single-amino acid changes, but of the three, only ApoE4 is a risk factor for Alzheimer's disease. (wustl.edu)

Nutritional components of PWC16 such as proximates, amino acids and fatty acids were compared with unmodified rice counterparts. (canada.ca)
To address this, we use an integrated set of omics tools coupled with new informatics approaches to identify and characterize core metabolic pathways in model syntrophic communities when growing on unstudied or poorly studied classes of substrates ( i.e. , amino acids, carboxylates, and long chain fatty acids). (ucla.edu)

Lipid II is a membrane-anchored cell-wall precursor that is essential for bacterial cell-wall biosynthesis. (ecmdb.ca)

Chlorophyll is responsible for photosynthesis, where sunlight is absorbed and stored in the plant as sugars and proteins. (dickiedirect.co.nz)

In-silico characterization revealed LoRGA6 loci code for 912 amino acids long polypeptide with a TIR motif at the N terminal and eight LRR motifs at the C terminal. (bvsalud.org)
LIPG spans 10 exons and 9 introns and encodes a polypeptide of 500 amino acids. (biomedcentral.com)

It is also part of the StarD4 subfamily of START domain proteins, sharing 34% sequence identity with STARD4. (wikipedia.org)
It is thought to be related in amino acid sequence to segments of apolipoprotein B and the microsomal transfer protein responsible for the assembly of low-density lipoproteins. (rcsb.org)
N-terminal amino acid sequence analysis of the purified DPP IV revealed that the N-terminus is not processed. (nature.com)
Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)

Cor a 8 was purified from raw hazelnut extract, displaying the physicochemical properties of a member of the nsLTP protein family, such as high resistance against enzymatic degradation. (biomedcentral.com)

Microalgae can divert cellular resources towards lipid accumulation under conditions of stress, and identifying the molecular trigger for this response could aid in engineering improved lipid productivity, a precursor for biofuel production. (biomedcentral.com)
A large proportion of the protein content of yolk is derived from vitellogenin, which is a precursor to lipoproteins and phosphoproteins. (thepoultryhub.com)
Lipovitellin is another essential precursor of proteins in egg yolk. (thepoultryhub.com)

The protein (allergen) that causes this kind of allergy is tough and the allergenicity survives in processed foods such as purees, nectars and juices. (manchester.ac.uk)
This allergen is called lipid transfer protein (LTP), but is also referred to as Mal d 3. (manchester.ac.uk)

StAR-related lipid transfer protein 5 is a protein that in humans is encoded by the STARD5 gene. (wikipedia.org)
BASF has provided data on the identity of rice line PWC16, a detailed description of the modification method and breeding history, information on the modified gene, the resulting protein and its mode of action and the stability of trait expression. (canada.ca)
For zinc content, a highly significant SNP was detected in a gene encoding UPF0678 fatty acid-binding protein. (bvsalud.org)
The gene encoding ArsR/methyltransferase fusion protein, arsR M , was amplified and expressed in Escherichia coli BL21 (DE3), and this strain showed resistance to arsenic in the present of 0.25-6 mM As(III), aresenate, or pentavalent roxarsone. (biomedcentral.com)
The term "vitellogenin" refers to both the gene and the expressed protein. (thepoultryhub.com)
CF27 exhibits a large number of genomic islands (mostly containing genes of unknown function), suggesting that a large number of genes has been acquired by horizontal gene transfer over time. (frontiersin.org)
The underlying genetic abnormality in harlequin ichthyosis is a mutation in the lipid-transporter gene ABCA12 on chromosome 2. (medscape.com)
In vitro studies have demonstrated normalization of lipid transport when the wild-type ABCA12 gene is transferred to keratinocytes of patients with harlequin ichthyosis. (medscape.com)
The MTTP gene provides instructions for making a protein called microsomal triglyceride transfer protein. (medlineplus.gov)
Most MTTP gene mutations lead to the production of microsomal triglyceride transfer protein with reduced or absent function, preventing the formation of beta-lipoproteins. (medlineplus.gov)
Gunduz M, Ozaydin E, Atar MB, Koc N, Kirsaclioglu C, Kose G, Cefalu AB, Averna M, Tarugi P. Microsomal triglyceride transfer protein gene mutations in Turkish children: A novel mutation and clinical follow up. (medlineplus.gov)

STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5. (wikipedia.org)

[ 6 ] ABCA12 encodes a transmembrane protein that mediates lipid transport. (medscape.com)

Phosphoinositide phosphatases play an essential but as yet not well-understood role in lipid-based signal transduction. (embl.de)

The effect of 100 mM NaCl salt stress on lipid content in wild-type CC124 C. reinhardtii has revealed a 50-fold increase from approximately 0.1 µg TAG 10 -6 cells to approximately 5 µg TAG 10 -6 cells [ 9 ], to reach similar levels to those found for this strain under nitrogen deprivation. (biomedcentral.com)
Nitrogen is a primary component of amino acids which are the building blocks of proteins. (dickiedirect.co.nz)
Thus, by adding nitrogen to soil the protein content in plants is increased. (dickiedirect.co.nz)
the nitrogen of the amino group is in a ring. (flashcardmachine.com)

The apolipoprotein E family consists of three major protein isoforms: apolipoprotein E4 (ApoE4), ApoE3, and ApoE2. (wustl.edu)

After analysis of deduced amino acid sequences from cloned cDNAs of dipeptidyl peptidase IV (DPP IV) and aminopeptidase A (APA), it was noticed that DPP IV and APA are type II membrane proteins that have one transmembrane domain near the N-terminus. (nature.com)
These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. (unl.edu)

Egg yolks are mainly made up of fat- and water-soluble vitamins and minerals, while egg white contains more protein. (thepoultryhub.com)

The protein is a 213 amino acids long, consisting almost entirely of a StAR-related transfer (START) domain. (wikipedia.org)

The flavin redox state is also sensed by specific amino acids. (uni-goettingen.de)

At micromolar concentrations, lipid-free ApoE exists predominantly as tetramers. (wustl.edu)

Brewster angle microscopy has been used to characterise the association of peripheral membrane proteins with lipid monolayers (with Dr A Beeby, Durham University). (dur.ac.uk)

Post-translational modifications to aquaporin-0 are being examined by mass spectrometry and reveal a diverse lipidation profile at each of the two lipidation sites of the protein (with Prof. R. A. Quinlan, Biological Sciences, Durham University). (dur.ac.uk)
The membrane-binding properties of proteins from enveloped viruses are being characterised by a combination of microscopy, chemical biology and structral biology approaches (with Dr R. P. Yeo, Biological Sciences, Durham University). (dur.ac.uk)
Protein Architecture and Biological Function. (netlify.app)
Lipids: Structure and Biological Function. (netlify.app)

A wheat lipid transfer protein 3 could enhance the basal thermotolerance and oxidative stress resistance of Arabidopsis. (uni-bielefeld.de)
The thiamine- and flavin-dependent peripheral membrane protein pyruvate oxidase from E. coli (EcPOX) catalyzes the oxidative decarboxylation of the central metabolite pyruvate to CO2 and acetate with a concomitant electron transfer step to ubiquinone 8 (Q8), a membrane-bound mobile carrier of the respiratory chain. (uni-goettingen.de)

Also targeted for study are their associated oxidation reduction reactions, electron transfer pathways, modes of energy conservation and other essential cell functions. (ucla.edu)
This ABCA12 -mediated lipid-transfer system is essential to the transfer of lipids from the cytosol of the corneocyte into lamellar granules. (medscape.com)

This study shows that proteins can be secreted and confined in snake venom extracellular vesicles (SVEVs) presenting a size distribution between 50 nm and 500 nm. (nature.com)
Normal extrusion of lipid from these granules into the extracellular space cannot occur, and lipid lamellae are not formed. (medscape.com)

Protein glycosylation, or the attachment of sugar moieties (glycans) to proteins, is important for protein stability, activity, and immunogenicity. (biorxiv.org)
Stability of the protein was investigated by simulated gastric and duodenal digestion assays. (biomedcentral.com)
A fundamental understanding of protein stability and the mechanism of denaturant action must ultimately rest on detailed knowledge about the structure, solvation, and energetics of the denatured state. (lu.se)

So far, 10 hazelnut allergens were identified, among those the ns lipid transfer protein, Cor a 8. (biomedcentral.com)
Hazelnut lipids were extracted employing the hexane method. (biomedcentral.com)
Upon addition of hazelnut lipids this response was remarkably increased. (biomedcentral.com)
In cellular assays the allergenic activity of Cor a 8 was considerably increased when adding hazelnut lipids, thus showing the impact of food matrix on the allergenicity of a single food protein. (biomedcentral.com)

Using fluorescence correlation spectroscopy (FCS), intermolecular fluorescence resonance energy transfer (FRET), and sedimentation methods, we found that the association-dissociation reaction of ApoE can be modeled with a monomer-dimer-tetramer process. (wustl.edu)

T (rs2000813) polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. (biomedcentral.com)
Serum lipid parameters were also correlated with several environmental factors in the both ethnic groups. (biomedcentral.com)

Serine-to-alanine mutation at position 53 of the Kv7.5 amino terminus abrogated its ability to confer forskolin sensitivity to Kv7.4. (aspetjournals.org)
this mutation replaces the protein building block (amino acid) glycine with a premature stop signal at position 865 (written as Gly865Ter or G865X) in the instructions used to make the microsomal triglyceride transfer protein. (medlineplus.gov)

STARD5 binds both cholesterol and 25-hydroxycholesterol and appears to function to redistribute cholesterol to the endoplasmic reticulum with which the protein associates and/or the plasma membrane. (wikipedia.org)

The aims of this study were to measure the relative contributions of exogenous and endogenous nutrients to the formation of eggs by captive female Zebra Finches and to investigate the transfer of material from the body reserves to the developing eggs. (gla.ac.uk)

Specifically, by using lipid nanodiscs as cellular membrane mimics, we obtained yields of up to 440 µg/mL for the single-subunit OST enzyme, 'Protein glycosylation B' (PglB) from Campylobacter jejuni , as well as for three additional PglB homologs from Campylobacter coli, Campylobacter lari , and Desulfovibrio gigas . (biorxiv.org)

Soil Virus Offers Insight into Maintaining Microorganisms Through a collaborative effort, researchers have identified a protein in soil viruses that may promote soil health. (doe.gov)

These differences in protein abundance have given greater understanding of the mechanism by which salt stress promotes fatty acid accumulation in the un-sequenced microalga C. nivalis as it switches to a non-growth state, whereas C. reinhardtii does not have this response. (biomedcentral.com)
In general, the amine hormones are synthesized from the amino acid tyrosine, and stored before their release, although the storage mechanism varies depending on the type of the hormone. (supportgroupsfornurses.org)

High salinity is an overlooked stressor for lipid accumulation, largely due to the relatively low number of microalgae that have been identified to respond in this manner. (biomedcentral.com)
The initial spinal cord trauma and subsequent ischemia produce an accumulation of glutamate around the injury site ( Amar & Levy 1999 ). (scireproject.com)
Spatial lipidomics revealed an accumulation of highly unsaturated and shortened lipids and reduction of sphingolipids throughout the brains of cPSAP DAT mice. (nature.com)

At the cellular level, we have limited understanding of central metabolic pathways, electron transfer reactions and physiological interactions that occur among syntrophic partners. (ucla.edu)

Once the provirus is integrated into the host cell DNA, it is transcribed using typical cellular mechanisms to produce viral proteins and genetic material. (msdmanuals.com)

We have used host-guest chemistry 5 to test the hypothesis that aromatic amino acids have thermodynamically significant interactions with the headgroups of neutral lipids such as phosphatidylcholines. (dur.ac.uk)

Functional prediction analyses suggested that ArsR M is a difunctional protein with transcriptional regulation and methyltransferase activities. (biomedcentral.com)
SVEVs isolated from lyophilized venoms collected from four different species of snakes ( Agkistrodon contortrix contortrix , Crotalus atrox , Crotalus viridis and Crotalus cerberus oreganus ) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMPs, serine proteinases, PLA 2 , LAAO, 5′nucleotidase, C-type lectin, CRISP and Disintegrin. (nature.com)

Lipovitellin contains a heterogeneous mixture of about 16% (w/w) noncovalently bound lipid, mostly phospholipid. (rcsb.org)

Previous X-ray structural studies at ambient temperature described several different protein domains including a large cavity in each subunit of the dimeric protein. (rcsb.org)
Lipid II consists of one GlcNAc-MurNAc-pentapeptide subunit linked to a polyiosoprenoid anchor 11 subunits long via a pyrophosphate linker. (ecmdb.ca)

LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. (unl.edu)

[ 3 ] The B fragment binds to a receptor on the surface of the susceptible host cell, which proteolytically cleaves the membrane lipid layer enabling segment A to enter. (medscape.com)

Vitamin E supplementation improves lipid profile, decreases insulin and HOMA-IR levels. (tocotrienolresearch.org)

CYS-3 also directly regulated the expression of genes involved in mitochondrial electron transfer. (escholarship.org)

1991. Bioconcentration factors and lipid solubility. (cdc.gov)

Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. (unl.edu)

The conformations of the bound lipid and the interactions between protein and lipid provide insights into the factors governing lipoprotein formation. (rcsb.org)
This membrane anchor is attached to the protein surface by hydrophobic interactions with the protein core. (uni-goettingen.de)
MRD is among the few methods that can provide molecular-level informa- tion about protein solvation in native as well as denatured states, and it is used here to simultaneously monitor the interactions of urea and water with the unfolding protein. (lu.se)
1 nsec) interactions of urea and water with the native and denatured protein. (lu.se)
If this is the case, interactions, but it is not clear whether denaturants like urea then solvent denaturation can be driven simply by the ex- act directly by binding to the protein surface or indirectly by posure of more binding sites in the denatured protein perturbing solvent-mediated hydrophobic interactions or by (Schellman 1987). (lu.se)

Anatomy24

Organisms21

Diseases9

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology1

Phenomena and Processes52

Technology, Industry, Agriculture9

Information Science4

Health Care3

Nucleic10

Metabolism11

Membranes10

Peptides2

Macromolecules2

Peptide4

Synthesis6

Molecules3

Enzymes6

Bilayer5

Residues2

Fatty acids2

Biosynthesis1

Photosynthesis1

Polypeptide2

Sequence4

Degradation1

Precursor3

Allergen2

Gene11

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Nitrogen4

Apolipoprotein1

Transmembrane2

Vitamins1

Acids long1

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Concentrations1

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Biological4

Oxidative2

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Hazelnut4

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19911

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Interactions5