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  • mutations
  • The two sequences differ by 11 mutations and share 22% and 24% sequence identity with the wild-type protein. (caltech.edu)
  • Finally, we show that HO expression is reduced in yeast strains containing grf10 null mutations and that full expression of a heterologous promoter containing a SWI5-dependent HO upstream activation sequence element requires GRF10. (pnas.org)
  • homeobox sequences
  • Furthermore, comparative distance analyses of homeobox sequences reveal a correlation between gene divergence rate and species radiation success with insects showing the highest rate of homeobox sequence evolution. (nih.gov)
  • In these analyses (Neighbor-Joining, NJ) with published homeobox sequences the new homeobox sequences for lab, pb, Dfd, Ubx, abd-A, Abd-B group into the expected clades. (nih.gov)
  • A Neighbour Joining analysis of only the six potentially unambiguous new homeobox sequences (lab, pb, Dfd, Ubx, Abd-B) groups all new fragments into the expected clades of homologs from other insects and thus confirms the results of NCBI Blast (Fig. 2), except for abd-A which appears paraphyletic. (nih.gov)
  • Based on the partial homeobox sequences we cannot unambiguously distinguish between Scr and Antp homeobox fragments in Diplura, Archaeognatha, Ephemeroptera, Odonata, Plecoptera and Dermaptera. (nih.gov)
  • species
  • This study first sequenced the ten blowfly species other than C. vicina and L. sericata . (hindawi.com)
  • Based on the bcd sequences of these 12 blowfly species, a phylogenetic tree was constructed that discriminates the subfamilies of Calliphoridae (Luciliinae, Chrysomyinae, and Calliphorinae) and most blowfly species. (hindawi.com)
  • These gene sequences are important in the evolution of insect developmental biology and are potentially useful for identifying insect species in forensic science. (hindawi.com)
  • transcriptional
  • The highly conserved homeodomain sequence in evolution and the restricted expression in the heart suggest that CSX1 plays an important role in the development and differentiation of the human heart and that there may be two different mechanisms in transcriptional regulation by the CSX1 protein, homeodomain-dependent and -independent mechanisms. (ahajournals.org)
  • δEF1/ZFH-1 Zn-finger-homeodomain proteins are distinguished by two arrays of highly similar C2H2-type Zn-finger domains and a centrally located homeodomain, and can act as transcriptional repressors through recruitment of the corepressor C-terminal binding protein (CtBP). (biologists.org)
  • This region includes the Pdx1 homeobox gene, a transcriptional activator of insulin , which has undergone massive sequence change, likely contributing to diabetes and adaptation to low caloric intake. (pnas.org)
  • differentiation
  • Accumulating evidence has suggested that homeodomain-containing proteins play critical roles in regulating the tissue-specific gene expression essential for tissue differentiation and in determining the temporal and spatial patterns of development. (ahajournals.org)
  • genome sequence
  • We thank Nik Putnam, Dan Rokshar, and other members of the amphioxus team at the Joint Genome Institute, Walnut Creek, California, for their very considerable efforts in determining the B. floridae genome sequence and making it available to the research community, and Linda Holland, Nori Satoh and Jeremy Gibson-Brown for important contributions to promotion and coordination of the project. (springer.com)
  • analysis
  • Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). (nih.gov)
  • A single putative OTP gene product was found in 17-week human fetal brain tissue by Western blot analysis using a novel polyclonal antibody raised against a conserved 13-amino-acid sequence at the C-terminus of the OTP protein. (nih.gov)
  • Even their full length homeodomain sequences do not allow an unambiguous assignment in a standard distance analysis (Fig. S1). (nih.gov)
  • vertebrates
  • Therefore, to understand the early evolutionary history of the vertebrates, we need to reveal the evolutionary sequence of the emergence of these novel structures. (ijbs.com)
  • binds
  • The homeodomain-containing protein encoded by CSX1a binds to Csx/Nkx-2.5 binding sequences and transactivates the sequence-containing luciferase reporter gene. (ahajournals.org)
  • A nuclear protein was found that binds to a novel trinucleotide repeat sequence in the 5'-upstream region of a rat brain voltage-sensitive calcium channel a1 subunit that activates an enhancerless chloramphenicol acetyltransferase reporter gene. (nih.gov)
  • novel
  • In regard to these results and our previous finding that ∼200 homeodomain proteins contain eIF4E binding sites, we propose that homeodomain modulation of eIF4E activity is a novel means through which this family of proteins implements their effects on growth and development. (asm.org)
  • evolution
  • Gene family support nodes are shown, except in cases where these are not recovered as monophyletic (Hox families, NK2, NK4, and Vent) due to uneven rates of sequence evolution and complex histories. (springer.com)