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  • serine
  • The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a conserved serine residue on the ACP by the action of holo-acyl carrier protein synthase (ACPS), a 4'-phosphopantetheinyl transferase. (wikipedia.org)
  • The release of the product from the carrier protein is achieved through acylation of the active site serine of TE in which the decapeptide is transferred from the thiol ether to the serine residue. (wikipedia.org)
  • binds
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • There are 2 main steps involved: the protein binds to a non-specific site on the DNA and then it diffuses along the DNA chain until it locates a target site, a process referred to as sliding. (wikipedia.org)
  • peptides
  • Polypeptide toxins and many antibacterial peptides, such as colicins or hemolysins, and certain proteins involved in apoptosis, are sometimes considered a separate category. (wikipedia.org)
  • permease
  • The most recent families added include the PAAP (Putative Amino Acid Permease), LIVCS (Branched Chain Amino Acid:Cation Symporter), NRAMP (Natural Resistance-Associated Macrophage Protein), CstA (Carbon starvation A protein), KUP (K⁺ Uptake Permease), BenE (Benzoate:H⁺ Virginia Symporter), and AE (Anion Exchanger). (wikipedia.org)
  • As of this edit, this article uses content from "The Amino Acid/Auxin Permease (AAAP) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. (wikipedia.org)
  • oxidation
  • Ned Budisa made seminal contributions to our understanding of the role of methionine oxidation in prion protein aggregation and has discovered the roles of proline side chain conformations (endo-exo isomerism) in translation, folding and stability of proteins. (wikipedia.org)
  • Next a still unidentified protein catalyzes the selective oxidation of the benzene (as shown in Fig. 2). (wikipedia.org)
  • Putative
  • Putative bifunctional protein of 748 aas and 12 TMSs with an N-terminal sodium:alanine symporter domain and a C-terminal phosphatidylserine decarboxylase proenzyme domain. (tcdb.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Gene
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. (wikipedia.org)
  • encode
  • 74-79) Point mutations in the genes that encode arginine vasopressin and or its carrier protein neurophysin II underlie most cases of the familial, autosomal dominant disorder neurohypophyseal diabetes insipidus. (wikipedia.org)
  • Recombinant
  • The antibody detects a 75 kDa band on SDS-PAGE immunoblots of human PAK6 recombinant protein phosphorylated with ERK2. (abcam.com)
  • ab45376 detects a 95kDa protein corresponding to the apparent molecular mass of Semaphorin 3A on SDS-PAGE immunoblots of human recombinant Sema3A/Fc chimera. (abcam.com)
  • Synthetic
  • Ned Budisa applies the Selective Pressure Incorporation (SPI) method that enables single and multiple in vivo incorporations of synthetic (i.e. non-canonical) amino acid analogs in proteins, preferably by sense codon reassignment. (wikipedia.org)
  • Various attempts have been made by engineers to mimic the process of facilitated transport in synthetic (i.e., non-biological) membranes for use in industrial-scale gas and liquid separations, but these have met with limited success to date, most often for reasons related to poor carrier stability and/or dissociation of the carrier from the passive transport. (wikipedia.org)
  • mutations
  • Carriers of germline mutations in CDKN2A have besides their high risks of melanoma also increased risks of pancreatic, lung, laryngeal and oropharyngeal cancers and tobacco smoking exacerbates carriers' susceptibility for such non-melanoma cancers. (wikipedia.org)
  • atypical
  • Purpose Review aberrations of insulin signaling to atypical proteins kinase C (aPKC) in muscles and liver that generate cardiovascular risk elements, including, weight problems, hypertriglyceridemia, hypercholesterolemia, insulin level of resistance and blood sugar intolerance in type 2 diabetes mellitus (T2DM), and obesity-associated metabolic symptoms (MetSyn). (biomasswars.com)
  • The mupirocin cluster exhibits an atypical acyltransferase (AT) organization, in that there are only two AT domains, and both are found on the same protein, MmpC. (wikipedia.org)
  • kinase
  • as well as the downstream molecule extracellular indication regulated proteins kinase (ERK) 1/2, which induced the upregulation of p53 and Bcl-2-linked X proteins, mediating the next mobile apoptosis and proliferation in IECs. (biomasswars.com)
  • p16 (also known as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene. (wikipedia.org)
  • hydrophobic
  • Alkaline phosphatase in E. coli is uncommonly soluble and active within elevated temperature conditions such as 80 °C. Due to the kinetic energy induced by this temperature the weak hydrogen bonds and hydrophobic interactions of common proteins become degraded and therefore coalesce and precipitate. (wikipedia.org)
  • Peptide
  • Background Cardiac stress may trigger production of the 40\kDa peptide fragment produced from the amino terminus from the cardiac myosin\binding protein C. function, cell viability, hypertrophy, or possibility of success. (biomasswars.com)
  • mutation
  • This domain recruits clathrin and other proteins responsible for the endocytosis of LDL, therefore this mutation inhibits LDL internalization. (wikipedia.org)
  • Aceruloplasminemia is caused by a mutation (a five-base pair insertion in exon 7) in the CP gene, which provides instructions for making a protein called ceruloplasmin, a protein involved in iron transport and processing. (wikipedia.org)
  • pathogen
  • Pneumolysin (PLY), an associate from the category of Gram-positive bacterial, cholesterol-dependent, -barrel pore-forming cytolysins, may be the main proteins virulence aspect from the dangerous respiratory pathogen, (pneumococcus). (biomasswars.com)
  • This interest has been fueled in part by the recent discovery of a family of highly conserved pattern recognition receptor proteins known as Toll-like receptors (TLRs) believed to be involved in innate immunity as receptors for pathogen- associated molecular patterns (PAMPs). (allindianpatents.com)
  • They contain DNA that codes for specific proteins (antigens) from a pathogen. (wikipedia.org)
  • cellular
  • Taking a systems approach, we develop and summarise the view that "serum ferritin" actually originates from damaged cells (and thus reflects cellular damage), that it contains some iron but has lost or liberated most of its normal content, and that since the protein part of ferritin is assumed to be benign, that it is this (initially) free iron that correlates with and is causative of disease. (rsc.org)
  • variants
  • At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4. (wikipedia.org)
  • this transcript contains an alternate open reading frame (ARF) that specifies a protein that is structurally unrelated to the products of the other variants. (wikipedia.org)
  • interacts
  • This sequence was originally called Box A, which in now known to be the sequence that interacts with the homologue of the archaeal TATA-binding protein (TBP). (wikipedia.org)
  • structural
  • It can be activated by collectin proteins which recognize the structural pattern of polysaccharide on the surface of microorganisms. (scirp.org)
  • Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)
  • degradation
  • This precludes the movement of the receptor from the ER to the Golgi, and leads to degradation of the receptor protein. (wikipedia.org)
  • The ARF product functions as a stabilizer of the tumor suppressor protein p53, as it can interact with and sequester MDM2, a protein responsible for the degradation of p53. (wikipedia.org)
  • vitro
  • Leukocyte cell-derived chemotaxin-2 (LECT2) is a protein first described in 1996 as a chemotactic factor for neutrophils, i.e. it stimulated human neutrophils to move directionally in an in vitro assay system. (wikipedia.org)
  • promoter
  • Regulation of p16 is complex and involves the interaction of several transcription factors, as well as several proteins involved in epigenetic modification through methylation and repression of the promoter region. (wikipedia.org)
  • indicate
  • These findings indicate that LECT is an evolutionary conserved protein, has one or more important functions, and may be involved in various diseases. (wikipedia.org)
  • interaction
  • NPs may interact with these proteins in a similar way, and the interaction may lead to beneficial outcomes in vaccine delivery. (scirp.org)
  • We investigated the interaction of PEGylated and un-PEGylated PLGA NPs with Recombinant Human Mannose-Binding Protein (HMBP) in an effort to understand the effect of surface modification on their binding to the protein. (scirp.org)
  • PRC1 and PRC2 are two protein complexes that modify the expression of p16 through the interaction of various transcription factors that execute methylation patterns that can repress transcription of p16. (wikipedia.org)
  • belongs
  • This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like domains, 7 LDL-R class A domains, and 6 LDL-R class B repeats. (wikipedia.org)
  • immune responses
  • Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
  • Because these proteins are recognised as foreign, when they are processed by the host cells and displayed on their surface, the immune system is alerted, which then triggers immune responses. (wikipedia.org)
  • cell
  • The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. (wikipedia.org)
  • Alkaline phosphatase in E. coli is located in the periplasmic space and can thus be released using techniques that weaken the cell wall and release the protein. (wikipedia.org)
  • found
  • Serum ferritin" presents a paradox, as the iron storage protein ferritin is not synthesised in serum yet is to be found there. (rsc.org)
  • It is found in all proteins and in some artificial sweeteners. (wikipedia.org)
  • The TATA box was found in protein coding genes transcribed by RNA polymerase II. (wikipedia.org)
  • essential
  • These biochemicals can be joined together to make polymers such as DNA and proteins, essential macromolecules of life. (wikipedia.org)
  • Because the plasmid is the "vehicle" from which the immunogen is expressed, optimising vector design for maximal protein expression is essential. (wikipedia.org)
  • domain
  • A third domain of the protein is rich in O-linked oligosaccharides but appears to show little function. (wikipedia.org)
  • e.g. a truncation of the receptor protein at residue number 660 leads to domains 3,4 and 5 of the EGF precursor domain being missing. (wikipedia.org)
  • Biotin protein ligases have an additional C-terminal domain which participates in biotin adenylation and dimerization. (wikipedia.org)
  • Biotin protein ligases may also have an additional N-terminal domain required for DNA binding, although this domain is not always present. (wikipedia.org)
  • functions
  • Enzyme adsorption onto carriers functions based on chemical and physical phenomena such as van der Waals forces, ionic interactions, and hydrogen bonding. (wikipedia.org)
  • function
  • Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte cells that regulates the function of other cells: it is a hepatocyte-derived, hormone-like, signaling protein. (wikipedia.org)
  • type
  • Selection of a carrier is dependent upon the surface area, particle size, pore structure, and type of functional group. (wikipedia.org)
  • These AT domains are the only domains present on MmpC, while the other three type I PKS proteins contain no AT domains. (wikipedia.org)
  • important
  • The archaea protein exhibits a greater symmetry in its primary sequence and in the distribution of electrostatic charge, which is important because the higher symmetry lowers the protein's ability to bind the TATA box in a polar manner. (wikipedia.org)
  • expression
  • Intron A may sometimes be included to improve mRNA stability and hence increase protein expression. (wikipedia.org)
  • One way of enhancing protein expression is by optimising the codon usage of pathogenic mRNAs for eukaryotic cells. (wikipedia.org)
  • cells
  • Using very sensitive methods, LECT2 protein can also be detected at low levels in the endothelial cells of hepatic arteries and veins including central veins. (wikipedia.org)
  • The DNA is injected into cells, whose "inner machinery" uses the DNA to synthesize the proteins. (wikipedia.org)