• Samples from 3 people per tissue type were processed through several steps, and then the protein fragments (peptides) were analyzed on high-resolution Fourier-transform mass spectrometers. (nih.gov)
  • Amyloid plaques are composed mainly of the peptides derived from the enzymatic cut of the β-amyloid precursor protein (APP). (medscape.com)
  • The family of peptides consists of two closely related peptides, each 23 amino acids, that inhibit growth of numerous species of bacteria and fungi in vitro. (nih.gov)
  • The peptides are derived from the protein synthesized in MHC class I - restricted, CD8+ cytotoxic T cytoplasm, fitting to the groove of the MHC class lymphocytes (CTLs) play an important role in I molecule. (who.int)
  • Sulfur was found at high levels in round L-granules in the granulocyte cytoplasm and in the cornified CE, correlating with the presence of the protein, loricrin ( approximately 7% Cys/Met residues). (nih.gov)
  • [ 7 ] This transmembrane protein is encoded in humans by a gene on chromosome 21 and its alternative splicing results in at least eight forms, with the form known as APP 695 (i.e., the one consisting of 695 amino acid residues) expressed predominantly in the brain. (medscape.com)
  • Apoliporotein H (ApoH, Beta-2 Glycoprotein I, Activated protein C-binding protein, Anticardiolipin cofactor or APC inhibitor) is a single chain glycoprotein consisting of 326 amino acid residues that can be divided into five short consensus repeat domains. (biovendor.com)
  • GYISTRVEM) spinning the amino acid residues 298-306 of NS3 of dengue virus types 2 and 4 was substituted for L to prepare the peptide Den2.4-9L with a complete H-2Kd-binding motif. (who.int)
  • Subcutaneous immunization of BALB/c mice with Den1.3-9L emulsified with complete Freund adjuvant (CFA) induced the CTLs which lysed the target cells (P815) pulsed with peptide Den1.3-9L as well as those pulsed with peptide Den1.3 corresponding to the amino acid residues 299-307 (GYISTRVGM) of NS3 of dengue virus serotypes 1 and 3. (who.int)
  • Media containing bovine serum albumin (BSA), fetal bovine serum. (botimageai.com)
  • Molecular structure Bovine serum albumin (BSA) - common protein derived from cows. (botimageai.com)
  • EXPERIMENTAL Methods Cell Tradition and Cardiomyocyte Isolation COS7 cells were cultured in Dulbecco's revised Eagle's medium comprising 10% fetal bovine serum, 1% penicillin/streptomycin, and 1% l-glutamine. (rawveronica.com)
  • It has been reported that the immunogenicity streptomycin, 10mM HEPES, and 10% heat- of antigen peptide correlates with its binding inactivated fetal calf serum (Complete affinity to MHC class I molecules. (who.int)
  • Pregnancy is characterized by physiologic changes in mineral metabolism, to allow calcium accretion in the fetal skeleton [ 1-3] . (who.int)
  • Previously, we reported that protein phosphatase 4 (PP4) was a novel regulator of hepatic insulin resistance and lipid metabolism, but its role in hepatic lipoapoptosis remains unexplored. (hindawi.com)
  • This may be due to the difficulty in distinguishing between effects, which may be either direct in the form of extra amino acids for the metabolism or indirect involving higher digestibility of poor feed thus increasing the protein level. (vikinggenetics.uk)
  • The team examined 30 normal human tissue and cell types: 17 adult tissues, 7 fetal tissues, and 6 blood cell types. (nih.gov)
  • The team detected proteins encoded by 2,350 genes across all human cells and tissues. (nih.gov)
  • The sudden appearance of overt human Zika virus infections that cross the placenta to damage fetal tissues, target sexual organs, and are followed in some instances by Guillain-Barré syndrome raises questions regarding whether these outcomes are caused by genetic mutations or if prior infection by other flaviviruses affects disease outcome. (cdc.gov)
  • When administered intravenously to an adequately hydrated subject, the oncotic (colloid osmotic) effect of 50 mL Albuked 20 is such that it will draw approximately a further 125 mL of fluid from the extravascular tissues into the circulation within 15 minutes, (1) thus increasing the total blood volume and reducing both hemoconcentration and whole blood viscosity. (nih.gov)
  • Molecular analysis of the CBG cDNA demonstrated a deduced length of the mature peptide of 408 amino acids, with five consensus sites for N-glycosylation. (uwo.ca)
  • Of products: proteins or peptide fractions obtained by enzymatical hydrolysis. (botimageai.com)
  • Anti-P immunodominant epitope is a single sequential epitope contained within a 22 amino acid carboxy terminal peptide shared by the three P proteins, 7 though evidence of antibodies recognising a conformational determinant(s) has also been obtained. (bmj.com)
  • These changes correlated with down-regulation of effectors of differentiation [secreted frizzled-related sequence protein 1 ( Sfrp1 ), insulin-like growth factor 1 receptor ( Igf1r ), wingless-related MMTV-integration site 4 ( Wnt4 ), Lim homeobox protein 1 ( Lhx1 ), E-cadherin]. (nih.gov)
  • Proteins are also more difficult to sequence than genes. (nih.gov)
  • In their new study, a team of researchers headed by Drs. Akhilesh Pandey at Johns Hopkins University and Harsha Gowda at the Institute of Bioinformatics in Bangalore, India, used an advanced form of mass spectrometry to sequence proteins and create a draft map of the human proteome. (nih.gov)
  • A 14 kDa basic protein isolated from rat lung lavage was demonstrated to be lysozyme by its amino acid sequence analysis. (nih.gov)
  • This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
  • Protein phosphatase 4 (PP4) is an evolutionarily conserved protein serine/threonine phosphatase that belongs to the PP2A family, and mouse PP4 protein shares 100% amino acid sequence identity with human PP4 [ 14 ]. (hindawi.com)
  • These domains can be fused together to create proteins that can bind a chosen DNA sequence. (biomedcentral.com)
  • The Cys 2 -His 2 zinc finger motif is the ideal structural scaffold on which to construct a sequence-specific protein. (biomedcentral.com)
  • In order to design a zinc finger protein (ZFP) structural domain that binds specific target sequences in the A20 gene promoter region, the structure and sequence composition of this promoter were analyzed by bioinformatics methods. (biomedcentral.com)
  • The target sequences in the A20 promoter were submitted to the on-line ZF Tools server of the Barbas Laboratory, Scripps Research Institute (TSRI), to obtain a specific 18 bp target sequence and also the amino acid sequence of a ZFP that would bind to it. (biomedcentral.com)
  • Here, we applied convolutional networks for the prediction of localization of the cytoskeletal proteins from the localization of the other proteins. (frontiersin.org)
  • In general, the milder types of AIS (4 and 5 in the list below) are caused by simple missense mutations with single codon/single amino acid difference, while CAIS and the nearly complete forms result from mutations that more severely affect the shape and structure of the protein. (t-vox.org)
  • ApoH is a major antigen for antiphospholipid antibodies present in patients with antiphospholipid syndrome (APS), which is related to venous and arterial thrombosis, fetal loss, and thrombocytopenia. (biovendor.com)
  • Use as a diluent for antigens, antibodies, and other proteins. (botimageai.com)
  • The antibodies induced by one protein variant were shown to be qualitatively similar to responses induced by other vaccine platforms. (nature.com)
  • The common ribosome-inactivating proteins gelonin, saporin and ricin have been investigated when coupled to antibodies against neuroblastoma-enriched receptors, e.g. gangliosides GD2 and GD3 [ 6 - 8 ]. (oncotarget.com)
  • OBJECTIVE To assess the prevalence and clinical and serological associations of anti-ribosomal P protein antibodies (anti-P antibodies) in patients with connective tissue diseases (CTDs) and investigate the immunobiological nature of autoantibody clustering in which anti-P antibodies play a part. (bmj.com)
  • A close association of IgG antibodies with P proteins and with cardiolipin was seen in lupus sera (p=0.0009, odds ratio 18.33). (bmj.com)
  • In 2020, there were 20,854 fetal deaths at 20 weeks' gestation or later in the United States, with a fetal mortality rate of 5.74 deaths per 1,000 live births and fetal deaths in this population. (medscape.com)
  • [ 6 ] The 2020 US fetal mortality rate for deaths that occurred at 20-27 weeks' gestation was 2.97, and those that occured at 28 weeks' gestation or later had a fetal mortality rate of 2.78. (medscape.com)
  • Lysozyme was detectable in type II pneumocytes by immunocytochemistry and by a quantitative immunoassay of lung homogenates of fetal lungs at Day 20 of gestation. (nih.gov)
  • Plasma CBG concentrations increase during late gestation, but the stimulus for this increase and its consequences in the fetal sheep are not known. (uwo.ca)
  • Chronically catheterized fetal and adult sheep were used to examine the changes in late gestation of plasma CBG concentrations, plasma CBG glycosylation, total and free cortisol, and effects of glucocorticoids on plasma CBG. (uwo.ca)
  • There is a change in CBG glycosylation in neonatal sheep from a fetal type to an adult-like type, but no transplacental transfer of CBG in rate gestation. (uwo.ca)
  • Fetal growth is greatest during the last 60 days of gestation and therefore traditionally it was not felt necessary to increase energy intake until the 3rd trimester. (selectbreeders.com)
  • A total of 22 women had resumed the diet before or during their index pregnancy, eight (33%) women had contacted the metabolic clinic before conception, and 11 (46%) had contacted the metabolic clinic after conception but by week 10 of gestation. (cdc.gov)
  • Valproic acid (VPA), an anti-seizure medication, is known to increase markers of oxidation and also increase the risk of neural tube defects (NTDs) when taken during pregnancy. (nih.gov)
  • This study aimed to investigate the associations of different dietary protein sources (total protein, animal protein, plant protein, and major dietary protein sources) during pregnancy with birth weight and the related adverse birth outcomes. (biomedcentral.com)
  • Multilevel linear or logistic regression models were used to estimate birth weight changes or ORs (95% CIs) for adverse birth outcomes associated with different dietary protein sources during pregnancy. (biomedcentral.com)
  • Maternal nutrition during pregnancy, as an important modifiable factor, is critical for fetal growth. (biomedcentral.com)
  • Animal studies have shown that both insufficient and excessive dietary protein intake during pregnancy produced offspring with low birth weight [ 3 ]. (biomedcentral.com)
  • However, findings from human observational studies on the effect of dietary protein intake during pregnancy on birth weight are inconsistent. (biomedcentral.com)
  • However, the measurement of dietary protein intake during pregnancy has been mostly limited to total protein intake in the published human studies about birth weight and the related adverse birth outcomes. (biomedcentral.com)
  • Novel Targets of SARS-CoV-2 Spike Protein in Human Fetal Brain Development Suggest Early Pregnancy Vulnerability. (cdc.gov)
  • 2021). Vegan women can maintain their lifestyle but should regularly consult with a dietician to follow fetal growth during their pregnancy. (ncfoodinnovationlab.org)
  • Total calcium level decreases during pregnancy, due to hemodilution, while the ionized calcium level remains stable [2 ]. (who.int)
  • The TOR proteins are evolutionarily conserved serine/threonine kinases found in nearly all eukaryotic cells ( 8 ). (biomedcentral.com)
  • On the other hand, metabolome analyses have been used to identify changes in the biochemical behaviour of metabolites, such as amino acids, fatty acids and other organic substances. (nature.com)
  • Essential fatty acids must be provided in a pet's diet because they cannot be synthesized by a cat in sufficient amounts. (aspca.org)
  • Linoleic acid is an essential fatty acid for cats. (aspca.org)
  • Arachidonic acid, an omega-6 fatty acid, is also essential for cats for the maintenance of the skin and coat, for kidney function and for reproduction. (aspca.org)
  • Omega-6 and omega-3 fatty acids play a vital role in healing inflammation. (aspca.org)
  • Replacing some omega-6 with omega-3 fatty acids can lessen an inflammatory reaction-whether it is in the skin (due to allergies), the joints (from arthritis), the intestines (from inflammatory bowel disease) or even in the kidneys (from progressive renal failure). (aspca.org)
  • Omega-3 fatty acids found in fish oil supplements can help reduce the risk of heart disease by improving lipid profiles, reducing inflammation, and supporting overall cardiovascular health. (khedmeh.com)
  • Saturated free fatty acids (SFAs), which are increased significantly in NASH, are directly hepatotoxic which induce hepatocyte lipoapoptosis. (hindawi.com)
  • Circulating levels of saturated free fatty acids (SFAs) are increased significantly in NASH as compared to hepatosteatosis [ 4 ]. (hindawi.com)
  • improved reliance on fatty acids in diabetes or on glucose in pathological cardiac hypertrophy (1). (rawveronica.com)
  • ALA - Alpha-Linolenic Acid, the major, heart-healthy omega-3 fatty acid in food. (hh-ra.org)
  • DHA - Docosahexaenoic Acid, a long-chain omega-3 fatty acid. (hh-ra.org)
  • Conclusions: These findings support a functional link between AHR and WT1 in the regulation of renal morphogenesis and raise important questions about the contribution of human AHR polymorphisms to the fetal origins of adult-onset kidney disease. (nih.gov)
  • ApoH was described as a major urinary protein in the urine of patients with renal tubular disorders such as Wilson´s disease, Dent´s syndrome, Fanconi´s syndrome and renal tubular acidosis. (biovendor.com)
  • For example, the protein can retard the progression of clear cell renal cell carcinoma by inhibiting the NF-kB and HIF-2α signaling pathways ( 8 ). (spandidos-publications.com)
  • La ingesta de L-arginina por vía oral o intravenosa no mejora la función renal en la mayoría de las personas con ERC. (medlineplus.gov)
  • Follistatin-like protein 1 (FSTL1), a type of secretory glycoprotein, is expressed in most mammalian cells, with the exception of peripheral lymphocytes. (spandidos-publications.com)
  • Placentas from both mothers showed SARS-CoV-2-nucleocapsid protein and spike glycoprotein 1 in the syncytiotrophoblast, fetal vascular malperfusion, and significantly increased inflammatory and oxidative stress markers pyrin domain containing 1 protein, macrophage inflammatory protein 1 βη, stromal cell-derived factor 1, interleukin 13, and interleukin 10, whereas human chorionic gonadotropin was markedly decreased. (aap.org)
  • The deceased infant's brain showed evidence of SARS-CoV-2 by immunofluorescence, with colocalization of the nucleocapsid protein and spike glycoprotein around the nucleus as well as within the cytoplasm. (aap.org)
  • Previous studies have yielded inconsistent results on the association between maternal dietary protein intake and birth weight. (biomedcentral.com)
  • The results did not change when maternal protein was substituted for fat or carbohydrate. (biomedcentral.com)
  • Although as noted above, there are significant maternal-fetal implications even with mild reductions in hemoglobin. (glowm.com)
  • In adult animals, lysozyme accounts for about 169.0 micrograms/g of wet lung weight and 0.3% of the soluble proteins in lung homogenate. (nih.gov)
  • Additionally, expression of C12orf66 in fetal organs is higher than C12orf66 expression in the same adult organs. (wikipedia.org)
  • In fetal sheep, CBG biosynthesis is stimulated by glucocorticoids while in the adult, glucocorticoid administration produced a decrease in CBG biosynthesis. (uwo.ca)
  • Adult male guinea pigs weighing 725 to 750 g consumed daily 32 g of a purified diet containing crystalline amino acids (equivalent to 160 g protein/kg diet) as the sole nitrogen source (Schiller, 1977). (nih.gov)
  • In 2011 and 2012 I traveled to Mt. Everest to conduct field research investigating the effects of the amino acid leucine on body composition in trekkers and climbers. (utah.edu)
  • It is a complex, glycopeptide antibiotic containing amino acids and sugars and has high molecular 2,3 weight with activity in the pH range between 6.0 and 8.0. (bvsalud.org)
  • However, the total fertility rate in the United States declined to 1.64 children per woman in 2020. (medscape.com)
  • Spatiotemporal evaluation of the mouse embryonic redox environment and histiotrophic nutrition following treatment with valproic acid and 1,2-dithiole-3-thione during early organogenesis. (nih.gov)
  • Lamellipodia are one of the actin-dependent subcellular structures involved in cell migration and are mainly generated by the Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 2 (WAVE2) and the membrane remodeling I-BAR domain protein IRSp53. (frontiersin.org)
  • Through the use of chimeric proteins that fused fragments of wild type L1 to Green Fluorescent Protein (GFP) coding sequences, a short region was identified that was sufficient to inhibit high level synthesis and similar elements were detected in L2. (biomedcentral.com)
  • mTORC1 activates protein translation when the cell has sufficient amounts amino acids and energy. (wikipedia.org)
  • Interestingly, vegetarian and vegan dieters often consume less total protein than omnivorous eaters yet are closer to the daily recommended amounts for protein consumption (McCarty, Barroso-Aranda, & Contreras, 2009). (ncfoodinnovationlab.org)
  • Older adults should consume adequate amounts of high-quality dietary protein from a variety of protein sources to prevent age-related muscle loss (Domic, et al. (ncfoodinnovationlab.org)
  • Animal protein is of excellent quality and high bio-availibity, and is not undesirable in the right amounts. (stackexchange.com)
  • Biochemical characterization, comparative proteomics, and epigenetic screen all suggested that it was the interactome of several key proteins from different fractions of PSC-CM that delivered the multifaceted neuroprotection. (springer.com)
  • However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vaccine in a manner compliant with current Good Manufacturing Practice (cGMP). (nature.com)
  • In order to begin to understand the processes regulating HPV 31 infection we examined the synthesis of the HPV 31 capsid proteins, L1 and L2, using heterologous expression systems. (biomedcentral.com)
  • Lysozyme constitutes about 6.6% of the total soluble proteins in rat lung lavage. (nih.gov)
  • Genes control the most basic functions of the cell, including what proteins to make and when. (nih.gov)
  • Researchers have identified more than 20,000 protein-coding genes. (nih.gov)
  • The relationship between genes and proteins isn't a simple matter of one gene coding for one protein. (nih.gov)
  • The resulting draft human proteome map includes proteins encoded by more than 17,000 genes-about 84% of the total known protein-coding genes. (nih.gov)
  • KICSTOR is a complex of four proteins coded by the genes KPTN, ITFG2, C12orf66, and SZT2. (wikipedia.org)
  • C12orf66 interacts with the three proteins of the KICSTOR complex coded by the genes KPTN, ITFG2, and SZT2 as well as GATOR1. (wikipedia.org)
  • Every night when you sleep, your pituitary gland, a kidney-bean-size gland at the base of your brain, goes to work, squirting out hgh, a polypeptide consisting of 191 amino acids, calcul calorie journalier. (botimageai.com)
  • While the total calcitriol levels double in the first trimester, free calcitriol levels do not increase until the third trimester, and remain so into lactation [2, 4] . (who.int)
  • Protein supply during the dry period and the significance for subsequent milk and milk protein performance during lactation is uncertain. (vikinggenetics.uk)
  • During the last part of the dry period, the level should be between 12-13% crude protein, so that the cow becomes accustomed to the lactation feed and the increased needs of the foetus. (vikinggenetics.uk)
  • The young guinea pig seems to have a relatively high dietary requirement for arginine, folic acid, and selected minerals, although this may not prove to be true as more information on specific nutrient requirements becomes available. (nih.gov)
  • The abnormal expression of follistatin‑like protein 1 (FSTL1) in various tumors is a crucial regulator of the biological process of tumorigenesis. (spandidos-publications.com)
  • Western blot analysis demonstrated no significant change in the expression of total Cx43 protein. (biomedcentral.com)
  • BMP-2 and TGF-β1 do not alter expression of Cx43 at the mRNA or protein level. (biomedcentral.com)
  • Western analysis of Cx43 protein expression for control, BMP-2, and TGF-β1 groups after treatment for 24 h (top panel) and 48 h (bottom panel) in the absence (-) or presence (+) of ALP. (biomedcentral.com)
  • Concomitant with genome amplification is activation of the late promoter which directs expression of the E1^E4, E5 late proteins as well as the capsid proteins L1 and L2. (biomedcentral.com)
  • Expression of capsid proteins is restricted to differentiated epithelial cells and is regulated by both transcriptional and post-transcriptional mechanisms. (biomedcentral.com)
  • Here we investigated the potential vulnerability of human neuroblastoma cells to protease activity derived from botulinum neurotoxin type C. We show that following retinoic acid treatment, human neuroblastoma cells, SiMa and SH-SY5Y, acquire a neuronal phenotype evidenced by axonal growth and expression of neuronal markers. (oncotarget.com)
  • Further study revealed that PP4 induced JNK activation and lipoapoptosis-related protein expression by regulating the RAC1/MLK3 pathway instead of the PERK/CHOP pathway. (hindawi.com)
  • Immunofluorescence and cell protein fractionation revealed no detectable change in the localization of Cx43 between the cytosol and plasma membrane. (biomedcentral.com)
  • Protein localization in cells has been analyzed by fluorescent labeling using indirect immunofluorescence and fluorescent protein tagging. (frontiersin.org)
  • The impact of Zn2+ signals upon post-synaptic receptors (especially amino acid receptors) and the neurotoxic effects of excess synaptically- released Zn2+ (as occurs in seizures, ischemia, and head trauma) were both reviewed. (nih.gov)
  • Interaction Between Hyaluronic Acid and Its Receptors INTERACTION BETWEEN HYALURONIC ACID AND ITS RECEPTORS (CD44, RHAMM) REGULATES THE ACTIVITY OF INFLAMMATION AND CANCER Topic Editor: David Naor, Hebrew University of Jerusalem, Israel The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (pdfhost.io)
  • In the ovine fetus, plasma cortisol is bound by its high affinity binding protein corticosteroid-binding globulin (CBG). (uwo.ca)
  • This means that instead of adding chemicals to experiments to manipulate atoms and molecules-as chemists traditionally do-he is using the innate tools within biological systems, in this case enzymes, to create new kinds of protein molecules. (ucsf.edu)
  • Nuclear pores within the membrane allow small molecules and ions to cross back and forth, while larger molecules need to transport proteins to help them through. (medicalnewstoday.com)
  • In addition to the localization of GATOR1 to the lysosome, KICSTOR is also necessary for the regulation of mTORC1 signaling by amino acid or glucose deprivation. (wikipedia.org)
  • Normally, amino acid or glucose deprivation inhibits mTORC1 signaling. (wikipedia.org)
  • However, loss of any one protein in the four protein KICSTOR complex resulted in a lack of inhibition of mTORC1 by amino acid or glucose deprivation and increased mTORC1 signaling. (wikipedia.org)
  • Thus, KICSTOR is a negative regulator of mTORC1 signaling that functions by localizing GATOR1 to the lysosomal surface as well inhibiting mTORC1 during periods of amino acid or glucose deprivation. (wikipedia.org)
  • How the KICSTOR complex directly inhibits mTORC1 as well as senses amino acid or glucose deprivation remains to be elucidated. (wikipedia.org)
  • Results: Hydrocarbon challenge of metanephri from C57 mice altered Wilms' tumor suppressor gene ( Wt1 ) mRNA splice variant ratios and reduced mRNAs of the Wt1 transcriptional targets syndecan-1 ( Sdc1 ) paired box gene 2 ( Pax2 ), epidermal growth factor receptor ( Egfr ), and retinoic acid receptor, alpha ( Rar α). (nih.gov)
  • Moreover, little is known about the effects of dietary protein intake from different sources on fetal growth. (biomedcentral.com)
  • Birth weight is an important indicator for fetal growth. (biomedcentral.com)
  • However, the underlying mechanisms of fetal growth have not been fully elucidated. (biomedcentral.com)
  • Among the nutrients studied, protein in particular appears to play a major role for fetal growth. (biomedcentral.com)
  • However, while fetal growth is greatest in the last trimester, more recent research (Reynolds et al. (selectbreeders.com)
  • Mares who do not gain weight during the last trimester will be utilizing their own body energy stores to support fetal growth. (selectbreeders.com)
  • Taurine is required for the prevention of eye and heart disease, as well as reproduction, fetal growth and survival. (aspca.org)
  • Nutritionally, plant-based proteins vary in their amino acid contents, often lacking some amino acids that are essential for human growth and homeostasis. (ncfoodinnovationlab.org)
  • In response to stimulation, mTOR regulates cell growth through modulation of many processes, including protein synthesis, ribosome biogenesis and autophagy ( 8 ). (biomedcentral.com)
  • Bone morphogenetic proteins (BMPs) and transforming growth factor-βs (TGF-βs) are important regulators of bone repair and regeneration. (biomedcentral.com)
  • Athletes and active individuals may use supplements like protein powder, creatine, and branched-chain amino acids to enhance performance, muscle recovery, and muscle growth. (khedmeh.com)
  • AAT maintenance requirements are very low, and although AAT (amino acids absorbed in the intestine) for foetal growth doubles during the dry period, the overall need is still low. (vikinggenetics.uk)
  • Nuclear translocation triggers proteolytic degradation of AHR protein, a signaling event that defines the biological responsiveness to AHR ligands ( Roberts and Whitelaw 1999 ). (nih.gov)
  • A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B activity and tumor necrosis factor (TNF)-mediated programmed cell death. (biomedcentral.com)
  • In addition, GNMT binds carcinogens such as polyaromatic hydrocarbons and aflatoxins and prevents the deoxyribonucleic acid (DNA) adduct formation and cytotoxicity induced by these carcinogens ( 14 - 16 ). (biomedcentral.com)
  • Among Chinese pregnant women with low intake of protein, higher intake of dietary protein, in particular animal protein and dairy protein, is associated with higher birth weight and lower risks of LBW, SGA, and IUGR. (biomedcentral.com)
  • In short: minimal protein intake requirements are unknown to this level of precision. (stackexchange.com)
  • However, in affluent socio-economic conditions, protein-intake in observed patterns was found to be mostly adequate on average. (stackexchange.com)
  • This organ resembles that of the rabbit and possibly has similar digestive functions-e.g., synthesis of B vitamins and indispensable amino acids by microorganisms and recycling of intestinal contents by coprophagy (Hunt and Harrington, 1974). (nih.gov)
  • Treatment is completed with a course of retinoic acid to clear up residual tumour cells [ 2 ]. (oncotarget.com)
  • Water and food consumption was 7.5 mL/100 g BW/day and 4 g/100 g BW/day, respectively, in male guinea pigs weighing 698 ± 19 g and fed a nonpurified diet containing 20 percent crude protein (Tsao and Young, 1989). (nih.gov)
  • Requirements are low and can be met by a level of approximately 10% crude protein in the first half of the dry period. (vikinggenetics.uk)
  • Dropping below 12% crude protein is not recommended for dry cows because they need to utilize the energy in the feed ration. (vikinggenetics.uk)
  • Should Plant-Based and Other Alternative Proteins Supplant Animal-Derived Proteins? (ncfoodinnovationlab.org)
  • For the past few years, media coverage emphasized the growing need for plant-based and other alternative proteins to replace animal-derived proteins in the human diet. (ncfoodinnovationlab.org)
  • To maintain adequate protein in a diet, diets which incorporate animal-derived protein are easier to maintain, and easier to compose, than those without. (stackexchange.com)
  • His laboratory conducted research on how the lung's airspaces become fluid filled (mechanisms of pulmonary edema), how airspace fluid is cleared under both physiologic (fetal lung liquid at birth) and pathophysiologic (pulmonary edema) conditions and population-based studies to discover genetic influences on the development of bronchopulmonary dysplasia and the long term outcomes of neonatal lung disease. (stanford.edu)
  • Studies on the physiological effects of sulfamic acid and ammonium sulfamate. (cdc.gov)
  • These studies were undertaken to examine the stimulus for an increase in fetal plasma CBG, the mechanism of this increase, and the physiological significance of the increase. (uwo.ca)
  • 1 They may recognise ribosomal RNA 2 , 3 or protein epitopes within eukaryotic ribosome subunits. (bmj.com)
  • Researchers completed a draft map of the human proteome-the set of all proteins in the human body. (nih.gov)
  • The results demonstrate differential distribution of a secretory protein in rodent and human lungs and indicate that in the rat lysozyme could be used as an immunohistologic marker for type II pneumocytes and as an indicator of secretory activity and maturation of type II pneumocytes. (nih.gov)
  • Loss of the genomic locus 12q14 which contains the human protein encoding gene C12orf66 is linked to a number of developmental delays and neurodevelopment disorders such as macrocephaly. (wikipedia.org)
  • The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
  • Some sources are better at providing essential amino acids that are nitrogenous compounds the human body needs to sustain life. (ncfoodinnovationlab.org)
  • While deep sequencing and qPCR analysis have shown that L1 copy number is much higher in certain parts of the human brain, direct in vivo studies regarding detection of L1-encoded proteins is lacking due to ineffective reagents. (biomedcentral.com)
  • The amino acid sequences were next compared to known sequences. (nih.gov)
  • The fact that 193 of the proteins came from DNA sequences predicted to be non-coding means that we don't fully understand how cells read DNA, because clearly those sequences do code for proteins," Pandey says. (nih.gov)
  • X-ray crystallographic structures of antigen binding fragments of EDE1 and EDE2 in complex with the Zika virus envelope protein have been obtained ( 4 ). (cdc.gov)
  • The C12orf66 protein is one of four proteins in the KICSTOR protein complex which negatively regulates mechanistic target of rapamycin complex 1 (mTORC1) signaling. (wikipedia.org)
  • It regulates the ratio of S-adenosylmethionine to S-adenosylhomocysteine and serves as a folate binding protein ( 12 , 13 ). (biomedcentral.com)
  • We observed no associations of plant protein and other major dietary protein sources with birth weight and the above birth outcomes. (biomedcentral.com)
  • The primary sources of dietary protein are animal-based foods and plant-based foods [ 18 ]. (biomedcentral.com)
  • 2022). While plant-based proteins can meet the dietary needs of older adults for sustenance, other whole-food protein sources will supplement any essential amino acid deficiencies from maintaining a vegan diet. (ncfoodinnovationlab.org)
  • While mal- and undernourishment can occur in all dietary patterns, vegetarianism as such increases the risk for inadequate protein supply slightly, and veganism slightly more. (stackexchange.com)
  • You can see that the algorithm produces quite simple, exclusively plant-based meal-plans that probably very well exceed the recommended minimum for dietary protein input. (stackexchange.com)
  • Previous studies by others and ourselves showed that although proteasome activity was not associated with the intensity of green fluorescent protein fused by the degron motif, cells sorted by fluorescence indeed showed high tumourigenicity and therapy resistance. (nature.com)
  • Spatial and temporal fluctuations in total glutathione (GSH) and total cysteine (Cys) redox steady states were seen during a 24 h period of CD-1 mouse organogenesis in untreated conceptuses and following exposure to VPA and the Nrf2 antioxidant pathway inducer, 1,2-dithiole-3-thione (D3T). (nih.gov)
  • Activated JNK pathway induces the upregulation of proapoptotic Bcl-2 homology3- (BH3-) only proteins (PUMA and Bim), which are key regulators of hepatic lipoapoptosis [ 7 , 8 ]. (hindawi.com)
  • Do humans need high-protein foods? (stackexchange.com)
  • Do humans need high-protein foods, or does a diet consisting of unrefined starches and vegetables contain enough protein? (stackexchange.com)
  • No difference was reported in avoiding high-protein foods between women who were and who were not trying to conceive. (cdc.gov)
  • We have used energy-filtered electron microscopy and electron energy loss spectroscopy (EELS) to characterize the distributions of sulfur-rich proteins in granular layer cells of squamous stratifying epithelia and their redistribution in the cornified layer, with particular attention to assembly of the cornified cell envelope (CE). (nih.gov)
  • The discovery highlights the importance not only of studying genomics to understand cellular biology, but to study and understand the protein content of cells as well. (nih.gov)
  • The ability of CBG to modulate glucocorticoid negative feedback was examined in fetal pituitary cells in culture. (uwo.ca)
  • Connexin 43 (Cx43) has been shown to mediate GJIC in osteoblasts and it is the predominant gap junctional protein expressed in these murine osteoblast-like cells. (biomedcentral.com)
  • Cx43 is the predominant gap junctional protein expressed in this cell line and we hypothesized that Cx43 mediated intercellular communication in these osteoblast-like cells. (biomedcentral.com)
  • Conclusions from these studies include (i) CBG biosynthesis is a function of glucocorticoid concentrations, and (ii) in the fetus, CBG attenuates glucocorticoid negative feedback at the pituitary, allowing a progressive increase in fetal plasma ACTH, and a sustained drive toward parturition. (uwo.ca)
  • Significant correlations were demonstrated between plasma apoH concentrations and those of triglyceride and total cholesterol in some study groups. (biovendor.com)
  • (11-14) The production steps from Pooled Plasma to Effluent IV-1 in the Albuked 20 manufacturing process have been shown to decrease TSE infectivity of that experimental model agent (a total of ≥7.0 logs). (nih.gov)
  • Approximately 97% of either quinapril or quinaprilat circulating in plasma is bound to proteins. (nih.gov)
  • Dry cows should always be fed according to appetite and preferably with a Total Mix Ration (TMR). (vikinggenetics.uk)