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  • Gene
  • Almost simultaneously, analysis of an E. coli spoU gene deletion strain revealed that spoU encodes a tRNA (Gm18) methyltransferase [ 7 ], which catalyzes the transfer of a methyl group from S -adenosyl- l -methionine (AdoMet) to the 2'-OH of ribose of G18 in tRNA to produce Gm18 modification ( Figure 1 and Figure 2 ) [ 8 ]. (pubmedcentralcanada.ca)
  • mRNA
  • mRNA (messenger RNA): RNA that copies the coded message from DNA in the nucleus and carries the message into the cytoplasm. (slideserve.com)
  • First, RNA-Seq uses next-generation DNA sequencing to determine every mRNA transcript in a particular sample. (biomedcentral.com)
  • nucleotides
  • A dynamic contact map defines the edges connecting nodes (amino acids and nucleotides) in the physical network whose overall topology is presented as a network of communities, local substructures that are highly intraconnected, but loosely interconnected. (pnas.org)
  • inhibitors
  • The effect of V600E B-RAF on proliferation in mouse melanocytes and melanomas can be reversed by treatment of these cells with MEK inhibitors or with small interfering RNA (siRNA) to B-RAF. (aacrjournals.org)
  • Antiproliferative and proapoptotic effects of several HDAC inhibitors, including trichostatin A, depsipeptide, MS-275, sodium butyrate, valproic acid, pyroxamide, and suberoylanilide hydroxamic acid (SAHA), have been reported for prostate cancer cell lines ( 9 - 12 ). (aacrjournals.org)
  • messenger
  • The cfCRF-R1 messenger RNA is highly expressed in the brain, and its distribution pattern correlates well with that of mammalian CRF-R1, except for weak expression in the pituitary. (embl-heidelberg.de)
  • small
  • This study demonstrated that α v β 3 integrin increases survival of α v β 3 -LNCaP cells upon IR while small hairpin RNA (shRNA)-mediated knockdown of α v β 3 integrin in PC-3 cells sensitizes to radiation. (aacrjournals.org)
  • expression
  • In the present report, we address the question of expression of Grp , Nppb , and Nmb and their receptors in DRG and spinal cord through application of RNA-Seq. (biomedcentral.com)
  • role
  • RNA-Seq corroborates a primary itch afferent role for NPPB in mouse and potentially NPPB and NPPA in rats and humans, but does not support GRP as a primary itch neurotransmitter in mouse, rat, or humans. (biomedcentral.com)
  • known
  • Corticotropin releasing hormone (CRH, sometimes known as CRF) is an endogenous 41 amino acid peptide that has been implicated in the onset of pregnancy, the 'fight or flight' response, in addition to a large number of physiological disorders. (embl-heidelberg.de)
  • chemical
  • Therefore, the aims of this study are (a) to investigate whether glucolipotoxicity could impose ER stress and apoptosis in THP-1 human monocytes and (b) to investigate whether 4-Phenyl butyric acid (PBA), a chemical chaperone could resist the glucolipotoxicity-induced ER stress and apoptosis. (hindawi.com)
  • mouse
  • Human, rat and mouse cAMP phosphodiesterase isoforms (denoted PDE4D7s), as well as the DNA (RNA) encoding such polypeptides, are disclosed. (freepatentsonline.com)
  • RNA-Seq demonstrates that GRP is not transcribed in mouse, rat, or human sensory ganglia. (biomedcentral.com)