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  • ligand
  • Glutathione S -transferase (GST) pulldown experiments and far Western analyses demonstrated that the N-terminal region of SRC-1 (amino acids 1-212) alone does not bind the 50-kDa 12( S )-HETE binding protein, whereas GST/ΔSRC-1 1-1138 ligand-dependently pulled down a protein of ≈50 kDa in size. (pnas.org)
  • The receptor with its ligand bound transferrin is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. (wikipedia.org)
  • steroid
  • In this report, we present data showing that the 50-kDa 12( S )-HETE binding protein interacts as a homodimer with steroid receptor coactivator-1 (SRC-1) in the presence of 12( S )-HETE. (pnas.org)
  • hydrophobic
  • In humans, an interstitial chromosomal deletion of about 800 kilobases at 4q12 deletes the CHIC2 gene (i.e.cysteine rich hydrophobic domain 2 gene) to create an in-frame fusion of the FIP1L1 gene with the platelet-derived growth factor receptor alpha gene (PGDFRA) gene. (wikipedia.org)
  • regulate
  • This mechanism may provide metabolic crosstalk and act to regulate the NADH/NAD+ ratio in order to maintain optimal mitochondrial beta oxidation of fatty acids. (wikipedia.org)
  • peroxisome
  • The interaction between LXXLL-containing domains (LXDs) in SRC-1 and peroxisome proliferator-activated receptor-γ has been studied in great detail by crystallography ( 17 ). (pnas.org)
  • fatty
  • Farnesoid X receptor, or FXR, suppresses glycolysis and enhances fatty acid oxidation by increasing PDK4 expression and inactivating the PDH complex. (wikipedia.org)
  • In fact, it has been shown that insufficient downregulation of PDK mRNA in insulin-resistant individuals could be a cause of increased PDK expression leading to impaired glucose oxidation followed by increased fatty acid oxidation. (wikipedia.org)
  • Rather, current studies suggest that it is a receptor for certain metabolites of the polyunsaturated fatty acid, linoleic acid. (wikipedia.org)
  • Cognition diets for cats contain a greater portion of omega-3 fatty acids, especially docosahexaenoic acid (DHA) as well as eicosapentaenoic acid (EPA), and usually feature a variety of antioxidants and other supporting nutrients thought to have positive effects on cognition. (wikipedia.org)
  • The omega-3 fatty acids are a key nutrient in cognition for felines. (wikipedia.org)
  • Omega-3 fatty acids that support brain development and function are alpha-linolenic acid, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). (wikipedia.org)
  • In kittens and juvenile felines, omega-3 fatty acids are very important for the development of the brain, components of the nervous system and retinal accretion. (wikipedia.org)
  • 1997), when pregnant domestic felines were fed a diet high in omega-3 fatty acids that their offspring showed high levels of DHA in brain and retinal tissues. (wikipedia.org)
  • In the group that fed low concentrations of omega-3 fatty acid and omega-6 fatty acid, their kittens had extremely low amounts of DHA in these tissues which shows that young felines, have poor biosynthetic ability to produce these fatty acids. (wikipedia.org)
  • This study also showed hindered brain waves in kittens whose mother were fed low omega-3 and omega-6 diets which is a significant indicator, that these fatty acids aid in the development of the feline brain at a juvenile stage. (wikipedia.org)
  • Though young felines are not efficient at producing omega-3 fatty acids naturally, it is critical for cognitive function and brain development in regard to brain waves and glucose uptake. (wikipedia.org)
  • Felines, like other obligate carnivores, possess a small concentration of delta 6 desaturase which is an enzyme that converts omega-3 fatty acids such as alpha linolenic acid into DHA. (wikipedia.org)
  • This is what causes the poor bioavailability of essential fatty acids in felines, and why it is crucial in their diet. (wikipedia.org)
  • Omega-3 fatty acid also aids in uptake of glucose in the brain which is needed for energy for cognitive health. (wikipedia.org)
  • Though no studies in cats have been completed, it was found that rats with low levels of omega-3 fatty acids resulted in a decrease of glucose uptake in the brain. (wikipedia.org)
  • Omega-6 fatty acids are also needed in feline cognition diets. (wikipedia.org)
  • it was found that DHA and AA made up 20% of the fatty acids in the mammalian brain. (wikipedia.org)
  • The reaction carried out by these enzymes is as follows: CoA ester + H2O → free acid + coenzyme A These enzymes use the same substrates as long-chain acyl-CoA synthetases, but have a unique purpose in that they generate the free acid and CoA, as opposed to long-chain acyl-CoA synthetases, which ligate fatty acids to CoA, to produce the CoA ester. (wikipedia.org)
  • namely
  • Grell) includes four nuclear receptors, namely orthologue of RXR (NR2B), HNF4 (NR2A), COUP-TF (NR2F) and ERR (NR3B) that show a high degree of similarity with human orthologues. (peerj.com)
  • gene expression
  • Retinoic acid controls a wide variety of important biological systems by regulating eukaryotic gene expression (Chai et al. (google.com)
  • novel retinol dehydrogenases are useful for modulating the synthesis of retinoic acid and, therefore, are useful for modulating gene expression in numerous important biological systems. (google.com)
  • synthesis
  • Retinol dehydrogenase catalyzes the primary and rate-limiting step in the synthesis of retinoic acid from retinol. (google.com)
  • Furthermore, retinol dehydrogenase 4 is useful for catalyzing the synthesis of not only retinoic acid, but also dihydrotestosterone from 3alpha-androstane-diol (Gough et al. (google.com)
  • Therefore, to modulate the activity of this autophagic pathway, the cell stringently regulates the levels of the CMA receptor at the lysosomal membrane by controlling the degradation rates of LAMP-2A monomers in lysosomes and by de novo synthesis of LAMP-2A molecules. (wikipedia.org)
  • invention
  • The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) ##STR00001## or a. (patents.com)
  • The present invention is directed to 2-pyridyloxy-4-methyl compounds which are antagonists of orexin receptors. (patents.com)
  • molecules
  • The protein encoded by the ACOT2 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme A esters of various molecules to the free acid plus CoA. (wikipedia.org)
  • regulation
  • This protein is located in the matrix of the mitochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, reducing the conversion of pyruvate, which is produced from the oxidation of glucose and amino acids, to acetyl-CoA and contributing to the regulation of glucose metabolism. (wikipedia.org)
  • alpha
  • The product of PDGFRA, platelet-derived growth factor receptor alpha (PDGFRA), is a tyrosine kinase receptor of the RTK class III. (wikipedia.org)
  • Alpha-linolenic acid can be acquired from oils and seeds. (wikipedia.org)
  • Alpha-linolenic acid, was recommended at 0.02% on a dry matter basis and 0.05g per 1000 kcal ME per day. (wikipedia.org)