• receptor antagonist 6,7,8,9-tetrahydro-5[H]benzocyclohepte-5-ol-4-ylidene acetic acid (NCS-382), pointing to a specific effect of this drug. (123dok.org)
  • gamma-Aminobutyric Acid/*analogs & derivatives. (reference.md)
  • Principal metabolites, namely, 20, 24-oxide metabolites (M3 and M4), 26/27-carboxylic acid derivatives (M22 and M23) and a glucuronidated product (M28), were found in the rat plasma. (westminster.ac.uk)
  • The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. (justia.com)
  • Diorganotin(IV) Derivatives of Substituted Benzohydroxamic Acids with High Antitumor Acivity. (ulisboa.pt)
  • Diorganotin(IV) Derivatives of Arylhydroxamic Acids. (ulisboa.pt)
  • Benzoic acids, phenoxycarboxylic acids, pyridine carboxylic acids, and quinoline carboxylic acids (O(4) and L(27)) are herbicides that act similar to that of endogenous auxin (IAA) although the true mechanism is not well understood. (weedscience.com)
  • In E. coli glycerophospholipid metabolism, The biosynthesis of CDP-diacylglycerol (CDP-DG) involves condensation of phosphatidic acid (PA) and cytidine triphosphate, with elimination of pyrophosphate, catalysed by the enzyme CDP-diacylglycerol synthase. (ymdb.ca)
  • Imidazolinones, pyrimidinylthiobenzoates, sulfonylaminocarbonyltriazolinones, sulfonylureas, and triazolopyrimidines are herbicides that inhibit acetolactate synthase (ALS), also called acetohydroxyacid synthase (AHAS), a key enzyme in the biosynthesis of the branched-chain amino acids isoleucine, leucine, and valine (LaRossa and Schloss 1984). (weedscience.com)
  • Benzofuranes (WSSA Group 16), chlorocarbonic acids (Group 26), phosphorodithioates (Group 8), and thiocarbamates (Group 8) are examples of herbicides that are known inhibitors of several plant processes including: 1) biosynthesis of fatty acids and lipids which may account for reported reductions in cuticular wax deposition, 2) biosynthesis of proteins, isoprenoids (including gibberellins), and flavonoids (including anthocyanins), and 3) gibberellin synthesis inhibition which may result from the inhibition of kaurene synthesis. (weedscience.org)
  • Inhibition of glutathione S-transferases by photoactive calix[4]arene α-ketophosphonic acids (2022) Bioorganic and Medicinal Chemistry Letters, 77, статья № 129019. (org.ua)
  • Synthesis and separation of diastereomeric N-(1-phenylethyl)amides of inherently chiral hydroxydibenzoyloxy-calix[4]arene acetic acids (2022) Chirality, 34(11),pp.1466-1471.https://www.scopus.com/inward/record.uri?eid=2-s2.0 85136719766&doi=10.1002%2fchir.23503&partnerID=40&md5=21fd40d69ba3d6b5c9bc10e56bcd406. (org.ua)
  • As is the case with diacylglycerols, phosphatidylserines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. (ymdb.ca)
  • US 4,356,190 (Personal Products Co.) discloses the use of selected aminopolycarboxylic acid compounds for inhibiting the formation of short chain fatty acids by Corynebacterium on the skin surface. (allindianpatents.com)
  • Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. (acs.org)
  • In the framework of this thesis, the effects of exogenous administration of several non-essential amino acids and the participation of their specific transporters in brain metabolism were investigated in Guinea pig cortical brain slices and mouse brain tissues using a targeted neuropharmacological and metabolomic strategy. (edu.au)
  • GABA is synthesized in a single step from its precursor glutamate by glutamic acid decarboxylase. (wikipedia.org)
  • TO 97/02010 (Procter and Gamble Co.) discloses the use of chelators selected from the succinic acid, glutaric acid, and phosphonic acid classes as bactericidal compounds. (allindianpatents.com)
  • However, because of the deficiency, the final intermediate of the GABA degradation pathway, succinic semialdehyde, accumulates and cannot be oxidized to succinic acid and is therefore reduced to gamma-hydroxybutyric acid (GHB) by gamma-hydroxybutyric dehydrogenase. (wikipedia.org)
  • Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid bearing an alcoholic moiety. (123dok.org)
  • Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare autosomal recessive disorder of the degradation pathway of the inhibitory neurotransmitter γ-aminobutyric acid, or GABA. (wikipedia.org)
  • Glycines (glyphosate) are herbicides that inhibit 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase (Amrhein 1980) which produces EPSP from shikimate-3-phosphate and phosphoenolpyruvate in the shikimic acid pathway. (weedscience.com)
  • Under normal conditions, SSADH works with the enzyme GABA transaminase to convert GABA to succinic acid. (wikipedia.org)
  • Succinic acid can then be utilized for energy production via the Krebs cycle. (wikipedia.org)
  • GABA is metabolized by successive transamination and oxidation to yield succinic semialdehyde and succinic acid respectively via the catalyzing effects of GABA transaminase. (wikipedia.org)
  • The succinic semialdehyde can be converted into either succinic acid by SSADH or to GHB by the enzyme succinic semialdehyde reductase. (wikipedia.org)
  • In this paper, we extended our study on 4-aminoquinolines as human cholinesterase inhibitors on twenty-six new 4-aminoquinolines containing an n-octylamino spacer on C(4) and different substituents on the terminal amino group. (inra.fr)
  • Plant death results from events occurring in response to ALS inhibition and low branched-chain amino acid production, but the actual sequence of phytotoxic processes is unclear. (weedscience.com)
  • EPSP inhibition leads to depletion of the aromatic amino acids tryptophan, tyrosine, and phenylalanine, all needed for protein synthesis or for biosynthetic pathways leading to growth. (weedscience.com)
  • Inhibition of fatty acid synthesis presumably blocks the production of phospholipids used in building new membranes required for cell growth. (weedscience.com)
  • Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1. (icr.ac.uk)
  • It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. (reference.md)
  • The homeostatic regulation of amino acid concentrations is crucial for optimal brain function and development. (edu.au)
  • In cortical tissue slices L-aspartate increased brain metabolism concentration-dependently, L-ornithine significantly slowed it at higher concentrations (100 μmol/L), and the effects of LOLA was largely dependent on the balance of its two constituent amino acids. (edu.au)
  • It has been established that it is possible to control the degree of release of the drug over a wide time range by varying the porous structure and nature of the surface of the silica carrier and using a chitosan-based matrix, whose properties can be altered by introducing a crosslinking reagent, protonation or deprotonation of amino groups of a polymer. (isc.gov.ua)
  • These compounds have been used with perfluoroalkyl phosphonic acids (PFPAs) as surfactants in consumer products and as nonfoaming additives in pesticide formulations. (nih.gov)
  • Unlike the structurally related perfluoroalkyl sulfonic and carboxylic acids, little is known about the biological fate of PFPiAs. (nih.gov)
  • Currently, researchers use carbodiimides to different amino acids such as DCC and HOBt in the solid-phase synthesis to form essential protein peptides. (bestschoolnews.com)
  • As is the case with diacylglycerols, CDP-diacylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. (hmdb.ca)
  • Fatty acids containing 16, 18 and 20 carbons are the most common. (hmdb.ca)
  • CDP-DG(18:0/20:4(5Z,8Z,11Z,14Z)), in particular, consists of one chain of stearic acid at the C-1 position and one chain of arachidonic acid at the C-2 position. (hmdb.ca)
  • The stearic acid moiety is derived from animal fats, coco butter and sesame oil, while the arachidonic acid moiety is derived from animal fats and eggs. (hmdb.ca)
  • A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. (bvsalud.org)
  • Like most phosphinic acids, the potent and selective RXP03 inhibitor of different MMPs exhibited moderate absorption and low bioavailability, which impaired its use. (biomedcentral.com)
  • Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare autosomal recessive disorder of the degradation pathway of the inhibitory neurotransmitter γ-aminobutyric acid, or GABA. (wikipedia.org)
  • However, because of the deficiency, the final intermediate of the GABA degradation pathway, succinic semialdehyde, accumulates and cannot be oxidized to succinic acid and is therefore reduced to gamma-hydroxybutyric acid (GHB) by gamma-hydroxybutyric dehydrogenase. (wikipedia.org)
  • This is the first reported cleavage of a C-P bond in mammals, and the first attempt, with a single-dose exposure, to characterize the degradation of any perfluoroalkyl acid. (nih.gov)
  • In addition, there are a large number of chemical groups such as carboxyl, amino and hydroxyl groups in the heparin molecule, which provide the possibility for the modification of heparin, so heparin and its derivatives are widely used as drug carriers. (cd-bioparticles.net)
  • and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof. (patsnap.com)