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  • intracellular
  • In cultured human fibroblasts incubated under hypertonic conditions, the specific silencing of SNAT2 expression, obtained with anti-SNAT2 siRNAs, prevents the increase in system A transport activity, hinders the expansion of intracellular amino acid pool, and significantly delays cell volume recovery. (biomedsearch.com)
  • inhibitors
  • Software of the inhibitors to ASCT2-expressing cells in the lack of a natural amino acidity inhibits a tonic drip current that's transported by anions. (bioinbrief.com)
  • proton
  • Both steric interactions and proton affinity of the neutral reagents influenced the reaction rates. (biomedsearch.com)
  • High proton affinity of the neutral reagent apparently had a twofold effect. (biomedsearch.com)
  • If the proton affinity of the neutral reagent was too high, the reaction tended to become too exothermic and part of the host-guest complex decomposed instead of transforming to a new host-guest complex, effecting a decrease in the reaction rate. (biomedsearch.com)
  • The remaining portion of the host-guest complexes meanwhile reacted very fast with the neutral reagent due to high proton affinity causing an increase in the reaction rate. (biomedsearch.com)
  • Neutral amino acid/proton symporter. (uniprot.org)
  • role
  • These results demonstrate the pivotal role played by SNAT2 induction in the short-term hypertonic RVI and suggest that neutral amino acids behave as compatible osmolytes in hypertonically stressed cells. (biomedsearch.com)