Amino acids in cell cells zinc isotopes. Medical search. Frequent questions

Examples of alloys are brass (copper and zinc), bronze (mainly copper and tin), and white gold (gold and usually nickel, manganese, or palladium). (biologyonline.com)
Taking copper in combination with zinc, manganese, and calcium might slow bone loss in older women. (supplemented.net)
Raymond W. M. Kwong ABSTRACT Trace metals such as iron, copper, zinc and manganese play essential roles in various biological processes in fish, including development, energy metabolism and immune response. (biologists.com)

The chosen isotope can act as a label on that compound that can be identified through nuclear magnetic resonance (NMR) and mass spectrometry (MS). Some of the most common stable isotopes are 2H, 13C, and 15N, which can further be produced into NMR solvents, amino acids, nucleic acids, lipids, common metabolites and cell growth media. (wikipedia.org)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. (lookformedical.com)

Native insulin is a globular protein comprised of a zinc-coordinated hexamer. (lookformedical.com)
In some embodiments, the mutated HPV L1 capsid protein has an amino acid sequence alteration that modifies in the subject HPV serotype-specific immunogenicity of the capsid protein relative to a naturally-occurring capsid protein. (justia.com)
The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
An unnatural amino acid that is used experimentally to study protein structure and function. (lookformedical.com)
The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. (lookformedical.com)
These toxins inhibit the release of neurotransmitters at the neuromuscular junction by cleaving soluble NSF attachment protein receptor (SNARE) complex proteins in nerve cells, which prevents the fusion of neurotransmitter containing vesicles to cell membranes 2 . (cdc.gov)
The light chain is a zinc-metalloprotease which is responsible for the cleavage of three SNARE complex proteins including SNAP-25 (Synaptosome-associated protein of 25 kDa), synaptobrevin-2 (also termed VAMP-2) and syntaxin. (cdc.gov)
Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)

In this technique, one or more of the atoms of the molecule of interest is substituted for an atom of the same chemical element, but of a different isotope (like a radioactive isotope used in radioactive tracing). (wikipedia.org)
Radioactive isotopes can be tested using the autoradiographs of gels in gel electrophoresis. (wikipedia.org)
The radiation emitted by compounds containing the radioactive isotopes darkens a piece of photographic film, recording the position of the labeled compounds relative to one another in the gel. (wikipedia.org)
A radiogenic isotope tracer involves an isotope produced by radioactive decay, which is usually in a ratio with a non-radiogenic isotope (whose abundance in the earth does not vary due to radioactive decay). (wikipedia.org)
Stable isotope labeling involves the use of non-radioactive isotopes that can act as a tracers used to model several chemical and biochemical systems. (wikipedia.org)
Am-Americum are radioactive isotopes and have a half-life of 7,950 years. (mighty-90.com)
At-Atatine is a radioactive isotope with an extremely short half-life of 7.2 to 8 hours. (mighty-90.com)
Naturally occurring potassium is composed of three isotopes, of which 40 K is radioactive. (chemkits.eu)

Arsenic metabolism is affected by tissue and blood levels of zinc, selenium, arginine, choline, methionine, taurine, and quaniacetic acid, all of which affect methyl-group metabolism and polyamine synthesis which is the site of arsenic function in human physiology. (mighty-90.com)
Selenium, of course, is an antioxidant that works with vitamin E to protect cells from the damaging effects of free radicals. (radiationdangers.com)
It is important both for the prevention of selenium-related deficiency diseases and for its health promoting biological functions as part of the amino acid selenocysteine that is incorporated into the selenoproteins. (pharmanord.com)

1990. A review on biochemical roles, toxicity and interactions of zinc, copper and iron: IV. (cdc.gov)
Zinc and copper modulate differentially the P2X receptor. (cdc.gov)
Radial and median nerve conduction velocities in workers exposed to lead, copper, and zinc: A follow-up study for 2 years. (cdc.gov)
1992. Auditory event-related potential (P300) in relation to peripheral nerve conduction in workers exposed to lead, zinc, and copper: Effects of lead on cognitive function and central nervous system. (cdc.gov)
1994. Inhibition of Na+-glucose cotransport in kidney cortical cells by cadmium and copper: Protection by zinc. (cdc.gov)
1995. Copper and zinc metabolism in health and disease: Speciation and interactions. (cdc.gov)
1992. Use of zinc acetate to treat copper toxicosis in dogs. (cdc.gov)
You shouldn't take copper supplements and zinc supplements at the same time. (supplemented.net)
First row transition metals and general properties of their compounds (oxides, halides and suplhides), Inner transition elements, general feature: Chemistry of iron, copper, silver, gold zinc and mercury (occurrence and extraction without technical details). (successcds.net)

However, the most commonly used stable isotope tracers involve relatively light isotopes, which readily undergo fractionation in natural systems. (wikipedia.org)

1998. Interaction of blood lead and *-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. (cdc.gov)
A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. (lookformedical.com)
Recent studies have focused on asymmetric synthesis of structurally complex amino acids, using what has proved to be a very versatile radical-based methodology and also the use of structurally unusual heterocycles for masking the reactivity of synthetically valuable functional groups. (exeter.ac.uk)
The use of radical-based methodology in the synthesis of highly substituted amines and amino acids. (exeter.ac.uk)

the others are vitamins, essential fatty acids, and essential amino acids. (biologyonline.com)
A group of 16-carbon fatty acids that contain no double bonds. (lookformedical.com)
Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (lookformedical.com)
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. (lookformedical.com)
These fatty acids are not in glycerol ester form. (lookformedical.com)
Covalent attachment of LIPIDS and FATTY ACIDS to other compounds and PROTEINS. (lookformedical.com)
Triglycerides are a type of fat found in the blood that are made up of three fatty acids and a glycerol molecule. (lookformedical.com)
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon. (lookformedical.com)
A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (lookformedical.com)

A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. (lookformedical.com)

Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure. (lookformedical.com)
An essential branched-chain aliphatic amino acid found in many proteins . (lookformedical.com)

Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)
Twenty alpha-amino acids are the subunits which are polymerized to form proteins . (lookformedical.com)
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS . (lookformedical.com)
A modified xanthoproteic nitric acid test for proteins proved to be a rapid, and simple test to detect adulteration in both whole and finely ground nests, and would be suitable in the field where analytical facilities are not readily available. (researchgate.net)
Richard Burke SUMMARY The heavy metal zinc is an essential component of the human diet and is incorporated as a structural component in up to 10% of all mammalian proteins. (biologists.com)

Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation in neutron count) through a reaction, metabolic pathway, or cell. (wikipedia.org)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. (lookformedical.com)

It is an amino acid derivative and an essential cofactor for fatty acid metabolism. (lookformedical.com)

A branched-chain essential amino acid that has stimulant activity. (lookformedical.com)
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. (lookformedical.com)
Additionally, EBN contains essential elements such as calcium (1298 ppm), sodium (650 ppm), magnesium (330 ppm), potassium (110 ppm), phosphorous (40 ppm), zinc, and iron (30 ppm) (Marcone 2005) . (researchgate.net)
One of the remarkable components of EBN is sialic acid (N-acetylneuraminic acid), which constitutes a significant proportion of essential sugars in EBN, making up approximately 9% of the total essential sugars. (researchgate.net)

Isotope tracers are commonly used in the form of isotope ratios. (wikipedia.org)
Further discussion of the application of isotopic tracers in geology is covered under the heading of isotope geochemistry. (wikipedia.org)
Isotopic tracers are usually subdivided into two categories: stable isotope tracers and radiogenic isotope tracers. (wikipedia.org)
Stable isotope tracers involve only non-radiogenic isotopes and usually are mass-dependent. (wikipedia.org)

Taken together, this study highlights the discovery of a small-molecule CuB, which reprograms lipid metabolism for controlling mitochondrial dynamics via targeting PCK2 in cancer cells. (bvsalud.org)
One has but to examine the complex metabolic pathways in simple amino acid metabolism in the body to realize that deficiency of even a single element has the potential to wreak havoc with the complex central nervous system. (2medicalcare.com)

Animal and in vitro studies maintain that gamma aminobutyric acid (GABA) and glutamic acid decarboxylase (GAD) play fundamental metabolic roles in the pancreas and may be potential therapeutic targets in T1D. (nature.com)
Further, GABA-deficient islets did not show appropriate glucagon inhibition in response to increasing glucose concentrations in vitro 22 , suggesting that GABA is directly involved in the suppression of glucagon secretion in pancreatic alpha cells. (nature.com)
1976. The in vitro effect of zinc on the inhibition of human *-aminolevulinic acid dehydratase by lead. (cdc.gov)
and promoted the proliferation and invasiveness of breast cancer cells both in vivo and in vitro. (cancerindex.org)

The compounds produced using stable isotopes are either specified by the percentage of labeled isotopes (i.e. 30% uniformly labeled 13C glucose contains a mixture that is 30% labeled with 13 carbon isotope and 70% naturally labeled carbon) or by the specifically labeled carbon positions on the compound (i.e. 1-13C glucose which is labeled at the first carbon position of glucose). (wikipedia.org)
Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid. (lookformedical.com)
A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. (lookformedical.com)
14-carbon saturated monocarboxylic acids. (lookformedical.com)
C-13 is a stable carbon isotope. (lookformedical.com)
Amino acids which have a branched carbon chain. (lookformedical.com)

Ionisation of electrolytes, weak and strong electrolytes acid -base equilibrium, Bronsted & Lowry's concept of acids and bases on these concepts. (successcds.net)

The position of the isotopes in the products is measured to determine the sequence the isotopic atom followed in the reaction or the cell's metabolic pathway. (wikipedia.org)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)

Multiple immunological abnormalities have been reported in T1D patients including autoantibody production against the insulin molecule, the 65 kD isoform of glutamic acid decarboxylase (GAD65), various islet antigens, and the zinc transporter 8 (ZnT8) as well as decreased regulatory T cell (Treg) capacity to suppress T-cell mediated destruction of the islets of Langerhans 3 . (nature.com)

Then, lycorine noticeably triggered oxidative stress in CRC cells to cause mitochondrial membranes injury, and subsequently facilitated mitochondrial fission. (bvsalud.org)
The gorex of total phospholipids and cholesterol in the red cell membranes are normal or greater than in normal red cells, because you forced him to do lowezt. (forexkagireviews.com)

Astrocytes are an abundantly distributed population of glial cells in the central nervous system (CNS) that perform myriad functions in the normal and injured/diseased brain. (cdc.gov)

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. (lookformedical.com)

Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. (lookformedical.com)
The addition of an organic acid radical into a molecule. (lookformedical.com)

In theory, any element with two stable isotopes can be used as an isotopic tracer. (wikipedia.org)

Derivatives of caprylic acid. (lookformedical.com)
The aim of these studies has been to develop a much-needed general synthetic route to amino acids (and other amine derivatives) possessing a quaternary chiral centre alpha -to the nitrogen atom and in particular, alpha , alpha -disubstituted alpha -amino acids. (exeter.ac.uk)
The central theme of this methodology is the formation of alpha -aminoalkyl radicals from existing amino acid and alpha -amino alcohol derivatives by 1,5-hydrogen atom transfer and the subsequent trapping of these radicals with appropriate radicalphiles, thus generating quaternary centres with high efficiency and excellent stereocontrol. (exeter.ac.uk)

Antagonistic effects of zinc and aluminum on lead inhibition of *-aminolevulinic acid dehydratase. (cdc.gov)
Acid soils yield highest amounts of soil aluminum to plants. (mighty-90.com)

A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transamination of branched-chain AMINO ACIDS to 2-oxoglutarate. (lookformedical.com)
An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE , forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. (lookformedical.com)

1985. Effects of marginal zinc deficiency on subclinical lead toxicity in the rat neonate. (cdc.gov)

Subsequently, mRNA was extracted, and reverse transcription-polymerase chain reaction(RT-PCR) was used to measure the mRNA transcription of multiple cytokines in RAW264.7 cells. (bvsalud.org)
Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. (lookformedical.com)

In addition to these statistics, even low limits of daily intake set as RDA requirements were not met by the population in general for Vitamin E, Vitamin B6, magnesium or zinc to mention only a few of many which could be cited. (2medicalcare.com)

A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. (lookformedical.com)

It is shown that in aqueous solutions, zinc phthalocyanines with cholinyl peripheral substituents form complexes with negatively charged DND based on electrostatic interactions. (allergy-link.com)

This occurs in tissue cell cytosol, with high activity in the duodenum, liver , and kidney. (lookformedical.com)

Accordingly, there is an unmet need for targeting of solid tumor cells for the treatment of malignant diseases that will show an affinity for cancer cells, deliver therapeutic payloads that inhibit proliferation and/or destroy cancerous tumor cells without inhibiting and/or destroying normal cells. (justia.com)
The proliferation of tumor cells is characterized by inflammation of tumor sites, the ability of tumor cells to evolve HSPG (heparan sulphate proteoglycans) in a similar manner to basal membrane Keratinocytes, and the presence of various growth factor receptors known to congregate at the surface of tumor cells. (justia.com)

Specific knockdown of IDH1 or SIRT1 markedly aggrieved lycorine-mediated oxidative stress and mitochondrial fragmentation in CRC cells. (bvsalud.org)

Regarding Type 1 diabetes(T1D), animal/islet-cell studies found that GABA promotes insulin secretion, inhibits α-cell glucagon and dampens immune inflammation, while GAD immunization may also preserve β-cells. (nature.com)

Rapidly growing breast mass could hardly ever become metastasis GS-1101 kinase activity assay from rhabdomyosarcoma, leukaemia, lymphoma, primitive neuroectodermal tumours, Ewing sarcoma, malignant melanoma and renal cell carcinoma.3 However, the size of such masses is not usually as gigantic as in our individual. (columbiagypsy.net)
Therefore, we concluded that ZNF326 is highly expressed in breast cancer, is associated with poor prognosis, and plays a vital role in promoting the malignant phenotype of breast cancer cells by interacting with DBC1. (cancerindex.org)

A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis. (lookformedical.com)

Together with iron, it enables the body to form red blood cells. (supplemented.net)

Potassium ions are necessary for the function of all living cells. (chemkits.eu)

By studying the ratio between two isotopes of the same element, we avoid effects involving the overall abundance of the element, which usually swamp the much smaller variations in isotopic abundances. (wikipedia.org)
1998. The effect of zinc supplementation on the effects of lead on the rat testis. (cdc.gov)

The body responds to the influx of dietary potassium, which raises serum potassium levels, with a shift of potassium from outside to inside cells and an increase in potassium excretion by the kidneys. (chemkits.eu)

It is found in all body tissues and plays a role in making red blood cells and maintaining nerve cells and the immune system. (supplemented.net)
Amino acids that are not synthesized by the human body in amounts sufficient to carry out physiological functions. (lookformedical.com)

As revealed by mechanism analysis, JFG extract enhanced the phosphorylation of p38, ERK1/2, IRF3, STAT1, and STAT3 in RAW264.7 cells induced by CpG. (bvsalud.org)

Furthermore, the combination of lycorine and sirtuins blocker nicotinamide (NAM) exhibited a synergic therapeutic effect in CRC cells. (bvsalud.org)
1988. Antagonistic effect of zinc in lead treated developing chick embryos. (cdc.gov)

The invention also provides nanosphere particle preparations that are useful for selectively delivering therapeutic, diagnostic, and/or other agents to cancer cells of subjects without eliciting a serotype-specific immunogenic response in the subjects. (justia.com)
Many therapeutic agents cannot be delivered effectively to treat cancerous cells by conventional means such as ingestion, injection, inhalation, and topical application because many of these agents are subject to rapid degradation. (justia.com)

The reactant is 'labeled' by replacing specific atoms by their isotope. (wikipedia.org)

Once hyperglycemia appears, more than 70% of islet beta cell mass has been eradicated 4 . (nature.com)

For example, those agents that target actively dividing cells are not able to discriminate between actively dividing cancer cells and actively dividing healthy cells. (justia.com)
Thus, in the process of destroying or inhibiting the rapidly dividing cancer cells, many of the healthy cells are also damaged. (justia.com)
Mechanistically, co-immunoprecipitation and immunofluorescence assays both demonstrated that ZNF326 interacted with deleted in breast cancer-1 (DBC1) in breast cancer cells. (cancerindex.org)
Prognostic significance of MATR3 in stage I and II non-small cell lung cancer patients. (nih.gov)

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

MANGANESE3

Nucleic2

Protein8

Radioactive8

Selenium3

Copper9

Fractionation1

Synthesis4

Fatty acids9

Lipids1

Aliphatic2

PROTEINS5

Detectable2

Cofactor1

Essential4

Tracers4

Metabolism2

Vitro4

Carbon6

Equilibrium1

Sequence2

Glutamic1

Membranes2

Abundantly1

Compounds1

Organic2

Stable1

Derivatives3

Aluminum2

Enzyme that catalyzes2

Deficiency1

Reaction2

Magnesium1

Arginine1

Peripheral1

LIVER1

Proliferation2

Oxidative1

Insulin1

Malignant2

Oxidation1

Iron1

Ions1

Effects2

Potassium1

Body2

Mechanism1

Effect2

Therapeutic2

Specific1

Mass1

Cancer4