Amino acid sequence that binds. Medical search. Frequent questions

Of these three proteins, TBG has the highest affinity for T4 and T3 but is present in the lowest concentration relative to transthyretin and albumin, which also bind T3 and T4 in circulation. (wikipedia.org)
Several experimental techniques have been proposed to identify the DNA-binding sites and investigate the interaction modes between proteins and DNAs. (nature.com)
There is an urgent need for computational tools that can rapidly and reliably identify DNA-binding sites in DNA-binding proteins. (nature.com)
Gideon Dreyfuss (University of Pennsylvania School of Medicine, Philadelphia): "Protein structural comparisons led to the discovery of identifying and unifying features shared by RNA-binding proteins of the nucleus and cytoplasm. (the-scientist.com)
RNP-CS proteins display binding preferences for specific RNA sequences, and several have been shown to interact with pre-mRNA sequences important for pre-mRNA processing. (the-scientist.com)
Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
Moreover, as the word 'coding' refers to the relationship between nucleic acids and proteins, rather than the mere transcription of DNA into RNA, it is logical to call the strand with the mRNA sequence the coding strand, as in the first example. (genomicglossaries.com)
Binding sites of other proteins which are similar to the binding site of the target protein can offer hints for possible side effects of a new drug prior to clinical studies. (uni-marburg.de)
Moreover, binding site comparisons are used as an idea generator for bioisosteric replacements of individual functional groups of the newly developed drug and to unravel the function of hitherto orphan proteins. (uni-marburg.de)
The structural comparison of binding sites is especially useful when applied on distantly related proteins as a comparison solely based on the amino acid sequence is not sufficient in such cases. (uni-marburg.de)
The Automatic Search for Ligand Binding Sites in Proteins of Known Three-dimensional Structure Using only Geometric Criteria. (uni-marburg.de)
The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
Parvalbumin is a glycoprotein that belongs to calcium binding family of EF-hand superfamily of proteins. (usda.gov)
However, it remains unclear where these proteins bind on the AChR and how the interactions are regulated. (jneurosci.org)
We identified 78 amino acid sequences from self proteins presented in the lungs of sarcoidosis patients, some of which were well-known autoantigens such as vimentin and ATP synthase. (jci.org)
Recently, it has been recognized that membrane-bound ribosomes are crucial for biogenesis of integral membrane proteins in E. coli , thus renewing interest in ribosome targeting to and association with the membrane in this organism. (rupress.org)
Sanofi developed Praluent®, a monoclonal antibody that also targets PCSK9 to prevent it from binding to and destroying LDL-R proteins. (klgates.com)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
In addition to the 10 cysteines there are only 16 identical amino acids in the proteins from human, rhesus monkey, baboon, pig, rat and mouse. (lu.se)
The tree-dimensional structure of human and porcine MSP are very similar in spite of only a 50 % identity in the amino acid sequences of the two proteins. (lu.se)
Serum amyloid A and alpha-1 acid glycoprotein are transport proteins, and fibrinogen is a coagulation factor. (msdmanuals.com)
Antibodies recognize specific configurations (epitopes, or antigenic determinants) on the surfaces of antigens (eg, proteins, polysaccharides, nucleic acids). (msdmanuals.com)
zooepidemicus strains in association with differences in M-like protein-mediated binding of host plasma proteins. (lu.se)

The knowledge about DNA-binding residues, binding specificity and binding affinity helps to not only understand the recognition mechanism of protein-DNA complex, but also give clues for protein function annotation. (nature.com)
Bullock and Fersht 8 have shown that mutations of DNA-binding residues, such as those on the tumor repressor protein P53, may predispose individuals to cancer. (nature.com)
Protein sequence information mainly consists of amino acid residue composition, biochemical features of amino acid residues and evolutionary information in terms of position-specific scoring matrices (PSSM). (nature.com)
Yan and his coworkers 11 trained a Naïve Bayes classifier by using only sequence information, such as the identities of the target residue and its sequence neighboring residues. (nature.com)
The protein consists of some 1217 amino acid residues and a 28-residue signal peptide. (unifi.it)
1] Notably, Amgen's patents do not claim any particular antibody by amino acid sequence, but instead claim the entire genus of antibodies that bind to at least one of 15 specified amino acid residues of PCSK9 and block PCSK9 from binding to LDL-R. The specifications disclose a trial-and-error process "used to generate and screen antibodies that bind to PCSK9 and block PCSK9 from binding to LDL-Rs. (klgates.com)
3] Sanofi argued that Amgen's patents did not disclose enough species of antibodies to provide written description support for claims to the entire genus of antibodies that bind to PCSK9 at the specified amino acid residues. (klgates.com)
The fine specificity, as determined by the requirement of particular amino acid residues in the epitope, is shifted in these new antibody fragments. (lu.se)

Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)

Using the fluorogenic substrate succinyl-Ala-Ala-Ala-4-methylcoumaryl-7-amide (Suc-Ala-Ala-Ala-MCA), containing the sequence similar to the cleavage sites for proTGF-alpha processing, we identified a putative candidate proTGF-alpha-converting enzyme in the membrane fractions of Chinese hamster ovary (CHO) cells. (nih.gov)
Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)

The whole amino acid sequence of nidogen was deduced from cDNA clones isolated from expression libraries and confirmed to approximately 50% by Edman degradation of peptides. (unifi.it)
Binding Mechanisms of Amyloid-like Peptides to Lipid Bilayers and Effects of Divalent Cations. (acs.org)
The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)
HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. (jci.org)
This approach can be extended to characterize HLA-bound peptides in various autoimmune settings. (jci.org)
In this issue of the JCI , two separate studies on MHC-bound peptides reopen the debate on the utility of peptides for the purposes of vaccination and treatment of autoimmune diseases. (jci.org)
peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
Short peptides (8 to 12 amino acids, excluding Cys) bind selectively to nanoparticles composed of Au, Pd, and montmorillonite depending on the sequence of amino acids, as evidenced by laboratory screening of several billion peptides. (aps.org)

In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. (nature.com)

In contrast to mouse FcRn, which binds to IgGs from multiple different species, human FcRn is surprisingly stringent in binding specificity. (nih.gov)
Here, we have used site-directed mutagenesis in combination with interaction (surface plasmon resonance) studies, with the goal of generating human FcRn variants that more closely resemble mouse FcRn in binding specificity. (nih.gov)
These studies define the molecular basis for the marked difference in binding specificity between human and rodent FcRn, and give insight into how human FcRn recognizes IgGs. (nih.gov)
A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)
The molecular reasons for binding versus non-binding and the specificity toward a certain surface are analyzed by molecular dynamics simulation, using recent force field extensions for fcc metals and sheet silicates to reproduce surface and interface energies with $ (aps.org)

Wang and his coworkers 12 investigated the discriminative power of three sequence features from protein sequence, including the side chain pKa value, the hydrophobicity index and the molecular mass of an amino acid. (nature.com)
Molecular biologists describing DNA sequences or referring to one of the two strands of double- stranded DNA frequently use complementary pairs of terms, such as coding/ non- coding, sense/ nonsense or transcribing/ non- transcribing. (genomicglossaries.com)
AGT is a high molecular weight molecule (49.548), made up of 453 amino acids (aa) synthesized in the liver. (hindawi.com)

In the cell-free reconstitution system, the membrane-bound Suc-Ala-Ala-Ala-MCA-hydrolyzing enzyme from CHO cells was also activated by phorbol ester in the presence of the soluble fraction, ATP, and vanadate. (nih.gov)
Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells. (unifi.it)
Peptide-Membrane Binding: Effects of the Amino Acid Sequence. (acs.org)
Here, we demonstrate that βSyn and γSyn have a reduced affinity towards membranes compared to αSyn, and that direct interaction of βSyn or γSyn with αSyn results in reduced membrane binding of αSyn. (biorxiv.org)
V-ATPase is made of two subcomplexes: a cytosolic V 1 that carries out ATP hydrolysis, and a membrane bound V o that is responsible for proton translocation. (upstate.edu)
A-type ephrins bind A-type receptors, which are tethered to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. (rndsystems.com)
Only membrane bound or Fc-clustered ephrin ligands are capable of activating the receptor in vitro . (rndsystems.com)
Together, these findings suggest that agrin-induced phosphorylation of the β subunit motif increases the stoichiometry of rapsyn binding to the AChR, thereby helping to stably cluster the receptor and anchor it at high density in the postsynaptic membrane. (jneurosci.org)
Here we show that in cells depleted of the SRP protein, Ffh or the translocon component SecE, the ribosomal targeting pathway is blocked downstream and unprecedented, membrane-bound FtsY-ribosomal complexes are captured. (rupress.org)
Membrane-bound ribosomes in E. coli were extensively studied over 20 years ago. (rupress.org)
Each of the three is composed of two subunits: S1, the membrane distal region, including the receptor-binding and N-terminal domains, and S2, the membrane-proximal protein. (forbes.com)

Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. (embl.de)

After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
Amgen's patents share a common specification and are directed toward antibodies that help rid the body of "bad cholesterol" or "low-density lipoprotein" cholesterol known as LDL-C. Those antibodies target PCSK9, a naturally occurring protein, and prevent PCSK9 from binding to and destroying liver cell receptors (LDL-R) that help extract LDL-C from the bloodstream. (klgates.com)
Mutations that alter the structure of the binding site render monoclonal antibodies useless. (forbes.com)
they are called variable because the amino acids they contain are different in different antibodies. (msdmanuals.com)
These findings show that phage display technology might modify the binding properties of pre-existing, high affinity antibodies. (lu.se)

At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
B-type ephrins bind to B-type receptors, which have a single transmembrane domain and a cytoplasmic region. (rndsystems.com)

[2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)
Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)
This international collaboration provides researchers with free access to a central hub for identifying protein sequences, the lineup of amino acids that determine a protein's 3D structure and function, such as an antibody that binds to specific viruses and bacteria. (udel.edu)
We show here that the reactivity of a high affinity, virus-neutralizing human antibody against the AD-2 epitope of cytomegalovirus gB can be modified by introducing other Vkappa sequences together with the original VH sequence. (lu.se)
It was also evident that the VH/Vkappa pairing was not promiscuous, since antibody fragments selected by phage display retained light chain sequences very similar to the original hybridoma-derived light chain, proving that a high affinity interaction was very dependent on a co-operativity between both variable domains. (lu.se)

We report the observation of intermediate structures in the self-assembly of the peptide KFE8 (FKFEFKFE), designed with alternating polar and nonpolar amino acids. (acs.org)
Drug-Embedded Nanovesicles Assembled from Peptide-Decorated Hyaluronic Acid for Rheumatoid Arthritis Synergistic Therapy. (acs.org)
The method's focus is to globally detect mass differences, not to assign peptide sequences or modifications to individual spectra. (lu.se)
The goal is to assign acquired spectra to known peptide sequences and potential co- and post-translational modifica- tions. (lu.se)

Thyroxine-binding globulin (TBG) is a globulin protein that in humans is encoded by the SERPINA7 gene. (wikipedia.org)
This amino acid sequence is conserved in organisms as diverse as yeast and humans. (the-scientist.com)
MSP is also present in other mammals, the amino acid sequence is, however, very different from that of humans. (lu.se)

Therefore, a reliable identification of DNA-binding sites in DNA-binding protein is important for protein function annotation, in silico modeling of transcription regulation and site-directed mutagenesis. (nature.com)
These approaches depend on sequence databases that are used by the engines to match real spectra to theoretical in silico spectra. (lu.se)

While the genomic sequence of DcAOX2a was previously described, we characterize here the complete genomic sequence of DcAOX1 . (frontiersin.org)

The MHC class I-related receptor, FcRn, is involved in binding and transporting immunoglobulin G (IgG) within and across cells. (nih.gov)
Isoform E lacks a mitochondrial targeting sequence and so is distributed to both cytosol and the nucleus when expressed in cultured cells. (nih.gov)
The cryo-EM analysis also revealed a population of free V 1 bound to Oxidation Resistance 1 (Oxr1p), a poorly characterized protein that has been implicated in protecting cells from oxidative stress. (upstate.edu)
Here, we investigated the effect of dicalcin, a Ca2+-binding protein, on the invasion and metastasis of ovarian cancer (OC) cells. (bvsalud.org)

A recent study from the Wilkens lab in collaboration with Seoul National University uncovered a novel mechanism of yeast V-ATPase regulation based on biochemical experiments and cryo electron microscopy (cryo-EM) structures of holo V-ATPase and Oxr1 bound V 1 subcomplex. (upstate.edu)
Biochemical experiments showed that Oxr1p binds and promotes V-ATPase disassembly. (upstate.edu)

Synthetic antisense DNAs are used to hybridize to complementary sequences in target RNAs or DNAs to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
The DNA-binding domain (DBD) of the hGRα corresponds to amino acids 420-480 and contains 2 zinc finger motifs through which the hGRα binds to specific DNA sequences, the glucocorticoid-response elements (GREs) in the promoter region(s) of target genes. (medscape.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)

To the best of our knowledge, there is no method that can predict the binding site of SAM in a given protein sequence. (edu.in)
They are typically trained from a set of input features, which can be generally divided into three categories: protein sequence information, protein structure information and a combination of the two categories. (nature.com)
a small section of the protein sequence, resulting in an abnormal protein. (medlineplus.gov)
The proposed method is novel because it works independently of protein sequence databases and without any prior knowledge about modifica- tions. (lu.se)
PTMs from this list in conjunction with a protein sequence and a few precursor masses. (lu.se)

The sequence contains a conserved tyrosine (Y390) whose phosphorylation is induced by agrin and whose mutation abolished clustering of β loop chimeras and their ability to inhibit agrin-induced clustering of the endogenous AChR. (jneurosci.org)

This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. (rndsystems.com)

Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)

a Domain organization of the four subunits of human Pol δ and amino acid sequence of PCNA-interacting (PIP-box) motifs. (nature.com)

Furthermore, specific point mutations in these portable flanking sequences modulated the production and antigenicity of epitopes. (jci.org)

The smaller polypeptide of M(r) ~73 kDa yielded an N-terminal amino-acid sequence that was homologous to laccase-like polyphenol oxidases (E.C. 1.10.3.2) from loblolly pine (Pinus taeda L.), poplar (Populus euramericana (Dode) Guinier) and Arabidopsis. (who.int)
The larger polypeptide (M(r) ~77 kDa) yielded an N-terminal amino-acid sequence that was homologous with a range of plant subtilisin-like serine proteinases. (who.int)

In the present work, accelerated methods for the comparison of protein binding sites as well as an extended procedure for the assessment of ligand poses in protein binding sites are presented. (uni-marburg.de)
Methods for the assessment of ligand poses in protein binding sites are also used in the early phase of drug development within docking programs. (uni-marburg.de)
These programs are utilized to screen entire libraries of molecules for a possible ligand of a binding site and to furthermore estimate in which conformation the ligand will most likely bind. (uni-marburg.de)
How to Measure the Similarity Between Protein Ligand-binding Sites. (uni-marburg.de)
Pocketome via Comprehensive Identification and Classification of Ligand Binding Envelopes. (uni-marburg.de)
A simple and fuzzy method to align and compare druggable ligand-binding sites. (uni-marburg.de)
The human GR is a modular protein composed of distinct regions illustrated in panel B in the image below, as follows: (1) The amino-terminal A/B region, also called immunogenic or N-terminal domain (NTD) and (2) the C, D, and E regions, which correspond to the DNA-binding domain, the hinge region, and the ligand-binding domain, respectively. (medscape.com)
The NTD of the hGRα contains a major transactivation domain, termed activation function (AF)-1, which is located between amino acids 77 and 262 of the hGRα and is ligand-independent. (medscape.com)

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is an intracellular pattern recognition receptor that recognizes bacterial peptidoglycan (PG) containing meso-diaminopimelic acid (mesoDAP) and activates the innate immune system. (amrita.edu)

Our data suggest that all three synucleins affect synapse function, but only αSyn mediates the downstream function of vesicle clustering and SNARE-complex assembly, while βSyn and γSyn modulate the activity of αSyn through regulating its binding to synaptic vesicles. (biorxiv.org)

All ephrin ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. (rndsystems.com)

Oligonucleotide which displays specific binding to a protein or other target, often selected by an iterative cycle of affinity- based enrichment. (genomicglossaries.com)

Nidogen contains two consensus sequences for tyrosine sulfation and for asparagine beta-hydroxylation, two N-linked carbohydrate acceptor sites and, within one of the EGF-like repeats an Arg-Gly-Asp sequence. (unifi.it)
There are two structural groups of ephrin ligands which bind to a family of receptor tyrosine kinases (Eph). (rndsystems.com)
Indeed, we found that rapsyn associated with CD4-β loop chimeras in a phosphorylation-dependent manner, and that agrin increased the ratio of rapsyn binding to wild type AChR but not to AChR-β 3F/3F , which lacks β loop tyrosine phosphorylation sites. (jneurosci.org)

Furthermore, binding of human fibrinogen is associated with specific SzM types. (lu.se)

in December 2006, UniMod lists 495 modifications including 144 amino acid substitutions [6]. (lu.se)

Weak sequence homologies (25%) were detected between some regions of nidogen, the LDL receptor, thyroglobulin and the EGF precursor. (unifi.it)
Protein binding site comparisons are frequently used receptor-based techniques in early stages of the drug development process. (uni-marburg.de)
Soluble monomeric ephrin ligands bind the receptor but do not induce receptor autophosphorylation and activation. (rndsystems.com)
Here, we define a phosphorylation-dependent binding site on the receptor that mediates agrin-induced clustering. (jneurosci.org)
The targets in the Spike protein are the primary receptor-binding domain (RBD) and the secondary N-terminal domain (NTD). (forbes.com)
The receptor-binding domain atop S1 can assume two configurations: up, capable of binding the ACE 2 receptor, or down, non-binding (Figure 1). (forbes.com)

Terrestrial animals such as reptiles and mammals predominantly use DPHK sequences in both IRF3 and 7. (cdc.gov)

Result: This manuscript describes a method SAMbinder, developed for predicting SAM interacting residue in a protein from its primary sequence. (edu.in)
Most of the existing computational approaches employed only the sequence context of the target residue for its prediction. (nature.com)
In the present study, for each target residue, we applied both the spatial context and the sequence context to construct the feature space. (nature.com)
We have discovered that erythrocyte frataxin is in fact a novel isoform of frataxin (isoform E) with 135-amino acids and an N-terminally acetylated methionine residue. (nih.gov)
At a certain spot in its amino acid sequence, PHL7 carries a leucine where other enzymes carry phenylalanine residue. (sciencealert.com)
These results suggest that the phenylalanine/leucine replacement could be partially responsible for the changes in per-residue binding energy contributions in PHL7," the authors write . (sciencealert.com)

For example, human FcRn does not bind to mouse IgG1 or IgG2a and interacts only weakly with mouse IgG2b. (nih.gov)
Partial amino acid sequence of human thyroxine-binding globulin. (wikipedia.org)
With the exception of their divergent C-terminal tails, human CB2 R shares 82% amino acid sequence identity with mouse and rat CB2 R. (rndsystems.com)
Prominent Binding of Human and Equine Fibrinogen to Streptococcus equi subsp. (lu.se)
zooepidemicus strains that the M-like protein SzM is crucial for the binding of fibrinogen to the bacterial surface and for survival in equine and human blood. (lu.se)
zooepidemicus isolates of equine and human origins were compared with regard to SzM sequences and binding of equine and human fibrinogens. (lu.se)
The N-terminal 216 amino acids of the mature SzM were found to exhibit a high degree of diversity, but the majority of human isolates grouped in three distinct SzM clusters. (lu.se)
Plasma protein absorption assays and flow cytometry analysis revealed that pronounced binding of human fibrinogen is a common phenotype of human S. equi subsp. (lu.se)
These results suggest that SzM-mediated binding of human fibrinogen is an important virulence mechanism of zoonotic S. equi subsp. (lu.se)
The reference sequence was derived from Ensembl Human sequence AL391069.11.1.121357 . (lu.se)

These are identical through amino acid 727, but then diverge, with hGRα having an additional 50 amino acids and hGRβ having an additional, nonhomologous 15 amino acids. (medscape.com)

Even though the function of MSP is not known it has been found that it binds very strongly to CRISP-3, another protein with an unknown function. (lu.se)

RabV shares only 75%-77% the past 40 years, and several virus strains were isolated nucleotide identity and 89%-90% amino acid identity with from mosquitoes, rodents, and migrating birds (3). (cdc.gov)

The sense strand has the same sequence as the mRNA transcript. (genomicglossaries.com)
H.sapiens mRNA for DNA binding regulatory factor. (lu.se)

All models were trained, tested, and evaluated on 145 SAM binding protein chains where no two chains have more than 40\% sequence similarity. (edu.in)
Efficient Similarity Retrieval for Protein Binding Sites based on Histogram Comparison. (uni-marburg.de)

Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. (the-scientist.com)
The catalytic subunit (p125) harbours the polymerase and exonuclease activities, and a metal-binding C-terminal domain (CTD). (nature.com)
CTD C-terminal domain, OB oligonucleotide binding domain, PDE phosphodiesterase domain. (nature.com)
Another motif, DPHK, is in the DNA-binding domain. (cdc.gov)

By making deletions in the β loop we defined a 20 amino-acid sequence that is sufficient for clustering. (jneurosci.org)

The most highly conserved motif within the RBD is the ribonucleoprotein consensus sequence (RNP-CS). (the-scientist.com)

And so, when labeled hormone is added, since TBG is so high, once equilibrium between the binding of endogenous thyroid hormone and the labeled hormone is achieved, less free labeled hormone will be available for uptake into the resin. (wikipedia.org)
Thus, when the labeled hormone is added, since so little TBG is available in the blood, after equilibrium is achieved, only a small portion of it will bind, leaving plenty available for uptake by the resin. (wikipedia.org)

An analysis of the number of binding sites in the spatial context of the target site indicates that the interactions between binding sites next to each other are important for protein-DNA recognition and their binding ability. (nature.com)
The conformations of the bound lipid and the interactions between protein and lipid provide insights into the factors governing lipoprotein formation. (rcsb.org)

Bacterial Peptidoglycan with Amidated Meso-diaminopimelic Acid Evades NOD1 Recognition: an Insight into NOD1 Structure-Recognition. (amrita.edu)

Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. (wikipedia.org)
The comparison between our proposed PDNAsite method and the existing methods indicate that PDNAsite outperforms most of the existing methods and is a useful tool for DNA-binding site identification. (nature.com)
The antigen binding site is circled. (wikipedia.org)
However, neither the site of rapsyn binding by the AChR nor the factors regulating binding to it are known. (jneurosci.org)

There is a need to develop a method for predicting SAM binding sites in a protein for designing drugs against SAM associated disease. (edu.in)
So, for instance, if the patient is truly hypothyroid, and TBG levels are normal, then there are many sites open for binding on the TBG, since the total thyroid hormone level is low. (wikipedia.org)
In contrast, however, if the patient is truly hyperthyroid, and TBG levels are normal, the patient's endogenous hormone will saturate the TBG binding sites more, leaving less room for the labeled hormone, which allows greater binding to the resin. (wikipedia.org)
Binding sites for laminin and collagen IV are present on the C-terminal globule but not yet precisely localized. (unifi.it)
It also inhibits EMT and ROS1, a kinase that shares 77% of amino acid sequences of adenosine triphosphate (ATP)-binding sites with the ALK. (medpagetoday.com)

Anatomy14

Organisms18

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes80

Disciplines and Occupations1

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Proteins26

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Putative2

Peptides9

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Molecular3

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Antibodies5

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Peptide4

Humans3

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Modulate1

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Receptor6

Mammals1

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Human10

Identical1

Another protein1

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