Amino acid sequence protein precursors. Medical search. Frequent questions

Mass spectrometric evidence suggested that the protein presented microheterogeneity at its termini, i,e,, truncated forms presumably due to processing heterogeneity, The present characterization of the 2S ASP-Ib protein, the second 2S albumin from Ricinus communis seeds, demonstrates that the 237-residue precursor protein codes for two different heterodimer proteins containing 97 and 99 residues each, This system should be useful for studying the posttranslational processing of plant storage proteins. (unifesp.br)
All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. (novusbio.com)
Analysis of their deduced amino acid sequences revealed several important differences from prototypic subtype B strains, including changes in the number and distribution of cysteine residues, substantial length differences in hypervariable regions, and premature truncations in the gp41 domain. (duke.edu)
A cDNA clone encoding a protein consisting of 189 amino acid residues including a sodefrin sequence was isolated from a Cynops pyrrhogaster abdominal gland cDNA library. (wiley.com)
This clone encoded a precursor protein of 192 amino acid residues, including a sodefrin-like peptide sequence with substitutions of two amino acid residues. (wiley.com)
[6] APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. (handwiki.org)
The peptide had 60 amino acid residues and a non-amidated C terminus. (phoenixpeptide.com)
The derived amino acid sequence indicates that the protein precursor consists of 383 amino acid residues including a N-terminal presequence peptide of 52 residues. (unipr.it)
Recombinant Human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF-homologous portion of the Epigen precursor. (peprotech.com)
The first 84-amino acid residues correspond to a typical transit sequence for the signal directing OEE1 to its appropriate compartment of chloroplast. (biu.ac.il)
The precursor of the S protein was cleaved into S1 and S2 fragments, which comprised 541 and 626 amino acid residues, respectively. (virosin.org)

This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. (wikipedia.org)
Containing the catalytic site, the beta subunit PMPCB protein cleaves presequences (transit peptides) from mitochondrial protein precursors and releases of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2. (wikipedia.org)
Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)
Alignment of the amino acid sequence of aprotinin with the Kunitz domains of human proteins allowed the identification and design of a family of peptides, named Angiopeps. (aspetjournals.org)
Amyloid precursor protein is cut by enzymes to create smaller fragments (peptides), some of which are released outside the cell. (medlineplus.gov)
Currently, dietary proteins are investigated not only from the nutritional or functional point of view, but also as raw material for obtaining peptides , 1 since any source of dietary protein is likely to provide functional peptides. (hi-peptide.com)
AD is pathologically characterized by the deposition of pathogenic Aβ peptides that are derived from larger integral membrane proteins, termed β-amyloid precursor proteins (APPs). (jneurosci.org)
To accomplish this, precursor isolation windows are widened such that multiple peptides are usually co-fragmented in the same MS/MS scan. (nature.com)
When experiment-specific spectrum library generation is either impossible or impractical, as is frequently the case with non-model organisms, sequence variants, splice isoforms, or scarce sample quantities, software tools such as Pecan 10 and DIA-Umpire 11 can detect peptides from DIA experiments without a spectrum library by directly searching every peptide in FASTA databases. (nature.com)
Gas-phase fractionation 12 (GPF) improves detection rates with these tools 10 by injecting the same sample multiple times with tiled precursor isolation windows, allowing each injection to have narrower windows (and thus fewer co-fragmented peptides) with the same instrument duty cycle. (nature.com)
While this method is often prohibitively expensive because it requires enough instrument time and protein content for multiple injections for each sample, the use of multiple GPF injections can be applied just to pooled samples to generate DIA-only chromatogram libraries that make it easier to detect peptides in single-injection DIA experiments 13 . (nature.com)
Recently it has become possible to accurately predict spectra from peptide sequences 14 , 15 , but direct searching of single-injection DIA data has remained problematic, in part due to the false discovery rate (FDR) correction required when considering all possible tryptic peptides in a FASTA database. (nature.com)

This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. (wikipedia.org)
Human CXCL10 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted protein. (rndsystems.com)
BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
Mouse ANG 3 cDNA encodes a 509 amino acid (aa) precursor protein with a 21 aa signal peptide. (reliatech.de)
The human IL-11 gene encodes a precursor protein containing 199 amino acids. (creative-proteomics.com)

[ 4 ] It is also important to understand that the same polypeptide sequence can produce many different patterns of interresidue or intraresidue interactions. (medscape.com)
For people with Alzheimer's disease, "humanin" was a name given to the 24-amino acid polypeptide encoded by this sequence of genes, identical to that of the mitochondrial 16S rRNA. (dailynewsmall.com)
Results showed that the S gene was 3501 bp encoding a polypeptide of 1167 amino acids. (virosin.org)
This suggests that the ability to fibrillate is an intrinsic property of a polypeptide chain and that the native structure is not necessarily the only ordered structure that each protein can assume. (uni-goettingen.de)
It had been suggested that alpha and beta polypeptides could be synthesized via a common precursor polypeptide. (rti.org)

100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined. (novusbio.com)
The amino acid sequence of mature spinach chloroplast O- acetylserine(thiol)lyase shows 40 and 57% homology with its bacterial counterparts. (unipr.it)
The N-terminal amino acids sequence of this protein had a significant homology with mature region of oxygen evolving enhancer protein 1 (OEE1) precursor. (biu.ac.il)
Although the sequence homology is much higher between the human and mouse counterparts for ANG1 (97%) and ANG2 (85%), mouse ANG3 is believed to be an ortholog of human ANG4 based on chromosomal localization studies. (reliatech.de)
The nt sequence shows 45-62% homology to those of bovine, ovine, rat, and mouse beta-caseins. (wikigenes.org)

Data from which amino acid sequences used for phylogenetic analyses were deduced: DANV, Dandenong virus (GenBank accession nos. (cdc.gov)
B) The amino acid sequence of the human hMC2R is presented (accession number - NP-001278840.1). (endocrinology-journals.org)
ACCESSION AP009048-129 PROTEIN_ID BAB96710.2 SOURCE Escherichia coli str. (nig.ac.jp)

One of these, derived from a patient with rapid CD4 cell decline, contained an amino acid substitution in a highly conserved endocytosis signal (Y721C), as mediated virus entry with very poor efficiency, although they did not contain sequence changes predicted to alter protein function. (duke.edu)
Amyloid-beta precursor protein is an ancient and highly conserved protein . (handwiki.org)
The extracellular E2 domain, a dimeric coiled coil and one of the most highly conserved regions of the protein from Drosophila to humans. (handwiki.org)
The structures of rat and human GALP-(1-60) were deduced from cloned cDNA, which indicated that the amino acid sequences 1-24 and 41-53 were highly conserved between humans, rats, and pigs. (phoenixpeptide.com)
To exploit highly conserved and difficult drug targets, including multipass membrane proteins, monoclonal antibody discovery efforts increasingly rely on the advantages offered by divergent species such as rabbits, camelids, and chickens. (bvsalud.org)

The APP gene provides instructions for making a protein called amyloid precursor protein. (medlineplus.gov)
The most common APP gene variant changes one of the protein building blocks (amino acids) in the amyloid precursor protein. (medlineplus.gov)
The term "vitellogenin" refers to both the gene and the expressed protein. (thepoultryhub.com)
The spike gene (S) of Infectious bronchitis virus (IBV) CK/CH/LDL97Ⅰ/97 isolate was amplified，cloned, sequenced and analyzed. (virosin.org)
The homologies of nucleotide and amino acid sequences of S1 gene between CK/CH/LDL97Ⅰ/97 and 27 reference IBV strains ranged from 60.6% to 99.6%, and 50.5% to 99.1%, respectively. (virosin.org)
Weighted gene correlation network analysis (WGCNA) can identify groups of biologically related proteins using only protein intensity values by constructing protein correlation networks. (stanford.edu)
The IL-11 gene contains a 7 kb gene sequence, with 5 exons and 4 introns, located on chromosomes 19q13.3-19q13.4. (creative-proteomics.com)

Scale bars indicate amino acid substitutions per site. (cdc.gov)
2007). Amino acid positions where amino acid substitutions as a result of a spontaneous point mutation that resulted in type 1 FGD and blocked activation of the mutant receptor (Chung et al . (endocrinology-journals.org)
in December 2006, UniMod lists 495 modifications including 144 amino acid substitutions [6]. (lu.se)

[ 6 ] In humans, about 23 different unrelated proteins are known to form amyloid fibrils in vivo. (medscape.com)

3, 137-155 (1996) REFERENCE 9 AUTHORS Fujita,N., Mori,H., Yura,T. and Ishihama,A. TITLE Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region JOURNAL Nucleic Acids Res. (nig.ac.jp)

They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)

Sequence comparison with several pyridoxal 5'-phosphate- containing proteins reveals the presence of a lysine residue assumed to be involved in cofactor binding. (unipr.it)
In B. gymnorrhiza, the predicted amino acid sequence of the mature protein starts at the residue number 85 of the open reading frame. (biu.ac.il)
The sequence of the alpha 2 beta cDNA shows the presence of a single Arg residue between Gln 142 of the alpha 2 chain and Ileu 1 of the beta chain. (rti.org)

Two of these fragments are called soluble amyloid precursor protein (sAPP) and amyloid beta (β) peptide. (medlineplus.gov)
When these protein fragments are released from the cell, they can accumulate in the brain and form clumps called amyloid plaques. (medlineplus.gov)

Phylogenetic tree of A) glycoprotein precursor (GPC), B) nucleoprotein (NP), C) Z protein, and D) L protein. (cdc.gov)
Moreover, transiently expressed glycoprotein precursor molecules varied considerably in both size and carbohydrate content. (duke.edu)

Mammalian von Willebrand factor (VWF), a multifunctional protein involved in maintaining homeostasis. (embl.de)
Mammalian bone morphogenetic protein-binding (BMP-binding) endothelial regulator protein. (embl.de)
Mammalian vitellogenin, a major lipoprotein in many oviparous animals, which is a precursor of a lipid-binding product named as lipovitellin. (embl.de)
Here, we show that APP can coimmunoprecipitate NEEP21 from nontransgenic mouse brain and from mammalian cells stably coexpressing both proteins. (jneurosci.org)

Expression of mouse zonadhesin mRNA is evident only within the testis, and the protein is found exclusively on the apical region of the sperm head. (embl.de)
Pretreatment of rats with antisense peptide nucleic acid targeted to galanin receptor type 1 mRNA abolished the effect of galnon, suggesting mediation of its anticonvulsant properties through this receptor subtype. (phoenixpeptide.com)
In vitro translation of human liver mRNA hybridizing with this cDNA gives a protein mol. (rti.org)

Evidences showed that MPP was involved in the proteolytic maturation of Frataxin, a protein responsible for iron homeostasis. (wikipedia.org)
Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. (peprotech.com)
Prohormone convertase 1 (PC1), mediating the proteolytic processing of neural and endocrine precursors, is thought to be regulated by the neuroendocrine protein proSAAS. (elsevierpure.com)
We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. (frontiersin.org)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
The method can be used for automated detection of chemical/post- translational modifications, quality control of experiments and labelling approaches, and to control the modification settings of protein identification tools. (lu.se)
The goal is to assign acquired spectra to known peptide sequences and potential co- and post-translational modifica- tions. (lu.se)

Scholars@Duke publication: Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization. (duke.edu)
To generate a more representative panel of genetically diverse envelope genes, we PCR amplified, cloned, and sequenced complete gp160 coding regions of 35 primary (peripheral blood mononuclear cell-propagated) HIV-1 isolates collected at major epicenters of the current AIDS pandemic. (duke.edu)
IL-11 can regulate the expression of plasma protein genes in hepatocytes and induce acute phase protein production. (creative-proteomics.com)

Amyloid fibrils are protein polymers comprising identical monomer units (homopolymers). (medscape.com)
The amino acid sequence of mature BDNF is identical in all mammals examined. (rndsystems.com)
The amino acid sequence of GALP-(9-21) was completely identical to that of galanin-(1-13). (phoenixpeptide.com)
Amino acid positions that were identical in four or more of the sequences are in red. (endocrinology-journals.org)
The deduced amino acid sequence consisted of 322 amino acids and was 87% identical to that of Nicotiana tabacum. (biu.ac.il)
The primary amino acid sequence of the two isoforms is identical. (bvsalud.org)

Amyloid-beta precursor protein ( APP ) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons . (handwiki.org)
The etiology of Parkinson's disease (PD) is linked with cellular inclusions in the substantia nigra pars compacta region of the brain that are enriched in the misfolded presynaptic protein α -synuclein ( α S) and death of the dopaminergic neurons. (hindawi.com)
The major constituent of LBs is aggregated α -synuclein ( α S), an intrinsically unfolded protein predominantly localized in the presynaptic regions of dopaminergic neurons. (hindawi.com)

Phylogenetic analysis of Luna virus proteins based on the amino acid sequence, Zambia, 2009. (cdc.gov)
Phylogenetic analyses of full-length env sequences indicated that the panel included members of all major sequence subtypes of HIV-1 group M (clades A to G), as well as an intersubtype recombinant (F/B) from an infected individual in Brazil. (duke.edu)
Phylogenetic analysis of S1 proteins indicated that CK/CH/LDL97Ⅰ/97, Q1, J2 and T3 formed a separated cluster, which might belong to a novel genotype of IBV. (virosin.org)

There are four isoforms of this enzyme, differing by amino acid sequence composition and quaternary structure. (encyclopedia.pub)

The method's focus is to globally detect mass differences, not to assign peptide sequences or modifications to individual spectra. (lu.se)

In the Iowa type, the amino acid aspartic acid is switched with the amino acid asparagine at position 23 (written as Asp23Asn or D23N). (medlineplus.gov)
Second, there are no sugar chain sites associated with aspartic acid. (creative-proteomics.com)

In Drosophila, localized Jeb activates Alk and the downstream Ras/mitogen-activated protein kinase cascade to specify a select group of visceral muscle precursors as muscle-patterning pioneers. (nsjbio.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

A low molecular weight galanin receptor agonist, 7-((9-fluorenylmethoxycarbonyl)cyclohexylalanyllysyl)amino-4-methylcoumarin (galnon) was found to displace (125)I-galanin with micromolar affinity at Bowes cellular and rat hippocampal membranes. (phoenixpeptide.com)
The extent of production is 25-fold higher than in chloroplast from spinach leaves and the recombinant protein presents the relative molecular mass and immunological properties of the natural enzyme from spinach leaf chloroplast. (unipr.it)
Surprisingly, proteins with very different amino acid sequences and three-dimensional structures aggregate into amyloid fibrils that share common characteristics, such as a similar morphology and a specific beta-sheet-based molecular architecture. (uni-goettingen.de)
One of the key molecular events in skin sensitization is protein haptenation, i.e. the chemical modification of self-skin protein(s) thus forming macromolecular immunogens. (cdc.gov)
The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)

After cleavage, the matured PMPCB protein is 49.5 KDa in size and has a theoretical pI of 5.76. (wikipedia.org)
To identify direct protease substrates, you have to further validate substrate candidates by comparing the prime and non-prime amino acids of each identified N-terminus with the protease cleavage motif. (github.io)
The cleavage site sequence was RRTGR. (virosin.org)

These proteins either arise from proteins expressed by cells at the deposition site (localized), or they precipitate systemically after production at a local site (systemic). (medscape.com)
Researchers speculate that it may bind to other proteins on the surface of cells or help cells attach to one another. (medlineplus.gov)
Amino acid positions where a single alanine substitution decreased the activation of the mutant receptor expressed in OS3 adrenal cells are shaded in blue (Chen et al . (endocrinology-journals.org)
The proteins that we take through the diet provide us with the necessary amino acids for the development and maintenance of the cells and tissues of our body. (hi-peptide.com)
A 75 bp sORF [short open reading frame] was found in all clones that protected cells against cell death triggered by a mutant version of amyloid precursor protein (APP), a probable etiology of Alzheimer's disease. (dailynewsmall.com)
Humanin also inhibits cells' apoptosis (the death of cells) by targeting the protein, Bax. (dailynewsmall.com)
There are several cells in which the Bax cytosolic protein is inactive. (dailynewsmall.com)
The lymphoproliferative responses of spleen cells clearly showed that the spleen cells from both groups of mice were able to proliferate in the presence of NP protein. (virosin.org)
The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
Expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. (nsjbio.com)
The knockdown of expression in ALK-mutated cells, but also in cell lines overexpressing the wildtype protein, led to a marked decrease of cell proliferation. (nsjbio.com)
Besides, IL-11 can increase the production of proteins in the liver during acute inflammation, and inhibit the formation of fat cells. (creative-proteomics.com)

Notice that the given digestion enzyme is "ArgC", even if the proteins were digested using trypsin. (github.io)
The tests used for protein C testing can include enzyme-linked immunosorbent assay (ELISA), chromogenic assays, and the activated partial thromboplastin time (aPTT)-based functional protein C assay. (medscape.com)
ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2). (lu.se)

In addition, all subtype E and three subtype G viruses initially classified on the basis of partial env sequences were found to cluster in subtype A in the 3' half of their gp41 coding region, suggesting that they are also recombinant. (duke.edu)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)

It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. (sigmaaldrich.com)
A tetrameric form of α S has also been identified in human tissues that has been postulated as the inactive storage form of this structurally dynamic protein due to its aggregation resistance [ 6 , 7 ]. (hindawi.com)

[ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
An additional common property of aggregation into amyloid fibrils is the presence of partially or fully unfolded states of the misfolding proteins. (uni-goettingen.de)
ins in amyloid fibrils are still only understood in outline.Here in Chapter 3, it is demonstrated, by a combination of solution-state and solid-state NMR spectroscopy, that the structure of amyloid fibrils of á-synuclein (aS) is directly correlated to the conformational properties of the unfolded state and monomeric state of misfolding proteins. (uni-goettingen.de)

If the activity and concentrations of protein C and protein S antigens are normal, this usually indicates clotting regulation is adequate. (medscape.com)

In addition to these factors, mass spectrometric analysis revealed the presence of NEEP21 as a novel interacting protein. (jneurosci.org)
Consequently, a lot of effort is put into identifying the constituent proteins using mass spectrometric methods. (lu.se)

Furthermore, using sequence analysis of human genomic DNA, researchers concluded that the amino acids important for catalysis by COX-1 are conserved and are equally important for catalysis by COX-2. (medscape.com)

The deduced amino acid sequences reveal that ALK is a novel receptor tyrosine kinase having a putative transmembrane domain and an extracellular domain. (nsjbio.com)

The mouse homologue of human CXCL10, CRG-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human CXCL10. (rndsystems.com)
Numerous studies have shown that human nitric oxide (HN) has protective effects on various cell types against stress conditions and apoptosis through modulating signaling systems, such as the JAK/STAT pathway and the BCL-2 family of proteins. (dailynewsmall.com)
Moreover, iron interactions with N-terminally acetylated α S, the physiologically relevant form of the human protein, will be addressed to shed light on the current understanding of protein dynamics and the physiological environment in the disease state. (hindawi.com)
The PC1 inhibitory sequence is mostly confined within a 10-12-amino acid segment near the C terminus of the conserved human proSAAS and contains the critical KR 244 dibasic motif. (elsevierpure.com)
The PC1 inhibitory sequence is mostly confined within a 10-12-amino acid segment near the C terminus of the conserved human proSAAS and contains the critical KR244 dibasic motif. (elsevierpure.com)
To investigate the APP in vivo interactome in an unbiased manner, we generated mice that harbor a mouse prion protein promoter-driven cDNA encoding human APP-695 fused to a C-terminal affinity tag. (jneurosci.org)
It shares 47%, 46% and 54% aa sequence identity with mouse ANG1, mouse ANG2 and human ANG4, respectively. (reliatech.de)
Human biology is tightly linked to proteins, yet most measurements do not precisely determine alternatively spliced sequences or posttranslational modifications. (stanford.edu)
An amino acid sequence from the C-terminus of human ALK (LFRLRHFPCGNVNYGYQQQ) was used as the immunogen for this ALK antibody (100% homologous in human, mouse and rat). (nsjbio.com)
The reference sequence was derived from Ensembl Human sequence AC007283.3.1.127361 . (lu.se)

The additional LE sequence at P1′-P2′, resulted in a competitive substrate cleaved by PC1 at KR 244 ↓ LE 246 . (elsevierpure.com)

Amyloidosis results from the accumulation of pathogenic amyloids-most of which are aggregates of misfolded proteins-in a variety of tissues. (medscape.com)
By controlling access to the brain, the blood-brain barrier (BBB) restricts the entry of proteins and potential drugs to cerebral tissues. (aspetjournals.org)
This protein is found in many tissues and organs, including the brain and spinal cord (central nervous system). (medlineplus.gov)

Humanin has at least two receptors, one of which is the immune-modulating protein-coupled formylpeptide receptor-like-1, which reduces inflammation. (dailynewsmall.com)

The Flemish type is caused by replacement of the amino acid alanine with glycine at position 21 (written as Ala21Gly or A21G). (medlineplus.gov)
The black bar demarcates the amino acid positions where single alanine mutations were made for the experiments presented in Figs 4 and 5 . (endocrinology-journals.org)

We have isolated and characterized a full-length cDNA (1432 bp) from a lambda gt11 library of spinach leaf encoding the complete precursor of the chloroplast isoform. (unipr.it)
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. (bvsalud.org)
The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). (bvsalud.org)

[12] The amyloid beta region of the protein, located in the membrane-spanning domain, is not well conserved across species and has no obvious connection with APP's native-state biological functions. (handwiki.org)
Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
A recently identified membrane-type 6 matrix metalloproteinase (MT6-MMP) has a hydrophobic stretch of 24 amino acids at the C-terminus. (ox.ac.uk)
Using this tag, we prepared mild detergent lysates from transgenic mouse brain cortical membrane preparations and isolated a number of previously identified APP-interacting proteins. (jneurosci.org)
Aβ is liberated from type I integral membrane proteins, termed β-amyloid precursor proteins (APPs), by the concerted action of β-secretase (BACE1) and γ-secretase (for review, see Selkoe, 2002 ). (jneurosci.org)

The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. (novusbio.com)

Apoptosis is induced by the apoptosis-inducing protein Bax (Bcl2-associated X protein), present in both normal development and many disorders. (dailynewsmall.com)

Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and NaCl with BSA as a carrier protein. (novusbio.com)

Likewise, a cDNA clone encoding a molecule comparable to the sodefrin precursor was obtained from a Cynops ensicauda abdominal gland cDNA library. (wiley.com)

Apolipoprotein B segments and the microsomal transfer protein responsible for low-density lipoprotein assembly are believed to be related to the amino acid sequence. (thepoultryhub.com)

Thus, this study demonstrates that using proteomic methods on our transgenic model can uncover important in vivo APP-interacting proteins that will provide insights into the biology of APP. (jneurosci.org)
Thus, this study demonstrates that our transgenic model can uncover important in vivo APP-interacting proteins that will contribute to our understanding of APP processing in in vivo settings. (jneurosci.org)

Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)

Low-density lipoproteins (LDLs), which account for 65% of egg yolk protein, high-density lipoproteins (HDLs), phosvitin, and livetins make up the rest. (thepoultryhub.com)
A large proportion of the protein content of yolk is derived from vitellogenin, which is a precursor to lipoproteins and phosphoproteins. (thepoultryhub.com)

The Mitochondrial-processing peptidase subunit beta precursor protein is 54.4 KDa in size and composed of 489 amino acids. (wikipedia.org)
The majority of mitochondrial proteins is nuclear-coded, which necessitates proper translocations of mitochondrial targeting proteins. (wikipedia.org)
Many mitochondrial proteins are synthesized in a precursor form that contains mitochondria targeting sequence. (wikipedia.org)
It is likely that altered activity of the mitochondrial processing peptidases is essential to ensure the correct maturation of mitochondrial proteins and that altered activity of these proteases will have dramatic effects in the activity, stability and assembly of mitochondrial proteins. (wikipedia.org)
HN is released as a peptide comprising 24 or 21 amino acids, based on the cytoplasmic or mitochondrial translation site, accordingly, cellular stress. (dailynewsmall.com)
Bacterial Bax protein undergoes a conformational shift in response to death stimuli, resulting in its translocation to mitochondrial membranes, where its insertion and apoptogenic proteins are released. (dailynewsmall.com)

Several lipid transport proteins are members of its family. (thepoultryhub.com)
He localized the biologic activity to a fraction of lipid soluble acids that he termed "prostaglandin," hypothesizing that these substances originate in the prostate gland. (medscape.com)

Egg yolks are mainly made up of fat- and water-soluble vitamins and minerals, while egg white contains more protein. (thepoultryhub.com)

In addition to transporting proteins and lipids from the liver through the blood to the growing oocytes, vitellogenin also forms part of the protein in egg yolk. (thepoultryhub.com)
Vitellogenin is a famous Proteins In Egg Yolk that appears in nearly all egg-laying birds, amphibians, reptiles, fish, and invertebrates. (thepoultryhub.com)

Both common and "unusual" N-termini are identified, where "unusual" means that the protein N-terminus was changes. (github.io)
This is best explained by an example: directly after translation, a protein has exactly one N-terminus. (github.io)
When a protease is cutting the protein in half, each half has its own N-terminus. (github.io)
While the N-terminus of the first half protein is exactly the same as the one of the full protein precursor ("native N-terminus"), the N-terminus of the second half is different ("neo-N-terminus") and depends on the amino acid sequence where the protein was cut. (github.io)
It has the characteristic structural motifs of angiopoietins including the coiled coiled domain near the amino-terminus and a fibrinogen like domain at the C-terminus. (reliatech.de)
By removing the 21 amino acid sequence at the N-terminus, it becomes a monomer consisting of 178 amino acids. (creative-proteomics.com)

volume = {285}, number = {32}, pages = {24307--24312}, abstract = {Inhibitory serpins are metastable proteins that undergo a substantial conformational rearrangement to covalently trap target peptidases. (cnrs.fr)

Protein C deficiency is considered mild at plasma levels greater than 20 IU/dL but below the reference range. (medscape.com)
Severe protein C deficiency is a value of less than 1 IU/dL or if protein C is not detectable. (medscape.com)
The severity of the risk is dependent on the magnitude of the deficiency and/or the degree of dysfunction of the protein. (medscape.com)
A thrombin-generation-based test has also been shown to detect protein C deficiency. (medscape.com)
If an acquired deficiency is identified, protein C or protein S concentrations may be monitored occasionally as the underlying condition progresses or resolves. (medscape.com)

Emma Lundberg's group has a wealth of experience in using microscopy to yield biological images that paint a picture of this cell-to-cell heterogeneity of protein expression information, and joining her lab has deepened my expertise in integrating datasets to perform innovative analyses of single-cell protein expression. (stanford.edu)

2) A FASTA protein database for the organism of interest. (github.io)

Many mechanisms of protein function contribute to amyloidogenesis, including "nonphysiologic proteolysis, defective or absent physiologic proteolysis, mutations involving changes in thermodynamic or kinetic properties, and pathways that are yet to be defined. (medscape.com)

Lipovitellin is another essential precursor of proteins in egg yolk. (thepoultryhub.com)

In the Italian type, glutamic acid is replaced with the amino acid lysine (written as Glu22Lys or E22K) and in the Arctic type, glutamic acid is replaced with the amino acid glycine (written as Glu22Gly or E22G). (medlineplus.gov)

All types of amyloid consist of one major fibrillar protein that defines the type of amyloid. (medscape.com)

Anatomy19

Organisms22

Diseases2

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Psychiatry and Psychology1

Phenomena and Processes78

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Health Care1

Residues11

Peptides12

Encodes7

Polypeptide5

Homology5

Accession3

Highly conserved5

Gene7

Substitutions3

Humans1

Nucleic Aci1

Defined as monotropic int1

Residue3

Fragments2

Glycoprotein2

Mammalian4

MRNA3

Proteolytic4

Post-Translational3

Genes3

Identical6

Neurons3

Phylogenetic3

Isoforms1

Peptide sequences1

Aspartic acid2

Mitogen-activa2

Molecular5

Cleavage3

Cells12

Enzyme3

Recombinant4

Inactive2

Amyloid fibrils3

Antigens1

Mass spectrometric2

GENOMIC1

Transmembrane1

Human10

Substrate1

Tissues3

Receptor1

Alanine2

Isoform3

Membrane5

BDNF1

Apoptosis1

Carrier protein1

Molecule1

Lipoprotein1

Vivo2

Quaternary1

Lipoproteins2

Mitochondrial6

Lipid2

Soluble1

Vitellogenin2

Terminus6

Inhibitory1

Deficiency5

Analyses1

FASTA1

Proteolysis1

Lipovitellin1

Lysine1

Fibrillar1