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  • leucine
  • In particular, a leucine (L) to tyrosine (Y) mutation in the S1 segment of AMPA receptors is sufficient to block desensitization, whereas KA receptors naturally contain a tyrosine residue at the equivalent position (Y751 in GluR6) but retain the fast-desensitizing phenotype. (jneurosci.org)
  • Mutation of a leucine residue in the third coiled-coil heptad impaired CWMV CRP activity for suppression of local silencing, but not for the promotion of cell-to-cell movement of Potato virus X (PVX). (biomedsearch.com)
  • histidine
  • Ionic/ionizable groups of the L-valine, L-phenylalanine and L-histidine residues are able to modify the swelling properties of the hydrogel on the basis of their thermodynamic characteristics. (omicsonline.org)
  • mutants
  • We generated a series of GluR6 mutants that converted individual S2 domain residues to their AMPA receptor equivalents. (jneurosci.org)
  • The association constants for the four mutants with the two enzymes show that the enlargement of the volume of the P1 residue is accompanied by an increase of the binding energy, which is more pronounced for bovine chymotrypsin. (rcsb.org)
  • glutamate
  • To test the predictive value of these models, all four stereoisomers of the antagonist 1-(phenanthren-2-carbonyl) piperazine-2,3-dicarboxylic acid (PPDA) were docked into the NR2B glutamate-binding site model. (aspetjournals.org)
  • receptors
  • Various S2 mutations had effects on the kinetics of desensitization and recovery from desensitization, but no single amino acid substitution was found to block desensitization, as in the L/Y mutant AMPA receptors, or to prevent desensitization to KA. (jneurosci.org)
  • experimental
  • Experimental, predicted and calculated NMR chemical shifts for the amino protons and α-, β- and carbonyl carbon atoms of the dehydrated residues are consistent with a significant charge redistribution. (rsc.org)
  • Role
  • In this study, two conserved amino acid residues of CXCR1 on the transmembrane domain (TM) 3 and TM6, \(Leu128^{3.43}\) (L128) and \(Val247^{6.40}\) (V247), respectively, were selectively substituted with other amino acids to investigate the role of these conserved residues in CXCR1 activation. (harvard.edu)
  • pocket
  • Steric repulsion of the P1 Val residue by the walls of the S1 pocket of both enzymes prevents the P1 Val side-chain from adopting the most optimal chi1 value. (rcsb.org)
  • although
  • As things are, you can easily re-define the compositions of the 20 standard amino acids by editing unimod.xml, although this will be inadvisable in most cases. (matrixscience.com)
  • file
  • Within Mascot, the compositions of the amino acid residues are taken from a file called unimod.xml in the Mascot config directory, which contains a dump of the information in the public Unimod database. (matrixscience.com)
  • code
  • The Amino Acid Table widget displays general information on amino acids (name, 3-letter code, 1-letter code, triplet and standard color code) conformed with the IUPAC-IUB recommendations. (bluechillies.com)